The Institute represents the field of immunology in research, teaching and veterinary diagnostics at the TiHo. Head of the institute is Prof. Dr. Bernd Lepenies (Infection Immunology) and head of the diagnostics is Apl.-Prof. Dr. Hans-Joachim Schuberth (Veterinary Immunology) working together with a skilled team of Post-Docs, PhD-students, veterinarians and technical assistants.
Our research combines aspects of innate immunity of different species. In this context we focus on myeloid cells (such as monocytes, macrophages, dendritic cells, granulocytes) with a particular interest into how these cell subsets recognize and respond to pathogens via pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and C-type lectin receptors (CLRs). Projects of our institute address questions of how these PRRs modulate immune responses, contribute to protection, immune pathology and innate immune memory. To this end, we employ relevant in vitro systems and murine, bovine and equine models to translate findings to humans and large animals.
Key aspects of the Infection Immunologyinclude
- Role of C-type lectin receptors in infection and inflammation
- Generation of tools for lectin-based research
- Utilization of lectin receptors for cell targeting and immune modulation
Key aspects of the Veterinary Immunology include
- Bovine immunology
- Monocyte-macrophage differentiation and polarization
- Trained immunity
- Nutritive immunomodulation
- Reproduction immunology
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