TiHo Hannover Logo
    • The TiHo
      • About TiHo
      • Mission Statement
      • Foundation
      • Presidium
      • Prizes and Honors
      • Funding opportunities
      • TiHo Alumni Network
      • Society of Friends of the TiHo
      • Veterinary Medicine History Museum and University Archive
    • Career
      • Personnel Development
    • Administration
      • IT-Service
      • Event Management & Room Rental
    • News & Publications
      • News
      • Events
    • International Academic Office
      • International Academic Office
    • Employee Representatives
      • Staff Council
    • Equal Opportunities Office
      • Equal Opportunities Office Home
      • Equal Opportunity
      • Family
      • Diversity
      • about us
    • Library
      • Library
      • Borrowing and Ordering
      • Search and Find
      • Learning and Working
      • Writing and Publishing
    • General information for students
      • Contact
      • Lecture periods and re-registration
      • Lecture catalogue
      • TiHo online portals for studying and teaching
      • Counselling and support services
      • International Academic Office
    • For prospective students
      • Veterinary medicine
      • Studying biology
      • Studying food technology
    • For students
      • Veterinary medicine
      • Biology
      • Food Process and Product Engineering
    • Student life
    • Doctoral studies
      • Doctoral studies Dr. med. vet.
      • Doctoral studies Dr. rer. nat.
      • Enrollment, re-registration and de-registration
    • PhD & Graduate School
      • Graduate School HGNI
      • PhD Programme "Animal and Zoonotic Infections"
      • PhD Programme "Systems Neuroscience"
      • PhD Programme "Veterinary Research and Animal Biology"
    • Centre for Teaching
      • Information about the centre for teaching
      • E-Learning Service
    • Clinics
      • Clinic for Poultry
      • Department of Small Mammal, Reptile and Avian Medicine and Surgery
      • Clinic for Small Animals
      • Clinical Centre for Farm Animals
      • Clinic for Horses
      • Unit for Reproductive Medicine
    • Institutes
      • Institute for Anatomy
      • Institute of Biochemistry
      • Institute of Biometry, Epidemiology and Information Processing
      • Institute for Immunology
      • Institute of Food Quality and Food Safety
      • Institute of Microbiology
      • Institute for Parasitology
      • Department of Pathology
      • Department of Pharmacology, Toxicology and Pharmacy
      • Institute of Physiology and Cell Biology
      • Institute of Terrestrial and Aquatic Wildlife Research (ITAW)
      • Institute for Animal Nutrition
      • Institute of Animal Genomics
      • Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour (ITTN)
      • Institute of Animal Ecology
      • Institute of Virology
      • Institute of Zoology
    • Special units and Research Centers
      • Institute of General Radiology and Medical Physics
      • Research Center for Emerging Infections and Zoonoses
    • Field stations
      • Field Station for Epidemiology (Bakum)
      • Institute of Terrestrial and Aquatic Wildlife Research
      • WING - Science for innovative and sustainable poultry farming
  • DE
  • EN
Emergency
HomepageClinics & InstitutesInstitutesInstitute of Physiology and Cell BiologyResearch

Research

  • Physiology
    • Prof. Dr. Gemma Mazzuoli-Weber
    • Neurogastroenterology Team
      • Kristin Elfers, PhD
      • Videos
    • Gastrointestinal Physiology Team
      • Gastrointestinal Physiology Team
      • Melanie Brede, PhD
      • Dr. rer. nat. Alexandra Muscher-Banse
    • Organoid Research Group – The Pig as a Model System
      • Pascal Hoffmann, PhD
  • Cell Biology Team
    • Cell Biology Team
    • Team
    • Home
      • Teaching
      • Events and News
    • Research
      • Research
      • Methods
      • Publications
    • Contact us
  • Research
  • Teaching
  • Publications
  • History
  • Precision mechanic workshop
    • Precision mechanical workshop
    • Gallery
924 results.
-
Digestibility of Nutrients
Project Investigators: Prof. Dr. C. Visscher; Dr. J. Hankel
Duration: Novemer 2021 until January 2022
Funding: Industry (Veterinary pharmaceuticals/Vaccines), 141.855 EUR
Project Details:
-
Show Details
Determination of the sound level in nursery compartments for pigs with regard to animal welfare and human health and safety
Ermittlung des Schallpegels in der Ferkelaufzucht mit Bezug zu Tier- und Arbeitsschutz
Project Investigators: Kroll, Laura; Fels, Michaela; Kemper, Nicole
Duration: May 2021 until Novemer 2022
Funding: QS-Wissenschaftsfonds, 30.000 EUR
Project Details:
The aim of this study is to determine the sound level in pigs' nursery compartments and to detect the effects of animal behaviour and barn technology on the sound level.
In addition, occupational safety will be considered in the study by identifying particular sound events to which both, animals and humans are exposed, and quantifying them with regard to the sound pressure level. The aim is to generate representative data on noise pollution in today's piglet rearing in Germany, to determine the origin of noise pollution and - if necessary - to identify potential for improvement in terms of animal welfare and occupational safety.
Results:

https://doi.org/10.1016/j.livsci.2024.105410

Show Details
Detection Dogs as first line screening method for SARS-CoV-2-infections
Detection Dogs as first line screening method for SARS-CoV-2-infections
Project Investigators: Holger Volk; Friederike Twele; Claudia Schulz
Duration: September 2021 until September 2022
Funding: COVID 19 Forschungsnetzwerk Niedersachsen COFONI, 48.638 EUR
Project Details:
Early detection of individuals with a SARS-CoV-2 infection remains the most important tool to interrupt the chain of infection. Several studies have already proven canines’ extraordinary olfactory acuity to detect SARS-CoV-2-infected individuals. However, with increasing knowledge about the virus, the variety and chronicity of the disease expression and an increase in the number of people that are vaccinated, some questions have not yet been answered. We will test a variety of hypotheses to further explore the use of detection dogs as a screening method for SARS-CoV-2-infections.
Results:

Dogs can distinguish SARS-CoV-2-infections from other viral infections. However, compared to earlier studies our scent dogs achieved lower diagnostic sensitivities. To deploy COVID-19 detection dogs as a reliable screening method it is therefore mandatory to include a variety of samples from different viral respiratory tract infections in dog training to ensure a successful discrimination process.

https://doi.org/10.3389/fmed.2021.749588

Cooperation Partners:

Medizinische Hochschule Hannover

Show Details
Back to culture
Back to culture - Corona-Spürhunde
Project Investigators: Holger Volk; Friederike Twele; Maren von Köckritz Blickwede; Claudia Schulz; Albert Osterhaus
Duration: June 2021 until July 2022
Funding: Niedersächsische Ministerium für Wissenschaft und Kultur, 1.225.000 EUR
Project Details:
Auf das Coronavirus trainierte Spürhunde werden in diesem Herbst bei mehreren Musikveranstaltungen eingesetzt und mit Antigen- und rtRT-PCR-Tests verglichen. Dies wird weitere Erkenntnisse darüber liefern, wie Corona-Spürhunde am besten bei der Detektion infizierten Menschen eingesetzt werden können.
Results:

www.backtoculture.de

Cooperation Partners:

Medizinischen Hochschule Hannover,

Universitätsklinikum Hamburg-Eppendorf,

Hannover Concerts,

Proevent,

Awias Aviation Services

Show Details
Basis_SOUVER@N - Creation of optimal, basic framework conditions for sustainable cross-university cooperation in Hochschule.digital Niedersachsen and the implementation of the SIHL project.
Basis_SOUVER@N - Schaffung optimaler, basaler Rahmenbedingungen für die nachhaltige hochschulübergreifende Kooperation in der Hochschule.digital Niedersachsen und die Durchführung des SIHL-Projekts
Project Investigators: Dr. Elisabeth Schaper
Duration: July 2021 until December 2022
Funding: Ministerium für Wissenschaft und Kultur (MWK) Niedersachsen, 127.000 EUR
Project Details:
Basis_SOUVER@N supports the joint project SOUVER@N through accompanying measures. The project aims to strengthen the cooperation of experts and to identify the heterogeneous technical and organizational framework conditions of the universities participating in the SOUVER@N joint project and to promote their compatibility.
Results:

An der Stiftung Tierärztliche Hochschule (TiHo) wurden im Rahmen des Verbundprojektes u.a. technische Voraussetzungen für die digitale Lehre erweitert sowie Dozierende beim digitalen Lehren und Studierende beim digitalen Lernen unterstützt. Anleitungen zur digitalen Lehre und zu digitalen Lerntechnologien wurden neu erstellt oder überarbeitet. Für Studierende wurde ein neues virtuelles Mikroskop für das Selbststudium geschaffen. Lehrveranstaltungsräume wurden mit Technik für die hybride Lehre bzw. für Vorlesungsaufzeichnungen ausgestattet, das Lernmanagementsystem Moodle, welches an der TiHo eingesetzt wird, wurde erweitert.

Cooperation Partners:

1) Universität Osnabrück

2) Carl von Ossietzky Universität Oldenburg

3) Leuphana Universität Lüneburg

4) Technische Universität Clausthal

5) Stiftung Universität Hildesheim

6) Universität Vechta

7) Medizinische Hochschule Hannover

8) ELAN e.V.

Show Details
Field study on sheep grazing in grasslands with common ragwort (Senecio jacobaea) from point of view of animal health and nature conservation
Feldstudie zur Schafbeweidung von Grünland mit Jakobs-Greiskraut (Senecio jacobaea) aus tiergesundheitlicher und naturschutzfachlicher Sicht
Project Investigators: Sabine Aboling; Martin Ganter
Duration: April 2020 until March 2022
Funding: Stiftung Naturschutz Schleswig-Holstein Eschenbrook 4 24113 Molfsee Behörde für Umwelt, Klima, Energie und Agrarwirtschaft (BUKEA) Neuenfelder Straße 19 21109 Hamburg Ministerium für Energiewende, Landwirtschaft, Umwelt, Natur und Digitalisierung des Landes Schleswig-Holstein (MELUND) Mercatorstr. 3 24106 Kiel, 156.504 EUR
Project Details:
Common ragwort (Senecio jacobaea L.) is a worldwide established plant containing toxic pyrrolizidine alkaloids (PA), which can lead to liver cirrhosis in livestock, especially cattle and
horses. Controlling ragwort, particularly in conservation areas, is difficult. As sheep seem more resistant to PA, sheep might be a natural defense against the observed spread of ragwort. We tested this in a two-year study on a ragwort-rich pasture with 12 sheep/hectare from May to October 2020-2021. We addressed three questions: (1) To what extent do sheep voluntarily ingest ragwort? (2) In what respect do feeding behavior and nutritional parameters correlate? (3) What impact does grazing have on the yield proportion and number of flowers of dominant plants?
Results:

We showed that sheep preferred ragwort without any harmful effects. The more ragwort was available and the more it contained

sugar, the higher the amount ingested by the sheep. Ragwort accounted for a significantly lower yield proportion of ingested biomass in the second year even though its number of flowers doubled. The yield of biomass of other herbs increased. From the point of view of animal health and nature conservation, sheep grazing on ragwort might be an option to reduce the amount of ragwort in pastures.

Cooperation Partners:

Universität Hamburg

Abteilung Angewandte Pflanzenökologie

Ohnhorststr. 18

22609 Hamburg


Dr. Aiko Huckauf

Stiftung Naturschutz Schleswig-Holstein

Eschenbrook 4

24113 Molfsee

Show Details
COVID-Protect - Efficacy of Nrf2 activators for preventing cell injury in COVID-19 - Subproject toxicity and efficacy studies
COVID-Protect - Wirksamkeit von Nrf2 Aktivatoren für die Verhinderung von Zellschädigung bei COVID-19 - Teilprojekt Toxizitäts- und Wirksamkeitsstudien
Project Investigators: Prof. Dr. Gisa Gerold
Duration: July 2020 until June 2022
Funding: BMBF, 261.911 EUR
Project Details:
Inflammation and associated lung injury, such as the acute respiratory distress syndrome (ARDS) are major causes of morbidity and and mortality in COVID-19. The Nrf2 transcription factor activates a comprehensive cell-protective and anti-inflammatory program. It is known from mouse models that pharmacological activation of Nrf2 and induction of this program protects animals from LPS-induced ARDS. In a cell line-based screen for agents against COVID-19, we found 2 Nrf2 activators that prevent the cytopathic effect of SARS-CoV-2 at nontoxic doses. Therefore, the aims of the present project are,
- the establishment of infection models based on
human respiratory epithelial cells, a model for the alveolar
epithelial cell barrier, and ex vivo culture of lung explants,
- Evaluation of the importance of the endogenous Nrf2 program for
the cellular response against SARS-CoV-2, and
- Verification of the 2 identified Nrf2 activators and
identification of additional protective agents via a
comprehensive screening of known Nrf2 activators.
Cooperation Partners:

PD Dr. Frank Pessler, Helmholtz-Zentrum für Infektionsforschung, Hannover

Show Details
PAC-CAMPY - Prevention and Control of Campylobacter-Infections - A "One-Health"-Approach - Specific mitigation strategies for reduction of Campylobacter along the food chain - second funding phase
PAC-CAMPY - Prävention und Bekämpfung von Campylobacter-Infektionen - Ein "One-Health"-Ansatz - Spezifische Minimierungsstrategien zur Reduktion von Campylobacter entlang der Lebensmittelkette - zweite Förderphase
Project Investigators: Prof. Dr. Madeleine Plötz; Dr. Sophie Kittler; Dr. Elisa Peh
Duration: October 2020 until September 2022
Funding: Drittmittelprojekt, gefördert durch Bundesministerium für Bildung und Forschung., 125.591 EUR
Project Details:
In the second funding period of this sub-project within the Pac-Campylobacter consortium, it aims at combining optimized measures in a synergistic large scale arrangement for reducing Campylobacter spp., meeting the requirements of commercial broiler production and livestock farming. This approach focuses on a combined application of different measures in a "One Health" approach along the entire food chain to reduce the public health risk effectively in a sustainable manner and provide practical support for veterinary public health authorities regarding this issue.
Results:

Poster Abstracts:

1. Bogun K, Peh E, Siekmann L, Plötz M, Kittler S; Untersuchungen zur Anwendung ausgewählter Säuren und Pflanzenextrakte sowie deren Kombination als Reduktionsmethode von Campylobacter spp. auf Hähnchenfleisch. 62. Arbeitstagung des Arbeitsgebietes Lebensmittelsicherheit und Verbraucherschutz der DVG, 25. bis 28. Oktober 2022

2. Bogun K, Peh E, Plötz M, Kittler S; Combination of a phage cocktail and an organic acid cocktail to reduce Campylobacter in broiler chickens - Examination of possible synergistic effects. 2nd German Phage Symposium, 23.-24.5.2022 Universität Hohenheim

3. Bogun K, Peh E, Siekmann L, Plötz M, Kittler S; Examination of selected organic acids and plant extracts and their combination as a reduction method against Campylobacter on chicken meat Zoonoses 2022 - International Symposium on Zoonoses Research 05.-07.10.2022 Berlin

Show Details
Optimization of bull semen for increased reproductive performance using microfluidic chips
Optimierung von Bullensperma für gesteigerte Reproduktionsleistung mittels mikrofluidischer Chips
Project Investigators: Bajcsy, Arpad Csaba; Oldenhof, Harriette
Duration: July 2020 until March 2022
Funding: Karl-Eibl-Stiftung (Form: Stipendium: 900€/Mo für Doktorand), 18.900 EUR
Project Details:
The aim of the first part of the dissertation project is to establish an innovative technology as a method of separating bull semen. The basis of this technology is the use of microfluidic chips. The second part of the project is to use this technology in genetically valuable breeding bulls whose ejaculates contain less than 70% forward-motility sperm. This technology could also be used to improve the quality of sex sorting of spermcells.
Results:

In this work we used samples with artificially induced damage for establishing protocols for flow cytometric analysis of sperm viability, as well as computer assisted analysis of sperm motility patterns. Moreover, we found that samples previously enriched with damaged sperm were especially useful for testing the effectiveness of different sperm selection procedures.

 

The major aim of this work was to evaluate how microfluidic chips perform in selecting high quality sperm, i.e., in comparison to other techniques such as swim-up and percoll density gradient centrifugation. In addition, we planned to test if sperm selected, using microfluidic chips exhibit better motility behavior, increased fertilization capacity in vitro, and wanted to evaluate the performance with the flow cytometric X/Y-sperm sorting.

 

Both, freshly diluted and cryopreserved sperm were tested also taking into account the variation among individuals. We determined that when using microfluidic sorting and swim-up methods, sperm recovery was low, however, sperm were of superior quality. Sperm recovery was higher after using percoll density gradient centrifugation, but this coincided with the presence of increased numbers of membrane damaged and motile sperm. In addition, the presence of a relatively high ratio of motile sperm in high quality sperm samples exhibited characteristic kinematic parameters including increased movement velocity and linearity; which was maintained when specimens were investigated in viscous media, mimicking oviductal fluid. In our hands, when compared with ordinary processing, remained that the increased sperm quality after microfluidic selection did not result an increased in vitro embryo production. Nonetheless, performing microfluidic sperm selection prior to flow cytometric sorting of X/Y-sperm appeared beneficial; since this improved initial sperm quality to required levels, reduced contents of debris and dead sperm during FACS sorting, and enabled to significantly improve sorting speed and the correctly oriented X-chromosome bearing sperm numbers in the population.

 

In conclusion, the use of microfluidic chips has great potential in reproductive medicine and veterinary assisted reproduction technologies. This is not only beneficial for any easier selection and enrichment of high quality sperm samples, which are more likely to fertilize an oocyte, but as a processing step, also for fulfilling the requirements needed for successful flow cytometric sorting of X/Y chromosome bearing sperm.

The use of microfluidic chips has great potential in reproductive medicine and veterinary assisted reproduction technologies. This is not only beneficial for any easier selection and enrichment of high quality sperm samples, which are more likely to fertilize an oocyte, but as a processing step, also for fulfilling the requirements needed for successful flow cytometric sorting of X/Y chromosome bearing sperm.

https://elib.tiho-hannover.de/receive/tiho_mods_00012249

Cooperation Partners:

Calisici, Oguz, Phytobiotics GmbH

Alkabes, Stephane, Masterrind GmbH Verden

Show Details
TBENAGER 2: Impact of population-based differences in ticks from natural herds on TBE virus transmission
TBENAGER 2: Einfluss von Populations-basierten Unterschieden in Zecken aus Naturherden auf die Übertragung des FSME Virus
Project Investigators: Prof. Osterhaus
Duration: September 2020 until August 2022
Funding: BMBF, 46.843 EUR
Project Details:
The aim of the project is to determine the genetic diversity of "tick-borne encephalitis virus" (TBEV; German:
Tick-borne encephalitis (TBE) virus) and the virus-specific T cell response
characterize. The hypothesis applies that TBEV-specific T cell responses with
different phenotypes and different protein specificity for protection or for
Neuropathogenesis of TBEV infections in humans and mice help to substantiate. the
detailed characterization of the T-cell immune response in humans and mice forms the basis for
future research on improved vaccines that more specifically stimulate the immune system and thus
could provide stronger and longer-lasting immunization protection.
Show Details
  • «
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
  • 11
  • 12
  • 13
  • 14
  • 15
  • 16
  • 17
  • 18
  • 19
  • 20
  • 21
  • 22
  • 23
  • 24
  • 25
  • 26
  • 27
  • 28
  • 29
  • 30
  • 31
  • 32
  • 33
  • 34
  • 35
  • 36
  • 37
  • 38
  • 39
  • 40
  • 41
  • 42
  • 43
  • 44
  • 45
  • 46
  • 47
  • 48
  • 49
  • 50
  • 51
  • 52
  • 53
  • 54
  • 55
  • 56
  • 57
  • 58
  • 59
  • 60
  • 61
  • 62
  • 63
  • 64
  • 65
  • 66
  • 67
  • 68
  • 69
  • 70
  • 71
  • 72
  • 73
  • 74
  • 75
  • 76
  • 77
  • 78
  • 79
  • 80
  • 81
  • 82
  • 83
  • 84
  • 85
  • 86
  • 87
  • 88
  • 89
  • 90
  • 91
  • 92
  • 93
  • »

TiHo-Services

  • University
  • Studies & Education
  • Clinics & Institutes

Information

  • Emergency service
  • How to get here

Contact

Stiftung Tierärztliche Hochschule Hannover
Bünteweg 2
30559 Hannover

Tel.: +49 511 953-60
Fax: +49 511 953-8050
info@tiho-hannover.de
www.tiho-hannover.de

Contact to the clinics & institutes

Facebook-Logo youtube-Logo Instagramm-Logo LinkedIn-Logo
  • Legal Information
  • Data Privacy
  • Whistleblower-System
  • Contact
© 2026 Stiftung Tierärztliche Hochschule Hannover