Overview of research projects

Funding: Deutsche Bundesstiftung Umwelt, 233.000 EUR

Project Details:
The project aims to develop a time- and location-based, digital, and mobile decision aid for citizens who have found a wild animal in nature. It enables the identification of the species and, based on the symptoms, provides a help recommendation through a decision tree. Specific contacts for further information are also provided.

Funding: Interreg VI-B Norseeprogramm EFRE (Mittel aus dem Europäischen Fonds für regionale Entwicklung - EFRE) Niedersächsisches Ministerium für Bundes- und Europangelegenheiten und Regionale Entwicklung, Hannover Mittel des Bundes, 411.143 EUR

Project Details:
The North Sea is one of the busiest shipping areas. In order to achieve the EU's climate targets, a massive expansion of wind farms is planned in the North Sea. The North Sea is also a valuable habitat for many species that are threatened by future maritime developments. This also includes the risk of noise pollution. DEMASK aims to encourage maritime decision-makers, spatial planners and industry stakeholders to address the issue of underwater noise by jointly planning scenarios for the future of the North Sea, improving the tools and knowledge to assess noise mitigation scenarios and setting strategic priorities that lead to a well-managed noise landscape.
DEMASK consists of three working groups. The centerpiece (WP1) is the joint scenario planning process. WP1 relies on stakeholder participation and is specifically designed to maximize the uptake of strategic policy priorities for noise mitigation. It defines and assesses the key policy scenarios for noise reduction. WP2 focuses on predicting the future noise situation. Finally, WP3 will carry out risk assessments for biodiversity in the North Sea for alternative action scenarios. Pilot projects will predict the noise scenarios for these alternative scenarios compared to the baseline situation and use these noise scenarios to assess the impacts of noise and the associated risks for indicator species. Risks will be assessed on the basis of sensitivity, distribution, habitat and exposure if the thresholds for the occurrence of biologically significant adverse effects (LOBE) are exceeded at the regional level. This work package is led by ITAW.

Cooperation Partners:

Projektkoordination, Rijkswaterstaat (RWS), Ministry of Infastructure and Water Management, Utrecht

Federal Maritime and Hydrographic Agency (BSH), Hamburg

TNO research, Den Haag

IVL Swedish Environmental Research Institute, Kristineberg

Royal Belgian Institute of Natural Sciences (RBINS), Brüssel

North Sea Foundation, Utrecht

Flanders Marine Institute (VLIZ), Oostende

JASCO Applied Sciences

Funding: MEKUN, 394.000 EUR

Project Details:
Amphibians worldwide are confronted with a variety of factors causing a rapid population declines. In Schleswig-Holstein, these population declines can also be in otherwise widely distributed species and cannot be explained by structural parameters alone, such as habitat loss and alteration. Other factors influencing amphibians can include toxicological contamination and invasive pathogens. The effects of those stressors on our native amphibians are largely unknown. Furthermore, the extent to which the different stressors interact is largely unknown, although it is assumed that they potentiate each other. In order to implement successful conservation measures in the long term, it is important to identify and evaluate the relevant stressors. Based on preliminary studies carried out at the Institute for Terrestrial and Aquatic Wildlife Research (ITAW) from 2021 to 2023, the project aims to investigate possible stressors for amphibians native to Schleswig-Holstein. This includes the continued monitoring of pathogens, such as fungi originating from Asia (Batrachochytrium dendrobatidis (Bd) and B. salamandrivorans (Bsal)) as well as Ranaviruses and herpes viruses. In addition, of animal-related data as well as data on habitat-specific factors are collected to be able to explain differences in the occurrence of infectious agents. The collection of habitat-related data includes water quality characteristics (e.g. pH value, water temperature) and analyses of possible contaminants correlation with utilization, structure and surrounding vegetation over the course of the year.
In addition to recording possible stressors and their interaction, this study aims to develop a basis to evaluate habitats in the course of species protection measures such as reintroduction projects.

Cooperation Partners:

Rachel Marschang und Christoph Leineweber, LABOKLIN GmbH, Bad Kissingen

Annika Jahnke und Nadin Ulrich, Helmholtz-Zentrum für Umweltforschung, Leipzig

Krishna Das, University oh Liege, Lüttich, Belgium

Arne Drews, Landesamt für Umwelt, Schleswig-Holstein

Christian Winkler, faunistische Gutachten

René Seifert, Bündnis Naturschutz in Dithmarschen e. V.

Funding: Ministerium für Energie­wende, Klimaschutz, Umwelt und Natur (MEKUN), 766.851 EUR

Project Details:
Common Eider (Somateria mollissima) is classified as endangered in Europe due to continuous the population declines. Meanwhile, its occurrence along the coast of Schleswig-Holstein has potential for conflict with the culturally established and economically important fisheries.
The methods investigated in the pilot study showed promising effects: the tested eider protection fence effectively protected the mussel lines from feeding damage by common eiders and there were clear differences to control lines that were freely accessible to the eiders. However, the measures have so far only been tested on a small scale. In order to investigate the practicability on a realistic scale, this follow-up project aims to extend the to a larger area and possibly include other deterring methods that have not been used in the pilot project.

The long-term objective is to find practicable methods that are applicable to commercially operated mussel farms and at the same time function in terms of animal welfare or can even contribute to the reduction of bycatch in other areas.

At the same time, necropsies of dead common eiders will be continued in order to provide information on the incidence of disease within the population, identify pathological changes and classify these in the context of the population decline. This includes bacteriological, virological and parasitological analyses. In addition, toxicological examinations will provide information on the animals' exposure to environmental pollutants.

Funding: Stiftung zur Förderung der Erforschung von Ersatz- und Ergänzungsmethoden zur Einschränkung von Tierversuchen, 125.000 EUR

Project Details:
Chronic pain represents a significant health problem affecting approximately 20 to 50% of the world's population. Therapeutic methods are largely developed in behavioral tests with induced pain in rodents. This approach does not allow for pain treatment, leading to severe distress for the animals. Nevertheless, therapeutics developed in animals are not always effective in humans. Therefore, two in vitro models using human cells will be developed to quantify neuron-mediated chronic pain with the highest possible predictive power. For this purpose, stem cell-derived sensory neurons will be used (1.) to develop a luciferase-based exocytosis assay to easily quantify the increased release of neuropeptides (Substance P and Calcitonin Gene-Related Peptide) involved in the chronic pain response. Additionally, (2.) an innervated skin model will be developed to quantify neurite outgrowth and the expression of regulated genes associated with chronic pain receptors and ion channels involved in signal transduction in vitro. The proof-of-concept for the use of these models in pharmacology and toxicology will be provided by inhibiting induced neuropeptide release, induced neurite outgrowth, and induced gene expression with therapeutically effective substances or by triggering them through the addition of exogenous substances. This approach allows for the modeling of molecular pathways of chronic pain development in vitro, directly in human cells, to avoid unnecessary animal experiments and to develop effective and safe therapeutics for humans. Following the project, the skin model will be adapted to model atopic dermatitis using induced pluripotent stem cells and primary cells from patients, aiming to bring specific in vitro disease models into application for the development of new therapies in cooperation with industrial partners. Furthermore, the project should serve as a foundation for further cross-disciplinary in vitro modeling, such as the simulation of chronic joint pain.

Cooperation Partners:

Prof. Dr. Annemarie Lang, Ph.D., University of Michigan

Funding: IDT Biologika und von der Coalition for Epidemic Preparedness Innovations (CEPI), 484.000 EUR

Project Details:
We will study the immunogenicity and efficacy of our vaccine candidate, MVA-MERS-S, when used in different single vaccination and vaccination-booster setting in the lethal k18-hDPP4-mouse model after MERS-CoV-challenge infection. Different vaccination schedules also include different time points of challenge infection. We will characterize the activation of MERS-CoV-specific antibodies and T cells. The protective efficacy will be analyzed by morbidity, mortality and viral load in the lung and the brain a target organs. Moreover, a histopathological examination of the upper and lower respiratory tract of the animals upon challenged with MERS-CoV will show any evidence of ADE and ERD, respectively. Another study will evaluate the impact of passively transfered sera from MVA-MERS-S vaccinated mice for the outcome of protection after challenge infection.

Funding: Niedersächsisches Ministerium für Ernährung, Landwirtschaft und Verbraucherschutz, 255.930 EUR

Project Details:
The mouflon or mouflon Ovis gmelini musimon only occurs in a few remaining populations in Lower Saxony. The mouflon should have a good chance of survival at least in some low mountain regions due to its predator avoidance strategy with short steep escapes up rocky slopes, but has become extinct in the lowland regions due to the presence of the wolf.
There is much discussion about the few animals in Lower Saxony and Germany in general: The mouflon is not originally native here (not autochthonous) and causes high levels of damage to forestry locally. On the other hand, it is classified as endangered by the IUCN in its native Corsica and Sardinia and is a symbolic species for hunters. Therefore, in this study we want to take a neutral view and use photo traps and direct observations to determine facts about abundance, behavior and enemy avoidance strategies as well as damage effects. In addition, surveys and interviews will be used to obtain the opinions of the various stakeholders (hunters, foresters, farmers, other nature lovers, etc.).
All of this data will be used to objectify the discussion about mouflon, large predators and human interests and to model the survival probabilities of Lower Saxony's mouflon populations in the presence of wolves and lynx.

Funding: Niedersächsisches Ministerium für Wissenschaft und Kultur, 178.000 EUR

Project Details:
Measure 1 consists of work package A, which is part of e-learning service. The use of the blended learning format in veterinary teaching is to be promoted. A further focus will be placed on strengthening the (e-)didactic skills of lecturers and the digital skills of students, for which training courses will be created for these target groups.

Measure 1 also includes work package B, which is located in the Clinical Skills Lab. The establishment of a surgical logbook is intended to strengthen students' surgical skills. To support the implementation of the surgical logbook, a training concept for teaching surgical skills is being developed.

Funding: BUND Landesverband Nidersachesen e.V., 37.018 EUR

Project Details:
Underwater noise from ship traffic, the construction of facilities in the water and on the coast or the explosion of ammunition in the sea is identified as a threat by various national and international expert assessments and has negative effects on marine animals in the Wadden Sea - especially on marine mammals, including porpoises. Many projects on the effects of noise pollution on marine mammals underwater are already being carried out at the ITAW. The ITAW is particularly concerned with the effects of underwater noise on harbor porpoises, with a particular focus on ship traffic, offshore constructions, and unexploded ordnance contaminated sites (e.g. BfN-UWE2, BMBF-COASTALFUTURE, EU project SATURN). In this joint project with BUND, ITAW will provide support with recommendations for measures to reduce the effects of underwater noise on porpoises, development of voluntary rules of conduct, participation in panel discussions and materials for exhibitions. Different target groups should be made aware of the need to reduce underwater noise through different offers (exhibitions, lectures in schools, raising awareness among recreational boat owners). At the same time, recommendations for concrete measures to reduce underwater noise pollution are being developed.

Funding: Bundesanstalt für Landwirtschaft und Ernährung (BLE), 134.128 EUR

Project Details:
The overall goal of the project is that farms that have high antibiotic use (ABU) can learn from farms that have comparably low ABU and the identification and optimization of parameters to improve animal health. The specific objectives of the project are: to improve biosecurity and overall hygiene of broiler chicken farms, to improve animal health of broiler chickens, to minimize the use of antibiotics, to transfer knowledge between broiler chicken farms with low and high ABU, and to optimize risk areas based on knowledge transfer.
There should be an intensive exchange of experiences between farmers who have different levels of ABU within the project. Thus, farms that have a high need for antibiotic use at the beginning of the project will learn which parameters they can and should optimize to improve animal health and minimize antibiotic use. Farm management factors that have a potential impact on animal health and consequent necessary ABU will be evaluated and collected during the practical phases of the project. These factors are divided into respective work packages (WP), including biosecurity of the farm and hygiene management (worked on by FLI & UROS), cleaning and disinfection (UROS), animal health and stable or herd management (TiHo and LMU), and knowledge transfer (UROS).
The project thus involves farms that have already been able to minimize their antibiotic use through innovative measures, optimized management and improved husbandry conditions. In addition, farms that are interested in improving animal health and minimizing antibiotic use and want to learn from other farms are invited to participate.

Cooperation Partners:

Uni ROS; Prof. Helen Louton

LMU München; PD Dr. Elke Rauch

FLI Insel Riems; PD Dr. Nicolai Denzin