Publications

2026

Clinical Relevance of Prostate-Specific Membrane Antigen-Lipid Rafts Association and Membrane Protein Interactions in Prostatic Adenocarcinoma.

Ben Jemaa A, Hoter A, Khelifi O, Sallami S, Nouira Y, Oueslati R, Naim HY.World J Oncol. 2026 Sep 4;17(5):765-774. doi: 10.14740/wjon2833. eCollection 2026 Oct.PMID: 42730435 Free PMC article.

Differential Trafficking Phenotypes of NPC1 Mutant Proteins Reveal Distinct Cholesterol Accumulation Profiles.

Mahmoud SA, Mergani A, von Köckritz-Blickwede M, Naim HY.J Inherit Metab Dis. 2026 May;49(3):e70186. doi: 10.1002/jimd.70186.PMID: 41982147 Free PMC article.

Congenital sucrase-isomaltase mutations worsen IBS-linked V15F dysfunction and trafficking.

Tannous S, Husein DM, Naim HY.Gut. 2026 Feb 11:gutjnl-2025-336813. doi: 10.1136/gutjnl-2025-336813. Online ahead of print.PMID: 41125338 Free article. No abstract available.

Characterization of 3D human pulmonary epithelial model morphology and oxygen status under normoxia and hypoxia.

Lynch-Miller M, Lockow S, Dümmer K, Henneck T, Olmer R, Jaboreck MC, Mergani AO, Wandrey M, Branitzki-Heinemann K, Brogden G, Naim HY, Martin U, Schulz C, Talbot SR, Meurer M, Baumgärtner W, von Köckritz-Blickwede M.Biochim Biophys Acta Mol Cell Res. 2025 Aug;1872(6):119980. doi: 10.1016/j.bbamcr.2025.119980. Epub 2025 Apr 30.PMID: 40315920 Free article.

2025

Domain-Specific Effects of Sucrase-Isomaltase Genotype in Irritable Bowel Syndrome.

Torices L, Bonfiglio F, Esteban-Blanco C, Zamfir-Taranu A, Naim HY, D'Amato M.Gastroenterology. 2025 Aug;169(2):346-348. doi: 10.1053/j.gastro.2025.01.242. Epub 2025 Feb 17.PMID: 39971164 Free article. No abstract available.

Rosa canina L. Methanol Extract and Its Component Rutin Reduce Cholesterol More Efficiently than Miglustat in Niemann-Pick C Fibroblasts.

2024

Wanes D, Al Aoua S, Shammas H, Walters F, Das AM, Rizk S, Naim HY.Int J Mol Sci. 2024 Oct 22;25(21):11361. doi: 10.3390/ijms252111361.PMID: 39518914 Free PMC article.

The molecular anti-metastatic potential of CBD and THC from Lebanese Cannabis via apoptosis induction and alterations in autophagy.

Younes M, Hage ME, Shebaby W, Al Toufaily S, Ismail J, Naim HY, Mroueh M, Rizk S.Sci Rep. 2024 Oct 27;14(1):25642. doi: 10.1038/s41598-024-76340-x.PMID: 39463375 Free PMC article.

Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients.

Zamfir-Taranu A, Löscher BS, Carbone F, Hoter A, Esteban Blanco C, Bozzarelli I, Torices L, Routhiaux K, Van den Houte K, Bonfiglio F, Mayr G, Corsetti M, Naim HY, Franke A, Tack J, D'Amato M.Clin Gastroenterol Hepatol. 2025 Jun;23(7):1228-1237.e10. doi: 10.1016/j.cgh.2024.09.004. Epub 2024 Oct 14.PMID: 39413891 Free article. Clinical Trial.

Urtica dioica: Anticancer Properties and Other Systemic Health Benefits from In Vitro to Clinical Trials.

Abi Sleiman M, Younes M, Hajj R, Salameh T, Abi Rached S, Abi Younes R, Daoud L, Doumiati JL, Frem F, Ishak R, Medawar C, Naim HY, Rizk S.Int J Mol Sci. 2024 Jul 8;25(13):7501. doi: 10.3390/ijms25137501.PMID: 39000608 Free PMC article. Review.

Glycosylation Modulation Dictates Trafficking and Interaction of SARS-CoV-2 S1 Subunit and ACE2 in Intestinal Epithelial Caco-2 Cells.

El Khoury M, Wanes D, Lynch-Miller M, Hoter A, Naim HY.Biomolecules. 2024 Apr 30;14(5):537. doi: 10.3390/biom14050537.PMID: 38785944 Free PMC article.

Lipid rafts disruption by statins negatively impacts the interaction between SARS-CoV-2 S1 subunit and ACE2 in intestinal epithelial cells.

El Khoury M, Naim HY.Front Microbiol. 2024 Jan 8;14:1335458. doi: 10.3389/fmicb.2023.1335458. eCollection 2023.PMID: 38260879 Free PMC article.

Dominant-negative effect of lactase missense variants: hetero-complex assembly with the wild-type enzyme impairs intracellular trafficking and digestive function.

Wanes D, Stellbrinck T, Marten LM, Santer R, Naim HY.Gut. 2024 Sep 9;73(10):e16. doi: 10.1136/gutjnl-2023-331370.PMID: 38124012 Free PMC article. No abstract available.

Impaired digestive function of sucrase-isomaltase in a complex with the Greenlandic sucrase-isomaltase variant.

Tannous S, Naim HY.Biochim Biophys Acta Mol Basis Dis. 2024 Feb;1870(2):166947. doi: 10.1016/j.bbadis.2023.166947. Epub 2023 Nov 10.PMID: 37951511 Free article.

2023

Alteration of cholesterol content and oxygen level in intestinal organoids after infection with Staphylococcus aureus.

Mergani A, Meurer M, Wiebe E, Dümmer K, Wirz K, Lehmann J, Brogden G, Schenke M, Künnemann K, Naim HY, Grassl GA, von Köckritz-Blickwede M, Seeger B.FASEB J. 2023 Dec;37(12):e23279. doi: 10.1096/fj.202300799R.PMID: 37902583

Interaction between the α-glucosidases, sucrase-isomaltase and maltase-glucoamylase, in human intestinal brush border membranes and its potential impact on disaccharide digestion.

Tannous S, Stellbrinck T, Hoter A, Naim HY.Front Mol Biosci. 2023 Mar 8;10:1160860. doi: 10.3389/fmolb.2023.1160860. eCollection 2023.PMID: 36968271 Free PMC article.

The Effect of Tamsulosin, Dutasteride Monotherapy and Tamsulosin-Dutasteride Combination on Prostate Smooth Muscle Contractility in BPH Model Wistar Strain Rattus Novergicus.

Daryanto B, Naim HY, Budaya TN.Med Arch. 2023 Feb;77(1):13-17. doi: 10.5455/medarh.2023.77.13-17.PMID: 36919125 Free PMC article.

Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients.

Zamfir-Taranu A, Löscher BS, Husein DM, Hoter A, Garcia-Etxebarria K, Etxeberria U, Gayoso L, Mayr G, Nilholm C, Gustafsson RJ, Ozaydin O, Zheng T, Esteban-Blanco C, Bozzarelli I, Bonfiglio F, Rizk S, Franke A, Bujanda L, Naim HY, Ohlsson B, D'Amato M.Gut. 2024 Mar 7;73(4):706-708. doi: 10.1136/gutjnl-2023-329695.PMID: 36878682 Free PMC article. No abstract available.

2022

The Synergistic Effects of Curcumin and Chemotherapeutic Drugs in Inhibiting Metastatic, Invasive and Proliferative Pathways.

Younes M, Mardirossian R, Rizk L, Fazlian T, Khairallah JP, Sleiman C, Naim HY, Rizk S.Plants (Basel). 2022 Aug 17;11(16):2137. doi: 10.3390/plants11162137.PMID: 36015440 Free PMC article. Review.

Severe pathogenic variants of intestinal sucrase-isomaltase interact avidly with the wild type enzyme and negatively impact its function and trafficking.

Husein DM, Rizk S, Hoter A, Wanes D, D'Amato M, Naim HY.Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1;1868(11):166523. doi: 10.1016/j.bbadis.2022.166523. Epub 2022 Aug 18.PMID: 35985447 Free article.

Biochemical Characterization of SARS-CoV-2 Spike RBD Mutations and Their Impact on ACE2 Receptor Binding.

Hoter A, Naim HY.Front Mol Biosci. 2022 May 23;9:893843. doi: 10.3389/fmolb.2022.893843. eCollection 2022.PMID: 35677879 Free PMC article.

Hypomorphic variants of lactase-phlorizin hydrolase in congenital lactase deficiency are trafficking incompetent and functionally inactive.

Marten LM, Wanes D, Stellbrinck T, Santer R, Naim HY.Biochim Biophys Acta Mol Basis Dis. 2022 Apr 1;1868(4):166338. doi: 10.1016/j.bbadis.2022.166338. Epub 2022 Jan 8.PMID: 35007711 Free article.

2021

IRE1-Mediated Unfolded Protein Response Promotes the Replication of Tick-Borne Flaviviruses in a Virus and Cell-Type Dependent Manner.

Breitkopf VJM, Dobler G, Claus P, Naim HY, Steffen I.Viruses. 2021 Oct 27;13(11):2164. doi: 10.3390/v13112164.PMID: 34834970 Free PMC article.

Proliferation and Differentiation of Intestinal Caco-2 Cells Are Maintained in Culture with Human Platelet Lysate Instead of Fetal Calf Serum.

Wanes D, Naim HY, Dengler F.Cells. 2021 Nov 5;10(11):3038. doi: 10.3390/cells10113038.PMID: 34831260 Free PMC article.

Adult sucrase-isomaltase deficiency masquerading as IBS.

Foley A, Halmos EP, Husein DM, Fehily SR, Löscher BS, Franke A, Naim HY, Gibson PR, D'Amato M.Gut. 2022 Jun;71(6):1237-1238. doi: 10.1136/gutjnl-2021-326153. Epub 2021 Oct 6.PMID: 34615726 Free PMC article. No abstract available.

Staphylococcus aureus Infection Influences the Function of Intestinal Cells by Altering the Lipid Raft-Dependent Sorting of Sucrase-Isomaltase.

Mergani A, Wanes D, Schecker N, Branitzki-Heinemann K, Naim HY, von Köckritz-Blickwede M.Front Cell Dev Biol. 2021 Aug 13;9:699970. doi: 10.3389/fcell.2021.699970. eCollection 2021.PMID: 34490251 Free PMC article.

The glucose-regulated protein GRP94 interacts avidly in the endoplasmic reticulum with sucrase-isomaltase isoforms that are associated with congenital sucrase-isomaltase deficiency.

Hoter A, Naim HY.Int J Biol Macromol. 2021 Sep 1;186:237-243. doi: 10.1016/j.ijbiomac.2021.07.030. Epub 2021 Jul 6.PMID: 34242650

Rare Hypomorphic Sucrase Isomaltase Variants in Relation to Irritable Bowel Syndrome Risk in UK Biobank.

Zheng T, Camargo-Tavares L, Bonfiglio F, Marques FZ, Naim HY, D'Amato M.Gastroenterology. 2021 Nov;161(5):1712-1714. doi: 10.1053/j.gastro.2021.06.063. Epub 2021 Jun 26.PMID: 34186061 Free article.No abstract available.

Rosa canina L. Can Restore Endoplasmic Reticulum Alterations, Protein Trafficking and Membrane Integrity in a Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Phenotype.

Wanes D, Toutounji M, Sebai H, Rizk S, Naim HY.Nutrients. 2021 Jan 29;13(2):441. doi: 10.3390/nu13020441.PMID: 33572926 Free PMC article.

2020

Predictors of COVID-19 severity: a systematic review and meta-analysis.

Mudatsir M, Fajar JK, Wulandari L, Soegiarto G, Ilmawan M, Purnamasari Y, Mahdi BA, Jayanto GD, Suhendra S, Setianingsih YA, Hamdani R, Suseno DA, Agustina K, Naim HY, Muchlas M, Alluza HHD, Rosida NA, Mayasari M, Mustofa M, Hartono A, Aditya R, Prastiwi F, Meku FX, Sitio M, Azmy A, Santoso AS, Nugroho RA, Gersom C, Rabaan AA, Masyeni S, Nainu F, Wagner AL, Dhama K, Harapan H.F1000Res. 2020 Sep 9;9:1107. doi: 10.12688/f1000research.26186.2. eCollection 2020.PMID: 33163160 Free PMC article.

Differential Effects of Sucrase-Isomaltase Mutants on Its Trafficking and Function in Irritable Bowel Syndrome: Similarities to Congenital Sucrase-Isomaltase Deficiency.

Husein DM, Rizk S, Naim HY.Nutrients. 2020 Dec 22;13(1):9. doi: 10.3390/nu13010009.PMID: 33375084 Free PMC article.

Ketogenic Diet: Impact on Cellular Lipids in Hippocampal Murine Neurons.

Dabke P, Brogden G, Naim HY, Das AM.Nutrients. 2020 Dec 18;12(12):3870. doi: 10.3390/nu12123870.PMID: 33352829 Free PMC article.

Mesenchymal to epithelial transition driven by canine distemper virus infection of canine histiocytic sarcoma cells contributes to a reduced cell motility in vitro.

Armando F, Gambini M, Corradi A, Becker K, Marek K, Pfankuche VM, Mergani AE, Brogden G, de Buhr N, von Köckritz-Blickwede M, Naim HY, Baumgärtner W, Puff C.J Cell Mol Med. 2020 Aug;24(16):9332-9348. doi: 10.1111/jcmm.15585. Epub 2020 Jul 6.PMID: 32627957 Free PMC article.

Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives.

Hoter A, Rizk S, Naim HY.Front Mol Biosci. 2020 Apr 15;7:60. doi: 10.3389/fmolb.2020.00060. eCollection 2020.PMID: 32351972 Free PMC article. Review.

TRAPγ-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms.

Dittner-Moormann S, Lourenco CM, Reunert J, Nishinakamura R, Tanaka SS, Werner C, Debus V, Zimmer KP, Wetzel G, Naim HY, Wada Y, Rust S, Marquardt T.J Med Genet. 2021 Mar;58(3):213-216. doi: 10.1136/jmedgenet-2019-106279. Epub 2020 Apr 24.PMID: 32332102

Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line.

Toutounji M, Wanes D, El-Harakeh M, El-Sabban M, Rizk S, Naim HY.Int J Mol Sci. 2020 Apr 15;21(8):2726. doi: 10.3390/ijms21082726.PMID: 32326391 Free PMC article.

Axonopathy and Reduction of Membrane Resistance: Key Features in a New Murine Model of Human G_M1-Gangliosidosis.

Eikelberg D, Lehmbecker A, Brogden G, Tongtako W, Hahn K, Habierski A, Hennermann JB, Naim HY, Felmy F, Baumgärtner W, Gerhauser I.J Clin Med. 2020 Apr 2;9(4):1004. doi: 10.3390/jcm9041004.PMID: 32252429 Free PMC article.

Different Trafficking Phenotypes of Niemann-Pick C1 Gene Mutations Correlate with Various Alterations in Lipid Storage, Membrane Composition and Miglustat Amenability.

Brogden G, Shammas H, Walters F, Maalouf K, Das AM, Naim HY, Rizk S.Int J Mol Sci. 2020 Mar 19;21(6):2101. doi: 10.3390/ijms21062101.PMID: 32204338 Free PMC article.

A mutation map for human glycoside hydrolase genes.

Hansen L, Husein DM, Gericke B, Hansen T, Pedersen O, Tambe MA, Freeze HH, Naim HY, Henrissat B, Wandall HH, Clausen H, Bennett EP.Glycobiology. 2020 Jul 16;30(8):500-515. doi: 10.1093/glycob/cwaa010.PMID: 32039448 Free PMC article.

Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus.

Kleine-Weber H, Schroeder S, Krüger N, Prokscha A, Naim HY, Müller MA, Drosten C, Pöhlmann S, Hoffmann M.Emerg Microbes Infect. 2020 Jan 21;9(1):155-168. doi: 10.1080/22221751.2020.1713705. eCollection 2020.PMID: 31964246 Free PMC article.

Digestive enzyme expression in the large intestine of children with short bowel syndrome in a late stage of adaptation.

de Laffolie J, Sheridan D, Reinshagen K, Wessel L, Zimmermann C, Stricker S, Lerch MM, Weigel M, Hain T, Domann E, Rudloff S, Nichols BL, Naim HY, Zimmer KP.FASEB J. 2020 Mar;34(3):3983-3995. doi: 10.1096/fj.201901758RR. Epub 2020 Jan 19.PMID: 31957074

2019 

The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines.

Ghanem P, Zouein A, Mohamad M, Hodroj MH, Haykal T, Abou Najem S, Naim HY, Rizk S.Nutrients. 2019 Nov 17;11(11):2808. doi: 10.3390/nu11112808.PMID: 31744219 Free PMC article.

The Functions and Therapeutic Potential of Heat Shock Proteins in Inflammatory Bowel Disease-An Update.

Hoter A, Naim HY.Int J Mol Sci. 2019 Oct 26;20(21):5331. doi: 10.3390/ijms20215331.PMID: 31717769 Free PMC article. Review.

Heterozygotes Are a Potential New Entity among Homozygotes and Compound Heterozygotes in Congenital Sucrase-Isomaltase Deficiency.

Husein DM, Wanes D, Marten LM, Zimmer KP, Naim HY.Nutrients. 2019 Sep 25;11(10):2290. doi: 10.3390/nu11102290.PMID: 31557950 Free PMC article.

Heat Shock Proteins and Ovarian Cancer: Important Roles and Therapeutic Opportunities.

Hoter A, Naim HY.Cancers (Basel). 2019 Sep 18;11(9):1389. doi: 10.3390/cancers11091389.PMID: 31540420 Free PMC article. Review.

Isolation and Quantification of Sphingosine and Sphinganine from Rat Serum Revealed Gender Differences.

Brogden G, Husein DM, Steinberg P, Naim HY.Biomolecules. 2019 Sep 7;9(9):459. doi: 10.3390/biom9090459.PMID: 31500283 Free PMC article.

The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer.

Hoter A, Rizk S, Naim HY.Cancers (Basel). 2019 Aug 16;11(8):1194. doi: 10.3390/cancers11081194.PMID: 31426412 Free PMC article. Review.

Impaired cell surface expression and digestive function of sucrase-isomaltase gene variants are associated with reduced efficacy of low FODMAPs diet in patients with IBS-D.

Husein DM, Naim HY.Gut. 2020 Aug;69(8):1538-1539. doi: 10.1136/gutjnl-2019-319411. Epub 2019 Jul 22.PMID: 31331993 Free PMC article. No abstract available.

Cellular and Molecular Adaptation of Arabian Camel to Heat Stress.

Hoter A, Rizk S, Naim HY.Front Genet. 2019 Jun 19;10:588. doi: 10.3389/fgene.2019.00588. eCollection 2019.PMID: 31275361 Free PMC article. Review.

Phylogenetic analysis reveals key residues in substrate hydrolysis in the isomaltase domain of sucrase-isomaltase and its role in starch digestion.

Chaudet MM, Amiri M, Marth N, Naim HY, Rose DR.Biochim Biophys Acta Gen Subj. 2019 Sep;1863(9):1410-1416. doi: 10.1016/j.bbagen.2019.06.011. Epub 2019 Jun 27.PMID: 31254546

Different Niemann-Pick C1 Genotypes Generate Protein Phenotypes that Vary in their Intracellular Processing, Trafficking and Localization.

Shammas H, Kuech EM, Rizk S, Das AM, Naim HY.Sci Rep. 2019 Mar 28;9(1):5292. doi: 10.1038/s41598-019-41707-y.PMID: 30923329 Free PMC article.

Congenital Lactase Deficiency: Mutations, Functional and Biochemical Implications, and Future Perspectives.

Wanes D, Husein DM, Naim HY.Nutrients. 2019 Feb 22;11(2):461. doi: 10.3390/nu11020461.PMID: 30813293 Free PMC article. Review.

2018

Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils.

Noack A, Gericke B, von Köckritz-Blickwede M, Menze A, Noack S, Gerhauser I, Osten F, Naim HY, Löscher W.Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9590-E9599. doi: 10.1073/pnas.1719642115. Epub 2018 Sep 25.PMID: 30254169 Free PMC article.

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease.

Hoter A, El-Sabban ME, Naim HY.Int J Mol Sci. 2018 Aug 29;19(9):2560. doi: 10.3390/ijms19092560.PMID: 30158430 Free PMC article. Review.

Molecular cloning, cellular expression and characterization of Arabian camel (Camelus dromedarius) endoplasmin.

Hoter A, Amiri M, Warda M, Naim HY.Int J Biol Macromol. 2018 Oct 1;117:574-585. doi: 10.1016/j.ijbiomac.2018.05.196. Epub 2018 May 27.PMID: 29847784

Starch Tolerance and the Short Bowel.

de Laffolie J, Naim HY, Rudloff S, Zimmer KP.J Pediatr Gastroenterol Nutr. 2018 Jun;66 Suppl 3:S68-S71. doi: 10.1097/MPG.0000000000001962.PMID: 29762383 Review.

Posttranslational Processing and Function of Mucosal Maltases.

Amiri M, Naim HY.J Pediatr Gastroenterol Nutr. 2018 Jun;66 Suppl 3:S18-S23. doi: 10.1097/MPG.0000000000001826.PMID: 29762371 Review.

Dietary starch breakdown product sensing mobilizes and apically activates α-glucosidases in small intestinal enterocytes.

Chegeni M, Amiri M, Nichols BL, Naim HY, Hamaker BR.FASEB J. 2018 Jul;32(7):3903-3911. doi: 10.1096/fj.201701029R. Epub 2018 Feb 20.PMID: 29465310

Differential Glycosylation and Modulation of Camel and Human HSP Isoforms in Response to Thermal and Hypoxic Stresses.

Hoter A, Amiri M, Prince A, Amer H, Warda M, Naim HY.Int J Mol Sci. 2018 Jan 30;19(2):402. doi: 10.3390/ijms19020402.PMID: 29385708 Free PMC article.

Inflammation induced ER stress affects absorptive intestinal epithelial cells function and integrity.

Chotikatum S, Naim HY, El-Najjar N.Int Immunopharmacol. 2018 Feb;55:336-344. doi: 10.1016/j.intimp.2017.12.016. Epub 2018 Jan 8.PMID: 29324356

2017

Differentiation and Functionality of Bone Marrow-Derived Mast Cells Depend on Varying Physiologic Oxygen Conditions.

Möllerherm H, Meier K, Schmies K, Fuhrmann H, Naim HY, von Köckritz-Blickwede M, Branitzki-Heinemann K.Front Immunol. 2017 Nov 30;8:1665. doi: 10.3389/fimmu.2017.01665. eCollection 2017.PMID: 29250065 Free PMC article.

Characterization of Mucosal Disaccharidases from Human Intestine.

Amiri M, Naim HY.Nutrients. 2017 Oct 10;9(10):1106. doi: 10.3390/nu9101106.PMID: 28994704 Free PMC article.

Impact of Virtual Patients as Optional Learning Material in Veterinary Biochemistry Education.

Kleinsorgen C, von Köckritz-Blickwede M, Naim HY, Branitzki-Heinemann K, Kankofer M, Mándoki M, Adler M, Tipold A, Ehlers JP.J Vet Med Educ. 2018 Summer;45(2):177-187. doi: 10.3138/jvme.1016-155r1. Epub 2017 Sep 8.PMID: 28885874

In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus.

Yaseen R, Branitzki-Heinemann K, Moubasher H, Setzer WN, Naim HY, von Köckritz-Blickwede M.Biomedicines. 2017 Jul 5;5(3):40. doi: 10.3390/biomedicines5030040.PMID: 28678207 Free PMC article.

Utilization and acceptance of virtual patients in veterinary basic sciences - the vetVIP-project.

Kleinsorgen C, Kankofer M, Gradzki Z, Mandoki M, Bartha T, von Köckritz-Blickwede M, Naim HY, Beyerbach M, Tipold A, Ehlers JP.GMS J Med Educ. 2017 May 15;34(2):Doc19. doi: 10.3205/zma001096. eCollection 2017.PMID: 28584867 Free PMC article.

Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection.

Möllerherm H, Branitzki-Heinemann K, Brogden G, Elamin AA, Oehlmann W, Fuhrmann H, Singh M, Naim HY, von Köckritz-Blickwede M.Front Immunol. 2017 May 11;8:541. doi: 10.3389/fimmu.2017.00541. eCollection 2017.PMID: 28553287 Free PMC article.

Structure-function analysis of human sucrase-isomaltase identifies key residues required for catalytic activity.

Gericke B, Schecker N, Amiri M, Naim HY.J Biol Chem. 2017 Jun 30;292(26):11070-11078. doi: 10.1074/jbc.M117.791939. Epub 2017 May 18.PMID: 28522605 Free PMC article.

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps.

Brogden G, Neumann A, Husein DM, Reuner F, Naim HY, von Köckritz-Blickwede M.J Vis Exp. 2017 Mar 29;(121):54667. doi: 10.3791/54667.PMID: 28447973 Free PMC article.

Case study on the pathophysiology of Fabry disease: abnormalities of cellular membranes can be reversed by substrate reduction in vitro.

Brogden G, Shammas H, Maalouf K, Naim SL, Wetzel G, Amiri M, von Köckritz-Blickwede M, Das AM, Naim HY.Biosci Rep. 2017 Apr 28;37(2):BSR20160402. doi: 10.1042/BSR20160402. Print 2017 Apr 30.PMID: 28351893 Free PMC article.

Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus.

Yaseen R, Blodkamp S, Lüthje P, Reuner F, Völlger L, Naim HY, von Köckritz-Blickwede M.J Negat Results Biomed. 2017 Feb 19;16(1):2. doi: 10.1186/s12952-017-0067-2.PMID: 28214466 Free PMC article.

Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients.

Gericke B, Amiri M, Scott CR, Naim HY.Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):817-826. doi: 10.1016/j.bbadis.2016.12.017. Epub 2017 Jan 3.PMID: 28062276 Free article.

 2016

Formation of Neutrophil Extracellular Traps under Low Oxygen Level.

Branitzki-Heinemann K, Möllerherm H, Völlger L, Husein DM, de Buhr N, Blodkamp S, Reuner F, Brogden G, Naim HY, von Köckritz-Blickwede M.Front Immunol. 2016 Nov 25;7:518. doi: 10.3389/fimmu.2016.00518. eCollection 2016.PMID: 27933059 Free PMC article.

Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.

Henström M, Diekmann L, Bonfiglio F, Hadizadeh F, Kuech EM, von Köckritz-Blickwede M, Thingholm LB, Zheng T, Assadi G, Dierks C, Heine M, Philipp U, Distl O, Money ME, Belheouane M, Heinsen FA, Rafter J, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Walter S, Simrén M, Karling P, Ohlsson B, Schmidt PT, Lindberg G, Dlugosz A, Agreus L, Andreasson A, Mayer E, Baines JF, Engstrand L, Portincasa P, Bellini M, Stanghellini V, Barbara G, Chang L, Camilleri M, Franke A, Naim HY, D'Amato M.Gut. 2018 Feb;67(2):263-270. doi: 10.1136/gutjnl-2016-312456. Epub 2016 Nov 21.PMID: 27872184 Free PMC article.

Alterations in membrane trafficking and pathophysiological implications in lysosomal storage disorders.

Kuech EM, Brogden G, Naim HY.Biochimie. 2016 Nov;130:152-162. doi: 10.1016/j.biochi.2016.09.011. Epub 2016 Sep 21.PMID: 27664461 Review.

Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein.

Diekmann L, Behrendt M, Amiri M, Naim HY.Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3119-3128. doi: 10.1016/j.bbagen.2016.10.016. Epub 2016 Oct 21.PMID: 27773655

Prostate-specific membrane antigen (PSMA) assembles a macromolecular complex regulating growth and survival of prostate cancer cells "in vitro" and correlating with progression "in vivo".

Perico ME, Grasso S, Brunelli M, Martignoni G, Munari E, Moiso E, Fracasso G, Cestari T, Naim HY, Bronte V, Colombatti M, Ramarli D.Oncotarget. 2016 Nov 8;7(45):74189-74202. doi: 10.18632/oncotarget.12404.PMID: 27713116 Free PMC article.

Molecular biology of the gut.

Naim HY, Zimmer KP, Nichols B.Mol Cell Pediatr. 2016 Dec;3(1):32. doi: 10.1186/s40348-016-0059-1. Epub 2016 Aug 12.PMID: 27518572 Free PMC article. No abstract available.

Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus.

Blodkamp S, Kadlec K, Gutsmann T, Quiblier C, Naim HY, Schwarz S, von Köckritz-Blickwede M.Vet Microbiol. 2017 Feb;200:52-58. doi: 10.1016/j.vetmic.2016.03.021. Epub 2016 Mar 31.PMID: 27062479

The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens.

Zeitouni NE, Chotikatum S, von Köckritz-Blickwede M, Naim HY.Mol Cell Pediatr. 2016 Dec;3(1):14. doi: 10.1186/s40348-016-0041-y. Epub 2016 Mar 22.PMID: 27002817 Free PMC article. Review.

The multiple roles of sucrase-isomaltase in the intestinal physiology.

Gericke B, Amiri M, Naim HY.Mol Cell Pediatr. 2016 Dec;3(1):2. doi: 10.1186/s40348-016-0033-y. Epub 2016 Jan 26.PMID: 26812950 Free PMC article.

A full list of publications can be found here: Naim HY - Search Results - PubMed