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100 results.
Understanding the impact of the chicken's makeup on IBDV pathogenesis - insight from the host perspective
Wie wirken sich unterschiedliche Merkmale des Huhnes auf die Pathogenese der Infektiösen Bursitis aus? - Erkenntnisse aus der Perspektive des Wirts
Project Investigators: Prof. Dr. Silke Rautenschlein
Duration: September 2025 until August 2029
Funding: Deutsche Forschungsgemeinschaft DFG, 401.271 EUR
Project Details:
Infectious bursal disease virus (IBDV) is one of the most important immunosuppressive chicken pathogens worldwide. Despite vigorous vaccination, IBDV field outbreaks occur. This project will investigate the role of different immune cell populations in infectious bursal disease pathogenesis and will address specifically the impact of age and genotype in this context. We will therefore contribute to the overall improvement of chicken health and welfare, and in addition may inform development of new farm animal vaccination strategies. The project is embedded in the DFG-research group "ImmunoChick"". "
Cooperation Partners:

PD Dr. Angela Berndt, FLI

PD Dr. S. Härtle, LMU München

Dr. T. von Heyl, TU München

Dr. S. Früh, FU Berlin

Prof. Dr. B. Kaufer, FU Berlin

Dr. El-Sayed Abdel-Whab, FLI, Riems

Prof. Dr. B. Schusser, TU München

Prof. Dr. J. Kaufman, University of Edinburgh

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Impact of morbillivirus infections upon respiratory innate immunity and pathology in wildlife carnivores (VIPER)
Auswirkungen von Morbillivirus-Infektionen auf die angeborene Immunität der Atemwege und die Pathologie bei wild lebenden Fleischfressern (VIPER)
Project Investigators: Prof. Andreas Beineke; Florian Wenzel
Duration: April 2025 until 2028
Funding: DFG (VIPER GRK)
Project Details:
Characterizing the impact of morbilliviruses upon innate responses and the integrity of respiratory epithelial cells.
-Generation and characterization of 3D-culture systems of different wildlife carnivore species
-Analyses of morbillivirus infections upon respiratory tract cells of wild carnivores in vivo and ex vivo
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Molecular identification of viral pathogens in formalin-fixed, paraffin-embedded tissues from dogs with non-suppurative encephalitis (VIPER)
Molecular identification of viral pathogens in formalin-fixed, paraffin-embedded tissues from dogs with non-suppurative encephalitis (VIPER)
Project Investigators: Prof. Wolfgang Baumgärtner; Dr. Christina Puff; Hannah Gerhards
Duration: September 2025 until August 2028
Funding: DFG (VIPER GRK)
Project Details:
Hypothesis:
Viral genomic sequences obtained from archived canine formalin-fixed, paraffin embedded tissue of the central nervous system and will allow establishing a cause-consequence relationship between the detected known and unknown viral pathogen and pathological findings.
Aim and objectives:
The general aim of the project is further identify the viral cause of canine diseases of the central nervous system.
-By using conventional histology and immunochistochemistry of archived tissues from the last 6 decades to identify cases of non-supprative encephalitis of unknown origin
-Suspected virus infection will be further substantiated by applying double-stranded RNA or selected interferon stimulated genes specific antibodies and a probe specific for interferon β.
-Followed by ribonucleic acid extraction from the selected FFPE tissues, RT-qPCR using pan-genus primer and/or NGS. Alignment to reference genomes available in databases will be used to detect known viral pathogens and related unknown viruses
-Investigation of the pathogenesis of the discovered virus by studying cell tropism and the distribution of the virus in the host organism using in situ hybridization for the distribution of the pathogen
Cooperation Partners:

Institut für Virusdiagnostik, Friedrich Löffler Institut

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Phenotypical and molecular characterization of short- and long- term lesions in the hamster following SARS-CoV-2 infection with special emphasis on the diffuse endocrine system and nervous system. (VIPER)
Phänotypische und molekulare Charakterisierung von Kurzzeit- und Langzeitschäden einer SARS-CoV-2 Infektion im Hamster, mit besonderem Augenmerk auf das diffuse endokrine System und das Nervensystem. (VIPER)
Project Investigators: Prof. Wolfgang Baumgärtner; Eva Leitzen; Nils Eckmann; Laura Heydemann
Duration: April 2025 until 2028
Funding: DFG (VIPER GRK)
Project Details:
Motile cilia are microtubule-based, hair-like projections on the luminal membrane of epithelial cells in conducting airways. Through their continuous wave-like beating, they evacuate mucus secreted by goblet cells, thereby contributing to muco-ciliary clearance (MCC). In this function, motile cilia are actors of the first-line defense against inhaled pathogens. Dysregulated cilia will have a long-term effect on MCC and predispose for further diseases. Similarly, the diffuse endocrine system plays an essential role in respiratory tract imbalances. However, underlying pathogenetic mechanisms are not well understood, neither in various organs nor in the trachea and larynx. Therefore, the envisioned study will enhance our understanding of short- and potential long-term effects of SARS-CoV-2 infection in the upper respiratory tract and its associated endocrine and nervous system.
Cooperation Partners:

Institut für Virologie, Universität Münster,

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, U.S.A (Klaus Schughart),

Helmholtz-Zentrum für Infektionsforschung (HZI), Braunschweig (Robert Geffers),

Medizinisch Hochschule Hannover (Peter Claus)

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Correlation of microglial morphology and their transcriptomic signature in TMEV-infected OT-I and OT-II mice with and without adoptive transfer of GFP/RFP expressing CD8+ and CD4+ T cells
Korrelation der Mikroglia-Morphologie und ihrer transkriptomischen Signatur in TMEV-infizierten OT-I- und OT-II-Mäusen mit und ohne adoptiven Transfer von GFP/RFP-exprimierenden CD8+ und CD4+ T-Zellen
Project Investigators: Prof. Andreas Beineke; Prof. Wolfgang Baumgärtner; Charlotte Sophie Kinder; Anna Reiß
Duration: April 2025 until 2028
Funding: DFG (VIPER GKR)
Project Details:
This project aims to investigate the effect of an early (3 days post infection [dpi]) and a late (8 dpi) adoptive transfer of green (GFP) and red fluorescent (RFP) T- cells on the microglial morphology and transcriptomic data in TMEV- infected OT-I and OT-II mice. The contribution of CD8+ and CD4+ T cell subsets for viral clearance and course of clinical disease will be investigated individually as well as the general pathomorphology and immune response with special focus on microglia morphology and transcriptomic data.
Cooperation Partners:

Institut für Neuroimmunologie und Multiple-Sklerose-Forschung der Universitätsmedizin Göttingen

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Isolation and characterisation of the microbiome and microbially associated peptides and their influence on the immune system of reptiles
Isolation und Charakterisierung des Mikrobioms sowie mikrobiell assoziierter Peptide und deren Einfluss auf das Immunsystem von Reptilien
Project Investigators: Hetterich; Pees
Duration: 2025 until 2028
Project Details:
Charakterisierung Darmflora und deren Einfluss aus das Immunsystem bei Reptilien
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GRK VIPER 3- Role of adipose tissue as a silent reservoir for respiratory virus replication
GRK VIPER 3/80-7- Die Rolle des Fettgewebes als stilles Reservoir für die Replikation von Atemwegsviren
Project Investigators: Prof. Gabriel
Duration: April 2025 until 2028
Funding: DFG, 45.000 EUR
Project Details:
Role of adipose tissue as a silent reservoir for respiratory virus replication
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DFG Research Training Group 2485 VIPER Project: Role of salivary gland tissue in infection of pigs with respiratory and intestinal viruses
DFG Graduiertenkolleg VIPER (2485) Projekt: Die Bedeutung des Speicheldrüsengewebes bei der Infektion von Schweinen mit respiratorischen und intestinalen Viren
Project Investigators: Paul Becher
Duration: April 2025 until 2028
Funding: DFG, 250.000 EUR
Project Details:
It is well known that a number of viral pathogens can be detected in saliva of infected humans and animals. However, for most of these viruses the source of their presence in saliva and in the oral cavity remains unknown. While it has been reported that human salivary glands can be infected by SARS-CoV-2 and some other viruses, the role of salivary gland tissues in infection of pigs with respiratory and most enteric viruses has not been addressed so far. To characterize infection of porcine salivary glands by both respiratory viruses (influenza A virus, porcine respiratory coronavirus) and enteric viruses (transmissible gastroenteritis virus, porcine rotavirus A), differentiated salivary gland epithelial cells and organoid cultures from pigs were established by the group of the PI. In addition to porcine influenza viruses, human and avian influenza viruses will be used to investigate a possible role of porcine salivary glands in interspecies transmission and evolution of influenza virus.
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DFG Research Training Group 2485 VIPER Project: Viral infections of the bovine placenta: role of innate immunity and mechanism of diaplacental transmission
DFG Graduiertenkolleg VIPER (2485) Projekt: Virale Infektionen der bovinen Plazenta: Rolle der angeborenen Immunität und Mechanismus der diaplazentaren Übertragung
Project Investigators: Paul Becher
Duration: April 2025 until 2028
Funding: DFG, 250.000 EUR
Project Details:
The bovine epithelia-choreal placenta protects the fetus from infections with numerous pathogens. However, some viruses, such as bovine viral diarrhea virus (BVDV) or bluetongue virus, are able to cross the placenta barrier during pregnancy. In the case of BVDV, diaplacental infection with non-cytopathogenic (ncp) viruses between the 40th and 125th day of gestation is a mandatory prerequisite for the establishment of persistent infections and is therefore of outstanding epidemiological importance. In contrast, infection of pregnant animals with cytopathogenic (cp) BVDV does not lead to the birth of persistently infected offspring.
An important aspect of the placenta's barrier function against pathogens is innate immunity. First, we want to investigate the innate immune response of polarized bovine placenta cells to dsRNA applied to either the basolateral or apical compartment. Moreover, we will examine the efficiency of viral replication and release of BVDV and other bovine viruses, and characterize the innate immune response after basolateral and apical infection.
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GRK VIPER 3/80-9- Glycoprotein-mediated immune evasion mechanisms of human and animal pneumoviridea
GRK VIPER 3/80-9- Glykoprotein-vermittelte Mechanismen der Immunabwehr von Pneumoviren bei Mensch und Tier
Project Investigators: Prof. Rimmelzwaan
Duration: April 2025 until 2028
Funding: DFG, 45.000 EUR
Project Details:
Glycoprotein-mediated immune evasion mechanisms of human and animal pneumoviridea
Show Details
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