Brogden, Graham PhD


Wissenschaftlicher Mitarbeiter

PhD, Master of Research

 

Tel: 0511 953-8579

Fax: 0511 953-8587

 

e-mail schreiben

Projekte und Aufgaben

  • E-Learning: Erstellen von Fallbeispielen
  • Lipidanalysen von Geweben aus Fischen unter Infektion
  • Analyse von Granulozytenfunktionen von Fischen

Forschungsinteressen

  • Pathogen-Wirt-Interaktionen
  • Rolle von Lipiden bei Infektion und Erkrankung
  • E-Learning

Wissenschaftlicher Werdegang

Research positions

01/2015- : Postdoctoral researcher, Department of Physiological Chemistry/ Fish Disease Research Unit, Infection Biochemistry Research Group, University of Veterinary Medicine, Hannover, Germany.

 

07/2014-12/2014: Postdoctoral researcher, Department of Physiological Chemistry, Infection Biochemistry Research Group, University of Veterinary Medicine, Hannover, Germany.

 

04/2014-06/2014: Postdoctoral researcher, Fish Disease Research Unit, University of Veterinary Medicine, Hannover, Germany.

 

08/2012-04/2014: Postdoctoral researcher, Department of Physiological Chemistry, Infection Biochemistry Research Group, University of Veterinary Medicine, Hannover, Germany. 

 

06-08/2012: Researcher, Fish Disease Research Unit, University of Veterinary Medicine, Hannover, Germany. 

 

05/2009-05/2012: PhD student, Fish Disease Research Unit, University of Veterinary Medicine, Hannover, Germany.

 

2007-2009: Master in Scientific Research Training (MRes) Keele University, topic: ‘The production of a recombinant form of carp Tumour Necrosis Factor a1 and a2 in a Eukaryotic system’.  

 

Education

2009-2013                  PhD, University of Veterinary Medicine Hannover, Germany

2007-2009                  MRes, Keele University, UK/Wageningen University, NL                      

2004-2007                  Bachelor in Biology and Geography, Keele University, UK

2002-2004                  A levels in Biology, Chemistry, Geography and General Studies, Clitheroe Royal Grammar School Sixth Form, UK

Publikationen

  • Brogden G*, Adamek M*, Proepsting M, Ulrich R, Hassan Y. Naim H. Y, Steinhagen D.  Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle. Veterinary Microbiology. 2015 doi:10.1016/j.vetmic.2015.05.024.
  • Raddatz B. B. R, Sun W, Brogden G, Sun Y, Kammeyer P, Kalkuhl A, Colbatzky F, Naim H. Y, Deschl U, Baumgärtner W, Ulrich R. Central nervous system de- and remyelination is independent from systemic cholesterol level in Theiler´s murine encephalomyelitis. Brain Pathology. 2015 DOI: 10.1111/bpa.12266
  • Adamek M, Rauch G, Brogden G, Steinhagen D. Effect of small interfering RNA based treatment of the Cyprinid herpesvirus 3 infection of common carp (Cyprinus carpio L.) cells in vitro. Pol J Vet Sci. 2014 17 (4): 733-735
  • Adamek M, Rakus KL, Brogden G, Matras M, Chyb J, Hirono I, Kondo H, Aoki T, Irnazarow I, Steinhagen D. Interaction between type 1 interferon and Cyprinus herpesvirus 3 in two genetic lines of common carp (Cyprinus carpio). Dis Aquat Organ. 2014 Sep 30;111(2):107-18
  • Neumann A, Brogden G, Jerjomiceva N, Brodesser S, Naim HY, von Köckritz-Blickwede M. Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps.  Eur J Cell Biol. 2014 Aug-Sept;93(8-9):247-54
  • Brogden G*, Krimmling T*, Adamek M, Naim HY, Steinhagen D, von Köckritz-Blickwede M. The effect of β-glucan on formation and functionality of neutrophil extracellular traps in carp (Cyprinus carpio L.). Dev Comp Immunol. 2014 Jun;44(2):280-5.
  • Brogden G, Propsting M, Adamek M, Naim HY, Steinhagen D. 2014 Isolation and analysis of membrane lipids and lipid rafts in common carp (Cyprinus carpio L.). Comp Biochem Physiol B Biochem Mol Biol. 2014;169:9-15
  • Syakuri H, Jung-Schroers V, Adamek M, Brogden G, Irnazarow I, Steinhagen D. Beta-glucan feeding differentiated the regulation of mRNA expression of claudin genes and prevented an intestinal inflammatory response post Aeromonas hydrophila intubation in common carp, Cyprinus carpio L. J Fish Dis. 2014 Feb 37(2): 149-156.
  • Syakuri H, Adamek M, Brogden G, Rakus KŁ, Matras M, Irnazarow I, Steinhagen D. Intestinal barrier of carp (Cyprinus carpio L.) during a cyprinid herpesvirus 3-infection: molecular identification and regulation of the mRNA expression of claudin encoding genes.Fish Shellfish Immunol. 2013 Jan;34(1):305-14. doi: 10.1016/j.fsi.2012.11.010. Epub 2012 Nov 26.
  • Adamek M, Syakuri H, Harris S, Rakus KŁ, Brogden G, Matras M, Irnazarow I, Steinhagen D. Cyprinid herpesvirus 3 infection disrupts the skin barrier of common carp (Cyprinus carpio L.).Vet Microbiol. 2013 Mar 23;162(2-4):456-70.
  • Brogden G*, von Kockritz-Blickwede M*, Adamek M, Reuner F, Jung-Schroers V, Naim HY, Steinhagen D. beta-Glucan protects neutrophil extracellular traps against degradation by Aeromonas hydrophila in carp (Cyprinus carpio). Fish Shellfish Immunol. 2012 33:1060-4.
  • Adamek M, Rakus KŁ, Chyb J, Brogden G, Huebner A, Irnazarow I, Steinhagen D. Interferon type I responses to virus infections in carp cells: In vitro studies on Cyprinid herpesvirus 3 and Rhabdovirus carpio infections.Fish Shellfish Immunol. 2012 Sep;33(3):482-93.
  • Rakus KŁ, Irnazarow I, Adamek M, Palmeira L, Kawana Y, Hirono I, Kondo H, Matras M, Steinhagen D, Flasz B, Brogden G, Vanderplasschen A, Aoki T. Gene expression analysis of common carp (Cyprinus carpio L.) lines during Cyprinid herpesvirus 3 infection yields insights into differential immune responses. Dev Comp Immunol. 2012 May;37(1):65-76.
  • Maalouf, K., Jia, J., Rizk, S., Brogden, G., Keiser, M., Das, A., Naim, H.Y., 2009. A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV. Journal of Inherited Metabolic Disease 33, 445-449