Research

Funding: TIB, 104.334 EUR

Project Details:
Within the framework of this joint project of the TiHo with the MHH, it is planned to thematically expand and extend the OER collection "Animal Welfare and Ethics" on the Lower Saxony OER platform "Twillo" to include OER contributions on agricultural livestock farming, also from the perspective of public health ethics, taking into account the One Health concept. This is based on the great importance of agriculture for Lower Saxony. Agriculture there has a share of 8.9% of the gross domestic product. The planned OER will address the economic importance of the individual livestock branches as well as the different forms of animal husbandry and the state animal welfare initiative referring to it. Animal ethics, as an established branch of philosophical ethics, is sometimes very critical of farm animal husbandry. However, the ethical discussion of farm animal husbandry from the perspective of medical and public health ethics remains largely unaddressed, especially in the German-speaking world. Therefore, the OER should also support Twillo users in understanding the basics of the human-animal relationship in farm animals.

Results:

The OER named in the application were created and uploaded to twillo.de:

OER "Economic importance of agricultural pig farming"

OER "Economic importance of agricultural cattle farming"

OER "Economic importance of agricultural chicken husbandry"

OER "Forms of husbandry in pig fattening"

OER "Forms of husbandry in chicken fattening"

OER "Housing systems for cattle on conventional dairy and fattening farms"

OER "Farming husbandry systems for chickens"

As there were legal changes to the state animal welfare label by the end of the approval period, the OER "state animal welfare label" could not be created. Instead, the following OER was created:

OER "economic importance of livestock farming"

Cooperation Partners:

MHH

Funding: Niedersächsisches Ministerium für Wissenschaft und Kultur, 110.550 EUR

Project Details:
Social media are playing a rapidly growing role in human communication. If content is posted, imitated or shared on Social media which can impair animal welfare, it potentially reaches a broad mass of people. This project is intended to initiate a social debate on the subject of animal welfare on Social media, which is scientifically based. The aim is to educate potential users about the animals' expressive behaviour and needs, as well as the potential relevance of various depictions for animal welfare. Several functional groups such as universities, schools, veterinarians, pet shops and the (print) media are involved for this purpose.

Results:

A targeted search for pet videos with animal suffering was carried out on the platforms TikTok, Instagram and YouTube. Numerous videos with animal welfare relevance were found, which were categorized according to their content. The scientific analysis of animal behaviour in the videos was the basis for determining the animal welfare relevance. In 82.4% of the videos analysed, the animals showed signs of stress. In 53.3% of the videos there was a risk of injury to the animals, and in 29.7% of the videos the animals were suspected of being in pain. The results of an online survey with 3,256 participants showed that 98.5% of respondents had already contact with animal videos. 41.7% of respondents said that they never/almost never searched for animal videos themselves and 73.8% said that they often/very often had animal videos suggested by the platforms' algorithms. Various print and online media reported on the project (e.g. Spiegel, Zeit (Leo), Hannoversche Allgemeine and various specialist magazines). In addition, those responsible for the project gave interviews on radio, television and in a podcast. Posters, flyers, logos as well as GIFS and PDF files were also made available to the public. Various functional groups were involved as multipliers through lectures at events and teaching opportunities for schools.

Funding: Rentenbank, 90.000 EUR

Project Details:
The project aims at the integration of animal welfare as a constant dimension in the concept of sustainability. The work is done on conceptional levels and by use of case studies of selected kind of farm animals.

Results:

Using one of the resulting models, we can show that animal welfare is a protected good among many other sustainability goods, but due to its categorical difference it cannot be implemented as an equivalent element alongside the other sustainability dimensions in a sustainability concept. We were therefore unable to achieve a "genuine" integration of animal welfare as a constitutive component, but we were able to achieve a meaningful positioning via the social dimension of sustainability as a connecting link.

Since a decision is required in the case of conflicting objectives despite categorical differences, we have developed a reflection model as a proposal for dealing with this problem, which can serve as a basis for weighting in the case of value preference decisions. We have demonstrated its applicability in detail using a specific example.

Overall, we have been able to clearly distinguish ourselves from other concepts in the current sustainability discourse, among other things through the well-founded selection of arguments that can be applied from an ethical perspective.

The absolute goal of the sustainability debate in connection with animal husbandry and animal welfare is not clearly discernible from the discourse situation, so that there is still motivation to participate by contributing valid arguments.

 

Using one of the resulting models, we can show that animal welfare is a protected good among many other sustainability goods, but due to its categorical difference it cannot be implemented as an equivalent element alongside the other sustainability dimensions in a sustainability concept. We were therefore unable to achieve a "genuine" integration of animal welfare as a constitutive component, but we were able to achieve a meaningful positioning via the social dimension of sustainability as a connecting link.

Since a decision is required in the case of conflicting objectives despite categorical differences, we have developed a reflection model as a proposal for dealing with this problem, which can serve as a basis for weighting in the case of value preference decisions. We have demonstrated its applicability in detail using a specific example.

Overall, we have been able to clearly distinguish ourselves from other concepts in the current sustainability discourse, among other things through the well-founded selection of arguments that can be applied from an ethical perspective.

The absolute goal of the sustainability debate in connection with animal husbandry and animal welfare is not clearly discernible from the discourse situation, so that there is still motivation to participate by contributing valid arguments.

The design of a model with a high degree of concretization that adequately takes animal welfare into account is currently considerably limited by the fact that objectively measurable thresholds are not yet available.

Funding: Roland und Elfriede Schauer-Stiftung, 92.200 EUR

Project Details:
This project focuses on the identification and characterization of glycosylated helminth ligands (protein/lipid) of host C-type lectin receptors (CLRs), in particular Dectin-1, Dectin-2, CLEC12A and DC-SIGN. Further, we plan to investigate how the respective CLR/ligand interactions affect innate responses of host immune cells.

Funding: MWK, 22.000 EUR

Project Details:
The importance of the highly conserved protein Nsp15 for the infection of cells by coronaviruses has been studied in detail in recent years. As an endonuclease, it rapidly recognizes and degrades both single-stranded (ssRNA) and double-stranded RNA (dsRNA). In addition, evidence from animal models suggests immunomodulatory properties of Nsp15 during early viral infection, leading to a delayed immune response. This process is ultimately involved in the development of acute respiratory failure, which is the main cause of COVID-19 mortality. As part of this funding program, we plan to develop new inhibitors of this protein through structure-guided design. Promising compounds will be characterized with respect to their ADME and physicochemical properties in order to obtain orally bioavailable compounds for the treatment of future viral pandemics.

Results:

https://www.umg.eu/forschung/corona/cofoni/

Funding: MWK, 220.890 EUR

Project Details:
CRISPR/Cas13-mediated antiviral therapy against SARS-CoV-2 and its variants: a novel technology to target viral genome

Results:

https://www.umg.eu/forschung/corona/cofoni/

Funding: Frauenhofer ITEM, 278.466 EUR

Project Details:
Frauenhofer ITEM-Therapeutic treatment against SARS-CoV-2 with inhaled VHH from BiondVax - Efficacy program in hamsters

Funding: Frauenhofer ITEM, 331.375 EUR

Project Details:
Therapeutic treatment against SARS-CoV-2 with inhaled VHH from BiondVax - Efficacy Program in Hamsters

Funding: Verein für Bioökonomieforschung (FBF), 9.600 EUR

Project Details:
The FBF funded project "Influence of stress during rearing management and later eligibility in sperm production" revealed a clear difference in a developed management score and in mean testosterone concentrations between young bulls with good versus poor sperm quality. However, due to a lack of sensitivity, hormone measurements could not be used as adequate diagnostic tests to identify very good or bad bulls with regard to their later performance and performance persistence, neither at an age of four months nor later at the first semen collection.
This more in-depth study is designed to search for better biomarkers using proteomics as non-target approach. Bulls with a very good versus bad performance persistence over two years will be analyzed by mass spectrometry using the plasma samples collected close to the first semen collection during the preliminary project. Data sets of the mass spectrometric measurements with identified peptides will be matched with a bovine protein database to finally name proteins of the plasma samples. Both groups of bulls will be compared with respect to the proteins identified and the amounts of the same.
In order to establish test methods that are as practicable as possible, promising fertility-associated proteins will subsequently be measured in the blood samples from all age classes investigated during bull calf rearing using commercially available ELISA kits. These data will be used to establish reference ranges and thresholds using receiver operating characteristic (ROC) analyses. Optimally, suitable biomarkers in the blood allow an early preselection of bull calves that are eligible for the collection of quantitatively and qualitatively good semen.

Cooperation Partners:

Institut für Toxikologie, Medizinische Hochschule Hannover

Funding: DFG, 110.700 EUR

Project Details:
Tetraspanins are evolutionary conserved integral membrane proteins of 200-350 amino acid lengths. Through their large extracellular loop they mediate protein - protein and protein - lipid interactions in cellular membranes thereby shaping membrane microdomains called ?tetraspanin webs?. In humans and mice 33 tetraspanins are described and mosquito species express at least 15 tetraspanin orthologs. In mammalian cells, tetraspanins are host co-factors for several viruses including papillomaviruses, influenza virus, hepatitis C virus, HIV-1 and coronaviruses (Gerold et al., 2015; Bruening et al. 2018; Banse et al., 2018; Alberione et al. 2020; Palor et al., 2020). For hepatitis C virus, colleagues and we showed that the tetraspanin CD81 is a host range determining factor (Vogt et al. 2013; Scull et al., 2015; von Schaewen et al., 2016).
The proposed project aims at characterizing in detail, which of the 33 human tetraspanins in addition to CD81 are host factors for alphaviruses and whether tetraspanins from reservoir species, dead end host species and transmitting mosquito vectors serve as host factors of alphaviruses. Thereby the work will contribute to the understanding of the molecular composition and function of alphavirus replication complexes and determine the role of tetraspanins in species range, transmission and consequently emergence of alphaviruses.