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2309 results.
DFG Research Training Group 2485 VIPER Project: The role of flavivirus NS1 proteins in viral pathogenesis
DFG Graduiertenkolleg VIPER (2485) Projekt: Die Rolle der Flavivirus NS1 Proteine in der viralen Pathogenese
Project Investigators: Dr. Imke Steffen
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Show Details
Exposition of companion animals, livestock and wildlife against tick-borne encephalitis (TBE) virus in Lower Saxony, Germany
Exposition von Haus-, Nutz- und Wildtieren gegenüber Frühsommer-Meningoenzephalitis (FSME)-Virus in Niedersachsen
Project Investigators: Prof. Dr. C. Strube, PhD; Prof. Dr. S. Becker; Prof. Dr. R. Mischke; Prof. Dr. M. Ganter; Prof. Dr. K. Feige
Duration: January 2019 until End 2023
Funding: Elanco, 20.000 EUR
Project Details:
In recent years, the incidence of Tick-borne encephalitis (TBE) has increased in areas that are not considered official risk areas. In Germany, most of these areas are located in southern Germany, however, in the beginning of 2019, the National Institute of Public Health (Robert-Koch-Institut) declared a district in the Northern Germ federal state Lower Saxony as official risk area. In order to better assess the TBE risk for humans and animals in Lower Saxony and to obtain information on the localisation of natural foci, sera from livestock, pet and wild animals from Lower Saxony will be tested for TBE antibodies. Serum collection will particularly include districts in which human TBE cases have occurred.
Cooperation Partners:

Dr. U. Nagel-Kohl, LAVES, Hannover

Prof. Dr. Gerhard Dobler, Nationales Konsiliarlabor für FSME, München

Show Details
FibrOmics - Translating Omics studies into clinically relevant insights for lung fibrosis patients
FibrOmics - Translating Omics studies into clinically relevant insights for lung fibrosis patients
Project Investigators: Prof. Dr. Klaus Jung
Duration: October 2019 until September 2023
Funding: Niedersächsisches Minsiterium für Wissenschaft und Kultur, 201.000 EUR
Project Details:
Das vom Niedersächsischen Minsiterium für Wissenschaft und Kultur geförderte Projekt wird über die integrative Analyse von Transkriptom-Datensätzen zu einem besseren Verständnis der zugrundeliegenden Mechanismen der Lungenfibrose und hieraus ableitbarerer therapeutischer und diagnostischer Strategien führen. Das interdisziplinäre Konsortium mit Partnern der TiHo, der MHH und des Frauenhofer ITEMs verbindet klinische und molekularbiologische Expertise mit bioinformatischen Kompetenzen. Das ermöglicht die Integration von Daten aus der neuartigen Technologie der RNA-Sequenzierung auf Einzelzellebene. Das Projekt verspricht, neue Instrumente zur verbesserten Diagnostik und Therapien der Lungenfibrose zu entwickeln.
Cooperation Partners:

Dr. Davide DeLuca (Medizinische Hochschule Hannover), Prof. Dr. Antje Prasse (Medizinische Hochschule Hannover), Dr. Sylvia Escher (Fraunhofer Institut für Toxikologie und Experimentelle Medizin, Hannover), Dr. Jeanette Koschmann (geneXplain GmbH, Braunschweig)

Show Details
New strategies for the therapy of viral neuroinflammation
New strategies for the therapy of viral neuroinflammation
Project Investigators: Prof. U. Kalinke, TWINCORE
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Show Details
DFG Research Training Group 2485 VIPER Project: Robust algorithms for bioinformatics in virus research.
DFG Graduiertenkolleg VIPER (2485) Projekt: Robuste Algorithmen für die Bioinformatik in der Virusforschung. algorithms for bioinformatics in virus research.
Project Investigators: Prof. Dr. Klaus Jung
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Show Details
DFG Research Training Group 2485 VIPER Project: Hepatitis C virus-related equine hepacivirus cell entry and receptor usage
DFG Graduiertenkolleg VIPER (2485) Projekt: Hepatitis C virus-related equine hepacivirus cell entry and receptor usage
Project Investigators: Paul Becher; Eike Steinmann
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Show Details
Investigation of potential viral etiology and associated pathogenesis in disease syndromes of unknown cause
Investigation of potential viral etiology and associated pathogenesis in disease syndromes of unknown cause
Project Investigators: Prof. Dr. W. Baumgärtner; Madeleine de le Roi
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Results:

https://wwwnc.cdc.gov/eid/article/29/5/23-0172_article

Show Details
Identification of host-specific and viral factors in the transmission of the canine distemper virus between different animal species
Identification of host-specific and viral factors in the transmission of the canine distemper virus between different animal species
Project Investigators: Prof. Dr. A. Beineke; PD Dr. M. Ludlow
Duration: April 2019 until September 2023
Funding: DFG, 329.905 EUR
Project Details:
The VIPER research and training program will cover the global chain of events involved in virus emergence, all the way from virus discovery, isolation, molecular characterization, surveillance, and pathogenesis, towards animal and public health impact and intervention strategies including new approaches for prevention and control.

The VIPER research projects are subdivided into three pillars:

virus discovery, host range and transmission
virus-host cell interactions and pathogenesis, and
immune interference and intervention strategies.
Results:

1) https://pubmed.ncbi.nlm.nih.gov/35491822/

(Geiselhardt F, Peters M, Jo WK, Schadenhofer A, Puff C, Baumgärtner W, Kydyrmanov A, Kuiken T, Piewbang C, Techangamsuwan S, Osterhaus ADME, Beineke A, Ludlow M. Development and Validation of a Pan-Genotypic Real-Time Quantitative Reverse Transcription-PCR Assay To Detect Canine Distemper Virus and Phocine Distemper Virus in Domestic Animals and Wildlife. J Clin Microbiol. 2022 May 18;60(5):e0250521. doi: 10.1128/jcm.02505-21. Epub 2022 May 2. PMID: 35491822; PMCID: PMC9116185.)

 

2) https://pubmed.ncbi.nlm.nih.gov/36038706/

(Geiselhardt F, Peters M, Kleinschmidt S, Chludzinski E, Stoff M, Ludlow M, Beineke A. Neuropathologic and molecular aspects of a canine distemper epizootic in red foxes in Germany. Sci Rep. 2022 Aug 29;12(1):14691. doi: 10.1038/s41598-022-19023-9. PMID: 36038706; PMCID: PMC9424316.)

Show Details
PumaZu - Concept for improvement of animal health and stable environment in turkey barns in Lower Saxony
PumaZu - Konzept zur Verbesserung der Tiergesundheit und Optimierung des Stallklimas in niedersächsischen Putenmastställen
Project Investigators: Schäfers, Stephanie; Kemper, Nicole
Duration: February 2019 until February 2023
Funding: Europäische Innovationspartnerschaft "Produktivität und Nachhaltigkeit in der Landwirtschaft" (EIP Agri), 272.300 EUR
Project Details:
Existing ventilation systems in open barns always pose challenges for turkey fatteners, especially in the cold seasons. In order to ensure a sufficient influx of fresh air, the blinds in open barns must be opened even in cold, damp weather. With this form of gravity ventilation, the cold, moist air enters directly into the animal area. As a result, the risk for the occurrence of respiratory diseases and the development of damp litter increases. Therefore, within the framework of this project, the use of a new type of ventilation system in open barns is to be tested in cooperation between turkey fatteners, consultants and science. By modifying existing ventilation systems in open barns, the input of cold supply air is to be reduced without causing a deterioration of the barn climate. In addition, "drinking bars" will be set up in a second step. This restructuring of the barn interior is intended to create larger resting areas for the animals. At the same time, the aim is to reduce the area where wet litter can occur due to increased water entry.
Cooperation Partners:

Landwirtschaftskammer Niedersachsen

PAL Stalleinrichtungen GmbH

Praxisbetriebe

Show Details
Influence of "vaginal seeding" on early calf health
Einfluss von "vaginal seeding" auf die frühe Kälbergesundheit
Project Investigators: PD Dr. Maike Heppelmann; Prof. Hans-Joachim Schuberth
Duration: Beginning 2018 until December 2023
Funding: Gesellschaft der Freunde, 18.000 EUR
Project Details:
In human medicine caesarean section seemed to be a risk factor for the development of immunologic and metabolic diseases in children, which can be partially counteracted with "vaginal seeding", the exposure of the offspring to maternal vaginal fluids directly after caesarean section. The aim of this study was to investigate the effect of "vaginal seeding" on early calf health born via caesarean section.
Results:

https://nbn-resolving.org/urn:nbn:de:gbv:95-115783

https://nbn-resolving.org/urn:nbn:de:gbv:95-121609

Cooperation Partners:

FLI Braunschweig, Institut für Tierernährung, Prof. Deanicke, F. Billenkamp

Show Details
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