Publications

Dam, S., Tscherne, A., Engels, L., Sutter, G., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2025). Design and evaluation of a poly-epitope based vaccine for the induction of influenza A virus cross-reactive CD8 + T cell responses. Scientific Reports, 15, Article 10586. https://doi.org/10.1038/s41598-025-95479-9
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Guilfoyle, K., Mirolo, M., van, van der, Lombardo, M. S., Störk, T., Rimmelzwaan, G., Ludlow, M., & Osterhaus, A. (2025). Susceptibility of calf lung slice cultures to H5N1 influenza virus. Emerging Microbes & Infections, 14(1), Article 2432368. https://doi.org/10.1080/22221751.2024.2432368
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Quiñones-Parra, S. M., Gras, S., Nguyen, T. H. O., Farenc, C., Szeto, C., Rowntree, L. C., Chaurasia, P., Sant, S., Boon, A. C. M., Jayasinghe, D., Rimmelzwaan, G. F., Petersen, J., Doherty, P. C., Uldrich, A. P., Littler, D. R., Rossjohn, J., & Kedzierska, K. (2025). Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors. Science Immunology, 10(104), Article eadn3805. https://doi.org/10.1126/sciimmunol.adn3805
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Aregay, A., Slunečko, J., Korva, M., Bogovic, P., Resman Rus, K., Knap, N., Beicht, J., Kubinski, M., Saletti, G., Avšič-Županc, T., Steffen, I., Strle, F., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2024). Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins. Npj Vaccines, 9, Article 141. https://doi.org/10.1038/s41541-024-00936-7
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Aregay, A., Slunečko, J., Bogovic, P., Korva, M., Resman Rus, K., Knap, N., Beicht, J., Kubinski, M., Saletti, G., Steffen, I., Strle, F., Avšič-Županc, T., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2024). Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity. Emerging Microbes & Infections, 13(1), Article 2317909. https://doi.org/10.1080/22221751.2024.2317909
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Aregay, A., Slunečko, J., Bogovic, P., Korva, M., Rus, K. R., Knap, N., Beicht, J., Kubinski, M., Saletti, G., Steffen, I., Sterle, F., Avšič-Županc, T., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2024). Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity. In 8th World One Health Congress: abstract book (1089). https://globalohc.org/8WOHC
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Kubinski, M., Beicht, J., Gerlach, T., Aregay, A., Osterhaus, A. D. M. E., Tscherne, A., Sutter, G., Prajeeth, C. K., & Rimmelzwaan, G. F. (2024). Immunity to tick-borne encephalitis virus NS3 protein induced with a recombinant modified vaccinia virus Ankara fails to afford mice protection against TBEV infection. Vaccines, 12(1), Article 105. https://doi.org/10.3390/vaccines12010105
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Leroux-Roels, I., Prajeeth, K. C., Aregay, A., Nair, N., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., Kardinahl, S., Pelz, S., Bauer, S., D’Onofrio, V., Alhatemi, A., Jacobs, B., De Boever, F., Porrez, S., Waerlop, G., Punt, C., Hendriks, B., von, van de, et al. (2024). Safety and immunogenicity of the live-attenuated hRVFV-4s vaccine against rift valley fever in healthy adults: a dose-escalation, placebo-controlled, first-in-human, phase 1 randomised clinical trial. The Lancet: Infectious Diseases, 24(11), 1245–1253. https://doi.org/10.1016/S1473-3099(24)00375-X
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Meineke, R., Agac, A., Knittler, M.-C., Ludlow, M., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2024). Respiratory syncytial virus glycoprotein G impedes CX3CR1-activation by CX3CL1 and monocyte function. Npj Viruses, 2, Article 63. https://doi.org/10.1038/s44298-024-00075-9
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Prajeeth, C. K., Zdora, I., Saletti, G., Friese, J., Gerlach, T., Wilken, L., Beicht, J., Kubinski, M., Puff, C., Baumgärtner, W., Kortekaas, J., Wichgers Schreur, P. J., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2024). Immune correlates of protection of the four-segmented Rift Valley fever virus candidate vaccine in mice. Emerging Microbes & Infections, 13, Article 2373313. https://doi.org/10.1080/22221751.2024.2373313
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Schweitzer, F., Letoha, T., Osterhaus, A., & Prajeeth, C. K. (2025). Impact of tick-borne Orthoflaviviruses infection on compact human brain endothelial barrier. International Journal of Molecular Sciences, 26(5), Article 2342. https://doi.org/10.3390/ijms26052342
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Schweitzer, F., Schröder, L.-J., Friedrichs, A., Gudi, V., Skripuletz, T., Steffen, I., Palus, M., Růžek, D., Osterhaus, A., & Prajeeth, C. K. (2025). Mosquito- and tick-borne orthoflaviviruses cross an in vitro endothelial-astrocyte barrier. Frontiers in Cellular and Infection Microbiology, 15, Article 1624636. https://doi.org/10.3389/fcimb.2025.1624636
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Kubinski, M., Beicht, J., Gerlach, T., Aregay, A., Osterhaus, A. D. M. E., Tscherne, A., Sutter, G., Prajeeth, C. K., & Rimmelzwaan, G. F. (2024). Immunity to tick-borne encephalitis virus NS3 protein induced with a recombinant modified vaccinia virus Ankara fails to afford mice protection against TBEV infection. Vaccines, 12(1), Article 105. https://doi.org/10.3390/vaccines12010105
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Leroux-Roels, I., Prajeeth, K. C., Aregay, A., Nair, N., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., Kardinahl, S., Pelz, S., Bauer, S., D’Onofrio, V., Alhatemi, A., Jacobs, B., De Boever, F., Porrez, S., Waerlop, G., Punt, C., Hendriks, B., von, van de, et al. (2024). Safety and immunogenicity of the live-attenuated hRVFV-4s vaccine against rift valley fever in healthy adults: a dose-escalation, placebo-controlled, first-in-human, phase 1 randomised clinical trial. The Lancet: Infectious Diseases, 24(11), 1245–1253. https://doi.org/10.1016/S1473-3099(24)00375-X
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Prajeeth, C. K., Zdora, I., Saletti, G., Friese, J., Gerlach, T., Wilken, L., Beicht, J., Kubinski, M., Puff, C., Baumgärtner, W., Kortekaas, J., Wichgers Schreur, P. J., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2024). Immune correlates of protection of the four-segmented Rift Valley fever virus candidate vaccine in mice. Emerging Microbes & Infections, 13, Article 2373313. https://doi.org/10.1080/22221751.2024.2373313
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Beicht, J., Kubinski, M., Zdora, I., Puff, C., Biermann, J., Gerlach, T., Baumgärtner, W., Sutter, G., Osterhaus, A., Prajeeth, C. K., & Rimmelzwaan, G. F. (2023). Induction of humoral and cell-mediated immunity to the NS1 protein of TBEV with recombinant Influenza virus and MVA affords partial protection against lethal TBEV infection in mice. Frontiers in Immunology, 14, Article 1177324. https://doi.org/10.3389/fimmu.2023.1177324
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Kubinski, M., Beicht, J., Zdora, I., Biermann, J., Puff, C., Gerlach, T., Tscherne, A., Baumgärtner, W., Osterhaus, A., Sutter, G., Prajeeth, C. K., & Rimmelzwaan, G. F. (2023). A recombinant modified vaccinia virus Ankara expressing prME of tick-borne encephalitis virus affords mice full protection against TBEV infection. Frontiers in Immunology, 14, Article 1182963. https://doi.org/10.3389/fimmu.2023.1182963
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Kubinski, M., Beicht, J., Zdora, I., Saletti, G., Kircher, M., Petry-Gusmag, M., Steffen, I., Puff, C., Jung, K., Baumgärtner, W., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., & Prajeeth, C. K. (2023). Cross-reactive antibodies against Langat virus protect mice from lethal tick-borne encephalitis virus infection. Frontiers in Immunology, 14, Article 1134371. https://doi.org/10.3389/fimmu.2023.1134371
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Nair, N., Osterhaus, A., Rimmelzwaan, G., & Prajeeth, C. K. (2023). Rift Valley fever virus: infection, pathogenesis and host immune responses. Pathogens, 12(9), Article 1174. https://doi.org/10.3390/pathogens12091174
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Pilchová, V., Prajeeth, C. K., Jendrny, P., Twele, F., Meller, S., Pink, I., Volk, H. A., Osterhaus, A., von Köckritz-Blickwede, M., & Schulz, C. (2023). β-Propiolactone (BPL)-inactivation of SARS-Co-V-2: in vitro validation with focus on saliva from COVID-19 patients for scent dog training. In 32nd Annual Meeting of the Society of Virology: abstracts (P 267).
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Meineke, R., Stelz, S., Busch, M., Werlein, C., Kühnel, M., Jonigk, D., Rimmelzwaan, G. F., & Elbahesh, H. (2023). FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants. iScience, 26(4), Article 106309. https://doi.org/10.1016/j.isci.2023.106309
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Meineke, R. (2022). Inhibition of Host Kinase Activity: Effects on Influenza A Virus Infection and Host Cell Signaling. https://nbn-resolving.org/urn:nbn:de:gbv:95-117384
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Meineke, R., Stelz, S., Busch, M., Werlein, C., Kühnel, M., Jonigk, D., Rimmelzwaan, G. F., & Elbahesh, H. (2022). FDA-approved inhibitors of RTK/Raf signaling potently impair multiple steps of in vitro and ex vivo influenza A virus infections. Viruses, 14(9), Article 2058. https://doi.org/10.3390/v14092058
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Becker, T., Elbahesh, H., Reperant, L. A., Rimmelzwaan, G. F., & Osterhaus, A. D. M. E. (2021). Influenza vaccines: successes and continuing challenges. The Journal of Infectious Diseases, 224(Supplement 4), 405–S419. https://doi.org/10.1093/infdis/jiab269
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Palacios-Pedrero, M. Á., Osterhaus, A. D. M. E., Becker, T., Elbahesh, H., Rimmelzwaan, G. F., & Saletti, G. (2021). Aging and options to halt declining immunity to virus infections. Frontiers in Immunology, 12, Article 681449. https://doi.org/10.3389/fimmu.2021.681449
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Ricke-Hoch, M., Stelling, E., Lasswitz, L., Gunesch, A. P., Kasten, M., Zapatero-Belinchón, F. J., Brogden, G., Gerold, G., Pietschmann, T., Montiel, V., Balligand, J.-L., Facciotti, F., Hirsch, E., Gausepohl, T., Elbahesh, H., Rimmelzwaan, G. F., Höfer, A., Kühnel, M. P., Jonigk, D., et al. (2021). Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. PLoS ONE, 16(8), Article e0255335. https://doi.org/10.1371/journal.pone.0255335
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Di, H., Elbahesh, H., & Brinton, M. A. (2020). Characteristics of human OAS1 isoform proteins. Viruses, 12(2: 152). https://doi.org/10.3390/v12020152
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Meineke, R., Werlein, C., Kühnel, M., Jonigk, D., Rimmelzwaan, G. F., & Elbahesh, H. (2020). Differential susceptibility of pandemic H1N1 and seasonal H3N2 Influenza A viruses to clinically-approved small molecule kinase inhibitors. In Stiftung Tierärztliche Hochschule Hannover (Ed.), 13th Graduate School Days: 20/21 November 2020 / Stiftung Tierärztliche Hochschule Hannover (Zoo V 05). Stiftung Tierärztliche Hochschule Hannover.
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Saletti, G., Gerlach, T., Jansen, J. M., Molle, A., Elbahesh, H., Ludlow, M., Li, W., Bosch, B.-J., Osterhaus, A. D. M. E., & Rimmelzwaan, G. F. (2020). Older adults lack SARS CoV-2 cross-reactive T lymphocytes directed to human coronaviruses OC43 and NL63. Scientific Reports, 10: 21447. https://doi.org/10.1038/s41598-020-78506-9
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Bergmann, S., & Elbahesh, H. (2019). Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses. Virology, 534, 54–63. https://doi.org/10.1016/j.virol.2019.05.020
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