Research

Optimization of radiation protection and image quality in selected X-ray examinations in the clinic for cattle

Optimierung von Strahlenschutz und Bildqualität bei ausgewählten Röntgenuntersuchungen in der Klinik für Rinder

Project Investigators: Prof. Dr. H. Seifert; PD Dr. M. Heppelmann; Dr. M. Lüpke; TÄ J. Dierking

Duration: Mid 2018 until Beginning 2027

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Optimisation of the physical-technical parameters for reading and annealing of thermoluminescence dosemeters

Optimierung der physikalisch-technischen Parameter beim Auswerten und Tempern von Thermolumineszenzdosimetern

Project Investigators: Prof. Dr. Hermann Seifert; Dr. Matthias Lüpke; Cornelia Haferkamp

Duration: Beginning 2015 until Beginning 2027

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Thermography imaging as addition for diagnostic of inflammation and tumorous pathologies in the anatomic region of the equine head

Thermographie als bildgebendes Verfahren zur Ergänzung der Diagnostik bei entzündlichen und raumfordernden Erkrankungen im Kopfbereich des Pferdes

Project Investigators: Prof. Dr. Hermann Seifert; Prof. Dr. Bernhard Ohnesorge; Dr. Maren Hellige; Dipl.-Ing. Carsten Siewert

Duration: Beginning 2014 until Beginning 2027

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Experimental investigations using an opto-electronic measuring device (Perometer 1000 P) for determination of the volume of horse legs

Experimentelle Untersuchungen mit einem optoelektronischen Messgerät (Perometer 1000 P) zur Volumenbestimmung von Pferdebeinen

Project Investigators: Prof. Dr. Hermann Seifert; Dr. Sascha A. Bräuninger; TÄ Sarah Aurenz

Duration: Beginning 2013 until Beginning 2027

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Zoonotic Toxocara infections

Zoonotische Toxocara-Infektionen

Project Investigators: Prof. Dr. C. Strube, PhD; V. Rüster, PhD; Prof. Dr. F. Richter Assencio

Duration: Beginning 2012 until Mid 2027

Project Details:
Roundworms of the genus Toxocara can infect humans and persist in tissues for years or decades. Although the parasite cannot complete its life cycle, the infective larvae migrate through the body and can reach various organs, and thus cause considerable health damage. To characterise the zoonotic risk by roundworms, studies are being conducted on environmental contamination, human infections and evaluation of diagnostic tools. At the level of parasite-host interaction, in addition to immunological interactions, neurological damage in the host as a result of roundworm infection is also being characterised. Thus, not only larval distribution in the entire body of the host, but also the distribution of larvae and resulting damage in the brain is investigated. Here, neuropathological changes and gene regulation in the paratenic host are assessed by histopathology, molecular biological methods and behavioural studies.

Results:

Waindok, P., Janecek-Erfurth, E., Lindenwald, D. L., Wilk, E., Schughart, K., Geffers, R., Strube, C. (2022) Toxocara canis- and Toxocara cati-induced neurotoxocarosis is associated with comprehensive brain transcriptomic alterations. Microorganisms 10, 177

Waindok, P., Kann, S., Aristizabal, A., Dib, J. C., Strube, C. (2021) Toxocara seroprevalence and risk factor analysis in four communities of the Wiwa, an indigenous tribe in Colombia. Microorganisms 9, 1768

Raulf, M.-K., Lepenies, B., Strube, C. (2021) Toxocara canis and Toxocara cati somatic and excretory-secretory antigens are recognised by C-type lectin receptors. Pathogens 10, 321

Waindok, P., Raulf, M. K., Springer, A., Strube, C. (2020) The zoonotic dog roundworm Toxocara canis, a worldwide burden of public health. In: Strube C., Mehlhorn H. (Hrsg.) Dog Parasites Endangering Human Health. Parasitology Research Monographs, Band 13. Springer, Cham, Schweiz. S. 5-26

Strube, C., Waindok, P., Raulf, M. K., Springer, A. (2020) Toxocara-induced Neural Larva Migrans (neurotoxocarosis) in rodent model hosts. Advances in Parasitology 109, 189-218

Strube, C., Raulf, M. K., Springer, A., Waindok, P., Auer, H. (2020) Seroprevalence of human toxocarosis in Europe - a review and meta-analysis. Advances in Parasitology 109, 375-418

Cooperation Partners:

Prof. Dr. G. Gerold, Medizinische Universität Innsbruck, Österreich

Prof. Dr. B. Lepenies, Ludwig-Maximilians-Universität München

Prof. Dr. M. Pfeffer, Universität Leipzig

Dr. S. Kann, Missionsärztliches Institut Würzburg

Prof. Dr. M. Leschnik, Veterinärmedizinische Universität Wien, Österreich

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Examinations on the cerebrospinal fluid of the dog

Untersuchungen Liquor cerebrospinalis des Hundes

Project Investigators: Prof. Dr. Andrea Tipold; Michelle Prielipp

Duration: Mid 2009 until End 2027

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Aerial Survey of grey seals in the Wadden Sea of Lower Saxony and Hamburg-2025/2026

Kegelrobben-Kartierung im Niedersächsischen und Hamburgischen Wattenmeer per Flugzeug-2025/2026

Project Investigators: Prof. Prof. h. c. Dr. Ursula Siebert; Dr. Isabel Avila

Duration: October 2025 until August 2026

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Influence of a slow release GnRH agonist (Deslorelin) on gonadal activity in budgerigars (Melopsittacus undulatus)

Einfluss eines slow release GnRH-Agonisten (Deslorelin) auf die Gonadenaktivität bei Wellensittichen (Melopsittacus undulatus)

Project Investigators: Michael Pees; Marko Legler; Marion Schmicke; Lena Haas

Duration: January 2025 until January 2026

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Effects of a potassium channel modulator in a seizure model

Effekte eines Kalium-Kanal-Modulators im Epilepsiemodell

Project Investigators: Prof. Dr. M. Gernert

Duration: 2025 until December 2026

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MAGL inhibition as an experimental treatment strategy in epilepsies

MAGL-Hemmung als experimentelle Behandlungsstrategie bei Epilepsien

Project Investigators: Prof. Dr. M. Gernert

Duration: January 2025 until December 2026

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