Our research combines aspects of innate immunity of different species. In this context we focus on myeloid cells (such as monocytes, macrophages, dendritic cells, granulocytes) with a particular interest into how these cell subsets recognize and respond to pathogens via pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and C-type lectin receptors (CLRs). Projects of our institute address questions of how these PRRs modulate immune responses, contribute to protection, immune pathology and innate immune memory. To this end, we employ relevant in vitro systems and murine, bovine and equine models to translate findings to humans and large animals.