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Prof. Dr. Klaus Jung


Group Head, Genomics and Bioinformatics of Infectious Diseases


Institute for Animal Breeding and Genetics

University of Veterinary Medicine Hannover, Foundation
Bünteweg 17p
D-30559 Hannover

Telefon: +49 511 953-8878
Fax:        +49 511 953-8582

E-Mail:   klaus.jung@tiho-hannover.de


Curriculum Vitae

Since 2015:

Professor for Genomics and Bioinformatics of Infectious Diseases, Institute for Animal Breeding and Genetics, University of Veterinary Medicince Hannover



Habilitation (venia legendi: medical biometry and statistical bioinformatics), Georg-August-University Göttingen



Head of the Core Facility Medical Biometry and Statistical Bioinformatics, University Medical Center Göttingen



Postdoctoral Research Fellow, since 2013 Lecturer, Department of Medical Statistics, University Medical Center Göttingen



Postdoctoral Research Fellow, Medical Proteom Center, Ruhr-University Bochum



Dr. rer. nat., University of Dortmund



Doctoral student at the Graduate School 'Statistical Modelling', University of Dortmund



Studies of statistics and biology, University of Dortmund



Born in Wiesbaden


The research of Prof. Jung concentrates on the development of computational methods and tools for the analysis of `Omics' data, with a special focus on data from infection research. For further details on the research projects see the homepage of the group Genomics and Bioinformatics of Infectious Diseases.


Google scholar profile of Klaus Jung

PubMed record of Klaus Jung

ORCID of Klaus Jung: orcid.org/0000-0001-9955-748X




[1] Jung K (Ed.): Statistical Analysis in Proteomics. Springer, New York, 2015. [table of contents]


Journal articles (Bioinformatics / Biostatistics)


[21] Saremi B, Kohls M, Liebig P, Siebert U and Jung K (2020) Measuring Reproducibility of Virus Meta-Genomics Analyses using Bootstrap Samples from FASTQ-Files. Bioinformatics, online first. [abstract]


[20] Winter C, Kosch R, Ludlow M, Osterhaus, A and Jung K (2019) Network Meta-Analysis Correlates with Analysis of Merged Independent Transcriptome Expression Data. BMC Bioinformatics, 20:144. [abstract]


[19] Kosch R and Jung K (2019) Conducting Gene Set Tests in Meta-Analyses of Transcriptome Expression Data. Research Synthesis Methods, 10(1): 99-112. [abstract]


[18] Kruppa J, J WK, van der Vries E, Ludlow M, Osterhaus A, Baumgärtner W and Jung K (2018) Virus detection in high-throughput sequencing data without reference genome of the host. Infection, Genetics and Evolution, 66, 180-187. [abstract]


[17] Kruppa J, Lepenies B and Jung K (2018) A genetic algorithm for simulating correlated binary data from biomedical research. Computers in Biology and Medicine, 92, 1-8. [abstract]


[16] Kruppa J, van der Vries E, Jo WK, Postel A, Becher P, Osterhaus A and Jung K (2017) kmerPyramid: an interactive visualization tool for nucleobase and k-mer frequencies. Bioinformatics, 33, 3115-3116. [abstract], [R-package kmerPyramid].


[15] Kruppa J and Jung K (2017) Automated multigroup outlier identification in molecular high-throughput data using bagplots and gemplots. BMC Bioinformatics, 18:232. [abstract], [R-package gemPlot]


[14] Kruppa J, Kramer K, Beißbarth T and Jung K (2016): A simulation framework for correlated count data of feature subsets in high-throughput sequencing or proteomics experiments. Statistical Applications in Genetics and Molecular Biology, 15, 401-414. [abstract]


[13] Bayerlová M, Jung K, Kramer K, Klemm F, Bleckmann A and Beißbarth T (2015): Comparative study on gene set and pathway topology-based enrichment methods. BMC Bioinformatics, 16: 334. [abstract]


[12] Jung K, Dihazi H, Bibi A, Dihazi GH and Beißbarth T (2014): Adaption of the Global Test Idea to Proteomics Data with Missing Values. Bioinformatics, 30, 1424-30. [abstract], [R-package RepeatedHighDim]


[11] Leha A, Jung K and Beißbarth T (2013): Utilization of ordinal response structures in classification with high-dimensional expression data. Proceedings of the German Conference on Bioinformatics 2013, 90-100. [abstract]


[10] Fuchs M, Beißbarth T, Wingender E and Jung K (2013): Connecting high-dimensional mRNA and miRNA expression data for binary medical classification problems. Computer Methods and Programs in Biomedicine, 111, 592-601. [abstract]


[9] Artmann S*, Jung K*, Bleckmann A and Beißbarth T (2012): Detection of simultaneous Group Effects in microRNA Expression and related Target Gene Sets. PLoS ONE, 7, e38365. [abstract], [R-package miRtest] *equal contribution


[8] Jung K, Friede T and Beißbarth T (2011): Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes. BMC Bioinformatics, 12:288. [abstract], [R-Code]


[7] Leha A, Beißbarth T and Jung K (2011): Sequential Interim Analyses of Survival Data in DNA Microarray Experiments. BMC Bioinformatics, 12:127. [abstract], [R-package survGenesInterim]


[6] Jung K, Becker B, Brunner E and Beißbarth T (2011): Comparison of Global Tests for Functional Gene Sets in Two-Group Designs and Selection of Potentially Effect-causing Genes. Bioinformatics, 27, 1377-1383. [abstract], [R-package RepeatedHighDim]


[5] Jung K, Grade M, Gaedcke J, Jo P, Opitz L, Becker H, Ghadimi B M and Beißbarth (2010): A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data. Computer Methods and Programs in Biomedicine, 100, 132-139. [abstract]


[4] Jung K, Poschmann G, Podwojski K, Eisenacher M, Kohl M, Pfeiffer K, Meyer H E, Stühler K and Stephan C (2009): Adjusted Confidence Intervals for the Expression Change of Proteins observed in 2-Dimensional Difference Gel Electrophoresis. Journal of Proteomics and Bioinformatics, 2, 78-87. [abstract], [Java-Software Statistical DIGE Analyzer]


[3] Jung K, Quast K, Gannoun A and Urfer W (2006) A renewed approach to the nonparametric analysis of replicated microarray experiments. Biometrical Journal, 48, 245-254. [abstract], [R-package degenes]


[2] Jung K, Gannoun A, Sitek B, Apostolov O, Schramm A, Meyer H E, Stühler K and Urfer W (2006) Statistical evaluation of methods for the analysis of dynamic protein expression data from a tumor study. RevStat-Statistical Journal, 4, 67-80. [pdf]


[1] Jung K, Gannoun A, Stühler K, Sitek B, Meyer H E and Urfer W (2005) Analysis of dynamic protein expression data. RevStat-Statistical Journal, 3, 99-111. [pdf]


Journal articles (Medicine / Biology)


[111] Liebig K, Boelke M, Grund D, Schicht S, Bestehorn-Willmann M, Chitimia-Dobler L, Dobler G, Jung K and Becker S (2021) The stable matching problem in TBEV enzootic circulation: How important is the perfect tick-virus match? Microorganisms, accepted for publication.


[110] Delarocque J, Frers F, Huber K, Jung K, Feige K and Warnken T (2020) Metabolic changes in-duced by oral glucose tests in horses and their diagnostic use. Journal of Veterinary Internal Medicine, accepted for publication.


[109] Tost D, Strauss E, Jung K and Siebert U (2020) Impact of tourism on habitat use of black grouse (Tetrao tetrix) in an isolated population in northern Germany. PLOS ONE, accepted for publication.


[108] Liebig K, Boelke M, Grund D, Schicht S, Springer A, Strube C, Chitimia-Dobler L, Dobler G, Jung K and Becker S (2020) Tick populations from endemic and non-endemic areas in Germa-ny show differential susceptibility to TBEV. Scientific Reports, accepted for publications.


[107] Abuseir S, Naccache F, Jung K, Adwan G, Strube C and Becker SC (2020) Genetic characterization of Asian tiger mosquito Aedes albopictus in Palestine. Bulletin of Insectology, accepted for publication.


[106] Rohländer M, Otzen H, Rode K, Jung K, Schmicke M, Harborth T, Langeheine M, Brehm R and Bajcsy AC (2020) Histological Comparison of Testicular Needle Biopsy and En Bloc Samples in Abattoir Calves. Animals, 10(5): 918. [abstract]


[105] Lindenwald D, Monteiro J, Rautenschlein S, Meens J Jung K, Becker SC and Lepenies B (2020) Ovine C-type lectin receptor hFc-fusion protein library – a novel platform to screen for host-pathogen interactions. Veterinary Immunology and Immunopathology, 224: 110047. [abstract]


[104] Hilbold E, Distl O, Hoedemaker M, Wilkening S, Behr R, Rajkovic A, Langeheine M, Rode K, Jung K, Metzger J and Brehm R (2020) Loss of Cx43 in murine Sertoli cells leads to altered prepubertal Sertoli cell maturation and impairment of the mitosis-meiosis switch. Cells, 9(3), 676. [abstract]


[103] Koziolek M, Müller GA, Dihazi GH, Jung K, Altubar C, Wallbach M, Markovic I, Raddatz D, Jahn O, Karaköse H, Lenz C, Urlaub H, Dihazi A, Meziane A and Dihazi H (2020) Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients. Journal of Clinical Medicine,9: 639. [abstract]


[102] Hankel J, Jung K, Kuder H, Keller B, Keller C, Galvez E, Strowig T and Visscher, C. (2019) Caecal microbiota of experimentally Camyplobacter jejuni-infected chickens at different ages. Frontiers in Microbiology, 10: 2303. [abstract]


[101] Jo WK, van Elk C, van de Bildt M, van Run P, Petry M, Jesse ST, Jung K, Ludlow M,  Kuiken T and Osterhaus A (2019) An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species. Emerging Microbes & Infections, 8:1, 1383-1392. [abstract]


[100] Sliwinski K, Ronnenberg K, Jung K, Strauß E and Siebert U (2019) Habitat requirements of the European brown hare (Lepus europaeus Pallas 1778) in an intensively used agriculture region (Lower Saxony, Germany): BMC Ecology, 19:31. [abstract]


[99] Steinhoff L, Jung K, Meyerholz MM, Heidekorn-Dettmer J, Hoedemaker M and Schmicke M (2019) Thyroid hormone profiles and TSH evaluation during early pregnancy and the transition period in dairy cows. Theriogenology, 129: 23-28. [abstract]


[98] Jo WK, Kruppa J, Habierski A, van de Blildt M, Mazzariol S, Di Guardo G, Siebert U, Kuiken T, Jung K, Osterhaus A, Ludlow M (2018) Evolutionary evidence for multi-host transmission of cetacean morbillivirus. Emerging Microbes & Infections, 7(1): 201. [abstract]


[97] Kosch R, Delarocque J, Claus P, Becker SC and Jung K (2018) Gene expression profiles in neurological tissues during West Nile virus infection: a critical meta-analysis. BMC Genomics, 19: 530. [abstract]

[96] Blaschke M, Koepp R, Lenz C, Kruppa J, Jung K and Siggelkow H (2018) Crohn’s Disease Patient Serum Changes Protein Expression in a Human Mesenchymal Stem Cell Model in a lin-ear relationship to patients’ disease stage and to bone mineral density. Journal of Clinical and Translational Endocrinology, 13, 26-38. [abstract]

[95] Jo, W. K., Pfankuche, V. M., Lehmbecker, A., Martina, B., Rubio-Garcia, A., Becker, S., Kruppa J, Jung K, Klotz D, Metzger J, Ludlow, M., Baumgärtner W, van der Vries E, Osterhaus A (2018). Association of Batai Virus Infection and Encephalitis in Harbor Seals, Germany, 2016. Emerging infectious diseases, 24(9), 1691-1695. [pdf]

[94] Hollenbach J, Jung K, Noelke J, Gasse H, Pfarrer C, Koy M, Brehm R (2018) Loss of connex-in43 in murine Sertoli cells and its effects on blood-testis barrier formation and dynamics. PLOS ONE, 13(6), e0198100. [abstract]

[93] Piewbang C, Jo WK, Puff  C, van der Vries E, Kesdangsakonut S, Rungsipipat A, Kruppa J, Jung K, Baumgärtner W, Technagamsuwan S, Ludlow M, Osterhaus A (2018) Novel canine circovirus strains from Thailand: Evidence for genetic recombination. Scientific Reports, 8(1): 7524. [abstract]


[92] Thomer A, Gottschalk M, Christmann A, Naccache F, Jung K, Hewicker-Trautwein M, Distl O and Metzger J (2018) An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Scientific Reports, 8: 6374. [abstract]

[91] Uhde A-K, Ciurkiewicz M, Herder V, Khan MA, Hensel N, Claus P, Beckstette M, Teich R, Flo-ess S, Baumgärtner W, Jung K, Huehn J and Beineke A (2018) Intact interleukin-10 signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice. Scientific Reports, 8: 6106. [abstract]


[90] Jo WK, Piewbang C, Puff C, Ludlow M, van der Vries E, Banlunara W, Rungsipipat A, Kruppa J, Jung K, Baumgärtner W and Osterhaus A (2018) Canine bocavirus type-2 infection associated with intestinal lesions. Veterinary Pathology, 55(3), 434-441. [abstract]


[89] Schmidt, J., Zyba, V., Jung, K., Rinke, S., Haak, R., Mausberg, R. F., & Ziebolz, D. (2018). Effects of octenidine mouth rinse on apoptosis and necrosis of human fibroblasts and epithe-lial cells–an in vitro study. Drug and chemical toxicology, 41(2), 182-187.

[88] Kettwig M, Ohlenbusch A, Jung K, Steinfeld R, Gärtner, J (2018) Cathepsin D Polymorphism C224T in Childhood onset neurodegenerative Disorders - No Impact for Childhood Demetia. Journal of Pediatric Genetics, 7, 14-18. [abstract]


[87] Herold S., Kumar P., Jung K., Graf I., Menkhoff H., Schulz X., Bähr M. and Hein K. (2016) CatWalk gait analysis in a rat model of Multiple Sclerosis. BMC Neuroscience, 17:78. [abstract]


[86] Obert D, Helms G, Sättler MB, Jung K, Kretzschmar B, Bähr M, Dechent P, Diem R and Hein K (2016): Brain metabolite changes in patients with relapsing-remitting and secondary progressive Multiple Sclerosis: a two-year follow-up study. PLOS ONE, 11: e162583. [abstract]


[85] Losensky G, Jung K, Urlaub H, Pfeifer F, Fröls S and Lenz C (2016) Shedding light on biofilm formation of Halobacterium salinarum R1 by SWATH-LC/MS/MS analysis of planktonic and sessile cells. Proteomics, accepted. [abstract]


[84] Dihazi H, Koziolek MJ, Datta RR, Wallbach M, Jung K, Heise D, Dihazi GH, Markovic I, Asif AR and Müller GA (2016) FABP1 and FABP3 Have High Predictive Values for Renal Replacement Therapy in Patients with Acute Kidney Injury. Blood Purification, 42, 202-213. [abstract]


[83] Schmidt J, Zyba V, Jung K, Rinke S, Haak R, Mausberg RF and Ziebolz D (2016) Cytotoxic effcts of octenidine mouth rinse on human fibroblasts and epithelial cells – an in vitro study. Drug and Chemical Toxicology, 39, 322-330. [abstract]


[82] Brockmeyer P, Hemmerlein B, Jung K, Fialka F, Brodmann T, Gruber RM, Schliephape H and Kramer FJ (2016) Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma. Mol Clin Oncol, 4, 298-302. [abstract]


[81] Knösel M, Nüser C, Jung K, Helms HJ, Engelke W and Sandoval P (2016) Interaction between deglutition, tongue posture, and malocclusion: A comparison of intraoral compartment formation in subjects with neutral occlusion or different types of malocclusion. Angle Orthod, 86, 697-705. [abstract]

[80] Haetscher N, Feuermann Y, Wingert S, Rehage M, Thalheimer FB, Weiser C, Bohnenberger H, Jung K, Schroeder T, Serve H, Oellerich T, Henninghausen L and Rieger MA (2015): STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nature Communications, 6: 8928. [abstract]


[79] Seegers J, Conen D, Jung K, Bergau L, Dorenkamp M, Munoz Exposito P, Lüthje L, Sohns C, Sossalla ST, Fischer TH, Hasenfuss G, Friede T, Zabel M (2015): Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators. EP Europace, 18, 1194-1202.[abstract]


[78] Schmidt H, Djukic M, Jung K, Holzgraefe M, Dechent P, von Steinbuechel N, Blocher J, Eiffert H, Schmidt-Samoa C (2015): Neurocognitive functions and braun atrophy after proven neuroborreliosis: a case-control study. BMC Neurology, 15: 139. [abstract]


[77] Ganster C, Kämpfe D, Jung K, Shirneshan K, Braulke F, Machherndl-Spandl S, Suessner S, Bramlage CP, Legler TJ, Koziolek MJ, Haase D, Schanz J (2015): New data shed light on Y-loss related pathogenesis in MDS. Genes, Chromosomes and Cancer, 54, 717-724. [abstract]


[76] Knösel M, Fendel C, Jung K, Sandoval P, Engelke WG (2015): Presurgical orthopedics by drink plates does not significantly normalize deglutition in infants with cleft lip and palate. Angel Orthodontist, 86, 315-323. [abstract]


[75] Wolf HA, Ihler F, Zeller N, Welz C, Jung K, Canis M and Steiner W (2015): (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer. European Archives of Oto-Rhino-Laryngology, 273, 1533-1541. [abstract]


[74] Gaedcke J, Leha A, Claus R, Weichenhan D, Jung K, Kitz J, Grade M, Wolff HA, Jo P, Doyen J, Gérard JP, Johnsen SA, Plass C, Beißbarth T, Ghadimi M (2014): Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. Oncotarget, 5, 8123-8135. [abstract]


[73] Krasnianski A, Kaune J, Jung K, Kretzschmar HA, Zerr I (2014): First symptom and initial diagnosis in sporadic CJD patients in Germany. Journal of Neurology, 261, 1811-1817. [abstract]


[72] Gutenberg A, Nischwitz MD, Gunawan B, Enders C, Jung K, Bergmann M, Feiden W, Egensperger R, Keyvani K, Stolke D, Sure U, Schroeder HWS, Warzok R, Schober R, Meixensberger J, Paulus W, Wassmann H, Stummer W, Blümcke I, Buchfelder M, van Landeghem FKH, Vajkoczy P, Günther M, Bedke J, Giese A, Rohde V, Brück W, Füzesi L and Sander B (2014): Predictive Chromosomal Clusters of Synchronous and Metachronous Brain Metastases in Clear Cell Renal Cell Carcinoma. Cancer Genetics, 207, 206-213. [abstract]


[71] Brockmeyer P, Jung K, Perske C, Schliephake H and Hemmerlein B (2014): Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma. International Journal of Oncology, 45, 273-281. [abstract]


[70] Rau TT, Agaimy A, Gehoff A, Geppert C, Jung K, Knobloch K, Langner C, Lugli A, Lurkin IG, Nagtegaal I, Rüschoff J, Saegert X, Sarbia M, Schneider-Stock R, Vieth M, Zwarthoff E and Hartmann A (2014): Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics. Virchows Archiv, 464, 663-672. [abstract]


[69] Mitteldorf C, Bertsch HP, Jung K, Thoms KM, Schön MP, Tronnier M and Kretschmer L (2014): Sentinel Node Biopsy Improves Prognostic Stratification in Patients with Thin (pT1) Melanomas and an Additional Risk Factor. Annals of Surgical Oncology, 21, 2252-2258. [abstract]


[68] Vollmann D, Woronowicz S, Kmiec L, Jung K, Zenker D, Seegers J, Sossalla S, Dorenkamp M, Sohns C, Lüthje L, Hasenfuss G and Zabel M (2013): Lead Failure Rates and Patient Mortality during Long-Term Follow-Up of Passive Fixation Sprint Fidelis Lead. EP-Europace, 16, 258-264. [abstract]


[67] Hackmann A, Wu H, Schneider U-M, Meyer K, Jung K and Krebber H (2014): Quality control of spliced mRNAs required the shuttling SR-proteins Gbp2 and Hrb1. Nature Communications, 5: 3123. [abstract]


[66] Wolff HA, Wolff CRW, Hess CF, Jung K, Sennhenn-Kirchner S, Hinterthaner M, Müller-Dornieden A, Körber W, Marten-Engelke K, Roedel R, Christiansen H and Engelke C (2013): High prevalence of curable stage second primary malignancies in patients after head and neck cancer. Strahlentherapy und Onkologie, 189, 874-880. [abstract]


[65] Psychogios M K, Schramm P, Frölich A M, Kallenberg K, Wasser K, Reinhardt L, Kreusch A, Jung K and Knauth M (2013): Alberta Stroke Program Early CT Scale Evaluation of Multimodal Computed Tomography in Predicting Clinical Outcomes of Stroke Patients Treated With Aspiration Thrombectomy. Stroke, 44, 2188-2193. [abstract]


[64] Braulke F, Jung K, Schanz J, Götze K, Müller-Thomas C, Platzbecker U, Germing U, Brümmendorf T H, Bug G, Ottmann O, Giagounidis A A N, Stadler M, Hofmann W-K, Schafhausen P, Lübbert M, Schlenk R F, Blau I W, Ganster C, Pfeiffer S, Shirneshan K, Metz M, Detken S, Seraphin J, Jentsch-Ullrich K, Böhme A, Schmidt B, Trümper L and Haase D (2013): Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes - First results from a prospective multicenter German diagnostic study. Leukemia Research, 37, 900-906. [abstract]


[63] Vasko R, Müller G A, Ratliff B B, Jung K, Gauczinski S, Koziolek M J (2013): Clinical judgment is the most important element in overhydration assessment of chronic hemodialysis patients. Clinical and Experimental Nephrology, 17, 563-568. [abstract]


[62] Balcarek P, Terwey A, Jung K, Wald T A, Frosch S, Schüttrunpf J P, Wachowski M M, Dathe H and Stürmer K M (2012): Influence of tibial slope asymmetry on femoral rotation in patients with lateral patellar instability. Knee Surgery, Sports Traumatology, Athroscopy, 21, 2155-2163. [abstract]


[61] Beyer F, Hertel D, Jung K, Fender, A C and Leuschner C (2013): Competition effects on fine root survival of Fagus sylvatica and Fraxinus excelsior. Forest Ecology and Management, 302, 14-22. [abstract]


[60] Xyda A, Haberland U, Klotz E, Jung K, Bock H C, Schramm R, Knauth M and Schramm P (2012): Diagnostic performance of whole brain volume perfusion CT in intra-axial brain tumors: Preoperative classification accuracy and histopathologic correlation. European Journal of Radiology, 81, 4105-4111. [abstract]


[59] Hennies S, Wolff H A, Jung K, Rave-Fränk M, Gaedcke J, Ghadimi M, Hess C F, Becker H, Hermann R H and Christiansen H (2012): Testicular radiation dose after multimodal curative therapy for locally advanced rectal cancer: Influence on hormone levels, quality of life, and sexual functioning. Strahlentherapie und Onkologie, 188, 926-932. [abstract]


[58] Koziolek M, Datta R D, Mattes H, Jung K, Heise D, Streich J H, Mühlhausen J, Mueller G A, and Dihazi H (2012): Predictors of renal replacement therapy in acute kidney injury. Nephron Extra, 2, 247-255. [abstract]


[57] Roessler M, Schmid D S, Michels P, Schmid O, Jung K, Stoeber J, Neumann P, Quintel M and Moerer O (2011): Early out-of-hospital non-invasive ventilation is superior to standard medical treatment in patients with acute respiratory failure: a pilot study. Emergency Medicine Journal, 29, 409-414. [abstract]


[56] Knösel M, Forslund L, Jung K and Ziebolz D (2012): Efficacy of different strategies in protecting enamel against demineralization during fixed orthodontic treatment. Journal of Orofacial Orthopedics, 73, 194-203. [abstract]


[55] Jung K, Engelke W and Knösel M (2011): Statistical Signal Processing Methods for Intra-oral Pressure Curve Analysis in Orthodontics. European Journal of Orthodontics, 34, 574-582. [abstract]


[54] Knösel M, Bojes M, Jung K and Ziebolz D (2012): Increased susceptibility for white-spot lesions by surplus orthodontic etching exceeding bracket base area. American Journal of Orthodontics and Dentofacial Orthopedics, 141, 574-582. [abstract]


[53] Koziolek MJ, Tampe D, Bähr M, Dihazi D, Jung K, Fitzner D, Klingel R, Müller GA and Kitze B (2011): Immunoadsorption therapy in MS patients with steroid-refractory optical neuritis. Journal of Neuroinflammation, 9: 80. [abstract]


[52] Jo P, Jung K, Grade M, Conradi L-C, Wolff H A, Kitz J, Becker H, Rüschoff J, Hartmann A, Beißbarth T, Müller-Dornieden A, Ghadimi M, Schneider-Stock R and Gaedcke J (2011): CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. Surgery, 151, 564-570. [abstract]


[51] Alt-Epping B, Nejad R K, Jung K, Groß U and Nauck F (2011): Symptoms of the oral cavity and their associations with local microbiological and clinical findings – a prospective survey in palliative care. Support Care Cancer, 20, 531-537. [abstract]


[50] Homayounfar K, Meis J, Jung K, Klosterhalfen B, Sprenger T, Conradi LC, Langer C and Becker H (2012): Ultrasonic scalpel causes greater depth of soft tissue necrosis compared to monopolar electrocautery at standard power level settings in a pig model. BMC Surgery, 12:3. [abstract]


[49] Lee D-H, Geyer E, Flach A-C, Jung K, Gold R, Flügel A, Linker R A, Lühder F (2012): Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination. Acta Neuropathologica, 123, 247-258. [abstract]


[48] Hahn W, Engelke B, Jung K, Dathe H, Kramer F-J, Rödig T, Kubein-Meesenburg D and Gruber R M (2011): The influence of occlusal forces on force delivery properties of aligners during rotation of an upper central incisor. Angle Orthdontist, 81, 1057-1063. [abstract]


[47] Knösel M., Jung K. and Bleckmann A. (2011): An analysis of dentistry-related YouTube contents and implications for professional lecturing. Journal of Dental Education, 75, 1558-1568. [abstract]


[46] Psychogios M K, Wachter D, Mohr A, Schramm P, Frölich A-M, Jung K, Rohde V, Knauth M (2011): Feasibility of flat panel angiographic computed tomography after intravenous contrast agent application in the postoperative evaluation of patients with clipped aneurysms. American Journal of Neuroradiology, 32, 1956-1962. [abstract]


[45] Balcarek P, Jung K, Frosch K-H and Stürmer K M (2011): Value of the Tibial Tuberosity-Trochlear Groove Distance in Patellar Instability in the Young Athlete. American Journal of Sports Medicine, 39, 1756-1761. [abstract]


[44] Knösel M and Jung K (2011) On the relevance of ‘ideal’ occlusion concepts for incisor inclination target definition. American Journal of Orthodontics and Dentofacial Orthopedics, 140, 652-659. [abstract]


[43] Danner C B, Hellms T, Jung K., Gunawan B, Didilis V, Füzesi L and Schöndube F A (2011) Prognostic values of chromosomal imbalances in squamous cell carcinoma and adenocarcinoma of the lung. Annals of Thoracic Surgery, 92, 1038-1043. [abstract]


[42] Jung K, Goerdt C, Lange P, Blocher J, Djukic M, Gerber J, Spreer A, Nau R, Otto M and Schmidt H (2011): The use of S100B and Tau Protein Concentrations in the Cerebrospinal Fluid for the Differential Diagnosis of Bacterial Meningitis: a Retrospective Analysis. European Neurology, 66, 128-132. [abstract]


[41] Xyda A, Haberland U, Klotz E, Bock H C, Jung K, Knauth M, Schramm R, Psychogios M N, Erb G, Schramm P (2011): Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: A feasibility study. European Radiology, 9, 1811-1819. [abstract]


[40] Kretschmer L, Starz H, Thoms K-M, Satzger I, Völker B, Jung K, Mitteldorf C, Bader C, Siedlecki K, Kapp A, Bertsch H P and Gutzmer R (2010): Age as a key factor influencing metastasizing patterns and disease-specific survival after sentinel lymph node biopsy for cutaneous melanoma. International Journal of Cancer, 129, 1435-1442. [abstract]


[39] Knösel M and Jung K (2011): Informational value and bias of videos related to orthodontics screened on a video-sharing Web site. Angle Orthodontist, 81, 532-539. [abstract]


[38] Danner B.C., Gerdes J.S., Enders C., Jung K., Sander B., Liersch T., Seipelt R., Gutenberg A., Gunawan B., Schöndube F.A. and Füzesi L. (2010): Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases. Cancer Genetics, 204, 122-128. [abstract]


[37] Varges D, Jung K, Gawinecka J, Heinemann U, Schmitz M, von Ahsen N, Krasnianski A, Amstrong V W and Zerr I (2011): Amyloid-beta 1-42 levels are modified by Apolipoprotein E epsilon4 in Creutzfeldt-Jakob Disease in a similar manner as in Alzheimer's Disease. Journal of Alzheimer's Disease, 23, 717-726. [abstract]


[36] Wolff H A, Raus I, Jung K, Schüler P, Herrmann M K, Hennies S, Vorwerk H, Hille A, Hess C F and Christiansen H (2011): High-grade Acute Organ Toxicity as a Positive Prognostic Factor in Primary Radiochemotherapy for Anal Carcinoma. International Journal of Radiation Oncology Biology Physics, 79, 1467-1478. [abstract]


[35] Engelke W, Jung K and Knösel M (2011): Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture. Clinical Oral Investigations, 15, 165-176. [abstract]


[34] Wolff H A, Daldrup B, Jung K, Overbeck T, Hennies S, Matthias C, Hess C F, Roedel R M W, Christiansen H (2011): High-grade acute organ toxicity as positive prognostic factor in adjuvant radiation and chemotherapy for locally advanced head and neck cancer. Radiology, 258, 864-871. [abstract]


[33] Wolff H A, Hennies S, Herrmann M K A, Rave-Fränk M, Eickelmann D, Virsik P, Jung K, Schirmer M, Ghadimi B M, Hess C F, Hermann R M and Christiansen H (2011): Comparison of micronucleus- and chromosome aberration technique for the documentation of cytogenic dam-age in radiochemotherapy treated patients with rectal cancer. Strahlentherapie und Onkologie, 187, 52-58. [abstract]


[32] Bramlage C, Cuneo A, Härtel D, Jung K, Witteck C-H, Högel R, Müller G A, Bramlage P and Tebbe U (2011): Nierenarterienstenose: Intervention oder medikamentöse Behandlung? Deutsche Medizinische Wochenschrift, 136, 76-81. [abstract]


[31] Psychogios M-N, Schramm P, Buhk J-H, Xyda A, Gröschel K, Jung K and Knauth M (2010): Angiographic CT after Intravenous Contrast Agent Application: A Noninvasive Follow-Up Tool after Intracranial Angioplasty and Stenting. American Journal of Neuroradiology, 31, 1886-1891. [abstract]


[30] Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T and Ghadimi B M (2010): Mutated KRAS Results in Overexpression of DUSP4, a MAP-Kinase Phosphatase, and SMYD3, a Histone Methyltransferase, in Rectal Carcinomas. Genes, Chromosomes and Cancer, 49, 1024-1034. [abstract]


[29] Balcarek P, Jung K, Ammon J, Walde T A, Frosch S, Schüttrumpf J P, Stürmer K M and Frosch K-H (2010): Anatomy of lateral patellar instability: Trochlear dysplasia and TT-TG distance is more pronounced in females who dislocate their patella. American Journal of Sports Medicine, 38, 2320-2327. [abstract]


[28] Knösel M, Jung K, Kinzinger G, Bauss O and Engelke W (2010): A controlled evaluation of oral screen effects on intra-oral pressure curve characteristics. European Journal of Orthodontics, 32, 535-541. [abstract]


[27] Lüers C, Hagenah G, Wachter R, Kleta S, Schaumberg J, Riedel S, Binder L, Jung K, Schmidt A and Pieske B (2010): Bedeutung der Surfactant-Proteine B und D in der Differentialdiagnostik der akuten Dyspnoe. Medizinische Klinik, 105, 611-618. [abstract]


[26] Braulke F, Schanz J, Jung K, Shirneshan K, Schulte K, Schuetze C, Steffens R, Trümper L and Haase D (2010): FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: Verification of the method and application to 27 MDS patients. Leukemia Research, 34, 1296-1301. [abstract]


[25] Opitz L, Salinas-Riester G, Grade M, Jung K, Jo P, Emons G, Ghadimi B M, Beissbarth T and Gaedcke J (2010): Impact of RNA degradation on gene expression profiling. BMC Medical Genomics, 3:36. [abstract]


[24] Knösel M, Mattysek M, Jung K, Sadat-Khonsari R, Kubein-Meesenburg D, Bauss O. and Ziebolz D (2010): Impulse debracketing compared to conventional debonding. Angle Orthodontist, 80, 1036-1044. [abstract]


[23] Schneider H, Kriebel T, Jung K, Gravenhorst V D and Paul T (2010): Catheter Ablation of Idiopathic Left and Right Ventricular Tachycardias in the Pediatric Population Using Noncontact Mapping. Heart Rhythm, 7, 731-739. [abstract]


[22] Knösel M, Mattysek S, Jung K, Kubein-Meesenburg D, Sadat-Khonsari R and Ziebolz D (2010): Suitability of orthodontic brackets for rebonding and reworking following removal by air pressure pulses and conventional debracketing techniques. Angle Orthodontist, 80, 461-467. [abstract]


[21] Wolff H A, Bosch J, Jung K, Overbeck T, Hennies S, Matthias C, Hess C F, Roedel R M and Christiansen H. (2010): High-grade acute organ toxicity as positive prognostic factor in primary radio(chemo)therapy for locally advanced, inoperable head and neck cancer. Strahlentherapie und Onkologie, 186, 262-268. [abstract]


[20] Dähn D, Martell J, Vorwerk H, Hess C F, Becker H, Jung K, Hilgers R, Wolff H A, Hermann R M and Christiansen H (2010): Determine irradiated lung volumes perioperative morbidity and mortality in patients after neoadjuvant radiochemotherapy for esophageal cancer? International Journal of Radiation Oncology Biology Physics, 77, 44-52. [abstract]


[19] Sprenger T, Rothe H, Jung K, Christiansen H, Conradi L C, Ghadimi B M, Becker H and Liersch T (2010): Stage II/III rectal cancer with intermediate response to preoperative radiochemotherapy: Do we have indications for individual risk stratification? World Journal of Surgical Oncology, 8:27. [abstract]


[18] Gutenberg A, Gerdes J S, Jung K, Sander B, Gunawan B, Bock H C, Liersch T, Brück W, Rhode V and Füzesi L (2010): High chromosomal instability in brain metastases of colorectal carcinoma. Cancer Genetics and Cytogenetics, 198, 47-51. [abstract]


[17] Hahn W, Engelke B, Jung K, Dathe H, Fialka-Fricke J, Kubein-Meesenburg D and Sadat-Khonsari R (2010): Initial Forces and Moments Delivered by Removable Thermoplastic Appliances during Rotation of an Upper Central Incisor. Angle Orthodontist, 80, 239-246. [abstract]


[16] Wolff H A, Gaedtcke J, Jung K, Hermann R M, Rothe H, Schirmer M, Liersch T, Herrmann M K A., Hennies S, Rave-Fränk M, Hess C F and Christiansen H (2010): High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathological tumour regression in multimodal treatment of locally advanced rectal cancer. Strahlentherapie und Onkologie, 186, 30-35. [abstract]


[15] Gaedcke J, Grade M, Jung K, Schirmer M, Jo P, Obermeyer C, Wolff H A, Herrmann M K, Beissbarth T, Becker H, Ried T and Ghadimi B M (2010): KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy. Radiotherapy and Oncology, 94, 76-81. [abstract]


[14] Kallenberg K, Bock H C, Helms G, Jung K, Wrede A, Buhk J-H, Giese A, Frahm J, Strik H, Dechent P and Knauth M (2009): Untreated Glioblastoma Multiforme: Increased Myo-inositol and Glutamine Levels in the Contralateral Cerebral Hemisphere at Proton MR Spectroscopy. Radiology, 253, 805-812. [abstract]


[13] Knösel M, Jung K, Attin T, Attin R, Kubein-Meesenburg D and Gripp-Rudolph L (2009): Systematic Evaluation of Features influencing the Accuracy of Third Order Measurements. European Journal of Orthodontics, 31, 547-555. [abstract]


[12] Rödel R M W, Matthias C, Blomeyer B D, Wolff H A, Jung K and Christiansen H (2009): The Impact of Distant Metastasis in Patients with Cervical Lymph Node Metastases from Cancer of Unknown Primary Site. Annals of Otology, Rhinology and Laryngology, 118, 662-669. [abstract]


[11] Knösel M, Jung K, Gripp-Rudolph L, Attin T, Attin R, Sadat-Khonsari R, Kubein-Meesenburg D and Bauss O (2009): Changes in Incisor 3rd-Order Inclination resulting from Vertical Variation in Lingual Bracket Placement. Angle Orthodontist, 79, 747-754. [abstract]


[10] Vasko R, Koziolek M, Ikehata M, Rastaldi M P, Jung K, Schmid H, Kretzler M, Müller G A, Strutz F (2009): Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. American Journal of Physiology - Renal Physiology, 296, 1452-1463. [abstract]


[9] Schillinger W, Hörnes N, Teucher N, Sossalla S, Sehrt D, Jung K, Hünlich M, Unsöld B, Geiling B, Ramadori G, Hilgers R, Schwörer H and Hasenfuss G (2009): Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers. Clinical Research in Cardiology, 98, 391-399. [abstract]


[8] Langenfeld E, Zanger U M, Jung K, Meyer H E and Marcus K (2009): Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver. Proteomics, 9, 2313-2323. [abstract]


[7] Knösel M, Jung K, Attin T, Engelke W, Kubein-Meesenburg D, Gripp-Rudolph L and Attin R (2009): On the Interaction between Incisor Crown-Root Morphology and 3rd-Order Angulation. Angle Orthodontist, 79, 454-461. [abstract]


[6] Knösel M, Attin R, Jung K, Brunner E, Kubein-Meesenburg D and Attin T (2009): Digital image color analysis compared to direct dental CIE colorimeter assessment under different ambient conditions. American Journal of Dentistry, 22, 67-72. [abstract]


[5] Müller T, Jung K, Ullrich A, Schrötter A, Meyer H E, Stephan C, Egensperger R and Marcus K (2008): Disease State, Age, Sex, and Post-Mortem Time-Dependent Expression of Proteins in AD vs. Control Frontal Cortex Brain Samples. Current Alzheimer Research, 5, 562-571. [abstract]


[4] Toischer K, Kögler H, Tenderich G, Grebe C, Seidler C, van Nguyen P, Jung K, Knöll R, Körfer R and Hasenfuss G (2008) Elevated afterload, neuroendocrine stimulation and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation. Circulation: Heart Failure, 1, 265-271. [abstract]


[3] Bode M, Irmler M, Friedenberger M, May C, Jung K, Stephan C, Meyer H E, Lach C, Hillert R, Krusche A, Beckers J, Marcus K and Schubert W (2008) Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus. Proteomics, 8, 1170-1178. [abstract]


[2] Castaneda F, Rosin-Steiner S, and Jung K (2007) Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes. International Journal of Medical Sciences, 4, 28-35. [abstract]


[1] Stühler K, Pfeiffer K, Joppich C, Stephan C, Jung K, Müller M, Schmidt O, van Hall A, Hamacher M, Urfer W, Meyer H E and Marcus K (2006) Pilot study of the HUPO Brain Proteome Project: applying different two dimensional gel electrophoresis techniques to monitor proteomic changes during murine brain development. Proteomics, 6, 4899-4913. [abstract]


Other contributions in books and journals


[10] Jung K (2020) Methoden der Data Science in der Bioinformatik. In: Herrmann C, Berger U, Weiß C, Burkholder I, Rauch G and Kruppa J (Eds.): Zeig mir Health Data Science! Springer, Berlin, X-XII. [publisher website]


[9] Jung K, Vogel C, Zapf A and Frömke C (2019) Reproduzierbare Forschungsergebnisse: Anforderungen und Herausforderungen durch Data Science. mdi, 21(2), 45-48. [journal home]


[8] Jung K (2018) Contribution to the discussion "When should meta-analysis avoid making hidden normality assumptions?" Meta-analysis and normality assumptions in statistical bioinformatics. Biometrical Journal, 60(6), 1064-1065. [abstract]


[7] Kruppa J and Jung K (2017) Interaktive Tools für die Lehre der Statistischen Bioinformatik. In: Vonthein R, Burkholder I, Muche R and Rauch G (Eds.): Zeig mir mehr Biostatistik! Springer, Berlin, 17-30. [abstract]


[6] Jung K (2015) Statistical Aspects in Proteomic Biomarker Discovery. In: Jung K (Ed.): Statistical Analysis in Proteomics. Springer, New York, 293-310. [abstract]


[5] Kruppa J and Jung K (2015) Set-Based Test Procedures for the Functional Analysis of Protein Lists from Differential Analysis. In: Jung K (Ed.): Statistical Analysis in Proteomics. Springer, New York, 143-156. [abstract]


[4] Jung K (2010) Statistics in Experimental Design, Preprocessing, and Analysis of Proteomics Data. In: Hamacher M, Eisenacher M and Stephan C (Eds.): Data Mining in Proteomics. Springer, New York, 259-272. [abstract]


[3] Jung K (2010) Statistical Methods for Proteomics. In: Bang H, Zhou X K, Epps H L V and Mazumdar M (Eds.): Statistical Methods in Molecular Biology. Springer, New York, 497-508. [abstract]


[2] Urfer W, Grzegorczyk M and Jung K (2006) Statistics for proteomics: a review of tools for analyzing experimental data. Practical Proteomics, 1, 48-55. [abstract]


[1] Sitek B, Scheibe B, Jung K, Schramm A and Stühler K (2006) Difference Gel Electrophoresis (DIGE): the next generation of two-dimensional gel electrophoresis for clinical research. In: Marcus K, Stühler K, van Hall A, Hamacher M, Warscheid B and Meyer H E (Eds.): Proteomics in Drug Research. Wiley-VCH, Weinheim, 33-55. [abstract]


Research reports


[2] Jung K, Sitek B, Stühler K, Apostolov O, Schramm A, Eggert A, Urfer W and Meyer H E (2004) Statistical analysis of proteome changes upon ligand-activation of TRK-receptors using two-dimensional fluorescence difference gel electrophoresis. Research Report 2004/9, Department of Statistics, University of Dortmund.


[1] Jung K, Quast K and Urfer W (2004) Software tools for the selection of differentially expressed genes: degenes. Research Report 2004/8, Department of Statistics, University of Dortmund.


Theses and examination work


[3] Jung K (2013) Statistische Analyse molekularer Signaturen in Hochdurchsatzexperimenten und deren Verwendung zur Unterstützung therapeutischer Entscheidungen. Habilitationsschrift, Fakultät für Medizin, Georg-August-Universität Göttingen.


[2] Jung K (2006) Contributions to statistical techniques for the analysis of gene and protein expression data. Doctoral Thesis, Department of Statistics, University of Dortmund. [pdf]


[1] Jung K (2003) Ranking of differentially expressed genes. Master Thesis, Department of Statistics, University of Dortmund.

Awards & Certificates

2020: Poster award for my PhD student Babak Saremi for the contribution "A bootstrap approach to estimate false positives in viral meta genomics" (B. Saremi, M. Kohls, K. Jung) presented at the IBS-DR/GMDS-Workshop on Computational Models in Biology and Medicine 2020 in Bonn, Germany. 


2017: 1st price for the best teaching material in biometry (together with J. Kruppa; awarded by the working group teaching and didactics of biometry of the German Region of the International Biometric Sociecty)


2012: Certificate for Teaching in Higher Education (awarded by the University of Göttingen)

Activities in scientific societies

Stiftung Tierärztliche Hochschule Hannover
Institut für Tierzucht und Vererbungsforschung
Bünteweg 17p
30559 Hannover
Prof. Dr. Ottmar Distl
Tel.:+49 511 953-8875
Fax.:+49 511 953-8582
Labor für Molekulargenetik
Schnell- & Themenzugriffe
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