Research

Funding: MWK über Uni Göttingen, 732.193 EUR

Project Details:
Das SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-Type 2) ist der Erreger von COVID-19. Der bisherige Verlauf der COVID-19 Pandemie hat nachdrücklich gezeigt, dass eine koordinierte Bündelung von interdisziplinären und komplementären Expertisen notwendig ist, um die vielfältigen Aspekte der Biologie, der Pathologie und der Epidemiologie von SARS-CoV-2 zu entschlüsseln und die gewonnenen Erkenntnisse sowohl klinisch für die Behandlung von Patienteninnen und Patienten als auch für die Modellierung von Infektionsverläufen in der Bevölkerung einzusetzen. Um einen solch holistischen Ansatz leisten und umsetzen zu können, bietet das Bundesland Niedersachsen mit seinen international renommierten Wissenschaftsstandorten ideale Voraussetzungen. Das Forschungsnetzwerk COFONI arbeitet am Aufbau eines COVID-19 Forschungsnetzwerkes des Landes Niedersachsen (COFONI)um gebündelt Forschungsvorhaben zur Entwicklung neuer Strategien zur Bekämpfung von COVID-19 zu entwickeln. Hauptfokus der Technologieplattform Tiermodelle ist der Aufbau von Tiermodellen für COVID-19.

Project Details:
Cognitive dysfunction is characteristic to the prodromal stages of Parkinson´s disease, and more generally to synucleinopathies. We test novel therapeutic options for cognitive dysfunction associated with alpha-synuclein pathology. We base our interest on microRNAs (miRNAs) which are small endogenous RNAs, and will test the hypotheses that specific miRNAs that are downregulated in PD brains are associated with cognitive dysfunction and, when delivered into the diseased brain, can form the basis for miRNA replacement therapy.

Cooperation Partners:

Prof. Eran Hornstein (Weizmann Institute, Israel); Prof. Achim Aigner (Klinische Pharmakologie, Universität Leipzig)

Funding: MWK über Uni Göttingen, 8.400.000 EUR

Project Details:
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus Type 2) is the causative agent of COVID-19. The course of the COVID-19 pandemic so far has emphatically shown that a coordinated bundling of interdisciplinary and complementary expertise is necessary in order to decode the diverse aspects of the biology, pathology and epidemiology of SARS-CoV-2 and to use the knowledge gained clinically for the treatment of patients as well as for modeling the course of infection in the population. In order to be able to provide and implement such a holistic approach, the federal state of Lower Saxony offers ideal conditions with its internationally renowned science locations. We are therefore applying for financial support for collaborative research to set up a COVID-19 research network in the state of Lower Saxony (COFONI).

Funding: Bundesministerium für Ernährung und Landwirtschaft, 224.100 EUR

Project Details:
The aim of the project is to transfer an innovative concept for cold-storage of liquid preserved boar semen into practise. This enables the reduction of antibiotics in the preservation medium and additionally, the optimization of the transport logistics of the semen portions from semen collection centers to the sow farms. The environmental impact resulting from antibiotic use is reduced and possibilities for efficient use of boar semen are tested in practice. Thus, the CoolSperm project particularly promotes sustainability and efficiency in future-oriented pig breeding.

Results:

doi: 10.1016/j.theriogenology.2025.01.025

doi: 10.1371/journal.pone.0305280

doi: 10.1016/j.anireprosci.2024.107486

doi: 10.3390/antibiotics12050857

10.1016/j.anireprosci.2024.107486

Cooperation Partners:

Institut für Fortpflanzung landwirtschaftlicher Nutztiere

Förderverein Bioökonomieforschung (FBF e.V.)

Genossenschaft zur Förderung der Schweinehaltung eG (GFS)

Minitüb GmbH

Funding: Deutsche Forschungsgemeinschaft DFG, 331.800 EUR

Project Details:
Investigation of the role of T cells in the immune pathogenesis of the infectious bursitis virus. The project is embedded in the DFG-research group "ImmunoChick".

Cooperation Partners:

PD Dr. Angela Berndt, FLI

PD Dr. U. Methner, FLI

PD Dr. S. Härtle, LMU München

Prof. Dr. T. Göbel, LMU München

Prof. Dr. B. Kaspers, LMU München

Prof. Dr. B. Kaufer, FU Berlin

Prof. Dr. M. Meissner, LMU München

Prof. Dr. B. Schusser, TU München

Prof. Dr. J. Kaufman, University of Cambridge

Funding: EU, 955.230 EUR

Project Details:
It is widely recognised that noise entering the underwater environment from shipping and other human activities can disturb and harm aquatic animals. Studies have already shown these disturbance effects, while other research has suggested ways to reduce some of the noise generated by shipping. However, there are still gaps in our knowledge and understanding of how underwater noise can affect individual animals and entire populations.

This is now set to change with the SATURN consortium, which for the first time brings together leading European experts in bioacoustics, veterinary medicine, population biology, plus naval architecture and engineering in an EU-funded project. Key issues include:
- Identifying sounds that are most harmful to aquatic species and how they are generated and propagated;
- What are the short-term and cumulative long-term negative effects of noise from ships and boats on aquatic species in rivers and the sea;
- What are the most promising options for measuring and reducing the negative impacts of ship noise that can be applied to current and future ships.

Prof. Prof. h. c. Dr. Ursula Siebert, Director of the Institute for Terrestrial and Aquatic Wildlife Research at the TiHo, is the leader of the biological working group in this consortium, which investigates the influence of underwater noise on the behaviour, health and energy balance of aquatic organisms. Another important aspect supported by ITAW is public relations and communication.

Results:

Paper

"Unsealing behaviour: Variation in harbour seal (Phoca vitulina) responses to anthropogenic sound in relation to individual health"

https://www.sciencedirect.com/science/article/pii/S0025326X25002528?via%3Dihub

Funding: Bundesministerium für Landwirtschaft und Ernährung, Bundesprogramm Nutztierhaltung, 305.117 EUR

Project Details:
The goal of this project is to reduce the environmental pollution caused by the entry of antibiotics and resistant bacteria from pig breeding. Worldwide, antibiotics are added to liquid preserved semen portions in order to inhibit bacterial growth during semen storage.The present study aims to establish an innovative concept to eliminate bacteria without using conventional antibiotics. The concept is based on the photodynamic inactivation (PDI) of bacteria. Specifically, the aim is to inactivate microorganisms in boar semen using the photodynamic effect and, thus, to avoid bacterial growth and
exchange of resistance genes in the environment.

Results:

DOI: 10.3389/fmicb.2024.1429749

Cooperation Partners:

Humboldt Universität zu Berlin

Minitüb GmbH

Funding: Bundesinstitut für Risikobewertung, Berlin, 413.140 EUR

Project Details:
The project VetAmUR (Veterinary Antimicrobial Usage and Resistance) is a research project that, following the VetCab-S project, is carried out to describe the use of antimicrobials in farm animals in Germany as well as connect this with resistance data for those antimicrobials.

Background: Despite many independent investigations, no direct link between the information on antimicrobial usage and antimicrobial resistance could be estab-lished in German livestock husbandry so far. Therefore, an extensive and detailed risk assessment in regards to antimicrobial resistance is not possible, even though such an assessment is required on an international basis (Global Antimicrobial Re-sistance Surveillance System - GLASS, https://www.who.int/glass/en/). To accom-modate this demand, the VetAmUR project was initiated.

In the area of resistance data, the focus is on collecting data at farm level and de-scribing its heterogeneity with the aim of creating a standardised documentation template.

Additionally, specific periods within the fattening process and specific indications for antimicrobial administrations are documented and observed closely to deter-mine alternative treatments and prevention strategies.

Results:

Bonzelett C, Rehberg B, Winkelmann TS, Käsbohrer A, Kreienbrock L. Documentati-on of antimicrobial resistance data in veterinary practices in Germany. Berliner und Münchener Tierärztliche Wochenschrift. 2024;137:1-13 . doi: 10.2376/1439-0299-2023-14

Funding: Stiftung Innovation in der Hochschullehre, 1.349.525 EUR

Project Details:
The FERVET project addresses the digital teaching and review of mandatory clinical-practical skills in veterinary medicine studies and pursues three aims:
1. the enrichment of face-to-face, hybrid and virtual teaching through the development of simulators, the provision of digital teaching material, the development of a Virtual Learning Lab, the expansion of video production and the implementation of video annotations.
2. the further development and evaluation of existing formative and summative e-examination formats
3. the anchoring of the innovative measures in the university structures

Funding: Stiftung Innovation in der Hochschullehre, 549.540 EUR

Project Details:
The aim of the SOUVER@N project is to promote sovereign digital teaching and learning. This includes
1) the sovereign, i.e. competent and learning goal-oriented use of digital tools on the part of teachers and students (digital literacy) as well as
2) the professional development of high-quality digitally enriched teaching/learning concepts and content, and
3) the digital sovereignty of the universities as institutions strengthened by the network.

Results:

https://www.souveraenes-digitales-lehren-und-lernen.de/home/

Cooperation Partners:

1) Universität Osnabrück

2) Carl von Ossietzky Universität Oldenburg

3) Leuphana Universität Lüneburg

4) Technische Universität Clausthal

5) Stiftung Universität Hildesheim

6) Universität Vechta

7) Medizinische Hochschule Hannover

8) ELAN e.V. (1. Förderphase August 201 - Juli 2024)