About me
My name is Felix and I studied Biology at the Leibniz University in Hannover with a focus on immunology. Staying in Hannover, I received my M.Sc. degree in Animal Biology and Biomedical Sciences studying at the University of Veterinary Medicine. Since 2019, I am a PhD candidate in the Infection Immunology group of Prof. Dr. Bernd Lepenies at the Institute of Immunology with the labs situated in the Research Center for Emerging Infections and Zoonosis (RIZ).
Contact:
Felix.Stegmann(at)TiHo-Hannover.de
Since 2023, I am actively participating in science communication in the form of Science Slams. In this format, I am presenting my research project in an entertaining and understandable way to a diverse audiency within just 10 minutes. More info:
- Instagram: @stegmannfelix
- Twitter: @stegmannfelix
- LinkedIn: Felix Stegmann
My Project
My PhD project focuses on C-type lectin receptor (CLR) mediated trained innate immunity and its implications on the protection against heterologous stimuli with a specific focus on neuroinfections. Trained innate immunity describes reports of improved secondary responses in cells of the innate immune system as a de facto memory. This memory is primarily mediated through long-lasting epigenetic changes and their influence on chromatin organization including subsequent gene transcription. With this novel concept, new strategies arise to investigate CLR-mediated protection against infections. We therefore aim to investigate the effect of trained innate immunity inducers on underlying epigenetic modifications and functional changes in myeloid cells as well as their impact on neuroinfections.
My Expertise
- Trained Innate Immunity
- Chromatin Immunoprecipitation (ChIP)
- Flow cytometry
- CLR-binding studies
- ELISA and Immunoblotting
- Primary cell isolation
- Cell culture
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Publications
- Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions
Camarao, A.A.R., Gern, O.L., Stegmann, F., Mulenge, F., Costa, B., Saremi, B., Jung, K., Lepenies, B., Kalinke, U., Steffen, I., Microbiol Spectr, 2023 - CLEC12A Binds to Legionella pneumophila but Has No Impact on the Host’s Antibacterial Response
Klatt, A.B., Diersing, C., Lippmann , J., Mayer-Lambertz, S., Stegmann, F., Fischer, S., Caesar, S., Vernengo, F.F., Hönzke, K., Hocke, A.C., Ruland, J., Witzenrath, M., Lepenies, B., Opitz, B., International Journal of Molecular Sciences, 2023 - From structure to function – Ligand recognition by myeloid C-type lectin receptors
Fischer, S., Stegmann, F., Gnanapragassam, V.S., Lepenies, B., Computational and Structural Biotechnology Journal, 2022 - C-Type Lectins and Their Roles in Disease and Immune Homeostasis
Ebbecke, T., Diersing, C., Lindenwald, D. L., Stegmann, F., Lepenies, B., Comprehensive Glycoscience, 2021
