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2048 results.
DFG Research Training Group 2485 VIPER Project: Robust algorithms for bioinformatics in virus research.
DFG Graduiertenkolleg VIPER (2485) Projekt: Robuste Algorithmen für die Bioinformatik in der Virusforschung. algorithms for bioinformatics in virus research.
Project Investigators: Prof. Dr. Klaus Jung
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Show Details
FibrOmics - Translating Omics studies into clinically relevant insights for lung fibrosis patients
FibrOmics - Translating Omics studies into clinically relevant insights for lung fibrosis patients
Project Investigators: Prof. Dr. Klaus Jung
Duration: October 2019 until September 2023
Funding: Niedersächsisches Minsiterium für Wissenschaft und Kultur, 201.000 EUR
Project Details:
Das vom Niedersächsischen Minsiterium für Wissenschaft und Kultur geförderte Projekt wird über die integrative Analyse von Transkriptom-Datensätzen zu einem besseren Verständnis der zugrundeliegenden Mechanismen der Lungenfibrose und hieraus ableitbarerer therapeutischer und diagnostischer Strategien führen. Das interdisziplinäre Konsortium mit Partnern der TiHo, der MHH und des Frauenhofer ITEMs verbindet klinische und molekularbiologische Expertise mit bioinformatischen Kompetenzen. Das ermöglicht die Integration von Daten aus der neuartigen Technologie der RNA-Sequenzierung auf Einzelzellebene. Das Projekt verspricht, neue Instrumente zur verbesserten Diagnostik und Therapien der Lungenfibrose zu entwickeln.
Cooperation Partners:

Dr. Davide DeLuca (Medizinische Hochschule Hannover), Prof. Dr. Antje Prasse (Medizinische Hochschule Hannover), Dr. Sylvia Escher (Fraunhofer Institut für Toxikologie und Experimentelle Medizin, Hannover), Dr. Jeanette Koschmann (geneXplain GmbH, Braunschweig)

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New strategies for the therapy of viral neuroinflammation
New strategies for the therapy of viral neuroinflammation
Project Investigators: Prof. U. Kalinke, TWINCORE
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Show Details
Investigation of potential viral etiology and associated pathogenesis in disease syndromes of unknown cause
Investigation of potential viral etiology and associated pathogenesis in disease syndromes of unknown cause
Project Investigators: Prof. Dr. W. Baumgärtner; Madeleine de le Roi
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Results:

https://wwwnc.cdc.gov/eid/article/29/5/23-0172_article

Show Details
DFG Research Training Group 2485 VIPER Project: Hepatitis C virus-related equine hepacivirus cell entry and receptor usage
DFG Graduiertenkolleg VIPER (2485) Projekt: Hepatitis C virus-related equine hepacivirus cell entry and receptor usage
Project Investigators: Paul Becher; Eike Steinmann
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Show Details
Identification of host-specific and viral factors in the transmission of the canine distemper virus between different animal species
Identification of host-specific and viral factors in the transmission of the canine distemper virus between different animal species
Project Investigators: Prof. Dr. A. Beineke; PD Dr. M. Ludlow
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Results:

1) https://pubmed.ncbi.nlm.nih.gov/35491822/

(Geiselhardt F, Peters M, Jo WK, Schadenhofer A, Puff C, Baumgärtner W, Kydyrmanov A, Kuiken T, Piewbang C, Techangamsuwan S, Osterhaus ADME, Beineke A, Ludlow M. Development and Validation of a Pan-Genotypic Real-Time Quantitative Reverse Transcription-PCR Assay To Detect Canine Distemper Virus and Phocine Distemper Virus in Domestic Animals and Wildlife. J Clin Microbiol. 2022 May 18;60(5):e0250521. doi: 10.1128/jcm.02505-21. Epub 2022 May 2. PMID: 35491822; PMCID: PMC9116185.)

 

2) https://pubmed.ncbi.nlm.nih.gov/36038706/

(Geiselhardt F, Peters M, Kleinschmidt S, Chludzinski E, Stoff M, Ludlow M, Beineke A. Neuropathologic and molecular aspects of a canine distemper epizootic in red foxes in Germany. Sci Rep. 2022 Aug 29;12(1):14691. doi: 10.1038/s41598-022-19023-9. PMID: 36038706; PMCID: PMC9424316.)

Show Details
PumaZu - Concept for improvement of animal health and stable environment in turkey barns in Lower Saxony
PumaZu - Konzept zur Verbesserung der Tiergesundheit und Optimierung des Stallklimas in niedersächsischen Putenmastställen
Project Investigators: Schäfers, Stephanie; Kemper, Nicole
Duration: February 2019 until February 2023
Funding: Europäische Innovationspartnerschaft "Produktivität und Nachhaltigkeit in der Landwirtschaft"" (EIP Agri)", 272.300 EUR
Project Details:
Existing ventilation systems in open barns always pose challenges for turkey fatteners, especially in the cold seasons. In order to ensure a sufficient influx of fresh air, the blinds in open barns must be opened even in cold, damp weather. With this form of gravity ventilation, the cold, moist air enters directly into the animal area. As a result, the risk for the occurrence of respiratory diseases and the development of damp litter increases. Therefore, within the framework of this project, the use of a new type of ventilation system in open barns is to be tested in cooperation between turkey fatteners, consultants and science. By modifying existing ventilation systems in open barns, the input of cold supply air is to be reduced without causing a deterioration of the barn climate. In addition, "drinking bars"" will be set up in a second step. This restructuring of the barn interior is intended to create larger resting areas for the animals. At the same time, the aim is to reduce the area where wet litter can occur due to increased water entry. "
Cooperation Partners:

Landwirtschaftskammer Niedersachsen

PAL Stalleinrichtungen GmbH

Praxisbetriebe

Show Details
Development of the prerequisites for a national animal welfare monitoring. Selection and testing of suitable indicators for important terrestrial and aquatic farm animals for husbandry, transport and slaughter. Preparation and publication of a prototype for a monitoring report
Entwicklung der Grundlagen für ein nationales Tierwohl-Monitoring der Nutztierhaltung in Deutschland. Auswahl und Erprobung von geeigneten Indikatoren für die wichtigsten Nutztiere für Haltung, Transport und Schlachtung. Erstellung und Veröffentlichung eines Prototyps für einen Monitoring-Bericht
Project Investigators: Jung-Schroers, Verena
Duration: December 2018 until July 2023
Funding: Bundesanstalt für Landwirtschaft und Ernährung, 290.391 EUR
Project Details:
Tierwohl in der Nutztierhaltung ist ein kontrovers diskutiertes Thema. Gleichzeitig ist die Informationslage zum Stand des Tierwohls äußerst gering. Daten zu tierbezogenen Indikatoren für alle relevanten Gesundheitsbereiche (z.B. Lahmheiten, Verletzungen), Tierverhalten und Emotionen, zu ressourcenbezogenen Indikatoren (z.B. Platzangebot, Haltungsverfahren) und managementbezogenen Indikatoren (z.B. Eingriffe an den Tieren, Fütterung, Dauer der Säugeperiode) liegen kaum bzw. nur vereinzelt und nicht systematisch erhoben, vor. Zwar werden für die terrestrischen Nutztiere einige Daten, aus denen sich Aussagen zum Gesundheitsstatus der Tier und zu einzelnen Aspekten des Tierwohls ableiten lassen, regelmäßig erhoben (z.B. Schlachtbefunde, Antibiotikaverbrauch, Herkunftssicherungs- und Informationssystem für Tiere, Milchleistungsprüfung), sie können bisher aber nicht systematisch und im Zusammenhang ausgewertet werden. Gründe hierfür sind, dass die Daten nicht standardisiert erhoben werden und dadurch nicht vergleichbar sind, nur bestimmte Produktionsrichtungen und Tierarten erfasst werden oder keine Rechtsgrundlage für eine Tierwohl-bezogene Auswertung vorliegt. Ziel des Projektes ist es, die Grundlagen für ein regelmäßiges, indikatorengestütztes Monitoring und eine Berichterstattung über den Status des Tierwohls in der Nutztierhaltung in Deutschland sowie dessen Veränderung über die Zeit zu erarbeiten. Dieses Tierwohl-Monitoring soll die verschiedenen Dimensionen des Tierwohls in den relevanten Lebensabschnitten der Tiere (Haltung, Transport, Schlachtung) berücksichtigen. Neben den wichtigen terrestrischen Nutztieren (Rinder, Schweine, Geflügel) wird auch die Aquakultur einbezogen.
Cooperation Partners:

Thünen-Institut, 38116 Braunschweig

Friedrich-Loeffler-Institut 17493 Greifswald

Kuratorium für Technik und Bauwesen in der Landwirtschaft 64289 Darmstadt Deutschland

Universität Kiel 24098 Kiel Deutschland

Hochschule Osnabrück 49009 Osnabrück Deutschland

Statistisches Bundesamt 65189 Wiesbaden Deutschland

Show Details
Preliminary assessment of the distribution and conservation challenges of the Critically Endangered Microcebus gerpi
Preliminary assessment of the distribution and conservation challenges of the Critically Endangered Microcebus gerpi
Project Investigators: Apl. Prof. Dr. Ute Radespiel
Duration: May 2018 until December 2023
Funding: Houston Zoo, United States DAAD (reinvitation fellowship to RR), 2.364 EUR
Project Details:
The aims of this project are to: determine the limits of the distribution M. gerpi by sampling captured mouse lemurs at varying distances from Sahafina; we use molecular methods to confirm the taxonomic status of all captured mouse lemurs in the study region; determine the sensitivity of M. gerpi to habitat degradation; and based on these findings, formulate recommendations for this species' effective conservation. The chief outcomes of the project will be 1) clarification of the distribution of M. gerpi, and 2) formulation of a conservation action plan for M. gerpi, which will be used to update its IUCN status, and which will be enacted through separately-funded conservation activities including community outreach.
Results:

Rakotondravony, R.; Schüßler, D.; Rovanirina, V.S.R.; Ratsimbazafy, J.; Radespiel, U. (2023): Variation in abundance and habitat use of the Critically Endangered Microcebus gerpi across its fragmented range. Am. J. Primatol., 85(11), e23553. https://doi.org/10.1002/ajp.23553

Van Elst, T.; Schüßler, D.; Rakotondravony, D.; Rovanirina, V.S.T.; Veillet, A.; Hohenlohe, P.A.; Ratsimbazafy, J.H.; Rasoloarison, R.M.; Rasoloharijaona, S.; Randrianambinina, B.; Ramilison, M.L.; Yoder, A.D.; Louis, E.E. Jr.; Radespiel, U. (2023): Diversification processes in Gerp's mouse lemur demonstrate the importance of rivers and altitude as biogeographic barriers in Madagascar's humid rainforests. Ecol. Evol., 13: e10254. https://doi.org/10.1002/ece3.10254

Cooperation Partners:

Prof. Dr. Jonah Ratsinbazafy, University of Antananarivo, Madagascar

Dr. Romule Rakotondravony, Universitity of Mahajanga, Madagascar GERP (Groupe d´étude et de recherches sur les primates de Madagascar)

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Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain
Untersuchung von Mechanismen und Modellen, die die Zugänglichkeit von Therapeutika (IM2PACT) für das Gehirn vorhersagen
Project Investigators: Prof. Osterhaus
Duration: Novemer 2018 until Novemer 2023
Funding: EU, 295.313 EUR
Project Details:
Untersuchung von Mechanismen und Modellen, die die Zugänglichkeit von Therapeutika (IM2PACT) für das Gehirn vorhersagen
Show Details
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