S. Dai-Lun, U. Siebert, J. Lakemeyer, M. Grilo, I. Pawliczka, N.-H. Wu, P. Valentin-

Weigand, G. Herrler, L. Haas. A Highly Pathogenic Avian Influenza Virus (H5N8)

isolated from a Baltic Grey Seal. Submitted to EID (Dispatch)


D. Paegelow, C. Chhatbar, A. Beineke, X. Liu, A. Nerlich, M. Rohde, U. Kalinke,

R. Förster, S. Halle, P. Valentin-Weigand, M. Hornef, M. Fulde. The olfactory

epithelium as a portal of entry in neonatal CNS infection. Nature Commun

(revised version submitted)


J. Tong, Y. Fu, F. Meng, N. Krüger, P. Valentin-Weigand*, G. Herrler*. Paramyxovirus

surface glycoproteins enhance adherence of group B streptococci to respiratory

epithelial cells in a sialic acid-dependent manner Front Cell Infect Microbiol. 2018

Aug 17;8:280. doi: 10.3389/fcimb.2018.00280. eCollection 2018.*equal contribution


V. Rungelrath, C. Weiße, N. Schütze, U. Müller, M. Meurer, M. Rohde, J. Seele,

P. Valentin-Weigand, M. Kirschfink, A. Beineke, W. Schrödl, R. Bergmann, C.G. Baums.

IgM cleavage by Streptococcussuis reduces IgM bound to the bacterial surface and

is a novel complement evasion mechanism, Virulence 2018, 9:1, 1314-1337,

DOI: 10.1080/21505594.2018.1496778


J. Seele, S.C. Tauber, S. Bunkowski, C.G. Baums, P. Valentin-Weigand, N. de Buhr,

A. Beineke, A.l. Iliev, W. Brück, R. Nau. The inflammatory response and neuronal injury

in Streptococcus suis meningitis. BMC Infect Dis 2018 Jul 3; 18(1):297.

doi: 10.1186/s12879-018-3206-6


D. Vötsch, M. Willenborg, Y.B. Weldearegay, P. Valentin-Weigand. Streptococcus suis -

the “two faces” of a pathobiont in the porcine respiratory tract. Front Microbiol 2018

Mar 15;9:480. doi: 10.3389/fmicb.2018.00480.


J. Tong, Y. Fu, N.-H. Wu, M. Rohde, F. Meng, P. Valentin-Weigand*, G. Herrler*.

Sialic acid-dependent interaction of group B streptococci with influenza virus-infected

cells reveals a novel adherence and invasion mechanism. Cell Microbiol.2018;

20:e12818.*equal contribution


D. Mzinza, H. Fleige, K. Laarmann, S. Willenzon, J. Ristenpart, J. Spanier, G. Sutter,

U. Kalinke, P. Valentin-Weigand, R. Förster. Application of light sheet microscopy for

qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice.

Cell Mol Immunol 2018, Feb12. doi: 10.1038/cmi.2017.150.



N. Siemens, S. Oehmcke-Hecht, T.C. Mettenleiter, B. Kreikemeyer, P. Valentin-

Weigand, S. Hammerschmidt. Port d`entré for respiratory infections – does the

virus pave the way for bacteria? Front Microbiol 2017 Dec 21; 8:2602.

doi: 10.3389/fmicb.2017.02602. eCollection.


V. Rungelrath, J. Wohlsein, U. Siebert, J. Stott, E. Prenger-Berninghoff, U. von Pawel-

Rammingen, P. Valentin-Weigand, C.G. Baums, J. Seele. Identification of a novel

host- specific IgG protease in Streptococcus phocae subspecies phocae.

Vet Microbiol 2017; 201:42-48


A. Koczula, M. Jarek, C. Visscher, P. Valentin-Weigand, R. Goethe, J. Willenborg.

Transcriptomic Analysis Reveals Selective Metabolic Adaptation of Streptococcus suis

to Porcine Blood and Cerebrospinal Fluid. Pathogens. 2017 Feb 15;6(1). pii: E7.

doi: 10.3390/pathogens6010007.


N. De Buhr, F. Reuner, A. Neumann, C. Stump-Guthier, T. Tenenbaum, H. Schroten,

H. Ishikawa, K. Müller, A. Beineke, I. Hennig-Pauka, T. Gutsmann, P. Valentin-

Weigand, C.G. Baums, M. von Köckritz-Blickwede. Neutrophil extracellular trap

formation in the Streptococcus suis-infected cerebrospinal fluid compartment.

Cell Microbiol. 2017 Feb; 19(2). doi: 10.1111/cmi.12649.



N.-H. Wu, W. Yang, F. Meng, R. Dijkman, M. Matrosovich, V. Thiel, P. Valentin-Weigand,

G. Herrler. The differentiated airway epithelium infected by influenza viruses maintains

the barrier function despite a dramatic loss of ciliated cells. Sci Rep 2016 Dec 22;6:39668. doi: 10.1038/srep39668.


M. Seitz, P. Valentin-Weigand, J. Willenborg. Use of antibiotics and antimicrobial

resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus

suis. Curr Top Microbiol Immunol. 2016 Oct 15. [Epub ahead of print]


F. Warneboldt, S.J. Sander, A. Beineke, P. Valentin-Weigand, J. Kamphues,

C.G. Baums. Clearance of Streptococcus suis in stomach contents of differently fed growing pigs Pathogens 2016 Aug 6;5(3). pii: E56. doi: 10.3390/pathogens5030056.


J. Willenborg, A. Koczula, M. Fulde, A. de Greeff, A. Beineke, W. Eisenreich, C. Huber,

M. Seitz, P. Valentin-Weigand, R. Goethe. FlpS, the FNR-Like Protein of Streptococcus

suis is an essential, oxygen-sensing activator of the Arginine Deiminase System.

Pathogens. 2016 Jul 21;5(3). pii: E51. doi: 10.3390/pathogens5030051.


J. Seele, R. Nau, C.K. Prajeeth, M. Stangel, P. Valentin-Weigand, M. Seitz. Astrocytes

enhance Streptococcus suis-glia cell interaction in primary astrocyte-microglial cell

co-cultures. Pathogens. 2016 Jun 13;5(2). pii: E43. doi: 10.3390/pathogens5020043.


G.-J. Verkühlen, D. Pägelow, P. Valentin-Weigand, Marcus Fulde. SCM-positive

Streptococcus canis are predominant among pet-associated group G streptococci.

Berl Munch Tierarztl Wochenschr. 2016 May-Jun;129(5-6):247-50.


F. Meng, N.-H. Wu, M. Seitz, G. Herrler, P. Valentin-Weigand. Efficient suilysin-mediated

invasion and apoptosis in porcine respiratory epithelial cells after streptococcal

infection under air-liquid interface conditions. Scientific Reports 2016 May 27; 6:26748. doi:10.1038/srep26748.


C. Spoerry, J. Seele, P. Valentin-Weigand, C.G. Baums, U. von Pawel-Rammingen.

Identification and characterization of IgdE, a novel IgG degrading protease of

Streptococcus suis with unique specificity for porcine IgG. J Biol Chem 2016;



K.S. Doran, M. Fulde, N. Gratz, P.J. Kim, R. Nau, N.V. Prasadaro, A. Schubert-Unkmeir,

E.I. Tuomanen, P. Valentin-Weigand. Host-pathogen interactions in bacterial

meningitis. Acta Neuropathologica 2016; 131(2), 185-209,

DOI 10.1007/s00401-015-1531-z


Y.B. Weldearegay, A. Pich, E. Schieck, A. Liljander, N. Gicheru, H. Wesonga, F.

Thiaucourt, L. Kiirika, P. Valentin-Weigand, J. Jores, J. Meens. Proteomic

characterization of pleural effusion, a specific host niche of Mycoplasma mycoides

subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP).

J Proteomics 2016; 131:93-103.



T. Eisenberg, C. Hudemann, H. Hossain, A. Hewer, K. Tello, D. Bandorski, M. Rohde,

P. Valentin-Weigand, C.G. Baums. Characterization of five zoonotic Streptococcus

suis strains from Germany, including one isolate from a recent fatal case of

streptococcal toxic shock-like syndrome in a hunter. J Clin Microbiol 2015; 53:3912-



I. Eichhorn, K. Heidemanns, T. Semmler, B. Kinnemann, A. Mellmann, D. Harmsen,

M. Anjum, H. Schmidt, A. Fruth, P. Valentin-Weigand, J. Heesemann, S. Suerbaum,

H. Karch, L.H. Wieler. Highly virulent non-O157 EHEC serotypes reflect a similar

phylogenetic lineage, giving new insights into the evolution of typical EHEC. Appl

Environ Microbiol      2015; 81:7041-7047.


N.H. Wu, F. Meng, M. Seitz, P. Valentin-Weigand, G. Herrler. Sialic acid-dependent

interactions between influenza viruses and Streptococcus suis affect the infection

of porcine tracheal cells. J General Virol. 2015; 96:2557-2568


F. Meng, N.H. Wu, A. Nerlich, G. Herrler, P. Valentin-Weigand, M. Seitz. Dynamic viral-

bacterial interactions in a porcine precision-cut lung slice co-infection model: swine

influenza virus paves the way for Streptococcus suis infection in a two-step process.

Infect Immun. 2015; 83:2806-2815


J. Seele, A. Beineke, L.-M. Hillermann, B. Jaschok-Kentner, U. von Pawel-Rammingen,

P. Valentin-Weigand, C.G. Baums. The Immunoglobulin M-degrading enzyme of

Streptococcus suis, IdeSsuis, is involved in complement evasion. Vet Res 2015; 46:45


J. Seele, L.M. Hillermann, A. Beineke, M. Seitz, U. von Pawel-Rammingen, P. Valentin-

Weigand, C.G. Baums. The immunoglobulin M-degrading enzyme of Streptococcus

suis, IdeSsuis, is a highly protective antigen against serotype 2. Vaccine. 2015; 33(19):2207-2212


N. de Buhr, M. Stehr, A. Neumann, H.Y. Naim, P. Valentin-Weigand, M. von Köckritz-

Blickwede, C.G. Baums. Identification of a novel DNase of Streptococcus suis

(EndAsuis) important for neutrophil extracellular trap (NET) degradation during

exponential growth. Microbiology 2015;161:838-850


J. Willenborg, C. Huber, A. Koczula, B. Lange, W. Eisenreich, P. Valentin-Weigand,

R. Goethe. Characterization of the pivotal carbon metabolism of Streptococcus suis

serotype 2 under ex vivo and chemically defined in vitro conditions by isotopologue

profiling. J Biol Chem 2015; 290(9):5840-5845