Prof. Dr. Klaus Jung

Seit 2015
Professor für Genomik und Bioinformatik der Infektionskrankheiten, Institut für Tiergenomik, Tierärztliche Hochschule Hannover

2013
Habilitation (venia legendi: Medizinische Biometrie und Statistische Bioinformatik), Georg-August-Universität Göttingen

2012-2015
Leiter der Serviceeinheit "Medizinische Biometrie und Statistische Bioinformatik", Universitätsmedizin Göttingen

2007-2015
Postdoc, ab 2013 Privatdozent, Institut für Medizinische Statistik, Universitätsmedizin Göttingen

2006-2007
Postdoc, Medizinisches Proteom-Center, Ruhr-Universität Bochum

2006
Dr. rer. nat., Universität Dortmund

2004-2006
Promotionsstudent im Graduiertenkolleg "Statistische Modellbildung", Universität Dortmund

1999-2003
Studium der Statistik mit Nebenfach Biologie, Universität Dortmund

1977
Geboren in Wiesbaden

Auszeichnungen und Zertifikate

2020: Poster award for my PhD student Babak Saremi for the contribution "A bootstrap approach to estimate false positives in viral meta genomics" (B. Saremi, M. Kohls, K. Jung) presented at the IBS-DR/GMDS-Workshop on Computational Models in Biology and Medicine 2020 in Bonn, Germany.

2017: 1st price for the best teaching material in biometry (together with J. Kruppa; awarded by the working group teaching and didactics of biometry of the German Region of the International Biometric Sociecty)

2012: Certificate for Teaching in Higher Education (awarded by the University of Göttingen)

Öffentliche Verzeichnisse

• Google scholar profile of Klaus Jung
• PubMed record of Klaus Jung
• ORCID of Klaus Jung: orcid.org/0000-0001-9955-748X

Bioinformatische Fachartikel

[30] Hemandhar Kumar, S., Tapken, I., Kuhn, D., Claus, P., & Jung, K. (2024). bootGSEA: a bootstrap and rank aggregation pipeline for multi-study and multi-omics enrichment analyses. Frontiers in Bioinformatics, 4, 1380928. [open access, R-package bootGSEA]

[29] Selle M, Kircher K, Schwennen C, Visscher C and Jung K (2024) Dimension reduction and outlier detection of 3-D shapes derived from multi-organ CT images. BMC Medical Informatics and Decision Making, 24: 49. [open access]

[28] Kircher M, Säurich J, Selle M and Jung K (2023) Assessing Outlier Probabilities in Transcriptomics Data When Evaluating a Classifier. Genes, 2023, 14(2):387. [open access]

[27] Saremi B, Gusmag F, Distl O, Schaarschmidt F, Metzger J, Becker S and Jung K (2022) A comparison of strategies for generating artificial replicates in RNA-seq experiments. Scientific Reports, 12: 7170. [open access]

[26] Winter C, Camarao AAR, Steffen I and Jung K (2022) Network meta-analysis of transcriptome expression changes in different manifestations of Dengue virus infection. BMC Genomics, 23: 165. [open access]

[25] Kircher M, Chludzinski E, Krepel J, Saremi B, Beineke A and Jung K (2022) Augmentation of Transcriptomics Data for Improved Classification of Patients with Respiratory Diseases of Viral Origin. International Journal of Molecular Sciences, 23(5), 2481. [open access]

[24] Kohls M, Kircher M, Krepel J, Liebig P and Jung K (2021) Correcting the Estimation of Viral Taxa Distributions in Next-Generation Sequencing Data after Applying Artificial Neural Networks. Genes, 12 (1), 1755. [open access]

[23] Krepel J, Kircher M, Kohls M and Jung K (2021) Comparison of merging strategies for builidng machine learning models on multiple independent gene expression data sets. Statistical Analysis and Data Mining, online first. [open acces]

[22] Kohls M, Saremi B, Muchsin I, Fischer N, Becher P and Jung K (2021) A resampling strategy for studying robustness in virus detection pipelines. Computational Biology and Chemistry, 94, 107555. [abstract, R-code virDisco2]

[21] Saremi B, Kohls M, Liebig P, Siebert U and Jung K (2021) Measuring Reproducibility of Virus Meta-Genomics Analyses using Bootstrap Samples from FASTQ-Files. Bioinformatics, 37(8), 1068-1075. [abstract, Phyton-code RESEQ]

[20] Winter C, Kosch R, Ludlow M, Osterhaus A and Jung K (2019) Network Meta-Analysis Correlates with Analysis of Merged Independent Transcriptome Expression Data. BMC Bioinformatics, 20(1): 144. [open access, R-code for network meta-analysis]

[19] Kosch R and Jung K (2018) Conducting Gene Set Tests in Meta-Analyses of Transcriptome Expression Data. Research Synthesis Methods, 10, 99-112. [open access]

[18] Kruppa J, Jo WK, van der Vries E, Ludlow M, Osterhaus A, Baumgärtner W and Jung K (2018) Virus detection in high-throughput sequencing data without reference genome of the host. Infection, Genetics and Evolution, 66, 180-187. [abstract, R-code virDisco]

[17] Kruppa J, Lepenies B, Jung K (2018) A genetic algorithm for simulating correlated binary data from biomedical research. Computers in Biology and Medicine, 92, 1-8. [abtract, R-package RepeatedHighDim]

[16] Kruppa J, van der Vries E, Jo WK, Postel A, Becher P, Osterhaus A, Jung K (2017) kmerPyramid: an interactive visualization tool for nucleobase and k-mer frequencies. Bioinformatics, 33, 3115-3116. [open access, R-package kmerPyramid]

[15] Kruppa J and Jung K (2017) Automated multigroup outlier identification in molecular high-throughput data using bagplots and gemplots. BMC Bioinformatics, 18: 232. [open access, R-package gemPlot]

[14] Kruppa J, Kramer F, Beißbarth T and Jung K (2016): A simulation framework for correlated count data of feature subsets in high-throughput sequencing or proteomics experiments. Statistical Applications in Genetics and Molecular Biology, 15, 143-156. [open access]

[13] Bayerlová M, Jung K, Kramer K, Klemm F, Bleckmann A, Beißbarth T (2015) Comparative study on gene set and pathway topology-based enrichment methods. BMC Bioinformatics, 16:334. [open access]

[12] Jung K, Dihazi H, Bibi A, Dihazi GH and Beißbarth T (2014): Adaption of the Global Test Idea to Proteomics Data with Missing Values. Bioinformatics, 30, 1424-1430. [open access, R-package RepeatedHighDim]

[11] Leha A, Jung K and Beißbarth T (2013): Utilization of ordinal response structures in classifi-cation with high-dimensional expression data. Proceedings of the German Conference on Bioinformatics 2013, 90-100. [pdf]

[10] Fuchs M, Beißbarth T Wingender E and Jung K (2013): Connecting high-dimensional mRNA and miRNA expression data for binary medical classification problems. Computer Methods and Programs in Biomedicine, 111, 592-601. [open access]

[9] Artmann S, Jung K, Bleckmann A and Beißbarth T (2012): Detection of simultaneous Group Effects in microRNA Expression and related Target Gene Sets. PloS ONE, 7, e38365. [open access]

[8] Jung K, Friede T and Beißbarth T (2011): Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes. BMC Bioinformatics, 12:288. [open access, R-code]

[7] Leha A, Beißbarth T and Jung K (2011): Sequential Interim Analyses of Survival Data in DNA Microarray Experiments. BMC Bioinformatics, 12:127. [open access]

[6] Jung K, Becker B, Brunner E and Beißbarth T (2011): Comparison of global tests for functional gene sets in two-group designs and selection of potentially effect-causing genes. Bioin-formatics, 27, 1377-1383. [open access, R-package RepeatedHighDim]

[5] Jung K, Grade M, Gaedtcke J, Jo P, Opitz L, Becker H, Ghadimi BM and Beißbarth T (2010): A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data. Computer Methods and Programs in Biomedicine, 100, 132-139. [open access]

[4] Jung K, Poschmann G, Podwojski K, Eisenacher M, Kohl M, Pfeiffer K, Meyer HE, Stühler K and Stephan C (2009): Adjusted Confidence Intervals for the Expression Change of Proteins observed in 2-Dimensional Difference Gel Electrophoresis. Journal of Proteomics & Bioinformatics, 2, 78-87. [open access, JAVA-Tool Statistical DIGE Analyzer]

[3] Jung K, Quast K, Gannoun A and Urfer W (2006): A renewed approach to the nonparametric analysis of replicated microarray experiments. Biometrical Journal, 48, 245-254. [open access, R-package degenes]

[2] Jung K, Gannoun A, Sitek B, Apostolov O, Schramm A, Meyer HE, Stühler K and Urfer W (2006): Statistical evaluation of methods for the analysis of dynamic protein expression data from a tumor study. RevStat-Statistical Journal, 4, 67-80. [pdf]

[1] Jung K, Gannoun A, Stühler K, Sitek B, Meyer HE and Urfer W (2005): Analysis of dynamic protein expression data. RevStat-Statistical Journal, 3, 99-111. [pdf]

Biologische und Medizinische Fachartikel

[133] Papareddy, P., Selle, M., Partouche, N., Legros, V., Rieu, B., Olinder, J., Ryden, J., Bartakova, E., Holub, M., Jung, K., Pottecher, J. & Herwald, H. (2024). Identifying biomarkers deciphering sepsis from trauma-induced sterile inflammation and trauma-induced sepsis. Frontiers in Immunology, 14, 1310271. [open access]

[132] Hüneke, H., Langeheine, M., Rode, K., Jung, K., Pilatz, A., Fietz, D., Kliesch, S. & Brehm, R. (2023). Effects of a Sertoli cell-specific knockout of Connexin43 on maturation and proliferation of postnatal Sertoli cells. Differentiation. [open access]

[131] Camarão, A. A., Gern, O. L., Stegmann, F., Mulenge, F., Costa, B., Saremi, B., Jung, K., Lepenies, B., Kalinke, U. & Steffen, I. (2023). Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions. Microbiology Spectrum, e02192-23. [open access]

[130] Khaveh, N., Schachler, K., Berghöfer, J., Jung, K. and Metzger, J. (2023) Altered hair root gene expression profiles highlight calcium signaling and lipid metabolism pathways to be as-sociated with curly hair initiation and maintenance in Mangalitza pigs. Frontiers in Genetics, 14:1184015. [open access]

[129] Liebig, P., Filor, V., Scheumann, M., Buchholz, M. and Jung, K. (2023) Teaching academic staff to implement interactive graphics for their courses. Technology, Knowledge and Learn-ing, online first. [open access]

[128] Kubinski, M., Beicht, J., Zdora, I., Saletti, G., Kircher, M., Petry-Gusmag, M., Steffen, I., Puff, C., Jung, K., Baumgärtner, W., Rimmelzwaan, G.F., Osterhaus, A.D.M.E. & Prajeeth, C. K. (2023). Cross-reactive antibodies against Langat virus protect mice from lethal tick-borne en-cephalitis virus infection. Frontiers in Immunology, 14, 860. [open access]

[127] Hankel, J., Sander, S., Muthukumarasamy, U., Strowig, T., Kamphues, J., Jung, K. and Visscher, C. (2022) Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection. Frontiers in Veterinary Sciences, 9: 1004506. [open access]

[126] Tost, D., Ludwig, T., Strauss, E., Jung, K. and Siebert, U. (2022) Habitat selection of black grouse in an isolated population in northern Germany—the importance of mixing dry and wet habitats. PeerJ, 10, e14161. [open access]

[125] Paclacios-Pedrero, M.A., Jansen, A., Blume, C., Stanislawski, N., Jonczyk, R., Molle, A., Hernanzdez, M.G., Kaiser, F.K., Jung, K., Osterhaus, A.D.M.E., Rimmelzwaan, G.F., Saletti, G. (2022) Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults. Nature Aging, 2(10), 896-905. [open access]

[124] Liebig, P., Pröhl, H., Sudhaus-Jörn, N., Hankel, J., Visscher, C., & Jung, K. (2022). Interactive, Browser-Based Graphics to Visualize Complex Data in Education of Biomedical Sciences for Veterinary Students. Medical Science Educator, 1-13. [open access]

[123] Górriz-Martín, L., Koenig, A., Jung, K., Bergforth, W., von Soosten, D., Hoedemaker, M., & Bajcsy, Á. C. (2022). Comparison between a Calving Predictive System and a Routine Prepartal Examination in German Holstein Heifers and Cows. Veterinary Sciences, 9(4), 192. [open access]

[122]   Schön K, Lindenwald DL, Monteiro JT, Glanz J, Jung K, Becker SC, Lepenies B (2022) Vector and Host C-Type Lectin Receptor (CLR)-Fc Fusion Proteins as a Cross-Species Comparative Approach to Screen for CLR/Rift Valley Fever Virus Interactions. International Journal of Molecular Sciences, 23(6), 3243. [open access]

[121]   Bolder, M. F., Jung, K., & Stern, M. (2022). Seasonal variations of serotonin in the visual system of an ant revealed by immunofluorescence and a machine learning approach. Royal Society Open Science, 9(2), 210932. [open access]

[120] Stoff M, Ebbecke T, Ciurkiewicz M, Pavasutthipaisit S, Mayer-Lambertz S, Störk T, Pavelko KD, Baumgärtner W, Jung K, Lepenies B, Beineke A (2021) C-type lectin receptor DCIR contributes to hippocampal injury in acute neurotropic virus infection. Scientific Reports, 11(1), 1-16. [open access]

[119] Heitmann, A, Gusmag F, Rthjens FM, Maurer MA, Franze K, Schicht S, Jansen S, Schmidt-Chanasit J, Jung K and Becker S (2021) Mammals preferred: Reassortment of Batai and Bunyamwera orthobunyavirus occurs in mammalian but not insect cells, Viruses, 13(9), 1702. [open access]

[118] Wojak KP, Ungermann G, Ichsan I, Gomez-Molero E, Jung K, Weig M, Nauck F, Ziebolz D, Gräser Y, Nau R, Groß U, Alt-Epping B, Bader O (2021) Host age and denture wearing jointly contribute to oral colonization with intrinsically azole-resistant yeasts in the elderly. Microorganisms, 9(8), 1627. [open access]

[117] Sliwinski K, Strauß E, Jung K and Siebert U (2021) Comparison of spotlighting monitoring data of European brown hare (Lepus europaeus) relative population densities with infrared thermography in agricultural landscapes in Northern Germany. PLOS ONE, 16(7), e025084. [open access]

[116] Ghita L, Breitkopf Veronika, Mulenge F, Pavlou A, Gern OL, Duràn V, Prajeeth CK, Kohls M, Jung K, Stangel M, Steffen I and Kalinke U (2021) Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes. Journal of Neuroscience Research, 99(10), 2478-2492. [open access]

[115] Liu D, Caliskan S, Rashidfarokhi B, Oldenhof H, Jung K, Sieme H, Hilfiker A and Wolkers WF (2021) Fourier transform infrared spectroscopy coupled with machine learning classification as a tool for identification of oxidative damage in freeze-dried heart valves. Scientific Reports, 11(1), 12299. [open access]

[114] Ghita L, Spanier J, Chhatbar C, Mulenge F, Pavlou A, Larsen P-K, Waltl I, Lueder Y, Kohls M, Jung K, Best SM, Förster R, Stangel M, Schreiner D Kalinke U (2021) MyD88-signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS. Science Immunology, 6(60), eabc9165. [abstract]

[113] Hensel N, Santonicola P, Ciero F, Tapken I, Schüning T, Taiana M, Pagliari E, Joseph A, Fischer S, Heidrich N, Brinkmann H, Kubinski S, Bergmann A, Jung K, Corti S, Di Schiavi E and Claus Peter (2021) Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in Spinal Muscular Atrophy. PNAS, 118 (18), e2007785118.

[112] Delarocque J, Frers F, Huber K, Jung K, Feige K and Warnken T (2021) Metabolic impact of weight variations in Icelandic horses. PeerJ, 9, e10764.

[111] Liebig K, Boelke M, Grund D, Schicht S, Bestehorn-Willmann M, Chitimia-Dobler L, Dobler G, Jung K and Becker S (2021) The stable matching problem in TBEV enzootic circulation: How important is the perfect tick-virus match? Microorganisms, 9(1), 196.

[110] Delarocque J, Frers F, Huber K, Jung K, Feige K and Warnken T (2020) Metabolic changes induced by oral glucose tests in horses and their diagnostic use. Journal of Veterinary Internal Medicine, 35(1), 579-605.

[109] Tost D, Strauss E, Jung K and Siebert U (2020) Impact of tourism on habitat use of black grouse (Tetrao tetrix) in an isolated population in northern Germany. PLOS ONE, 15(9), e0238660.

[108] Liebig K, Boelke M, Grund D, Schicht S, Springer A, Strube C, Chitimia-Dobler L, Dobler G, Jung K and Becker S (2020) Tick populations from endemic and non-endemic areas in Germany show differential susceptibility to TBEV. Scientific Reports, 10(1), 1-10.

[107] Abuseir S, Naccache F, Jung K, Adwan G, Strube C and Becker SC (2020) Genetic characterization of Asian tiger mosquito Aedes albopictus in Palestine. Bulletin of Insectology, 73, 225-232.

[106] Rohländer M, Otzen H, Rode K, Jung K, Schmicke M, Harborth T, Langeheine M, Brehm  & Bajcsy A (2020) Histological comparison of testicular needle biopsy and en bloc samples in abattoir calves. Animals. 10(5), 918.

[105] Lindenwald D, Monteiro J, Rautenschlein S, Meens J, Jung K, Becker SC and Lepenies B (2020) Ovine C-type lectin receptor hFc-fusion protein library – a novel platform to screen for host-pathogen interactions. Veterinary Immunology and Immunopathology, 110047.

[104] Hilbold E, Distl O, Hoedemaker M, Wilkening S, Behr R, Rajkovic A, Langeheine M, Rode K, Jung K, Metzger J and Brehm R (2020) Loss of Cx43 in murine Sertoli cells leads to altered prepubertal Sertoli cell maturation and impairment of the mitosis-meiosis switch. Cells, 9(3), 676.

[103] Koziolek, M., Mueller, G. A., Dihazi, G. H., Jung, K., Altubar, C., Wallbach, M., ... & Dihazi, H. (2020). Urine E-cadherin: A marker for early detection of kidney injury in diabetic patients. Journal of clinical medicine, 9(3), 639.

[102] Hankel J, Jung K, Kuder H, Keller B, Keller C, Galvez E, Strowig T and Visscher C (2019) Caecal microbiota of experimentally Camyplobacter jejuni-infected chickens at different ages. Frontiers in Microbiology, 10, 2303.

[101] Jo WK, van Elk C, van de Bildt M, van Run P, Petry M, Jesse S, Jung K, Ludlow M, Kuiken T and Osterhaus A (2019) An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species. Emerging Microbes & Infections, 8(1), 1383-1392.

[100] Sliwinski K, Ronnenberg K, Jung K, Strauß E and Siebert U (2019) Habitat requirements of the European brown hare (Lepus europaeus Pallas 1778) in an intensively used agriculture region (Lower Saxony, Germany): BMC Ecology, 19(1), 31.

[99] Steinhoff L, Jung K, Meyerholz MM, Heidekorn-Dettmer J, Hoedemaker M and Schmicke M (2019) Thyroid hormone profiles and TSH evaluation during early pregnancy and the transition period in dairy cows. Theriogenology, 129, 23-28.

[98]  Ludlow M, Jo WK, Kruppa J, Habierski A, van de Bildt M, Mazzariol S, Di Giardo G, Siebert U, Kuiken T, Jung K and Osterhaus A (2018): Evolutionary Evidence for Multi-host Transmission of Cetacean Morbillivirus. Emerging Microbes & Infections, 7(1): 201.

[97] Kosch R, Delarocque J, Claus P, Becker SC and Jung K (2018) Gene expression profiles in neurological tissues during West Nile virus infection: a critical meta-analysis. BMC Genomics, 19(1), 530.

[96] Blaschke M, Koepp R, Lenz C, Kruppa J, Jung K and Siggelkow H (2018) Crohn’s Disease Patient Serum Changes Protein Expression in a Human Mesenchymal Stem Cell Model in a linear relationship to patients’ disease stage and to bone mineral density. Journal of Clinical and Translational Endocrinology, 13, 26-38.

[95] Jo WK, Pfankuche VM, Lehmbecher A, Byron M, Rubio A, Becker S, Kruppa J, Jung K, Metzger J, Ludlow M, Baumgärtner W, van der Vries E, Osterhaus A (2018) Association of Batai Virus Infection and Encephalitis in Harbor Seals, Germany, 2016. Emerging Infectious Diseases, 24, 1691-1695.

[94] Hollenbach J, Jung K, Noelke J, Gasse H, Pfarrer C, Koy M, Brehm R (2018) Loss of connexin43 in murine Sertoli cells and its effects on blood-testis barrier formation and dynamics. PLOS ONE, 13(6), e0198100.

[93] Piewbang C, Jo WK, Puff  C, van der Vries E, Kesdangsakonut S, Rungsipipat A, Kruppa J, Jung K, Baumgärtner W, Technagamsuwan S, Ludlow M, Osterhaus A (2018) Novel canine circovirus strains from Thailand: Evidence for genetic recombination. Scientific Reports, 8(1): 7524.

[92] Thomer A, Gottschalk M, Christmann A, Naccache F, Jung K, Hewicker-Trautwein M, Distl O and Metzger J (2018) An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Scientific Reports, 8: 6374.

[91] Uhde A-K, Ciurkiewicz M, Herder V, Khan MA, Hensel N, Claus P, Beckstette M, Teich R, Floess S, Baumgärtner W, Jung K, Huehn J and Beineke A (2018) Intact interleukin-10 signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice. Scientific Reports, 8: 6106.

[90] Piewbang C, Jo WK, Puff C, Ludlow M, van der Vries E, Banlunara W, Rungsipipat A, Kruppa J, Jung K, Baumgärtner W and Osterhaus A (2018) Canine bocavirus type-2 infection associated with intestinal lesions. Veterinary Pathology, 55(3), 434-441.

[89] Schmidt, J., Zyba, V., Jung, K., Rinke, S., Haak, R., Mausberg, R. F., & Ziebolz, D. (2018). Effects of octenidine mouth rinse on apoptosis and necrosis of human fibroblasts and epithelial cells–an in vitro study. Drug and chemical toxicology, 41(2), 182-187.

[88] Kettwig et al. (2018) Cathepsin D Polymorphism C224T in Childhood onset neurodegenerative Disorders - No Impact for Childhood Demetia. Journal of Pediatric Genetics, 7, 14-18.

[87] Herold S., Kumar P., Jung K., Graf I., Menkhoff H., Schulz X., Bähr M. and Hein K. (2016) CatWalk gait analysis in a rat model of Multiple Sclerosis. BMC Neuroscience, 17:78.

[86] Obert D., Helms G., Sättler M.B., Jung K., Kretzschmar B., Bähr M., Dechent P., Diem R. and Hein K. (2016): Brain metabolite changes in patients with relapsing-remitting and secondary progressive Multiple Sclerosis: a two-year follow-up study. PLOS ONE, 11: e0162583.

[85] Losensky G., Jung K., Urlaub H., Pfeifer F., Fröls S. and Lenz C. (2016) Shedding light on biofilm formation of Halobacterium salinarum R1 by SWATH-LC/MS/MS analysis of planktonic and sessile cells. Proteomics, 17(7), doi: 10.1002/pmic.201600111.

[84] Dihazi H., Koziolek M.J., Datta R.R., Wallbach M., Jung K., Heise D., Dihazi G.H., Markovic I., Asif A.R. and Müller G.A. (2016): FABP1 and FABP3 Have High Predictive Values for Renal Replacement Therapy in Patients with Acute Kidney Injury. Blood Purification, 42, 202-213.

[83] Schmidt J., Zyba V., Jung K., Rinke S., Haak R., Mausberg R.F. and Ziebolz D. (2016): Cytotoxic effcts of octenidine mouth rinse on human fibroblasts and epithelial cells – an in vitro study. Drug and Chemical Toxicology, 39, 322-330.

[82] Knösel M., Nüser C., Jung K., Helms H.-J., Engelke W. and Sandoval P. (2016): Interactionbetween deglutition, tongue posture, and malocclusion: A comparison of intra-oral compartment formation in subjects with neutral occlusion or different types of malocclusion. The Angle Orthodontist, 86, 697-705.

[81] Brockmeyer P., Hemmerlein B., Jung K., Fialka F., Brodmann T., Gruber R.M., Schliephake H. and Kramer F.-J. (2015): Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma. Molecular and Clinical Oncology, in press.

[80] Haetscher N., Feuermann Y., Wingert S., Rehage M., Thalheimer F.B., Weiser C., Bohnenberger H., Jung K., Schroeder T., Serve H., Oellerich T., Henninghausen L. and Rieger M.A. (2015): STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nature Communications, 6, 8928.

[79] Seegers J., Conen D., Jung K., Bergau L., Dorenkamp M., Exposito P.M., Lüthje L., Sohns C., Sossalla S.T., Fischer T.H., Hasenfuss G., Friede T. Zabel M. (2015): Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators. EP Europace, 18(8), 1194-1202.

[78] Schmidt H., Djukic M., Jung K., Holzgraefe M., Dechent P., von Steinbuechel N., Blocher J., Eiffert H., Schmidt-Samoa C. (2015): Neurocognitive functions and braun atrophy after proven neuroborreliosis: a case-control study. BMC Neurology, 15(1), 139.

[77] Ganster C., Kämpfe D., Jung K., Shirneshan K., Braulke F., Machherndl-Spandl S., Suessner S., Bramlage C.P., Legler T.J., Koziolek M.J., Haase D., Schanz J. (2015): New data shed light on Y-loss related pathogenesis in MDS. Gene, Chromosomes and Cancer, 54(12), 717-724.

[76] Knösel M., Fendel C., Jung K., Sandoval P. and Engelke, W.G. (2015): Pre-surgical orthopedics by drink plates does not significantly improve deviating deglutition in infants with cleft lip and palate. Angle Orthodontist, 86(2), 315-323.

[75] Wolf H.A., Ihler F., Zeller N., Welz C., Jung K., Canis M. and Steiner W. (2015): (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer. European Archives of Oto-Rhino-Laryngology, 273(6), 1533-1541.

[74] Gaedcke J., Leha A., Claus R., Weichenhan D., Jung K., Kitz J., Grade M., Wolff H.A., Saleno J., Jo P., Doyen J., Gérard J.P., Plass C., Beißbarth T. and Ghadimi M. (2014): Identification of a DNA methylation signature to predict Disease Free Survival in locally advanced rectal cancer. Oncotarget, 5(18), 8123.

[73] Krasnianski A., Kaune J., Jung K., Kretschmar H.A. and Zerr I. (2014): First symptom and initial diagnosis in sporadic CJD patients in Germany. Journal of Neurology, 261(9), 1811-1817.

[72] Gutenberg A., Nischwitz M.D., Gunawan B., Enders C., Jung K., Bergmann M., Feiden W., Egensperger R., Keyvani K., Stolke D., Sure U., Schroeder H.W.S., Warzok R., Schober R., Meixensberger J., Paulus W., Wassmann H., Stummer W., Blümcke I., Buchfelder M., van Landeghem F.K.H., Vajkoczy P., Günther M., Bedke J., Giese A., Rohde V., Brück W., Füzesi L. and Sander B. (2014): Predictive Chromosomal Clusters of Synchronous and Metachronous Brain Metastases in Clear Cell Renal Cell Carcinoma. Cancer Genetics, 207, 206-213.

[71] Brockmeyer P., Jung K., Perske C., Schliephake H. and Hemmerlein B. (2014): Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma. International Journal of Oncology, 45, 273-281.

[70] Rau T.T., Agaimy A., Gehoff A., Geppert C., Jung K., Knobloch K., Langner C., Lugli A., Lurkin I.G., Nagtegaal I., Rüschoff J., Saegert X., Sarbia M., Schneider-Stock R., Vieth M., Zwarthoff E. and Hartmann A. (2014): Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics. Virchow Archiv, 464, 663-672.

[69] Mitteldorf C., Bertsch H.P., Jung K., Thoms K.-M., Schön M.P., Tronnier M. and Kretschmer L. (2014): Sentinel node biopsy improves prognostic stratification in patients with thin (pT1) melanomas and an additional risk factor. Annals of Surgical Oncology, 21, 2252-2258.

[68] Vollmann D., Woronowicz S., Kmiec L., Jung K., Zenker D., Seegers J., Sossalla S., Dorenkamp M., Sohns C., Lüthje L., Hasenfuss G. and Zabel M. (2013): Lead Failure Rates and Patient Mortality during Long-Term Follow-Up of Passive Fixation Sprint Fidelis Lead. EP-Europace, 16, 258-264.

[67] Hackmann A., Wu H., Schneider U.-M., Meyer K., Jung K. and Krebber H. (2013): Quality control of spliced mRNAs required the shuttling SR-proteins Gbp2 and Hrb1. Nature Communications, 5: 3123.

[66] Wolff H.A., Wolff C.R.W., Hess C.F., Jung K., Sennhenn-Kirchner S., Hinterthaner M., Müller-Dornieden A., Körber W., Marten-Engelke K., Roedel R., Christiansen H., Engelke C. (2013): High prevalence of curable stage second primary malignancies in patients after head and neck cancer. Strahlentherapy und Onkologie, 189, 874-880.

[65] Psychogios M.K., Schramm P., Frölich A.M., Kallenberg K., Wasser K., Reinhardt L., Kreusch A., Jung K. and Knauth M. (2013): Alberta Stroke Program Early CT Scale Evaluation of Multimodal Computed Tomography in Predicting Clinical Outcomes of Stroke Patients Treated With Aspiration Thrombectomy. Stroke, 44, 2188-2193.

[64] Braulke F., Jung K., Schanz J., Götze K., Müller-Thomas C., Platzbecker U., Germing U., Brümmendorf T.H., Bug G., Ottmann O., Giagounidis A.A.N., Stadler M., Hofmann W.-K., Schafhausen P., Lübbert M., Schlenk R.F., Blau I.W., Ganster C., Pfeiffer S., Shirneshan K., Metz M., Detken S., Seraphin J., Jentsch-Ullrich K., Böhme A., Schmidt B., Trümper L. and Haase D. (2013): Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes - First results from a prospective multicenter German diagnostic study. Leukemia Research, 37, 900-906.

[63] Vasko R., Müller G.A., Ratliff B.B., Jung K., Gauczinski S., Koziolek M. J. (2013): Clinical judgment is the most important element in overhydration assessment of chronic hemodialysis patients. Clinical and Experimental Nephrology, 17, 563-568.

[62] Balcarek P., Terwey A., Jung K., Wald T.A., Frosch S., Schüttrunpf J.P., Wachowski M.M., Dathe H. and Stürmer K.M. (2013): Influence of tibial slope asymmetry on femoral rotation in patients with lateral patellar instability. Knee Surgery, Sports Traumatology, Athroscopy, 21, 2155-2163.

[61] Beyer F., Hertel D., Jung K., Fender A.C. and Leuschner C. (2013): Competition effects on fine root survival of Fagus sylvatica and Fraxinus excelsior. Forest Ecology and Management, 302, 14-22.

[60] Xyda A., Haberland U., Klotz E., Jung K., Bock H.C., Schramm R., Knauth M. and Schramm P. (2012): Diagnostic performance of whole brain volume perfusion CT in intra-axial brain tumors: Preoperative classification accuracy and histopathologic correlation. European Journal of Radiology, 81, 4105-4111.

[59] Hennies S., Wolff H.A., Jung K., Rave-Fränk M., Gaedcke J., Ghadimi M., Hess C.F., Becker H., Hermann R.H. and Christiansen H. (2012): Testicular radiation dose after multimodal curative therapy for locally advanced rectal cancer: Influence on hormone levels, quality of life, and sexual functioning. Strahlentherapie und Onkologie, 188, 926-932.

[58] Koziolek M., Datta R.D., Mattes H., Jung K., Heise D., Streich J.H., Mühlhausen J., Mueller G.A., and Dihazi H. (2012): Predictors of renal replacement therapy in acute kidney injury. Nephron Extra, 2, 247-255.

[57] Roessler M., Schmid D.S., Michels P., Schmid O., Jung K., Stoeber J., Neumann P., Quintel M. and Moerer O. (2012): Early Out-of-hospital Noninvasive Ventilation is Superior to Standard Medical Treatment in Patients with Acute Respiratory Failure - A Pilot Study. Emergency Medicine Journal, 29, 409-414.

[56] Knösel M., Forslund L., Jung K. and Ziebolz D. (2012): Efficacy of different strategies in protecting enamel against demineralization during fixed orthodontic treatment. Journal of Orofacial Orthopedics, 73, 194-203.

[55] Jung K., Engelke W. and Knösel M. (2012): Statistical Signal Processing Methods for Intra-oral Pressure Curve Analysis in Orthodontics. European Journal of Orthodontics, 34, 437-441.

[54] Knösel M., Bojes M., Jung K. and Ziebolz D. (2012): Increased susceptibility for white-spot lesions by surplus  orthodontic etching exceeding bracket base area. American Journal of Orthodontics and Dentofacial Orthopedics, 141, 574-582.

[53] Koziolek M.J., Tampe D., Bähr M., Dihazi D., Jung K., Fitzner D., Klingel R., Müller G.A. and Kitze B. (2012) Immunoadsorption therapy in MS patients with steroid-refractory optical neuritis. Journal of Neuroinflammation, 9: 80.

[52] Jo P., Jung K., Grade M., Conradi L.-C., Wolff H.A., Kitz J., Becker H., Rüschoff J., Hartmann A., Beißbarth T.,  Müller-Dornieden A., Ghadimi M., Schneider-Stock R. and Gaedcke J. (2012): CpG island methylator phenotype infers a poor prognosis in locally advanced rectal cancer. Surgery, 151, 564-570.

[51] Alt-Epping B., Nejad R.K., Jung K., Groß U. and Nauck F. (2012) Symptoms of the oral cavity and their associations with local microbiological and clinical findings – a prospective survey in palliative care. Support Care Cancer, 20, 531-537.

[50] Homayounfar K., Meis J., Jung K., Klosterhalfen B., Sprenger T., Conradi L.C., Langer C. and Becker H. (2012) Ultrasonic scalpel causes greater depth of soft tissue necrosis compared to monopolar electrocautery at standard power level settings in a pig model. BMC Surgery, 12:3.

[49] Lee D. H., Geyer E., Flach A.-C., Jung K., Gold R., Flügel A., Linker R. A., Lühder F. (2012): Central nervous system rather than immune cell derived BDNF mediates axonal protective effects early in autoimmune demyelination. Acta Neuropathologica, 123, 247-258.

[48] Hahn W., Engelke B., Jung K., Dathe H., Kramer F.-J., Rödig T., Kubein-Meesenburg D. and Gruber R. M. (2011): The influence of occlusal forces on force delivery properties of aligners during rotation of an upper central incisor. Angle Orthdontist, 81, 1057-1063.

[47] Knösel M., Jung K., and Bleckmann A. (2011): An analysis of dentistry-related YouTube contents and implications for professional lecturing. Journal of Dental Education, 75, 1558-1568.

[46] Psychogios M.K., Wachter D., Mohr A., Schramm P., Frölich A.-M., Jung K., Rohde V., Knauth M. (2011): Feasibility of flat panel angiographic computed tomography after intravenous contrast agent application in the postoperative evaluation of patients with clipped aneurysms. American Journal of Neuroradiology, 32, 1956-1962.

[45] Balcarek P., Jung K., Frosch K.-H. and Stürmer K. M. (2011) The Value of the Tibial Tuberosity-Trochlear Groove Distance in Patellar Instability in the Young Athlete, American. Journal of Sports Medicine, 39, 1756-1761.

[44] Knösel M. and Jung K. (2011): On the relevance of ‘ideal’ occlusion concepts for incisor inclination target definition. American Journal of Orthodontics and Dentofacial Orthopedics, 140, 652-659.

[43] Danner C.B., Hellms T., Jung K., Gunawan B., Didilis V., Füzesi L. and Schöndube F.A. (2011): Prognostic values of chromosomal imbalances in squamous cell carcinoma and adenocarcinoma of the lung. Annals of Thoracic Surgery, 92, 1038-1043.

[42] Jung K., Goerdt C., Lange P., Blocher J., Djukic M., Gerber J., Spreer A., Nau R., Otto M., Schmidt H. (2011): The use of S100B and Tau Protein Concentrations in the Cerebrospinal Fluid for the Differential Diagnosis of Bacterial Meningitis: a Retrospective Analysis. European Neurology, 66, 128-132.

[41] Xyda A., Haberland U., Klotz E., Bock H.C., Jung K., Knauth M., Schramm R., Psychogios M.N., Erb G., Schramm P. (2011): Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: A feasibility study. European Radiology, 9, 1811-1819.

[40]  Kretschmer L., Starz H., Thoms K.-M., Satzger I., Völker B., Jung K., Mitteldorf C., Bader C., Siedlecki K., Kapp A., Bertsch H.P. and Gutzmer R. (2010): Age as a key factor influencing metastasizing patterns and disease-specific survival after sentinel lymph node biopsy for cutaneous melanoma. International Journal of Cancer, 6, 1435-1442.

[39] Knösel M. and Jung K. (2011): Informational value and bias of videos related to orthodontics screened on a video-sharing Web site. Angle Orthodontist, 81, 532-539.

[38] Danner B.C., Gerdes J.S., Enders C., Jung K., Sander B., Liersch T., Seipelt R., Gutenberg A., Gunawan B., Schöndube F.A. and Füzesi L. (2010): Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases. Cancer Genetics, 204, 122-128.

[37] Varges D., Jung K., Gawinecka J., Heinemann U., Schmitz M., von Ahsen N., Krasnianski A., Amstrong V.W. and Zerr I. (2011): Amyloid-beta 1-42 levels are modified by Apolipoprotein E epsilon4 in Creutzfeldt-Jakob Disease in a similar manner as in Alzheimer's Disease. Journal of Alzheimer's Disease, 23, 717-726.

[36] Wolff H.A., Raus I., Jung K., Herrmann M.K., Hennies S., Vorwerk H., Hille A., Hess C.F. and Christiansen H. (2011): High-grade acute organ toxicity as positive prognostic factor in primary radiochemotherapy for anal carcinoma. International Journal of Radiation Oncology Biology Physics, 79, 1467-1478.

[35] Engelke W., Jung K. and Knösel M. (2011): Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture. Clinical Oral Investigations, 15, 165-176.

[34] Wolff H.A., Daldrup B., Jung K., Overbeck T., Hennies S., Matthias C., Hess C.F., Roedel R.M.W. and Christiansen H. (2011): High-grade acute organ toxicity as positive prognostic factor in adjuvant radio(chemo)therapy for locally advanced head and neck cancer. Radiology, 258, 864-871.

[33] Wolff H.A., Hennies S., Herrmann M.K.A., Rave-Fränk M., Eickelmann D., Virsik P., Jung K., Schirmer M., Ghadimi B.M., Hess C.F., Hermann R.M. and Christiansen H. (2011): Comparison of micronucleus- and chromosome aberration technique for the documentation of cytogenic damage in radiochemotherapy treated patients with rectal cancer. Strahlentherapie und Onkologie, 187, 52-58.

[32] Bramlage C., Cuneo A., Härtel D., Jung K., Witteck C.-H., Högel R., Müller G. A., Bramlage P. and Tebbe U. (2011): Nierenarterienstenose: Intervention oder medikamentöse Behandlung? Deutsche Medizinische Wochenschrift, 136, 76-81.

[31] Psychogios M. N., Schramm P., Buhk J. H., Xyda A., Gröschel K., Jung K. and Knauth M (2010): Angiographic computed tomography after intravenous contrast agent application: a noninvasive follow-up tool after intracranial angioplasty and stenting. American Journal of Neuroradiology, 31, 1886-1891.

[30] Gaedcke J., Grade M., Jung K., Camps J., Jo P., Emons G., Gehoff A., Sax U., Schirmer M., Becker H., Beissbarth T., Ried T. and Ghadimi B.M. (2010): Mutated KRAS Results in Overexpression of DUSP4, a MAP-Kinase Phosphatase, and SMYD3, a Histone Methyltransferase, in Rectal Carcinomas. Genes, Chromosomes and Cancer, 49, 1024-1034.

[29] Balcarek P., Jung K., Ammon J., Walde T.A., Frosch S., Schüttrumpf J.P., Stürmer K.M. and Frosch K.-H. (2010): Anatomy of lateral patellar instability: Trochlear dysplasia and TT-TG distance is more pronounced in females who dislocate their patella. American Journal of Sports Medicine, 38, 2320-2327.

[28] Knösel M., Jung K., Kinzinger G., Bauss O. and Engelke W. (2010): A Controlled Evaluation of Oral Screen Effects on Intraoral Athmospheric Pressure Curve Characteristics. European Journal of Orthodontics, 32, 535-541.

[27] Lüers C., Hagenah G., Wachter R., Kleta S., Schaumberg J., Riedel S., Binder L., Jung K., Schmidt A. and Pieske B. (2010): Bedeutung der Surfactant-Proteine B und D in der Differentialdiagnostik der akuten Dyspnoe. Medizinische Klinik, 105, 611-618.

[26] Braulke F., Schanz J., Jung K., Shirneshan K., Schulte K., Schuetze C., Steffens R., Trümper L. and Haase D. (2010): FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: Verification of the method and application to 27 MDS patients. Leukemia Research, 34, 1296-1301.

[25] Opitz L., Salinas-Riester G., Grade M., Jung K., Jo P., Emons G., Ghadimi B.M., Beissbarth T. and Gaedcke J. (2010) Impact of RNA degradation on gene expression profiling. BMC Medical Genomics, 3: 36.

[24] Knösel M., Mattysek M., Jung K., Sadat-Khonsari R., Kubein-Meesenburg D., Bauss O. and Ziebolz D. (2010): Impulse debracketing compared to conventional debonding. Angle Orthodontist, 80, 1036-1044.

[23] Schneider H., Kriebel T., Jung K., Gravenhorst V.D. and Paul T. (2010): Catheter Ablation of Idiopathic Left and Right Ventricular Tachycardias in the Pediatric Population Using Noncontact Mapping. Heart Rhythm, 7, 731-739.

[22] Knösel M., Mattysek S., Jung K., Kubein-Meesenburg D., Sadat-Khonsari R. and Ziebolz D. (2010): Suitability of orthodontic brackets for rebonding and reworking following removal by air pressure pulses and conventional debracketing techniques. Angle Orthodontist, 80, 461-467.

[21] Wolff H.A., Bosch J., Jung K., Overbeck T., Herrmann M.K., Hennies S., Vorwerk H., Hille A., Matthias C., Hess C.F., Roedel R.M. and Christiansen H. (2010): High-grade acute organ toxicity as positive prognostic factor in primary radio(chemo)therapy for locally advanced, inoperable head and neck cancer. Strahlentherapie und Onkologie, 186, 262-268

[20] Dähn D., Martell J., Vorwerk H., Hess C.F., Becker H., Jung K., Hilgers R., Wolff H.A., Hermann R.M. and Christiansen H. (2009): Determine irradiated lung volumes perioperative morbidity and mortality in patients after neoadjuvant radiochemotherapy for esophageal cancer? International Journal of Radiation Oncology Biology Physics, 77, 44-52.

[19] Sprenger T., Rothe H., Jung K., Christiansen H., Conradi L. C., Ghadimi B. M., Becker H. and Liersch T. (2010): Research Stage II/III rectal cancer with intermediate response to preoperative radiochemotherapy: Do we have indications for individual risk stratification? World Journal of Surgical Oncology, 8:27.

[18] Gutenberg A., Gerdes J.S., Jung K., Gunawan B., Bock H.C., Liersch T., Brück W., Rohde V. and Füzesi L. (2010):  High chromosomal instability in brain metastases of colorectal carcinoma. Cancer Genetics and Cytogenetics, 198, 47-51.

[17] Hahn W.E.A., Engelke B., Jung K., Dathe H., Fialka-Fricke J., Kubein-Meesenburg D. and Sadat-Khonsari (2010): Initial Forces and Moments Delivered by Removable Thermoplastic Appliances during Rotation of an Upper Central Incisor. Angle Orthodontist, 80, 239-246.

[16] Wolff H.A., Gaedtcke J., Jung K., Hermann R.M., Rothe H., Schirmer M., Liersch T., Herrmann M.K.A., Hennies S., Rave-Fränk M., Hess C.F. and Christiansen H. (2010): High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathological tumour regression in multimodal treatment of locally advanced rectal cancer. Strahlentherapie und Onkologie, 186, 30-35.

[15] Gaedtcke J., Grade M., Jung K., Schirmer M., Jo P., Obermeyer C., Wolff H.A., Herrmann M.K., Beißbarth T., Becker H., Ried T. and Ghadimi M. (2010): KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy. Radiotherapy and Oncology, 94, 76-81.

[14] Kallenberg K., Bock H.C., Helms G., Jung K., Wrede A., Buhk J.H., Giese A., Frahm J., Strik H., Dechent P. and Knauth M. (2009): Proton MR Spectroscopy Reveals Elevated Myo-Inositol and Glutamine in the Contralateral Hemisphere of Patients with Untreated Glioblastoma Multiforme. Radiology, 253, 805-812.

[13] Knösel M., Jung K., Attin T., Attin R., Kubein-Meesenburg D. and Gripp-Rudolph L. (2009): Systematic Evaluation of Features influencing the Accuracy of Third Order Measurements. European Journal of Orthodontics, 31, 547-555

[12] Rödel R.M.W., Matthias C., Blomeyer B.D., Wolff H.A., Jung K. and Christiansen H. (2009): Impact of Distant Metastasis in Patients with Cervical Lymph Node Metastases from Cancer of Unknown Primary Site (CUP). Annals of Otology, Rhinology and Laryngology, 118, 662-669.

[11] Knösel M., Jung K., Gripp-Rudolph L., Attin T., Attin R., Sadat-Khonsari R., Kubein-Meesenburg D. and Bauss O. (2009): Changes in Incisor 3rd-Order Inclination resulting from Vertical Variation in Lingual Bracket Placement. Angle Orthodontist, 79, 747-754.

[10] Vasko R., Koziolek M., Ikehata M., Rastaldi M.P., Jung K., Schmid H., Kretzler M., Müller G.A., Strutz F. (2009): Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. American Journal of Physiology - Renal Physiology, 296, 1452-1463.

[9] Schillinger W., Hörnes N., Teucher N., Sehrt D., Jung K., Sossalla S., Kleta S., Hünlich M., Geiling B., Bernhard U., Ramadori G., Hilgers R., Schwörer H. and Hasenfuss G. (2009): Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers. Clinical Research in Cardiology, 98, 391-399.

[8] Langenfeld E., Zanger U.M., Jung K., Meyer H.E. and Marcus K. (2009): Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver. Proteomics, 9, 2313-2323.

[7] Knösel M., Jung K., Attin T., Engelke W., Kubein-Meesenburg D., Gripp-Rudolph L. and Attin R. (2009): On the Interaction between Incisor Crown-Root Morphology and 3rd-Order Angulation. Angle Orthodontist, 79, 454-461.

[6] Knösel M., Attin R., Jung K., Brunner E., Kubein-Meesenburg D. and Attin T. (2009): Digital image color analysis compared to direct dental CIE colorimeter assessment under different ambient conditions. American Journal of Dentistry, 22, 67-72.

[5] Müller T., Jung K., Ullrich A., Schrötter A., Meyer H.E., Stephan C., Egensperger R. and Macus K. (2008): Disease State, Age, Sex, and Post-Mortem Time-Dependent Expression of Proteins in AD vs. Control Frontal Cortex Brain Samples. Current Alzheimer Research, 5, 562-571.

[4] Toischer K., Kögler H., Tenderich G., Grebe C., Seidler C., van Nguyen P., Jung K., Knöll R., Körfer R. and Hasenfuss G. (2008): Elevated afterload, neuroendocrine stimulation and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation. Circulation: Heart Failure, 1, 265-271.

[3] Bode M., Irmler M., Friedenberger M., May C., Jung K., Stephan C., Meyer H.E., Lach C., Hillert R., Krusche A., Beckers J., Marcus K. and Schubert W. (2008): Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus. Proteomics, 8, 1170-1178.

[2] Castaneda F., Rosin-Steiner S. and Jung K. (2007): Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes. International Journal of Medical Sciences, 4, 28-35.

[1] Stühler K., Pfeiffer K., Joppich C., Stephan C., Jung K., Mueller M., Schmidt O., van Hall A., Hamacher M., Urfer W., Meyer, H.E. and Marcus K. (2006): Pilot Study of the HUPO Brain Proteome Project: Applying different two dimensional gel electrophoresis techniques to monitor proteomic changes during murine brain development. Proteomics, 6, 4899-4913.

Buchkapitel und nicht-begutachtete Arbeiten

[11] Winter C. and Jung K. (2021) Mining Protein Expression Databases Using Network Meta-Analysis. In: Marcus et al. (Eds.) Quantitative Methods in Proteomics, Springer, New York, 419-431.

[10] Jung K. (2020) Methoden der Data Science in der Bioinformatik. In: Herrmann C, Berger U, Weiß C, Burkholder I, Rauch G and Kruppa J (Eds.): Zeig mir Health Data Science! Springer, Berlin, X-XII.

[9] Jung K., Vogel C., Zapf A. und Frömke C. (2019) Reproduzierbare Forschungsergebnisse: Anforderungen und Herausforderungen durch Data Science. Zeitschrift mdi – Forum der Medi-zin-Dokumentation und Medizin-Informatik. Angenommen zur Publikation.

[8] Jung K (2018) Contribution to the discussion of „When should meta-analysis avoid making hidden normality assumptions?” - Meta-analysis and normality assumptions in statistical bioin-formatics. Biometrical Journal, 60(6), 1064-1065.

[7] Kruppa J. and Jung K. (2017) Interaktive Tools für die Lehre der Statistischen Bioinformatik. In Burkholder, Muche, Rauch, Vonthein (Eds): Zeig‘ mir mehr Biostatistik. Springer Verlag, 17-30.

[6] Jung K. (2015) Statistical Aspects in Proteomic Biomarker Discovery. In: Jung K (Ed.): Statis-tical Analysis in Proteomics. Springer, New York, 293-310.

[5] Kruppa J. and Jung K. (2015) Set-Based Test Procedures for the Functional Analysis of Pro-tein Lists from Differential Analysis. In: Jung K (Ed.): Statistical Analysis in Proteomics. Springer, New York, 143-156.

[4] Jung K. (2010): Statistics in Experimental Design, Preprocessing, and Analysis of Proteomics Data. In: Hamacher M, Eisenacher M and Stephan C (Eds.): Data Mining in Proteomics. Sprin-ger, New York, 259-272.

[3] Jung K. (2010): Statistical Methods for Proteomics. In: Bang H., Zhou X.K., Van Epps H., and Mazumdar M. (Eds.): Statistical Methods in Molecular Biology. Springer, New York, 495-505.

[2] Urfer W., Grzegorczyk M. and Jung K. (2006): Statistics for Proteomics: a review of tools for analyzing experimental data. Practical Proteomics, 1, 48-55.

[1] Sitek B., Scheibe B., Jung K., Schramm A. and Stühler K. (2006): Difference Gel Electropho-resis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical Re-search. In: K. Marcus, K. Stühler, A. van Hall, M. Hamacher, B. Warscheid and H.E. Meyer (Eds.): Proteomics in Drug Research. Wiley-VCH, Weinheim, 33-55.

Doktorarbeiten
• Kircher, Magdalena (2023) Data augmentation and outlier detection for fitting machine learning models to transcriptomics data from infection research. Dissertation, Stiftung Tierärztliche Hochschule Hannover.
• Krepel, Jessica (2022) Training of Classifier Models from Multiple Independent Transcriptome Expression Studies. Dissertation, Stiftung Tierärztliche Hochschule Hannover.
• Saremi, Babak (2022) Assessment of robustness in computational analysis of high-throughput sequencing experiments using bootstrap samples from FASTQ-files. Dissertation, Stiftung Tierärztliche Hochschule Hannover.
• Kohls, Moritz (2022) Judging robustness and uncertainty in classifying sequencing reads in viral metagenomics. Dissertation, Stiftung Tierärztliche Hochschule Hannover.
• Liebig, Pamela (2021) Implementation and evaluation of interactive, browser-based graphics in veterinary education. Dissertation, Stiftung Tierärztliche Hochschule Hannover.
• Kosch, Robin (2019) Bioinformatical Meta Analysis of High-Throughput Expression Data from Neuroinfection Research. Dissertation, Stiftung Tierärztliche Hochschule Hannover.
• Kroschel, Lena-Kristina (2018) Retrospektive Analyse historischer Effekte in Kontrollgruppen bei Tierversuchen im Rahmen der Osteoporoseforschung. Dissertation, Georg-August-Universität Göttingen.

Masterarbeiten
• Rashid, G. (2023) Evaluation of Parameter Settings in the Computational Cell-Type Deconvolution of Lung Bulk RNA-seq Data.
• Spänig, M. (2022) Comparison of mathematical models for physiologically based kinetics of dermal uptake.
• Rommel, M. (2022) Computational Reproducibility of published Results from Transcriptome Studies using the Example of Spinal Muscular Atrophy.
• Säurich, J. (2021) Modelling the virome of harbor seals using machine learning.
• Bolder, M. (2021) Fitting of machine learning models for the recognition of season-dependent serotonin immune reactivity in the brain of Lasius niger.
• Ratzkowski, F. (2019) Robustness Evaluation of Transcriptome Analysis by Data Augmentation on the Example of Tuberculosis.

Bachelorarbeiten
• Ruff, S. (2022) Evaluation von Resamplingverfahren zur Analyse von Single-cell RNA-seq Daten.
• Charalambous, A. (2022) Ein Genetischer Algorithmus zum Clustern hoch-dimensionaler Genexpressionsdaten.
• Lüttig, N. (2021) Automatisierte Datenbankanalyse der räumlichen und zeitlichen Entwicklung viraler Genomsequenzen.
• Rehkopf, J. (2019) Simulation-Studies on the Robustness of Bioinformatical RNA-seq Analysis Using the Example of Lung Infection with H. influenzae.

• Mitgliedschaften:
  • German Region of the International Biometric Society (IBS-DR)
  • German Society for Medical Informatics, Biometry and Epidemiology (GMDS)
  • International Society for Computational Biology (ISCB)
  • Fachgruppe Bioinformatik (FaBI)
• Funktionen:
  • Seit 2023: Mitglied im Beirat der IBS-DR
  • Seit 2022: Stellv. Sprecher des GMDS-Fachausschusses "Medizinische Bioinformatik und Systembiologie"
  • 2016-2020: Schriftführer und Vorstandsmitglied der IBS-DR
  • Specher (2015-2018), danach stellv. Sprecher (2018-2022) der gemeinsamen AG "Statistische Methoden in der Bioinformatik" der IBS-DR und GMDS