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600 results.
Impact of morbillivirus infections upon respiratory innate immunity and pathology in wildlife carnivores (VIPER)
Auswirkungen von Morbillivirus-Infektionen auf die angeborene Immunität der Atemwege und die Pathologie bei wild lebenden Fleischfressern (VIPER)
Project Investigators: Prof. Andreas Beineke; Florian Wenzel
Duration: April 2025 until March 2028
Funding: DFG (VIPER GRK)
Project Details:
Characterizing the impact of morbilliviruses upon innate responses and the integrity of respiratory epithelial cells.
-Generation and characterization of 3D-culture systems of different wildlife carnivore species
-Analyses of morbillivirus infections upon respiratory tract cells of wild carnivores in vivo and ex vivo
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Optimization of Housing and Feeding in Organic Sow Husbandry to Improve Piglet Health
Optimierung der Haltung und Fütterung in der Öko-Sauenhaltung zur Verbesserung der ferkelgesundheit (Akronym: OHFÖS)
Project Investigators: Kramer, Lydia; Kemper, Nicole
Duration: December 2025 until Novemer 2028
Funding: Bundesanstalt für Landwirtschaft und Ernährung (Bundesprogramm ökologischer Landbau), 231.160 EUR
Project Details:
The overarching objective of the project is to improve the health of suckling and weaned piglets under organic farming conditions in free-farrowing systems and piglet rearing systems through optimized housing and feeding strategies, and to identify approaches for reducing piglet mortality. In addition to adapted housing and nutrition, an improved, farm-specific health and hygiene management system is intended to contribute substantially to stable herd health in organic production systems. Furthermore, the project aims to close existing knowledge gaps and generate new scientific insights for organic sow husbandry and piglet production through the investigation and evaluation of multiple research questions.
Cooperation Partners:

Landwirtschaftskammer Nordrhein-Westfalen

Georg-August Universität Göttingen

Universität Kassel

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AI-assisted control of floor temperatures and microclimate zones for optimal space utilization, improved hygiene, and enhancement of animal welfare in an animal-friendly housing system (AI-OptiTemp)
KI unterstützte Steuerung der Bodentemperaturen und Mikroklimazonen zur optimalen Flächennutzung, verbesserten Hygiene und Steigerung des Tierwohls in einem tiergerechten Birth-to-Finish System (KI-OptiTemp)
Project Investigators: Schumann, Sophia; Schulz, Jochen; Kemper, Nicole
Duration: October 2025 until September 2028
Funding: Gefördert mit Mitteln aus zukunft.niedersachsen, 612/ZERN 7897049-TiHo - Open Call, 301.520 EUR
Project Details:
Animal welfare and animal health are, among other factors, substantially influenced by the barn climate. Establishing an optimal barn climate is a complex task, and additional challenges arise from changes in the external climate.
In this project, conducted in collaboration with partners from academia and industry, barn climate parameters and floor temperatures in a forward-looking, animal-friendly housing system are adjusted on the basis of measurements, AI (artificial intelligence)-supported behavioral observations, and accompanying hygiene monitoring. The aim is to ensure that pigs in the rearing and fattening phases make optimal use of pen structures. At the same time, the project investigates from which point onward barn climate control based on the use of enthalpy values becomes meaningful. Furthermore, based on the collected data, heat transfer processes will be represented within a pen model in order to better understand their effects on the microclimate in individual pens.
Cooperation Partners:

Prof. Dr.-Ing. Markus Richter, Robin Kahlfeld, M. Sc,

Institut für Thermodynamik, Fakultät für Maschinenbau,

Leibniz Universität Hannover

Assoziierte Partner:

Big Dutchman AG

H. Bröring GmbH & Co. KG

VetVise GmbH

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Effects of moderate exercise training on the efficacy of selected antiseizure medications
Einfluss von Ausdauertraining auf die Wirksamkeit ausgewählter Anfallssuppressiva
Project Investigators: Prof. Dr. M. Gernert
Duration: End 2025 until End 2028
Funding: Teilfinanzierung durch die Prof. Dr. Peter und Jytte Wolf - Stiftung für Epilepsie, 19.200 EUR
Project Details:
Etwa ein Drittel aller Humanpatienten und Zweidrittel aller caninen Patienten mit Epilepsien werden mit den vorhandenen Medikamenten nicht anfallsfrei. Die Entwicklung neuer Therapiestrategien gehört daher zu den großen medizinischen Herausforderungen im Bereich der Epilepsieforschung. Pharmakologische Behandlungen mit Anfallssuppressiva (Antiepileptika) sind zudem mit dosis-abhängigen unerwünschten Nebenwirkungen assoziiert, so dass neben der Entwicklung neuer Medikamente zunehmend auch nicht-pharmakologische Begleit-therapien untersucht werden. Regelmäßiges aerobes Ausdauertraining kann einen therapeutischen Einfluss auf epileptische Anfälle haben und zudem eventuell die Wirksamkeit von Medikamenten direkt beeinflussen. Die Projekthypothese ist, dass sich die antikonvulsive Wirksamkeit verschiedener Klassen von Antiepileptika durch Kombination mit geeigneten Trainingsparametern verstärken lässt, so dass eine geringere Dosis der Medikamente für die Behandlung eingesetzt werden muss, was in der Folge das Risiko unerwünschter Nebenwirkungen senken sollte. Als Nebenhypothese postulieren wir, dass die zu verifizierende Wirksamkeitsverbesserung nicht auf eine Veränderung der Plasmakonzentration des Antiepileptikums zurückzuführen ist, sondern auf Veränderungen der Rezeptoren und Kanäle im epileptischen Netzwerk.
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Phenotypical and molecular characterization of short- and long- term lesions in the hamster following SARS-CoV-2 infection with special emphasis on the diffuse endocrine system and nervous system. (VIPER)
Phänotypische und molekulare Charakterisierung von Kurzzeit- und Langzeitschäden einer SARS-CoV-2 Infektion im Hamster, mit besonderem Augenmerk auf das diffuse endokrine System und das Nervensystem. (VIPER)
Project Investigators: Prof. Wolfgang Baumgärtner; Eva Leitzen; Nils Eckmann; Laura Heydemann
Duration: April 2025 until March 2028
Funding: DFG (VIPER GRK)
Project Details:
Motile cilia are microtubule-based, hair-like projections on the luminal membrane of epithelial cells in conducting airways. Through their continuous wave-like beating, they evacuate mucus secreted by goblet cells, thereby contributing to muco-ciliary clearance (MCC). In this function, motile cilia are actors of the first-line defense against inhaled pathogens. Dysregulated cilia will have a long-term effect on MCC and predispose for further diseases. Similarly, the diffuse endocrine system plays an essential role in respiratory tract imbalances. However, underlying pathogenetic mechanisms are not well understood, neither in various organs nor in the trachea and larynx. Therefore, the envisioned study will enhance our understanding of short- and potential long-term effects of SARS-CoV-2 infection in the upper respiratory tract and its associated endocrine and nervous system.
Cooperation Partners:

Institut für Virologie, Universität Münster,

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, U.S.A (Klaus Schughart),

Helmholtz-Zentrum für Infektionsforschung (HZI), Braunschweig (Robert Geffers),

Medizinisch Hochschule Hannover (Peter Claus)

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Isolation and characterisation of the microbiome and microbially associated peptides and their influence on the immune system of reptiles
Isolation und Charakterisierung des Mikrobioms sowie mikrobiell assoziierter Peptide und deren Einfluss auf das Immunsystem von Reptilien
Project Investigators: Hetterich; Pees
Duration: 2025 until 2028
Project Details:
Charakterisierung Darmflora und deren Einfluss aus das Immunsystem bei Reptilien
Show Details
Correlation of microglial morphology and their transcriptomic signature in TMEV-infected OT-I and OT-II mice with and without adoptive transfer of GFP/RFP expressing CD8+ and CD4+ T cells
Korrelation der Mikroglia-Morphologie und ihrer transkriptomischen Signatur in TMEV-infizierten OT-I- und OT-II-Mäusen mit und ohne adoptiven Transfer von GFP/RFP-exprimierenden CD8+ und CD4+ T-Zellen
Project Investigators: Prof. Andreas Beineke; Prof. Wolfgang Baumgärtner; Charlotte Sophie Kinder; Anna Reiß
Duration: April 2025 until March 2028
Funding: DFG (VIPER GKR)
Project Details:
This project aims to investigate the effect of an early (3 days post infection [dpi]) and a late (8 dpi) adoptive transfer of green (GFP) and red fluorescent (RFP) T- cells on the microglial morphology and transcriptomic data in TMEV- infected OT-I and OT-II mice. The contribution of CD8+ and CD4+ T cell subsets for viral clearance and course of clinical disease will be investigated individually as well as the general pathomorphology and immune response with special focus on microglia morphology and transcriptomic data.
Cooperation Partners:

Institut für Neuroimmunologie und Multiple-Sklerose-Forschung der Universitätsmedizin Göttingen

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DFG Research Training Group 2485 VIPER Project: Role of salivary gland tissue in infection of pigs with respiratory and intestinal viruses
DFG Graduiertenkolleg VIPER (2485) Projekt: Die Bedeutung des Speicheldrüsengewebes bei der Infektion von Schweinen mit respiratorischen und intestinalen Viren
Project Investigators: Paul Becher
Duration: April 2025 until March 2028
Funding: DFG, 250.000 EUR
Project Details:
It is well known that a number of viral pathogens can be detected in saliva of infected humans and animals. However, for most of these viruses the source of their presence in saliva and in the oral cavity remains unknown. While it has been reported that human salivary glands can be infected by SARS-CoV-2 and some other viruses, the role of salivary gland tissues in infection of pigs with respiratory and most enteric viruses has not been addressed so far. To characterize infection of porcine salivary glands by both respiratory viruses (influenza A virus, porcine respiratory coronavirus) and enteric viruses (transmissible gastroenteritis virus, porcine rotavirus A), differentiated salivary gland epithelial cells and organoid cultures from pigs were established by the group of the PI. In addition to porcine influenza viruses, human and avian influenza viruses will be used to investigate a possible role of porcine salivary glands in interspecies transmission and evolution of influenza virus.
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DFG Research Training Group 2485 VIPER Project: Viral infections of the bovine placenta: role of innate immunity and mechanism of diaplacental transmission
DFG Graduiertenkolleg VIPER (2485) Projekt: Virale Infektionen der bovinen Plazenta: Rolle der angeborenen Immunität und Mechanismus der diaplazentaren Übertragung
Project Investigators: Paul Becher
Duration: April 2025 until March 2028
Funding: DFG, 250.000 EUR
Project Details:
The bovine epithelia-choreal placenta protects the fetus from infections with numerous pathogens. However, some viruses, such as bovine viral diarrhea virus (BVDV) or bluetongue virus, are able to cross the placenta barrier during pregnancy. In the case of BVDV, diaplacental infection with non-cytopathogenic (ncp) viruses between the 40th and 125th day of gestation is a mandatory prerequisite for the establishment of persistent infections and is therefore of outstanding epidemiological importance. In contrast, infection of pregnant animals with cytopathogenic (cp) BVDV does not lead to the birth of persistently infected offspring.
An important aspect of the placenta's barrier function against pathogens is innate immunity. First, we want to investigate the innate immune response of polarized bovine placenta cells to dsRNA applied to either the basolateral or apical compartment. Moreover, we will examine the efficiency of viral replication and release of BVDV and other bovine viruses, and characterize the innate immune response after basolateral and apical infection.
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GRK VIPER 3/80-9- Glycoprotein-mediated immune evasion mechanisms of human and animal pneumoviridea
GRK VIPER 3/80-9- Glykoprotein-vermittelte Mechanismen der Immunabwehr von Pneumoviren bei Mensch und Tier
Project Investigators: Prof. Rimmelzwaan
Duration: April 2025 until March 2028
Funding: DFG, 45.000 EUR
Project Details:
Glycoprotein-mediated immune evasion mechanisms of human and animal pneumoviridea
Show Details
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