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2298 results.
SARS-CoV-2 infection in 20-month-old mice
SARS-CoV-2-lnfektion in 20-Monate alten Mäusen
Project Investigators: Maren von Köckritz-Blickwede
Duration: August 2023 until December 2023
Funding: HZI, 17.149 EUR
Project Details:
SARS-CoV-2 infection in 20-month-old mice
Show Details
Integrated One Health Surveillance for Antimicrobial Resistance (IT-AMR)
Integrierte One-Health-Überwachung der Resistenz gegen antimikrobielle Mittel (IT-AMR)
Project Investigators: Prof. Dr. L. Kreienbrock; Dr. S. Brogden
Duration: October 2022 until September 2023
Funding: Deutsche Forschungsgemeinschaft (DFG), 27.998 EUR
Project Details:
Antibiotic resistance is a growing public health problem worldwide and particular a challenge in low- and middle-income countries (LMICs). In order to combat antibiotic resistance, it is necessary to address this in line with the One Health approach.
The aim of the project is to develop a harmonized protocol for monitoring data on antibiotic resistance in an integrated One Health approach for humans, animals and the environment and to link the data from all three One Health areas directly with each other. Furthermore, the transmission pathways of antibiotic resistance or resistance genes are to be evaluated in order to be able to take measures against the transmission and development of resistance. Support for the development of international collaboration with cooperation partners from sub-Saharan Africa served to expand cooperation through on-site visits, discussions on currently used protocols and the identification of potential challenges.
Cooperation Partners:

- Department of Disease Control, School of Veterinary Medicine University of Zambia, Lusaka, Zambia

- Department of Disease Control & Environmental Health, Makerere University School of Public Health, Kampala, Uganda

Show Details
Module: Game over for risks in the workplace - VetSafetyGame: The game for occupational safety and infection protection in veterinary medicine - Innovation plus 2022/23 No. 48
Modul: Game over für Risiken am Arbeitsplatz - VetSafetyGame: Das Spiel zur Arbeitssicherheit und Infektionsschutz in der Tiermedizin - Innovation plus 2022/23 Nr. 48
Project Investigators: von Köckritz-Blickwede, Maren
Duration: March 2022 until December 2023
Funding: Niedersächsischen Ministerium für Wissenschaft und Kultur , 50.000 EUR
Project Details:
Veterinarians and their employees have a relatively high risk of accidents at work, whether in the clinic, in the diagnostic laboratory or in research. Occupational accident and illness risks in the workplace can be reduced through systematic prevention. Only those who know the specific risks and exposures can minimize them. Safety and health during studies, and later at work in the long term, are the areas that everything should revolve around here. Experience has shown that occupational safety and infection prevention are not the most popular topics and are often only considered relevant once a risk factor has been acutely identified or an accident has already occurred.
The aim of this project is to generate a game-based and collaborative course that uses interactive and digital elements as well as a workshop-based face-to-face event to convey the topic of active occupational safety using memorable practical examples and thus accompany the participants throughout their studies. The aim is to create a profound understanding with long-lasting learning success.
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Ligands of integrins for therapy against COVID-19
Liganden von Integrinen für die Therapie gegen COVID-19
Project Investigators: von Köckritz-Blickwede, Maren
Duration: January 2022 until December 2023
Funding: TU München, 158.232 EUR
Project Details:
We hypothesize that the stabilization of the vascular system by low-dose ligands to activate the integrin αvβ3 should have beneficial effects on COVID-19 infected patients. We here investigate the effects of the synthetic ligand cylengitide and 29P for integrin αvβ3 in an animal model of SARS-CoV-2 infected hamsters in which the destruction of the vascular system in association with formation of neutrophil extracellular traps has previously been documented.
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Frauenhofer ITEM- Therapeutic treatment against SARS-CoV-2 with inhaled VHH from BiondVax - Efficacy program in hamsters
Frauenhofer ITEM- Therapeutische Behandlung gegen SARS-CoV-2 mit inhaliertem VHH von BiondVax - Wirksamkeitsprogramm bei Hamstern
Project Investigators: Prof. Dr. Maren von Köckritz-Blickwede
Duration: September 2022 until September 2023
Funding: Frauenhofer ITEM, 278.466 EUR
Project Details:
Frauenhofer ITEM-Therapeutic treatment against SARS-CoV-2 with inhaled VHH from BiondVax - Efficacy program in hamsters
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COFONI Flex Fund CRISPR 11FF22
COFONI Flex Fund CRISPR 11FF22
Project Investigators: Prof. Dr. Maren von Köckritz-Blickwede; Prof. Dr. Albert Osterhaus; Prof. Dr. Asisa Volz
Duration: February 2022 until December 2023
Funding: MWK, 220.890 EUR
Project Details:
CRISPR/Cas13-mediated antiviral therapy against SARS-CoV-2 and its variants: a novel technology to target viral genome
Results:

https://www.umg.eu/forschung/corona/cofoni/

Show Details
Nsp15 inhibitors for preventing future viral pandemics (Nsp15 VIPA) (COFONI FLEX Fund 9FF22)
Nsp15-Inhibitoren zur Verhinderung künftiger viraler Pandemien (Nsp15 VIPA) (COFONI FLEX Fund 9FF22)
Project Investigators: Prof. Dr. Maren von Köckritz-Blickwede
Duration: April 2022 until December 2023
Funding: MWK, 22.000 EUR
Project Details:
The importance of the highly conserved protein Nsp15 for the infection of cells by coronaviruses has been studied in detail in recent years. As an endonuclease, it rapidly recognizes and degrades both single-stranded (ssRNA) and double-stranded RNA (dsRNA). In addition, evidence from animal models suggests immunomodulatory properties of Nsp15 during early viral infection, leading to a delayed immune response. This process is ultimately involved in the development of acute respiratory failure, which is the main cause of COVID-19 mortality. As part of this funding program, we plan to develop new inhibitors of this protein through structure-guided design. Promising compounds will be characterized with respect to their ADME and physicochemical properties in order to obtain orally bioavailable compounds for the treatment of future viral pandemics.
Results:

https://www.umg.eu/forschung/corona/cofoni/

Show Details
Interprofessional teamcommunication for the veterinary practice
Interprofessionelle Teamkommunikation für die tierärztliche Praxis
Project Investigators: Dr. Christin Kleinsorgen; Dr. Sandra Wissing; Dr. Verena Nerschbach
Duration: May 2022 until December 2023
Funding: Niedersächsisches Ministerium für Wissenschaft und Kultur , 50.000 EUR
Project Details:
Within a blended learning event, content on interprofessionalism and teamwork is delivered across professional groups via self-study units in TiHoMoodle, in video conferences and in live events in the communication room in the Clinical Skills Lab. With the help of actors, relevant aspects of communication between veterinarians and veterinary assistants as well as animal owners are simulated and practiced so that the foundation can be laid for effective and harmonious collaboration in veterinary practice.
Results:

OER-Beitrag: https://www.twillo.de/edu-sharing/components/collections?id=784dd823-e75e-48ed-a8c3-6de63136b02b

https://doi.org/10.3390/ani14020229

Show Details
Health investigation of dead marine mammals (seals) stranded and collected on Polish coast
Health investigation of dead marine mammals (seals) stranded and collected on Polish coast
Project Investigators: Prof. Prof. h. c. Dr. Ursula Siebert
Duration: September 2022 until February 2023
Funding: Universität Danzig , 31.328 EUR
Project Details:
For these project dead found seals, stranded at the polish coast, will be collected.
Within the scope of this project the ITAW will conduct health investigations of the stranded seals.
In the course of these investigations ITAW researchers will perform pathological examinations of internal organs and analysis of reproductive organs. The species of parasites the marine mammals potentially are infected by will be identified. Their age will be estimated and histological, virological and microbiological analysis conducted. So health reports based on postmortem analysis for each investigated animal will be prepared.
Show Details
Pharmacosmos
Pharmacosmos
Project Investigators: Prof. Dr. Isabel Hennig-Pauka
Duration: July 2022 until September 2023
Funding: Pharmacosmos A/S Holbaek (Dänemark), 35.200 EUR
Project Details:
Uniferon is an injectable 20% iron dextran for prevention and treatment of anaemia in swine. 200 mg iron is routinely administered to piglets within the first days of life to prevent development of anaemia. Empirical observations show, that iron deficiency can develop within the first four weeks of life despite this early preventive measure due to the high growth rates of modern cross-bred pigs. While the product Uniferon can be used in flexible volumes, so that an adaptation of the iron amount administered is possible, the competitor product Forceris can only be used in a fixed dosage of 1.5 ml containing 200 mg iron -gleptoferron in combination with 45 mg toltrazuril as a coccidiostaticum. The advantage of this combinatory product to address two different diseases by one single shot is counteracted by the lack of adjustment of the necessary amount of iron to prevent anaemia as long as possible. Different iron treatments in suckling piglets should be evaluated to review the traditional recommendations for iron applications and adjust them according to the higher genetic potential for growth in modern pig breeds if necessary.
Show Details
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