Research

Funding: Industrie, 260.000 EUR

Project Details:
Pre-clinical testing of a neuroprotective drug

Funding: Drittmittelprojekt, gefördert durch Fritz-Ahrberg-Stiftung., 15.000 EUR

Project Details:
The precise investigation of the muscle-to-meat transition after the slaughter of farm animals is important, because it (could) lead to a better understanding of the processes during these post-mortem changes. This allows the definition and analysis of influencing factors that may have a positive or negative effect on the meat quality. However, since an in vivo analysis of meat formation is difficult to standardize, in vitro models have been developed that are easier to standardize with regard to metabolites/ compositions (e.g. certain organelles such as mitochondria). Since the models have so far been scientifically investigated in pigs and chickens, the study will first establish an already published in-vitro model with pig muscles and then transfer it to bovine and possibly turkey muscles. These models will then be used to analyze the physiological muscle-to-meat transition after slaughter in more detail, also taking into account certain exogenous and endogenous factors, especially the mitochondria. The influence of mitochondria will be examined in more detail, as they have an (important) influence on meat formation. In addition, the models will be used to analyze (pathological) problems in meat formation (e.g. PSE, DFD).

Project Details:
The aim of this study is the validation of the automated analysis of cell count in bovine synovia using the ADVIA 2120i. Corresponding reference ranges for clinically normal joint aspirates should be developed to differentiate these from pathological samples. In addition, further examinations such as the determination of protein content and a microbiological examination of the samples are carried to analyse whether particular parameters can provide information on clinical appearance, diagnostics or therapy. Both macroscopically abnormal and normal joint aspirates are used for examination.

Project Details:
The aim of this study is to analyse the effect of four distict cytokines, which are important in early bovine pregnancy, on the gene expression in cultured primary bovine hepatocytes. PCR is used to detect how the hepatocellular IGFBP-expression changes when the cells are stimulated with different cytokines in different concentrations. This demonstrates the connection between immunological and endocrine changes in early pregnant cows. We particularly focus on IFNτ, the embryonic pregnancy recognition signal of ruminants.

Funding: Bundesministerium für Ernährung und Landwirtschaft, 46.497 EUR

Project Details:
The aim of the project is to establish he first agricultural skills lab to improve practical skills in training in order to promote better animal welfare in education. New social and political demands in agriculture, which may require new practical skills, can be implemented in the skills lab and learned and deepened in a protected learning environment. The agricultural skills lab is intended to address different target groups (trainees to become farmers/animal keepers, trainees to become master craftsmen, obtain relevant additional qualifications (e.g. insemination technicians) and students of agricultural science / livestock science) and encourage exchange and learning from one another and with one another between the different groups improve audiences.

Results:

https://www.lksh.de/presse/pressemitteilungen/news/artikel/show/deutschlands-erstes-agriskills-lab-steht-in-schleswig-holstein-heute-oeffnete-der-simulatoren-lernort-im-lvz-futterkamp

Cooperation Partners:

Lehr- und Versuchszentrum Futterkamp, Landwirtschaftskammer Schleswig-Holstein

Dr. Sophie Diers

Gutshof 1, 24327 Blekendorf

Funding: MEKUN, 233.834 EUR

Project Details:
In the previous four years a concept was developed to perform standardized necropsy and examination on all otters found dead in Schleswig-Holstein (SH), to allow for assessment of the general population health status. Even though most otters were roadkills and seemed comparatively healthy, zoonotic agentswere cultured from tissue samples and rare otter specialist parasites were recorded for the first time in Northern Germany. Combined dietaryanalysis includinghard part analysis and genetic metabarcoding were used to depictthe natural prey spectrum of otters. Knowlegde on the otters` diet is of utmost importance in various context, for example in the light of fisheries-otter conflicts. Cementum aging reveiled a rather young average age of the investigated otters from SH. Combined with the ongoing recolonization of the otter in SH, this might be an indication that the population has not finally established itself yet and we face a dynamic process. The findings of various environmental contaminants of concern in the otters from SH were of utmost importance and included potential microplastic particles, pharmaceuticals, rat poison, mercury or per- and polyfluorinated chemicals.

The aim of this project is to combine the expertise from previous years and transform the health assessments into a long-term post-mortem population health monitoring for otters in SH. As top predators, Eurasian otters are indicator species for environmental contaminants or infectious diseases in freshwater ecosystems, like marine mammals in their habitat. By adopting this indicator function, the collection of otter health data shall be continued to allow for the estimation of time trends in future population health assessments. Accordingly, otters found dead in SH will continued to be collected and investigated, including diagnostics such as histology, microbiology and parasitology. The main focus will be on diseased animals and such, where the cause of death is unclear. All other individuals will be screened for relevant indicator pathogens, including distemper virus or high pathogenic avian influenza virus. In addition, parasitological and microbiological investigations will be conducted if assumed necessary. To determine whether hard ticks infecting otters play a role in the transfer of vector-borne disease, all collected hard ticks (Ixodes) from previous years will be determined on a species level. The results will give an overview, which tick species are infecting otters and if the transfer of certain pathogens might play a role here.

In accordance with their role as indicator species of the aquatic environment, systematic mercury analysis will be conducted for the first time on otters from SH. An international collaboration within the EU investigated contaminants in otters and could show that mercury levels in some individuals from SH were very high compared to other top predators. For the planned analysis, samples from the biobank will be carefully selected to ensure a good coverage with regards to age, sex and location of finding. Moreover, first steps to develop biomarkers for environmental contaminants in otters will be made.

Eine systematische Fortführung der Untersuchungen der Fischotter in SH ist von zentraler Bedeutung, um langfristige Populationsentwicklungen einzuschätzen und beurteilen zu können. Als streng geschützte Art und wertvoller Indikator für das Ökosystem Süßwasser bietet ein strategisches Monitoring des Fischotters die Möglichkeit, Arten- und Naturschutz zu verbinden. Auch im Hinblick auf sich abzeichnende Interessenskonflikte, z.B. mit der Fischerei, kann eine solide Datengrundlage zum Fischotter wertvolle Informationsarbeit leisten und sachliche Diskussionen ermöglichen.

In order to estimate and evaluate long-term population trends of otters in SH, a systemic continuation of the post-mortem investigations is needed. As strictly protected species and suitable indicator for the freshwater ecosystem, a strategic monitoring of Eurasian otter represents a valuable tool to combine conservation of both wildlife and nature. Especially when looking at potential conflicts like the otter-fisheries interface, a well developed dataset on otters will help to create information based on scientific facts and ensure objective rather than emotional discussion.

Funding: Roland und Elfriede Schauer-Stiftung, 210.000 EUR

Project Details:
In this project, we hypothesize that glycosylated C-type lectin receptor (CLR) ligands induce a differential expression of CLRs by intestinal macrophages under bacterial dysbiosis, thereby leading to a modulated host immune response. This hypothesis will be tested by performing in vitro and in vivo studies.

Funding: Drittmittelprojekt, gefördert durch die Fritz-Ahrberg-Stiftung., 100.000 EUR

Project Details:
The consumption of short-ripened and nitrite-reduced raw sausages can pose a risk to the consumer if a lack of drying and altered ripening processes allow pathogenic and spoilage-causing bacteria to multiply. Bacillus species are used as starter cultures in modern biotechnological processes, but also in traditionally fermented products. They are able to form so-called bacteriocins. These are ribosomally synthesised peptides with a high antibacterial activity. An application of these bacteriocins in sausage production can extend the shelf life and prevent the occurrence of pathogenic germs. As starter cultures, bacteriocin-forming bacteria can make an important contribution to the safe production of short-ripened and nitrite-reduced raw sausages.
In this project, Bacillus species that have not been investigated so far are tested for their antimicrobial properties against meat-relevant spoilage and zoonotic pathogens (e.g. Campylobacter spp., listeria and salmonella). With an already established high-throughput method on a laboratory scale, this can be done with a hundred isolates simultaneously. Cell-free culture supernatants are obtained, which are subsequently used to identify the potential bacteriocins. Promising Bacillus isolates are tested in a second step in short-ripened and nitrite-reduced raw sausage products as a supplement to established starter cultures.

Results:

Natürliche Biokontrolle von Listeria monocytogenes in Rohwurst durch die Bakteriozin produzierenden Stämme Bacillus cereus MHI 86 und Bacillus thuringiensis 5-29. 65. Arbeitstagung des Arbeitsgebietes Lebensmittelsicherheit und Verbraucherschutz, Garmisch-Partenkirchen, Germany, 23.09.-25.09.2025.

 

Identifizierung und Charakterisierung von Thuricin-17-ähnlichen Bakteriozinen, produziert von Bacillus thuringiensis und Bacillus cereus Isolaten. 64. Arbeitstagung des Arbeitsgebietes Lebensmittelsicherheit und Verbraucherschutz, Garmisch-Partenkirchen, Germany, 24.09.- 27.09.2024.

 

Identification and characterisation of thuricin 17-like bacteriocins produced by Bacillus thuringiensis and Bacillus cereus isolates. 7th Joint Microbiology & Infection Conference, of the DGHM and VAAM, Würzburg, Germany, 02-05 June 2024, 176-177.

Funding: Bundesanstalt für Landwirtschaft und Ernährung (BLE), 415.089 EUR

Project Details:
The objective of this project is to reduce the use of antibiotics in broiler fattening by on-farm hatching. Onfarm hatching is intended to increase animal health and consequently reduce the incidence of bacterial diseases in the flocks. For this purpose, various parameters that can be influenced by on-farm hatching are
taken into account, collected, evaluated and made available to the practice.
The project is divided into two phases. In phase 1, four farms are accompanied that already use the method of on-farm hatching and thus have previous experience (lighthouse farms). The experiences of the lighthouse farms as well as the data collected in this first phase will be passed on in phase 2 as knowledge
transfer to six farms (two with fast-growing broiler, two with slow-growing broiler and two organic farms),
that are using on-farm hatching for the first time (newcomers).

Cooperation Partners:

Landwirtschaftskammer Niedersachsen

Ludwig-Maximilians-Universität München

Universität Rostock

Funding: Drittmittelprojekt, gefördert durch die Fritz-Ahrberg-Stiftung., 17.500 EUR

Project Details:
Comparative tests are carried out with different sample materials. Fresh pork, chicken and beef are used, as well as meat products from the categories of raw and cooked sausage and ham (raw and cooked ham).
Three selected sample thicknesses are examined in each case, depending on commercially available cuts and products on offer, in order to be able to assess the influence of the material height on the subsequent analyses. The actual tests then include the measurement of color and texture.
With regard to the color measurement (instrumentally by means of chromameter), an interaction between sample material, sample thickness and background color is examined. The aim is to sensitize subsequent projects to possible influences and misinterpretations in connection with the methodological implementation.
When assessing the texture, various attachment tools are available for instrumental measurement using TA.XTplus, which are to be selected and compared depending on the respective material. The aim is to evaluate the necessity of the different preparation-intensive measurements and to identify comparable tools as well as to compare the measurement results of the different tools.