Publikationen W. Löscher

Gailus, B., Naundorf, H., Welzel, L., Johne, M., Römermann, K., Kaila, K., & Löscher, W. (2021). Long-term outcome in a noninvasive rat model of birth asphyxia with neonatal seizures: Cognitive impairment, anxiety, epilepsy, and structural brain alterations. Epilepsia: The Journal of the International League Against Epilepsy, 0. https://doi.org/10.1111/epi.17050
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Galanopoulou, A. S., Löscher, W., Lubbers, L., O’Brien, T. J., Staley, K., Vezzani, A., D’Ambrosio, R., White, H. S., Sontheimer, H., Wolf, J. A., Twyman, R., Whittemore, V., Wilcox, K. S., Klein, B., O’Brien, T. J., & D’Ambrosio, R. (2021). Antiepileptogenesis and disease modification: progress, challenges, and the path forward - Report of the Preclinical Working Group of the 2018 NINDS‐sponsored antiepileptogenesis and disease modification workshop. Epilepsia Open, 6(2), 276–296. https://doi.org/10.1002/epi4.12490
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Gericke, B., Borsdorf, S., Wienböker, I., Noack, A., Noack, S., & Löscher, W. (2021). Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines. Fluids and Barriers of the CNS, 18. https://doi.org/10.1186/s12987-021-00266-z
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Hampel, P., Johne, M., Gailus, B., Vogel, A., Schidlitzki, A., Gericke, B., Töllner, K., Theilmann, W., Käufer, C., Römermann, K., Kaila, K., & Löscher, W. (2021). Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy. Neurobiology of Disease, 152: 105297. https://doi.org/10.1016/j.nbd.2021.105297
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Hampel, P., Römermann, K., Gailus, B., Johne, M., Gericke, B., Kaczmarek, E., & Löscher, W. (2021). Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice. Neuropharmacology, 185: 108449. https://doi.org/10.1016/j.neuropharm.2021.108449
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Hampel, P., Römermann, K., Gramer, M., & Löscher, W. (2021). The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain. Epilepsy & Behavior, 114(Pt A), 107616. https://doi.org/10.1016/j.yebeh.2020.107616
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Hampel, P., Römermann, K., Gramer, M., & Löscher, W. (2021). The search for brain-permeant NKCC1 inhibitors for the treatment of seizures: Pharmacokinetic-pharmacodynamic modelling of NKCC1 inhibition by azosemide, torasemide, and bumetanide in mouse brain. Epilepsy & Behavior, 114(Part A: 107616). https://www.sciencedirect.com/science/article/abs/pii/S1525505020307964?via%3Dihub
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Johne, M., Käufer, C., Römermann, K., Gailus, B., Gericke, B., & Löscher, W. (2021). A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia. Epilepsia: The Journal of the International League Against Epilepsy, 62(6), 1460–1471. https://doi.org/10.1111/epi.16912
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Johne, M., Römermann, K., Hampel, P., Gailus, B., Theilmann, W., Ala-Kurikka, T., Kaila, K., & Löscher, W. (2020). Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. Epilepsia: The Journal of the International League Against Epilepsy, 00: early access. https://doi.org/10.1111/epi.16778
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Löscher, W., & Kaila, K. (2021). Reply to the commentary by Ben-Ari and Delpire: Bumetanide and neonatal seizures: fiction versus reality. Epilepsia: The Journal of the International League Against Epilepsy, 62(4), 941–946. https://doi.org/10.1111/epi.16866
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