About me
My name is Felix Stegmann, and in 2024, I completed my PhD with the title 'Modulation of innate immune memory by bacterial and viral pathogens.' Previously, in 2019, I obtained my Master's degree in 'Animal Biology and Biomedical Sciences' from the University of Veterinary Medicine Hannover. I completed my Bachelor's degree in Biology with a focus on immunology at the Leibniz University Hannover. Currently, I work in the Infection Immunology group of Prof. Dr. Bernd Lepenies at the Institute of Immunology with the labs situated in the Research Center for Emerging Infections and Zoonosis (RIZ).
Contact:
Felix.Stegmann(at)TiHo-Hannover.de
Since 2023, I am actively participating in science communication in the form of Science Slams. In this format, I am presenting my research project in an entertaining and understandable way to a diverse audiency within just 10 minutes. More info:
- Instagram: @stegmannfelix
- LinkedIn: Felix Stegmann
My Project
My project focuses on C-type lectin receptor (CLR) mediated trained innate immunity and its implications on the protection against heterologous stimuli with a specific focus on neuroinfections. Trained innate immunity describes reports of improved secondary responses in cells of the innate immune system as a de facto memory. This memory is primarily mediated through long-lasting epigenetic changes and their influence on chromatin organization including subsequent gene transcription. With this novel concept, new strategies arise to investigate CLR-mediated protection against infections. We therefore aim to investigate the effect of trained innate immunity inducers on underlying epigenetic modifications and functional changes in myeloid cells as well as their impact on infections.
My Expertise
- Trained Innate Immunity
- Chromatin Immunoprecipitation (ChIP)
- Flow cytometry
- CLR-binding studies
- ELISA and Immunoblotting
- Primary cell isolation
- Cell culture
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Publications
- Myeloid C-type lectin receptors in host-pathogen interactions and glycan-based targeting
Stegmann, F., Lepenies, B., Curr. Opin. Chem. Biol., 2024 - Legionella pneumophila modulates macrophage functions through epigenetic reprogramming via the C-type lectin receptor Mincle
Stemann, F., Diersing, C., Lepenies, B., iScience, 2024 - Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions
Camarao, A.A.R., Gern, O.L., Stegmann, F., Mulenge, F., Costa, B., Saremi, B., Jung, K., Lepenies, B., Kalinke, U., Steffen, I., Microbiol Spectr, 2023 - CLEC12A Binds to Legionella pneumophila but Has No Impact on the Host’s Antibacterial Response
Klatt, A.B., Diersing, C., Lippmann , J., Mayer-Lambertz, S., Stegmann, F., Fischer, S., Caesar, S., Vernengo, F.F., Hönzke, K., Hocke, A.C., Ruland, J., Witzenrath, M., Lepenies, B., Opitz, B., International Journal of Molecular Sciences, 2023 - From structure to function – Ligand recognition by myeloid C-type lectin receptors
Fischer, S., Stegmann, F., Gnanapragassam, V.S., Lepenies, B., Computational and Structural Biotechnology Journal, 2022 - C-Type Lectins and Their Roles in Disease and Immune Homeostasis
Ebbecke, T., Diersing, C., Lindenwald, D. L., Stegmann, F., Lepenies, B., Comprehensive Glycoscience, 2021
