Research

Project Details:
The behavior of European hedgehogs after hindlimb amputation is insufficiently researched. While some literature suggests hedgehogs may cope well with such amputations, there is a lack of systematic studies to confirm this. This project aims to evaluate the gait of hedgehogs after hindlimb amputation during rehabilitation. Healthy four-legged and three-legged hedgehogs will be analyzed and compared using accelerometers to understand the impact on their movement and survival, ultimately contributing to more effective treatments and better outcomes for wildlife rehabilitation.

Project Details:
Salmonella-specific phages are isolated and characterized from bearded dragons. Their spectrum of activity is determined, and their in vitro and in vivo effectiveness is examined.

Cooperation Partners:

Robert-Koch-Institut RKI Wernigerode

Funding: Förderverein Bioökonomieforschung e.V. (FBF), 13.000 EUR

Project Details:
The aim is to research and establish a novel method for sorting bovine sperm in a joint project. Here, TiHo carries out its sub-project (A) and also works cooperatively with the also beneficiary partner Georg-August-Universität Göttingen, who carries out its sub-project (B).
The aim of the first project phase, in cooperation with GAU, is to define an optimized protocol for treating the bull semen with a TLR7/8 ligand to separate the sperm using Swim Up. At the same time, two methods for determining the ratio of the X:Y sperm (digital PCR vs. MoFlow XDP Cell Sorter) are compared.
In the second project phase, our targeted task is to further optimize the accuracy and efficiency, or sperm vitality, with the selected sorting method of the processed samples by using microfluidic chips.

Cooperation Partners:

Prof. Dr. Michael Hölker, Georg-August-Universität Göttingen, Dept. für Nutztierwissenschaften.

Project Details:
GnRH agonists are frequently used in practice to treat diseases of the reproductive system in privately reared laying hens. After surgical removal of the oviduct, suppression of gonadal activity is essential. The aim of the planned studies is to examine the influence of such a resection of the laying intestine on the effect of the slow-release GnRH agonist deslorelin in clinical use. In order to assess the effect of the GnRH agonist, the activity of the ovary and oviduct will be evaluated by determining the sex hormones and by sonographic examination.

Funding: Deutsche Bundesstiftung Umwelt, 233.000 EUR

Project Details:
The project aims to develop a time- and location-based, digital, and mobile decision aid for citizens who have found a wild animal in nature. It enables the identification of the species and, based on the symptoms, provides a help recommendation through a decision tree. Specific contacts for further information are also provided.

Funding: MEKUN, 133.105 EUR

Project Details:
The aim of the study applied for here is to investigate the habitat use of harbor porpoises in the western part of the Baltic Sea in a follow-up project using "passive-acoustic monitoring". To this end, harbor porpoise click detectors (C-PODs, Ceatacean_Porpoise_Detectors) were deployed at a total of four locations in March 2021 to record the presence of harbor porpoises. In August 2023, another station funded by the German Wildlife Foundation was deployed in the Baltic Sea. The monitoring stations in operation (Holnis, Bredgrund, Schleisand, Damp and Waabs) are intended to close the existing gap in the monitoring network between Fehmarn and Denmark. The habitat of harbor porpoises in the Baltic Sea is heavily influenced by human activities and factors that can have a negative impact on harbor porpoise populations. These include commercial shipping, tourist leisure activities, seismic surveys, military activities, fishing, offshore construction, blasting of old munitions, chemical and pharmaceutical pollution and marine litter.
In the Baltic Sea in particular, the harbor porpoise continues to be threatened by fishing with gillnets, in which harbor porpoises can end up as unintentional bycatch. In order to warn harbor porpoises of gillnets, acoustic warning devices are increasingly being used in the German Baltic Sea to warn porpoises of nets. These warning devices (Porpoise Alert = PAL) simulate the communication sound of harbor porpoises. Whether these devices lead to a reduction in by-catches has not yet been conclusively investigated. There is also currently no accompanying research to investigate whether these devices lead to the displacement of harbor porpoises.
The anthropogenic interventions described are only the most serious for the harbor porpoise. All these activities have a simultaneous effect on the harbor porpoise population and cannot be considered separately. The absence of older animals among the harbor porpoises captured and stranded in all study areas could be an indication that harbor porpoises in the Baltic Sea are affected by cumulative anthropogenic activities.

This study addresses the following questions:

1. Where do harbor porpoises occur in the western Baltic Sea?
2. Are there seasonal trends in the occurrence of harbor porpoises?
3. Which areas are of high ecological importance for harbor porpoises (e.g. foraging hotspots)?
4. Can the C-POD data collected as part of this monitoring be used to investigate the effects of blasting on harbor porpoises?
5. Can recommendations be derived from the results for certain periods when blasting should be considered more critically than in others?
6. Does the presence of PAL signals have an influence on the dating of harbor porpoises?

Funding: MEKUN, 172.488 EUR

Project Details:
The occurrence of harbor seals in the waters of Schleswig-Holstein has increased in recent years. At the same time, the seals are exposed to an increasing amount of human activity. These include chemical pollution, offshore wind turbine constructions, the Fehmarnbelt crossing, shipping, military and civilian detonations (munitions disposal), fishing, litter, habitat loss and other disturbances such as tourism. The increasing grey seal population in the North Sea has also led to the predation and rape of seals by grey seals in recent years.
As part of this research project, a total of 30 dead seals from the Schleswig-Holstein North Sea and Baltic Sea are to be examined in-depth for their state of health. These 30 individuals will be examined in addition to the 30 seals that will be necropsied as part of the project, which is funded by the Supreme Hunting Authority in the Ministry of Agriculture, Rural Areas, Europe and Consumer Protection of Schleswig-Holstein (MLLEV), bringing the total number of necropsied seals from Schleswig-Holstein to 60. Histological, microbiological and parasitological examinations will be carried out.

Funding: Niedersächsisches Ministerium für Ernährung, Landwirtschaft und Verbraucherschutz, 255.930 EUR

Project Details:
The mouflon or mouflon Ovis gmelini musimon only occurs in a few remaining populations in Lower Saxony. The mouflon should have a good chance of survival at least in some low mountain regions due to its predator avoidance strategy with short steep escapes up rocky slopes, but has become extinct in the lowland regions due to the presence of the wolf.
There is much discussion about the few animals in Lower Saxony and Germany in general: The mouflon is not originally native here (not autochthonous) and causes high levels of damage to forestry locally. On the other hand, it is classified as endangered by the IUCN in its native Corsica and Sardinia and is a symbolic species for hunters. Therefore, in this study we want to take a neutral view and use photo traps and direct observations to determine facts about abundance, behavior and enemy avoidance strategies as well as damage effects. In addition, surveys and interviews will be used to obtain the opinions of the various stakeholders (hunters, foresters, farmers, other nature lovers, etc.).
All of this data will be used to objectify the discussion about mouflon, large predators and human interests and to model the survival probabilities of Lower Saxony's mouflon populations in the presence of wolves and lynx.

Funding: Europäische Union, 142.547 EUR

Project Details:
The European Partnership on Animal Health and Welfare (EUPAHW) is a research and innovation initiative funded by the European Commission (EC) to control infectious diseases of animals, and to promote animal welfare. Due to the close link between animal health, animal welfare and human well-being, the One Health-One Welfare perspective takes a prominent position in the EUPAHW. Within the EUPAHW, the Institute for Terrestrial and Aquatic Wildlife Research will work with other partners on wildlife-livestock-human interface. The overall objective is to integrate the health of wild mammals and birds into the overall health surveillance and monitoring of livestock. Wildlife health surveillance contributes to the assessment of environmental health because wild animals may serve as sentinels for both terrestrial and aquatic ecosystems. Improving wildlife population monitoring and surveillance of wildlife pathogens/diseases aims to detect the emergence of pathogens and reduce the risk of transmission of infectious diseases between wildlife and livestock and even humans. The information is needed to design, apply and support sustainable livestock and wildlife management systems. In this context, the EUPAHW will assess the impact of climate change and human/anthropogenic activities such as hunting, trade, feeding, rewilding and translocation of wildlife on the spread of diseases and the establishment of invasive species.

Cooperation Partners:

56 Forschungsinstitutionen aus Europa (https://www.eupahw.eu)

Funding: IDT Biologika und von der Coalition for Epidemic Preparedness Innovations (CEPI), 484.000 EUR

Project Details:
We will study the immunogenicity and efficacy of our vaccine candidate, MVA-MERS-S, when used in different single vaccination and vaccination-booster setting in the lethal k18-hDPP4-mouse model after MERS-CoV-challenge infection. Different vaccination schedules also include different time points of challenge infection. We will characterize the activation of MERS-CoV-specific antibodies and T cells. The protective efficacy will be analyzed by morbidity, mortality and viral load in the lung and the brain a target organs. Moreover, a histopathological examination of the upper and lower respiratory tract of the animals upon challenged with MERS-CoV will show any evidence of ADE and ERD, respectively. Another study will evaluate the impact of passively transfered sera from MVA-MERS-S vaccinated mice for the outcome of protection after challenge infection.