Research

Funding: Europäische Union, 142.547 EUR

Project Details:
The European Partnership on Animal Health and Welfare (EUPAHW) is a research and innovation initiative funded by the European Commission (EC) to control infectious diseases of animals, and to promote animal welfare. Due to the close link between animal health, animal welfare and human well-being, the One Health-One Welfare perspective takes a prominent position in the EUPAHW. Within the EUPAHW, the Institute for Terrestrial and Aquatic Wildlife Research will work with other partners on wildlife-livestock-human interface. The overall objective is to integrate the health of wild mammals and birds into the overall health surveillance and monitoring of livestock. Wildlife health surveillance contributes to the assessment of environmental health because wild animals may serve as sentinels for both terrestrial and aquatic ecosystems. Improving wildlife population monitoring and surveillance of wildlife pathogens/diseases aims to detect the emergence of pathogens and reduce the risk of transmission of infectious diseases between wildlife and livestock and even humans. The information is needed to design, apply and support sustainable livestock and wildlife management systems. In this context, the EUPAHW will assess the impact of climate change and human/anthropogenic activities such as hunting, trade, feeding, rewilding and translocation of wildlife on the spread of diseases and the establishment of invasive species.

Cooperation Partners:

56 Forschungsinstitutionen aus Europa (https://www.eupahw.eu)

Funding: DFG, 122.183 EUR

Project Details:
Enteroinvasive bacterial pathogens are serious health threats for humans and animals as they can overcome the physical and innate immune barrier by the intestinal epithelium. There is evidence that such pathogens exploit host transcytotic pathways of different intestinal epithelial cell types that are otherwise used for antigen and nutrient uptake. Intestinal transcytosis and transcytosis pathways may considerably contribute to the disease outcome of infection. However, these processes are not fully understood. For example, it is not clear whether different pathogens share pathways for translocation. This project describes a research collaboration to clarify transcytosis of the enteroinvasive intracellular bacterial pathogens Salmonella enterica and Mycobacterium avium. Both Salmonella serovars and M. avium subspecies are known to use different intestinal cell types for entry into the host. However, translocation through the cells is largely unknown. The aim of this project is to define the mechanisms of translocation and the promoting factors by infecting intestinal epithelial organoids.

Cooperation Partners:

Prof.Dr. Guntram Graßl

Institut für Medizinische Mikrobiologie und Krankenhaushygiene

Medizinische Hochschule Hannover

Funding: Stiftung zur Förderung der Erforschung von Ersatz- und Ergänzungsmethoden zur Einschränkung von Tierversuchen, 125.000 EUR

Project Details:
Chronic pain represents a significant health problem affecting approximately 20 to 50% of the world's population. Therapeutic methods are largely developed in behavioral tests with induced pain in rodents. This approach does not allow for pain treatment, leading to severe distress for the animals. Nevertheless, therapeutics developed in animals are not always effective in humans. Therefore, two in vitro models using human cells will be developed to quantify neuron-mediated chronic pain with the highest possible predictive power. For this purpose, stem cell-derived sensory neurons will be used (1.) to develop a luciferase-based exocytosis assay to easily quantify the increased release of neuropeptides (Substance P and Calcitonin Gene-Related Peptide) involved in the chronic pain response. Additionally, (2.) an innervated skin model will be developed to quantify neurite outgrowth and the expression of regulated genes associated with chronic pain receptors and ion channels involved in signal transduction in vitro. The proof-of-concept for the use of these models in pharmacology and toxicology will be provided by inhibiting induced neuropeptide release, induced neurite outgrowth, and induced gene expression with therapeutically effective substances or by triggering them through the addition of exogenous substances. This approach allows for the modeling of molecular pathways of chronic pain development in vitro, directly in human cells, to avoid unnecessary animal experiments and to develop effective and safe therapeutics for humans. Following the project, the skin model will be adapted to model atopic dermatitis using induced pluripotent stem cells and primary cells from patients, aiming to bring specific in vitro disease models into application for the development of new therapies in cooperation with industrial partners. Furthermore, the project should serve as a foundation for further cross-disciplinary in vitro modeling, such as the simulation of chronic joint pain.

Cooperation Partners:

Prof. Dr. Annemarie Lang, Ph.D., University of Michigan

Funding: MEKUN, 172.488 EUR

Project Details:
The occurrence of harbor seals in the waters of Schleswig-Holstein has increased in recent years. At the same time, the seals are exposed to an increasing amount of human activity. These include chemical pollution, offshore wind turbine constructions, the Fehmarnbelt crossing, shipping, military and civilian detonations (munitions disposal), fishing, litter, habitat loss and other disturbances such as tourism. The increasing grey seal population in the North Sea has also led to the predation and rape of seals by grey seals in recent years.
As part of this research project, a total of 30 dead seals from the Schleswig-Holstein North Sea and Baltic Sea are to be examined in-depth for their state of health. These 30 individuals will be examined in addition to the 30 seals that will be necropsied as part of the project, which is funded by the Supreme Hunting Authority in the Ministry of Agriculture, Rural Areas, Europe and Consumer Protection of Schleswig-Holstein (MLLEV), bringing the total number of necropsied seals from Schleswig-Holstein to 60. Histological, microbiological and parasitological examinations will be carried out.

Funding: Interreg VI-B Norseeprogramm EFRE (Mittel aus dem Europäischen Fonds für regionale Entwicklung - EFRE) Niedersächsisches Ministerium für Bundes- und Europangelegenheiten und Regionale Entwicklung, Hannover Mittel des Bundes, 411.143 EUR

Project Details:
The North Sea is one of the busiest shipping areas. In order to achieve the EU's climate targets, a massive expansion of wind farms is planned in the North Sea. The North Sea is also a valuable habitat for many species that are threatened by future maritime developments. This also includes the risk of noise pollution. DEMASK aims to encourage maritime decision-makers, spatial planners and industry stakeholders to address the issue of underwater noise by jointly planning scenarios for the future of the North Sea, improving the tools and knowledge to assess noise mitigation scenarios and setting strategic priorities that lead to a well-managed noise landscape.
DEMASK consists of three working groups. The centerpiece (WP1) is the joint scenario planning process. WP1 relies on stakeholder participation and is specifically designed to maximize the uptake of strategic policy priorities for noise mitigation. It defines and assesses the key policy scenarios for noise reduction. WP2 focuses on predicting the future noise situation. Finally, WP3 will carry out risk assessments for biodiversity in the North Sea for alternative action scenarios. Pilot projects will predict the noise scenarios for these alternative scenarios compared to the baseline situation and use these noise scenarios to assess the impacts of noise and the associated risks for indicator species. Risks will be assessed on the basis of sensitivity, distribution, habitat and exposure if the thresholds for the occurrence of biologically significant adverse effects (LOBE) are exceeded at the regional level. This work package is led by ITAW.

Cooperation Partners:

Projektkoordination, Rijkswaterstaat (RWS), Ministry of Infastructure and Water Management, Utrecht

Federal Maritime and Hydrographic Agency (BSH), Hamburg

TNO research, Den Haag

IVL Swedish Environmental Research Institute, Kristineberg

Royal Belgian Institute of Natural Sciences (RBINS), Brüssel

North Sea Foundation, Utrecht

Flanders Marine Institute (VLIZ), Oostende

JASCO Applied Sciences

Funding: MEKUN, 394.000 EUR

Project Details:
Amphibians worldwide are confronted with a variety of factors causing a rapid population declines. In Schleswig-Holstein, these population declines can also be in otherwise widely distributed species and cannot be explained by structural parameters alone, such as habitat loss and alteration. Other factors influencing amphibians can include toxicological contamination and invasive pathogens. The effects of those stressors on our native amphibians are largely unknown. Furthermore, the extent to which the different stressors interact is largely unknown, although it is assumed that they potentiate each other. In order to implement successful conservation measures in the long term, it is important to identify and evaluate the relevant stressors. Based on preliminary studies carried out at the Institute for Terrestrial and Aquatic Wildlife Research (ITAW) from 2021 to 2023, the project aims to investigate possible stressors for amphibians native to Schleswig-Holstein. This includes the continued monitoring of pathogens, such as fungi originating from Asia (Batrachochytrium dendrobatidis (Bd) and B. salamandrivorans (Bsal)) as well as Ranaviruses and herpes viruses. In addition, of animal-related data as well as data on habitat-specific factors are collected to be able to explain differences in the occurrence of infectious agents. The collection of habitat-related data includes water quality characteristics (e.g. pH value, water temperature) and analyses of possible contaminants correlation with utilization, structure and surrounding vegetation over the course of the year.
In addition to recording possible stressors and their interaction, this study aims to develop a basis to evaluate habitats in the course of species protection measures such as reintroduction projects.

Cooperation Partners:

Rachel Marschang und Christoph Leineweber, LABOKLIN GmbH, Bad Kissingen

Annika Jahnke und Nadin Ulrich, Helmholtz-Zentrum für Umweltforschung, Leipzig

Krishna Das, University oh Liege, Lüttich, Belgium

Arne Drews, Landesamt für Umwelt, Schleswig-Holstein

Christian Winkler, faunistische Gutachten

René Seifert, Bündnis Naturschutz in Dithmarschen e. V.

Funding: Ministerium für Energie­wende, Klimaschutz, Umwelt und Natur (MEKUN), 766.851 EUR

Project Details:
Common Eider (Somateria mollissima) is classified as endangered in Europe due to continuous the population declines. Meanwhile, its occurrence along the coast of Schleswig-Holstein has potential for conflict with the culturally established and economically important fisheries.
The methods investigated in the pilot study showed promising effects: the tested eider protection fence effectively protected the mussel lines from feeding damage by common eiders and there were clear differences to control lines that were freely accessible to the eiders. However, the measures have so far only been tested on a small scale. In order to investigate the practicability on a realistic scale, this follow-up project aims to extend the to a larger area and possibly include other deterring methods that have not been used in the pilot project.

The long-term objective is to find practicable methods that are applicable to commercially operated mussel farms and at the same time function in terms of animal welfare or can even contribute to the reduction of bycatch in other areas.

At the same time, necropsies of dead common eiders will be continued in order to provide information on the incidence of disease within the population, identify pathological changes and classify these in the context of the population decline. This includes bacteriological, virological and parasitological analyses. In addition, toxicological examinations will provide information on the animals' exposure to environmental pollutants.

Project Details:
GnRH agonists are frequently used in practice to treat diseases of the reproductive system in privately reared laying hens. After surgical removal of the oviduct, suppression of gonadal activity is essential. The aim of the planned studies is to examine the influence of such a resection of the laying intestine on the effect of the slow-release GnRH agonist deslorelin in clinical use. In order to assess the effect of the GnRH agonist, the activity of the ovary and oviduct will be evaluated by determining the sex hormones and by sonographic examination.

Project Details:
Infections with adenoviruses have been detected in hand-reared Common swifts in connection with stomatitis. As part of this project, the virus is to be investigated in more detail and its spread in the wild population of swifts and swallows, as possible carriers, is to be determined in the Hanover area.

Funding: Bezirksamt Hamburg-Nord, 48.000 EUR

Project Details:
The establishment of pigeon lofts for urban pigeons is an important component in the management of the pigeon population for many cities. With this background, the influence of a newly installed pigeon loft for urban pigeons on the development and health status of the neighboring pigeon population, the occurrence of pigeon-specific pathogens and the contamination by pigeons in the catchment area will be investigated in the city of Hamburg over a period of two years.

Cooperation Partners:

Frau Dr. Anke Höfer

Fachamt Verbraucherschutz, Gewerbe und Umwelt:

Veterinärwesen und Lebensmittelüberwachung, Hamburg