Research

Anti-seizure and -epileptogenic effects of new, selective mTOR inhibitors

Antikonvulsive und antiepileptogene Wirkungen neuer, selektiver mTOR-Inhibitoren

Project Investigators: Prof. Dr. Wolfgang Löscher

Duration: Beginning 2018 until March 2021

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C-type lectin receptor-mediated effects on neurodegeneration and immunopathology in the brain following neurotropic virus infection

C-Typ Lektinrezeptor-vermittelte Effekte neurotroper Viren auf Neurodegeneration und Immunpathologie im Gehirn

Project Investigators: Prof. Dr. Bernd Lepenies; Prof. Dr. Andreas Beineke

Duration: March 2018 until February 2021

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Environmental dependent influences on the developmental refinement of excitatory inputs at an ultra-fast coincidence detector neuron

Umweltabhängige Einflüsse auf die entwicklungs-abhängigen Verfeinerung der erregenden Eingänge an einem ultra-schnellem Koinzidenzdetektor-Neuron

Project Investigators: Prof. Dr. Felix Felmy

Duration: March 2018 until March 2021

Funding: DFG, 352.662 EUR

Project Details:
Binaural coincidence detection relies on the precise excitation-inhibition interaction in neurons of the medial superior olive (MSO). This precision is achieved through alterations during late postnatal development, a period marked by the establishment of prominent structure-function relationships in the auditory system. How excitatory inputs to MSO neurons refine during late postnatal development is unknown. In this proposal, we plan to mechanistically investigate these processes, through quantification of the developmental changes of excitatory currents and the morphology of axonal input patterns. To unravel what drives these changes we will perform these experiments in gerbils raised in omnidirectional white noise, which suppresses relevant sensory spatial cues. Conversely, the impact of sound-evoked activity will be eliminated using cochlear ablations. Applying both forms of sensory manipulation will allow us to distinguish whether sound evoked activity or the experience of spatial cues is crucial for functionally important circuit refinements in the MSO. Thus, our study will provide a quantitative insight into mechanisms that drive the development of synaptic excitation at an ultrafast coincidence detector neuron important for sound source localization.

Results:

Kladisios N, Wicke KD, Pätz-Warncke C, Felmy F.: Species-Specific Adaptation for Ongoing High-Frequency Action Potential Generation in MNTB Neurons. Journal of Neuroscience 2023 Vol 43:2714-2729

Pätz C., Console-Meyer L., Felmy F.: Structural arrangement of auditory brainstem nuclei in the bats Phyllostomus discolor and Carollia perspicillata. Journal of Comp Neurology, 2022, Vol. 530, 2762-2781; IF: 3.028

Siveke I, Myoga MH, Grothe B, Felmy F.: Ambient noise exposure induces long-term adaptations in adult brainstem neurons. Scientific Reports 2021 Mar 4; 11:5139.

Franzen D.L., Gleiss S.A., Kellner C.J, Kladisios N., Felmy F.: Activity-dependent calcium signaling in neurons of the medial superior olive during late postnatal development. Journal of Neuroscience, 2020, Vol. 40(8):1689-1700

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Erasmus+: Hybrid educational and research training on the use of marine models in life sciences

Project Investigators: Prof. Dr. Bernd Schierwater

Duration: End 2018 until End 2021

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Evalutation of new cardiac Biomarkers in dogs with degenerative Mitral Valve Disease and healthy dogs

Untersuchung neuer cardialer Biomarker an Hunden mit Degenerativer Mitralklappenerkrankung und gesunden Hunden

Project Investigators: Dr. Jan-Peter Bach; Prof. Dr. I. Nolte; Dr. Lisa Harder; Eva Packeiser; Stephanie Klein

Duration: April 2018 until March 2021

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Development and evaluation of a system tailored to dengue virus for immunogenicity studies

Entwicklung und Evaluation eines auf Dengue-Virus zugeschnittenen Systems für Immunogenitätsstudien (DRIVE)

Project Investigators: Prof. Osterhaus

Duration: December 2018 until Novemer 2021

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Role of intestinal integrity and intestinal microbiome on Enterococcus infections in broilers

Rolle der Darmintegrität und des Darmmikrobioms bei Enterokokkeninfektionen von Masthähnchen

Project Investigators: Arne Jung; Gerhard Breves

Duration: December 2018 until December 2021

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Characterization of the adrenal glands and the pancreas of young dogs in computed tomographic imaging

Computertomographische Charakterisierung von Nebennieren und Pankreas heranwachsender Hunde

Project Investigators: Dr. L. Harder; Prof. Dr. I. Nolte; Dr. M. Lüpke; G. Büttelmann

Duration: May 2018 until December 2021

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Consultation team Animal welfare in practical use. Feeding and employment under scrutiny for more animal welfare in the housing of pullets and laying hens

Beratungsteam Tierwohl im praktischen Einsatz. Fütterung und Beschäftigung auf dem Prüfstand für mehr Tierwohl in der Jung- und Legehennenhaltung.

Project Investigators: Spindler, Birgit; Riedel, Anna; Kemper, Nicole

Duration: October 2018 until September 2021

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Effects of Campylobacter jejuni on the animal health of laying hens

Auswirkungen von Campylobacter jejuni auf die Tiergesundheit von Legehennen.

Project Investigators: Prof. Dr. Silke Rautenschlein

Duration: May 2018 until April 2021

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