Research

Funding: teilweise BMBF (Lichtenbergstipendium); Gesellschaft für Kynologische Forschung; Irene und Hans-Joachim Hahn-Stiftung, DAAD, 80.000 EUR

Project Details:
Die steril-eitrige Meningitis-Arteriitis des Hundes (SRMA)ist die häufigste entzündliche Erkrankung des zentralen Nervensystems des Hundes im Norddeutschen Raum. Mit Hilfe mehrerer Pathogenesestudien soll versucht werden, die Erkrankung besser zu charakterisieren, um neue Therapiestrategien entwickeln zu können. Die Zellpopulation in Liquor cerebrospinalis und Blut wurde mit Hilfe durchflusszytometrischer Studien charakterisiert. Studien zur Zytokinexpression sollen helfen, das Phänomen der hohen IgA Produktion zu erleuchten. Die Untersuchung von Toll-like Rezeptoren soll einen Hinweis auf die Ätiologie der Erkrankung liefern. Die Th17 Antwort, NETs und das Endocannabinoidsystem werden näher untersucht

Results:

Arianna Maiolini, Regina Carlson, M. Schwartz, G. Gandini and Andrea Tipold: "Determination of immunoglobulin A concentrations in the serum and cerebrospinal fluid of dogs: An estimation of its diagnostic value in canine steroid-responsive meningitis-arteritis." The Veterinary Journal, 191, 219-224, 2012

 

S.A. Moore, M.Y. Kim, Arianna Maiolini, Andrea Tipold and M.J. Oglesbee: "Extracellular hsp70 release in Canine Steroid Responsive Menintis-Arteritis." Vet Immunol Immunopathol., 145, 129-133, 2012

 

Arianna Maiolini, Regina Carlson and Andrea Tipold: "Toll-like receptors 4 and 9 are responsible for the maintenance of the inflammatory reaction in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis." J Neuroinflammation 9, 226 (1-12), 2012.

 

Arianna Maiolini, M. Otten, M. Hewicker-Trautwein, R. Carlson and Andrea Tipold: "Interleukin-6, vascular endothelial growth factor and transforming growth fator beta 1 in canine steroid responsive meningitis-arteritis." BMC Veterinary Research, 9:23, 1-10, 2013.

 

J. Freundt-Revilla, A. Maiolini, R. Carlson, M. Beyerbach, K. Rentmeister, T. Flegel, A. Fischer and Andrea Tipold: "Th17 skewed immune response and cluster of differentiation 40 ligand expression in canine steroid-responsive meningitis-arteritis, a large animal model for neutrophilic meningitis." J. Neuroinflammation 14:20, 2017. doi.10.1186/s12974-016-0784-3.

 

J.C. Wohlsein, M. Meurer, M. Mörgelin, J.N. Nessler, T. Flegel, H. Schenk, K. Jurina, K. Rentmeister, A. Fischer, T. Gödde, W. Baumgärtner, M. v.Köckritz-Blickwede and Andrea Tipold: "Neutrophil extracellular traps in CSF and serum of dogs with steroid-responsive meningitis-arteritis." Plos One 19(1):e0295268, 2024

Project Details:
Few standardized studies are available on the effect of slow-release GnRH agonists in avian patients. With this background, the aim of this study is to examine the influence of deslorelin, a slow-release GnRH agonist, on the gonadal activity of female and male budgerigars in order to optimize the clinical use of this drug. The activity of the gonads will be examined, for example, by determining the sex hormones and by radiographic assessment of the reproductive organs.

Project Details:
Preclinical investigations

Project Details:
Pre-clinical investigations

Project Details:
Blutchemische SDMA-Bestimmungen

Cooperation Partners:

LABOKLIN - Fachlabor für veterinärmedizinische Diagnostik

Funding: Australian Nuclear Science and Technology Organisation (ANSTO), 60.000 EUR

Project Details:
The high-energy cosmic radiation has a decisive influence on all manned space missions. The effect of this radiation on the model organism Trichoplax adhaerens (Placozoa) will be investigated in this project. Placozoans are the most simply organized multicellular animals and can give us crucial clues about the effect of cosmic radiation on humans.

Cooperation Partners:

Patrick Humbert, La Trobe University, Australia

Jens Hauslage, DLR, Köln

Funding: MEKUN, 133.105 EUR

Project Details:
The aim of the study applied for here is to investigate the habitat use of harbor porpoises in the western part of the Baltic Sea in a follow-up project using "passive-acoustic monitoring". To this end, harbor porpoise click detectors (C-PODs, Ceatacean_Porpoise_Detectors) were deployed at a total of four locations in March 2021 to record the presence of harbor porpoises. In August 2023, another station funded by the German Wildlife Foundation was deployed in the Baltic Sea. The monitoring stations in operation (Holnis, Bredgrund, Schleisand, Damp and Waabs) are intended to close the existing gap in the monitoring network between Fehmarn and Denmark. The habitat of harbor porpoises in the Baltic Sea is heavily influenced by human activities and factors that can have a negative impact on harbor porpoise populations. These include commercial shipping, tourist leisure activities, seismic surveys, military activities, fishing, offshore construction, blasting of old munitions, chemical and pharmaceutical pollution and marine litter.
In the Baltic Sea in particular, the harbor porpoise continues to be threatened by fishing with gillnets, in which harbor porpoises can end up as unintentional bycatch. In order to warn harbor porpoises of gillnets, acoustic warning devices are increasingly being used in the German Baltic Sea to warn porpoises of nets. These warning devices (Porpoise Alert = PAL) simulate the communication sound of harbor porpoises. Whether these devices lead to a reduction in by-catches has not yet been conclusively investigated. There is also currently no accompanying research to investigate whether these devices lead to the displacement of harbor porpoises.
The anthropogenic interventions described are only the most serious for the harbor porpoise. All these activities have a simultaneous effect on the harbor porpoise population and cannot be considered separately. The absence of older animals among the harbor porpoises captured and stranded in all study areas could be an indication that harbor porpoises in the Baltic Sea are affected by cumulative anthropogenic activities.

This study addresses the following questions:

1. Where do harbor porpoises occur in the western Baltic Sea?
2. Are there seasonal trends in the occurrence of harbor porpoises?
3. Which areas are of high ecological importance for harbor porpoises (e.g. foraging hotspots)?
4. Can the C-POD data collected as part of this monitoring be used to investigate the effects of blasting on harbor porpoises?
5. Can recommendations be derived from the results for certain periods when blasting should be considered more critically than in others?
6. Does the presence of PAL signals have an influence on the dating of harbor porpoises?

Funding: MEKUN, 172.488 EUR

Project Details:
The occurrence of harbor seals in the waters of Schleswig-Holstein has increased in recent years. At the same time, the seals are exposed to an increasing amount of human activity. These include chemical pollution, offshore wind turbine constructions, the Fehmarnbelt crossing, shipping, military and civilian detonations (munitions disposal), fishing, litter, habitat loss and other disturbances such as tourism. The increasing grey seal population in the North Sea has also led to the predation and rape of seals by grey seals in recent years.
As part of this research project, a total of 30 dead seals from the Schleswig-Holstein North Sea and Baltic Sea are to be examined in-depth for their state of health. These 30 individuals will be examined in addition to the 30 seals that will be necropsied as part of the project, which is funded by the Supreme Hunting Authority in the Ministry of Agriculture, Rural Areas, Europe and Consumer Protection of Schleswig-Holstein (MLLEV), bringing the total number of necropsied seals from Schleswig-Holstein to 60. Histological, microbiological and parasitological examinations will be carried out.

Project Details:
The behavior of European hedgehogs after hindlimb amputation is insufficiently researched. While some literature suggests hedgehogs may cope well with such amputations, there is a lack of systematic studies to confirm this. This project aims to evaluate the gait of hedgehogs after hindlimb amputation during rehabilitation. Healthy four-legged and three-legged hedgehogs will be analyzed and compared using accelerometers to understand the impact on their movement and survival, ultimately contributing to more effective treatments and better outcomes for wildlife rehabilitation.

Project Details:
Infections with adenoviruses have been detected in hand-reared Common swifts in connection with stomatitis. As part of this project, the virus is to be investigated in more detail and its spread in the wild population of swifts and swallows, as possible carriers, is to be determined in the Hanover area.