Research

Project Details:
The research project "WORMICs" investigates the three-dimensional genome structure of the giant mealworm (Tenebrio molitor) and the superworm (Zophobas atratus) in collaboration with the institutes of food quality and safety and animal nutrition. The overall aim is to support the development of novel protein sources and, in particular, to achieve a deeper understanding of the genetic basis of growth and developmental processes in these insect species. A special emphasis is placed on the genetics of growth and the genomic regulation of growth-related traits. A central focus of the project is the methodological advancement and optimization of 3D genomics protocols, covering the full workflow from sample preparation and library construction to sequencing. The resulting sequencing data are analyzed using advanced bioinformatics approaches to identify structural and functional genomic features.

Funding: Landwirtschaftskammer Niedersachen , 227.674 EUR

Project Details:
Since the ban on cage housing in Germany in 2010, many laying hens are kept in alternative housing systems with free-range access. In Lower Saxony, approximately 23% of laying hens are housed in conventional free-range systems, while around 16% are kept under organic farm conditions. Particularly in these systems, an increasing parasite burden from intestinal worms has been observed, as worm eggs accumulate in the outdoor areas, and there are only limited biosecurity measures available for prevention and treatment.
Depending on the intensity of the infestation, worm infections can lead to significant health impairments in laying hens. These include general well-being disturbances, reduced performance, delayed growth, gastrointestinal damage and, in severe cases, even death. Effective worm control presents a major challenge for many free-range farms, particularly for those operating under organic standards. Addressing this issue requires strategic planning, targeted interventions and subsequent success monitoring.
The "Worm-free" project focuses on alternative measures to reduce worm infestations in free-range laying hen flocks. Over the course of three years, 50 flocks will be monitored for one production cycle each. By continuously recording management practices and regularly assessing parasite loads, the effectiveness of different farm-specific interventions will be evaluated.
As part of the project, a web application is also being developed to support laying hen farmers in identifying the risk of increased parasite burdens in their flocks and implementing effective countermeasures.

Funding: Bundesministerium für Bildung und Forschung (BMBF)/PTJ Jülich, 165.805 EUR

Project Details:
In phase II of CREATE the subproject of the University of Veterinary Medicine Hannover, Foundation, aims at the identification and the establishment of health indicators for native marine mammal species in order to be able to assess the impacts of increasing anthropogenic activities on marine mammals and the marine ecosystem and to be able to detect them at an early stage. For this purpose, health data is analysed from about three decades, as well as data gained during the project, of native marine mammals from the German North Sea and Baltic Sea. The Knowledge gained in phase I on the spatial and temporal occurrence of bacteria and viruses will be used for more extensive investigations in phase II. The aim is to investigate a possible interaction between the occurrence of pathogenic bacteria and viruses and other infections, such as bacterial/viral co-infections or parasite infestation. It will also be analysed to what extent there is a connection between the determined causes of illness and death and the occurrence of certain pathogens. In this context, factors that are relevant to the population as a whole are of particular interest. The chronology of the data can be used to assess whether there have been changes in the burden on marine mammals over the last 30 years. Finally, the analysed data will be evaluated for their suitability for indicators, especially with regard to anthropogenic effects on marine mammal populations. The identification of such indicators would enable long-term monitoring strategies, promote the development of effective management measures and also feed into international agreements such as HELCOM and OSPAR. In addition, the data developed in the project will be used to create various Knowledge formats for stakeholders and thus communicate the here gained findings to the general public.

Cooperation Partners:

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, Bremerhaven inklusive Helmholtz-Institut für Funktionelle Marine Biodiversität an der Universität Oldenburg

Carl von Ossietzky Universität Oldenburg

Christian-Albrechts-Universität, Kiel

GEOMAR Helmholtz-Zentrum für Ozeanforschung Kiel

Humboldt-Universität zu Berlin

Leibniz-Institut für Ostseeforschung Warnemünde

Max-Planck-Institut für Marine Mikrobiologie, Bremen

Senckenberg Gesellschaft für Naturforschung

Leibniz-Zentrum f. Mar. Tropenforschung Bremen

Funding: Bundesministerium für Bildung und Forschung über Projektträger Jülich/Forschungszentrum Jülich GmbH, Rostock, 443.773 EUR

Project Details:
The habitat of marine mammals is strongly characterised by anthropogenic use in the North and Baltic Seas. Marine mammals are sensitive to Stressors such as maritime traffic, offshore wind energy development, pollution and fishing. These activities can lead to habitat degradation for marine mammals, as habitat loss or fragmentation often occurs.
The interdisciplinary and cross-scale end-to-end (E2E) modelling System developed in the first phase of CoastalFutures will be extended in phase II to model the occurrence of marine mammals under different future scenarios. This novel tool now offers the possibility to analyse the effects of climate change and anthropogenic activities on indicator species by generating a virtual environment. For the first time, simulations on the effectiveness of various management measures for the protection and Conservation of marine mammal populations can be carried out in phase II, thus providing Knowledge for action for the implementation of political decisions. The impact of underwater noise on harbour seals as a result of the expansion of offshore wind farms (OWFs) is estimated at population level using a multifactorial assessment. Animal movement models are extended to include aspects of animal physiology so that effects on the energy budget can be integrated, while the effects of other Stressors and management measures are also considered, taking future climate conditions into account. In addition, potential impacts, such as the role of OWFs as artificial reefs and noise impacts on marine mammals, will be analysed and assessed to explore negative and positive effects. This in turn leads to a quantitative assessment of the food and habitat base for marine mammals and the exposure to Stressors in the marine protected areas.

Cooperation Partners:

-Helmholtz-Zentrum Hereon, Institute of Coastal Systems - Analysis and Modeling

-Leibniz Institute for Baltic Sea Research, Warnemünde

-Technische Universität Braunschweig, Leichtweiß-Institute for Hydraulic Engineering and Water Resources

-Thünen-Institut (TI für Seefischerei, TI für Ostseefischerei)

-Leibniz Universität Hannover, Ludwig-Franzius-Institut

-Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, Bremerhaven

-Technische Universität Hamburg, Institute of River and Coastal Engineering

Assoziierte Partner:

-Bundesamt für Seeschifffahrt und Hydrographie

-Deutscher Wetterdienst

-Bundesanstalt für Wasserbau

- Bundesamt für Naturschutz

Funding: Bundesministerium für Bildung und Forschung / DLR, 182.810 EUR

Project Details:
Antimicrobial resistance (AMR) is a global health threat that involves complex, opaque transmission
processes between humans, animals and the environment. The particular role of wildlife and the
environment in the emergence, maintenance, dissemination and transmission of AMR bacteria and AMR genes is widely unknown. In the MARRES project, AMR bacteria from grey and harbour seals of the North and Baltic Sea and of sea water (environmental - eDNA) will be determined to perform a targeted surveillance of these two marine ecosystems. State of the art microbiological techniques, genome and metagenome sequencing will be applied. The evaluation of published human and animal AMR data of the investigated areas as well as on a global scale shall put the obtained results from this almost unexplored field into a One Health context. The approach covers three One Health settings of marine ecosystems as one of the greatest players in Global Health. It promises to provide relevant insight into transmission pathways of AMR bacteria, including pathogens, and of AMR determinants between humans, wildlife and the environment. A database for AMR associated to marine mammals in the Baltic Sea will be established following the FAIR principles. On a longer term, this project should be the starting point to establish a transnational network between experts in the field of AMR and marine biologists in Europe. The implementation of a harmonized AMR surveillance in the marine ecosystem sector will significantly contribute to AMR mitigation strategies and thus to public health.

Cooperation Partners:

Project coordination: Prof. Dr. Christa Ewers, Institute of Hygiene and Infectious Diseases of Animals, Justus Liebig University Giessen, Germany

Dr. Iwona Pawliczka vel Pawlik, University of Gdańsk, Institute of Oceanography, Hel Marine Station, Poland

Prof. Modestas Ruzauskas, Lithuanian University of Health Sciences, Microbiology and Virology Institute, Lithuania

Žilvinas Kleiva, PhD, Lithuanian Sea Museum, Lithuania

Martin Hölzer, Robert Koch Institute, Germany

Funding: BMEL, 318.427 EUR

Project Details:
The project is carried out on DIL e.V., Quakenbrück.
The aim of this project is to develop and evaluate a concept for the extraction and processing of proteins from brewer's yeast in the highest possible native and functional form on a pilot scale. The proteins and other valuable substances of the yeast are mostly located within the cells and are therefore not easily accessible for conventional extraction or precipitation. Therefore, cell disruption is necessary, in order to increase access to the proteins. Residues from the brewing process also adhere to the yeast. These include gluten and bitter substances from the hops. Therefore, in the first step the aim is to develop a process for removing the bitter substances and gluten as far as technically possible (AP 1). The yeast cells are then physically disrupted so that the proteins dissolved in the cell plasma can escape. For this purpose, two mechanical methods are used in this research project: (1) electroporation using pulsed electric fields (PEF, WP 3), and (2) ultra-high-pressure homogenization (UHPH, WP 2). After the cell disruption, the cell wall components are separated from the protein-rich suspension/solution using the principle of separation by density or centrifugal forces in a plate separator. The proteins obtained will then be processed and stabilized and examined for their sensory, techno-functional and nutritional properties (WP 4), as well as their suitability to produce selected exemplary food products (WP 5). Once the process has been established for brewer's yeast, it will be validated with yeasts from other sources (WP 6). Finally, a life cycle assessment (LCA, WP 7) will be carried out using the data obtained during the proejct to compare the environmental impact of the proteins obtained to protein of soy and milk. During the LCA, the entire process will be included, i.e. the energy requirements of the new technologies will also be taken into account and compared with the production process of soy and milk proteins. In cooperation with the industrial partners, the feasibility and economic viability of the entire process will be evaluated (AP 8).

Cooperation Partners:

Elea Technology GmbH, Leiber GmbH

Funding: Bundesanstalt für Landwirtschaft und Ernährung (BLE), 630.245 EUR

Project Details:
The FUETURE project aims to efficiently utilize regional feed resources to reduce greenhouse gas emissions and improve energy efficiency in broiler chicken production. It seeks to develop an innovative approach based on the use of adaptable and resilient sustainably cultivated feed crops and previously underutilized domestic crops. Sustainability will be strengthened by reducing imports of unsustainable soy products from overseas. The scientific objective is to formulate regional feed rations taking into account sustainability criteria and the availability of co-products to reduce the environmental footprint of chicken meat. The environmental impact will be significantly reduced through innovative feed technology and precise supplementation of feed additives. The project aims to strengthen more sustainable regional food production and supports the German sustainability strategy.

Cooperation Partners:

KWS Lochow GmbH, Technische Hochschule Bingen, IFF Braunschweig

Funding: DFG- Deutsche Forschungsgemeinschaft, 456.829 EUR

Project Details:
PREGROW-project aims to provide a single nuclei transcriptional profile of the pituitary and its downstream targets in miniature-sized and larger-sized pigs as a model for prepubescent growth control. This approach is meant to meet a big challenge we encounter in research work on growth: Body size is a whole-organism phenotype with many different tissues involved, and the variant effects are expected to be complex. For this reason, PREGROW aims at studying the genetic landscape of growth-axis-related tissues in the pig, providing a genetic resource for deciphering mechanisms of gene interplay, and underlying variant effects. The objective is to perform a functional trait-cell type enrichment for previously identified genome-wide associated growth and height loci obtained from GWAS by assigning them to cell types identified in gene expression data on single nuclei level. The project aims at identifying those genes, which are differential in large versus miniature pigs, and can thereby be considered as important fine-regulators of prepubescent growth in pigs, in addition to the known hormonal axis regulation by growth hormone/IGF.

Cooperation Partners:

Prof. Malte Spielmann, Universität zu Lübeck

Funding: Landesbetrieb für Küstenschutz, Nationalpark und Meeresschutz Schleswig-Holstein, Tönning, 83.205 EUR

Project Details:
As part of the seal live monitoring program, harbour seals and other seal species are caught with nets in the Schleswig-Holstein Wadden Sea. In addition to staff from the University of Veterinary Medicine Hannover, Foundation, this campaign is carried out with the help of experienced staff from the State Office for Coastal and Nature Conservation, seal hunters and other helpers. The seals are measured (including blubber thickness via ultrasound) and weighed. Blood, hair and faecal samples as well as swabs for bacteriology and virology are taken. Based on the samples, blood counts are drawn up and blood chemistry, cytology, microbiology, virology and serology tests are carried out. Furthermore, tests for heavy metals (hair and blood) and persistent organic pollutants are performed.In addition, parasitological examinations for the detection and species identification of parasites as well as cytological and pathological processing of changes in the animal body are done. If grey seals are caught during the seal catches, the named examinations will also be carried out on them.
The examinations are carried out in cooperation with the Institute of Virology and the Institute of Pathology at the University of Veterinary Medicine Hannover, the Institute of Hygiene and Infectious Diseases at the Justus Liebig University Giessen, the Freshwater and OCeanic science Unit of reSearch (FOCUS) of the University of Liege (Belgium) and the department of Ecological Chemistry of the Helmholtz Centre for Environmental Research GmbH (UFZ) Leipzig. In addition to these investigations, seals are also equipped with telemetry devices as part of other research projects and doctoral theses.

Cooperation Partners:

Institut für Hygiene und Infektionskrankheiten der Justus-Liebig-Universität Gießen

Freshwater and OCeanic science Unit of reSearch (FOCUS) der Universität Liege (Belgien)

Department Ökologische Chemie des Helmholtz-Zentrum für Umweltforschung GmbH (UFZ) Leipzig

Funding: UBA, 299.799 EUR

Project Details:
With the melting of the ice in the Arctic, new areas are becoming accessible for shipping routes, seismic oil exploration, extraction of critical raw materials for new technologies (e.g. rare earth elements), and other anthropogenic activities. All these activities have the potential to impact cetaceans.
Studies performed on rats and humans show that different chemicals (including PCBs and heavy metals) can cause hearing loss and/or effects of noise exposure are more pronounced. However, a correlation between hearing loss and high levels of PCBs or heavy metals in cetaceans has not been determined to date.

The aim of this project is to identify and quantify the effects of noise and chemical pollution on hearing in cetaceans in the Arctic. Since cetaceans rely on hearing for all their daily activities, it is crucial to understand how underwater noise and chemical pollution (or the cumulative effects of both stressors) could affect cetacean hearing.
To achieve this we will analyze ears of cetaceans that stranded or were legally harvested including complementary techniques to be able to identify lesions in the ear that are compatible with noise exposure. Samples of blubber and/or liver of the same animals will be analyzed for selected chemical pollutants to determine concentrations of persistent organic pollutants and chemical elements and correlate them with the findings of the ear analyses. If possible, the findings of the PIONEER project will be correlated with comprehensive post-mortem findings of each individual to determine the impact of the overall health status on the specific findings but also how cumulative effects of exposure (i.e. noise and chemical pollution) can affect cetacean health.
The novel approach of PIONEER combining the results of the analysis of hearing structures and concentrations of contaminants in several cetacean species in different countries along the Arctic will increase our understanding on the effects of underwater noise pollution on hearing and chemical pollution on health of wild populations.

Cooperation Partners:

Prof. Annika Jahnke (Helmholtz Zentrum für Umweltforschung - UFZ)

Prof. Krishna Das (Universität Lüttich, ULiege)

Dr. Marianna Pinzone (Universität Lüttich, ULiege, und Norwegisches Polarinstitut)