Publications

2017

A.S. Heinemann, S. Pirr, B. Fehlhaber, L. Mellinger, J. Burgmann, M. Busse, M. Ginzel, J. Friesenhagen, M. von Köckritz-Blickwede, T. Ulas, C.S. von Kaisenberg, J. Roth, T. Vogl, D. Viemann. In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock. FASEB J. 2017 Mar;31(3):1153-1164. Epub 2016 Dec 19.

 

2016

K. Branitzki-Heinemann, H. Möllerherm, L. Völlger, D.M. Husein, N. de Buhr, S. Blodkamp, F. Reuner, G. Brogden, H.Y. Naim, M. von Köckritz-Blickwede. Formation of Neutrophil Extracellular Traps under Low Oxygen Level. Front Immunol. 2016 Nov 25;7:518. eCollection 2016.

 

M. Henström, L. Diekmann, F. Bonfiglio, F. Hadizadeh, E.M. Kuech, M. von Köckritz-Blickwede, L.B. Thingholm, T. Zheng, G. Assadi, C. Dierks, M. Heine, U. Philipp, O. Distl, M.E. Money, M. Belheouane, F.A. Heinsen, J. Rafter, G. Nardone, R. Cuomo, P. Usai-Satta, F. Galeazzi, M. Neri, S. Walter, M. Simrén, P. Karling, B. Ohlsson, P.T. Schmidt, G. Lindberg, A. Dlugosz, L. Agreus, A. Andreasson, E. Mayer, J.F. Baines, L. Engstrand, P. Portincasa, M. Bellini, V. Stanghellini, G. Barbara, L. Chang, M. Camilleri, A. Franke, H.Y. Naim, M. D'Amato. Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut. 2018 Feb;67(2):263-270. Epub 2016 Nov 21.

 

N. de Buhr, F. Reuner, A. Neumann, C. Stump-Guthier, T. Tenenbaum, H. Schroten, H. Ishikawa, K. Müller, A. Beineke, I. Hennig-Pauka, T. Gutsmann, P. Valentin-Weigand, C.G. Baums, M. von Köckritz-Blickwede. Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment. Cell Microbiol. 2017 Feb;19(2). Epub 2016 Aug 31.

 

H. Möllerherm, M. von Köckritz-Blickwede, K. Branitzki-Heinemann. Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps. Front Immunol. 2016 Jul 18;7:265. eCollection 2016. Review. 

 

N. Jerjomiceva, H. Seri, R. Yaseen, N. de Buhr, W.N. Setzer, H.Y. Naim, M. von Köckritz-Blickwede. Guarea kunthiana Bark Extract Enhances the Antimicrobial Activities of

Human and Bovine Neutrophils. Nat Prod Commun. 2016 Jun;11(6):767-70.

 

L. Völlger, K. Akong-Moore, L. Cox, O. Goldmann, Y. Wang, S.T. Schäfer, H.Y. Naim, V. Nizet, M. von Köckritz-Blickwede. Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils. Biosci Rep. 2016 May 20;36(3). 

 

N. de Buhr, M. von Köckritz-Blickwede. How Neutrophil Extracellular Traps Become Visible. J Immunol Res. 2016;2016:4604713. Epub 2016 May 16. Review.

 

S. Blodkamp, K. Kadlec, T. Gutsmann, C. Quiblier, H.Y. Naim, S. Schwarz, M. von Köckritz-Blickwede. Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus. Vet Microbiol. 2017 Feb;200:52-58. Epub 2016 Mar 31.

 

M. von Köckritz-Blickwede, S. Blodkamp, V. Nizet. Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact for the Infected Host. Front Microbiol. 2016 Mar 30;7:402. 

 

N.E. Zeitouni, S. Chotikatum, M. von Köckritz-Blickwede, H.Y. Naim. The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens. Mol Cell Pediatr. 2016 Dec;3(1):14. Epub 2016 Mar 22. Review.

 

N.E. Zeitouni, P. Dersch, H.Y. Naim, M. von Köckritz-Blickwede. Hypoxia Decreases Invasin-Mediated Yersinia enterocolitica Internalization into Caco-2 Cells.

PLoS One. 2016 Jan 5;11(1):e0146103.

 

2015

L. Andzinski, N. Kasnitz, S. Stahnke, C.F. Wu, M. Gereke, M. von Köckritz-Blickwede, B. Schilling, S. Brandau, S. Weiss, J. Jablonska. Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer. 2016 Apr 15;138(8): 1982-93. Epub 2015 Dec 17. 

 

D.A. Stapels, A. Kuipers, M. von Köckritz-Blickwede, M. Ruyken, A.T. Tromp, M.J. Horsburgh, C.J. de Haas, J.A. van Strijp, K.P. van Kessel, S.H. Rooijakkers.

Staphylococcus aureus protects its immune-evasion proteins against degradation by neutrophil serine proteases. Cell Microbiol. 2016 Apr;18(4):536-45. Epub 2015 Oct 23.

 

S. Blodkamp, K. Kadlec, T. Gutsmann, H.Y. Naim, M. von Köckritz-Blickwede, S. Schwarz. In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus. Vet Microbiol. 2016 Oct 15;194:107-111.

 

H. Möllerherm, A. Neumann, K. Schilcher, S. Blodkamp, N.E. Zeitouni, P. Dersch, P. Lüthje, H.Y. Naim, A.S. Zinkernagel, M. von Köckritz-Blickwede. Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs). FEMS Microbiol Lett. 2015 Dec;362(23):fnv192. Epub 2015 Oct 12.

 

N.E. Zeitouni, J. Fandrey, H.Y. Naim, M. von Köckritz-Blickwede. Measuring oxygen levels in Caco-2 cultures. Hypoxia (Auckl). 2015 Oct 9;3:53-66. eCollection 2015.

 

M. Amiri, L. Diekmann, M. von Köckritz-Blickwede, H.Y. Naim. The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers. Nutrients. 2015 Aug 28;7(9):7209-30.

 

L.P. Coelho, C. Pato, A. Friães, A. Neumann, M. von Köckritz-Blickwede, M. Ramirez, J.A. Carriço. Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images. Bioinformatics. 2015 Jul 15;31(14):2364-70.

 

C.G. Baums, M. von Köckritz-Blickwede. Novel role of DNA in neutrophil extracellular traps. Trends Microbiol. 2015 Jun;23(6):330-1.

 

N. de Buhr, M. Stehr, A. Neumann, H.Y. Naim, P. Valentin-Weigand, M. von Köckritz-Blickwede, C.G. Baums. Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth. Microbiology. 2015 Apr;161(Pt 4):838-50.

 

2014

J. Austermann, J. Friesenhagen, S.K. Fassl, T. Ortkras, J. Burgmann, K. Barczyk-Kahlert, E. Faist, S. Zedler, S. Pirr, C. Rohde, C. Muller-Tidow, M. von Köckritz-Blickwede, C.S. von Kaisenberg, S.B. Flohe, T. Ulas, J.L. Schultze, J. Roth, T. Vogl, V. Viemann. Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions. Cell Reports 9, 1-12 December 24 (2014). Impact factor: 7.207.

 

D. Seinige, M. von Köckritz-Blickwede, C. Krischek, G. Klein, C. Kehrenberg.

Influencing factors and applicability of the viability EMA-qPCR for a detection and quantification of campylobacter cells from water samples. PLoS One. 2014 Nov 20;9(11):e113812. Impact factor: 3.534.

 

A. Neumann, E.T. Berends, A. Nerlich, E.M. Molhoek, R.L. Gallo, T. Meerloo, V. Nizet,

H.Y. Naim, M. von Köckritz-Blickwede. The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. Biochem J. 2014 Nov 15;464(1):3-11. Impact factor: 4.779.

 

D.A. Stapels, K.X. Ramyar, M. Bischoff, M. von Köckritz-Blickwede, F.J. Milder, M. Ruyken, J. Eisenbeis, W.J. McWhorter, M. Herrmann, K.P. van Kessel, B.V. Geisbrecht, S.H. Rooijakkers. Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13187-92. Impact factor: 9.809.

 

A. Neumann, G. Brogden, N. Jerjomiceva, S. Brodesser, H.Y. Naim, M. von Köckritz-Blickwede. Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps. Eur J Cell Biol. 2014 Aug-Sep;93(8-9):347-54.

Impact factor: 3.699

 

A. Neumann, L. Völlger, E.T.M. Berends, E.M. Molhoek, D.A.C. Stapels, M. Midon, A. Friães, A. Pingoud, S.H.M. Rooijakkers, R.L. Gallo, M. Mörgelin, V. Nizet, H.Y. Naim, M. von Köckritz-Blickwede. Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases. J Innate Immun. 2014;6(6):860-8. Impact factor: 4.557.

 

N. Jerjomiceva, H. Seri, L. Völlger, Y. Wang, N. Zeitouni, H.Y. Naim, M. von Köckritz-Blickwede. Enrofloxacin enhances the formation of neutrophil extracellular traps in bovine granulocytes. J Innate Immun. 2014;6(5):706-12. Impact factor: 4.557.

 

N. de Buhr, A. Neumann, N. Jerjomiceva, M. von Köckritz-Blickwede*, C.G. Baums*. Streptococcus suis DNase SsnA contributes to degradation of neutrophil extracellular traps (NETs) and evasion of NETmediated antimicrobial activity. Microbiology-SGM. 160(Pt 2):385-95 (2014). [* contributed equally to the manuscript]. Impact factor: 2.835.

 

G. Brogden, T. Krimmling, M. Adamek, H.Y. Naim, D. Steinhagen, M. von Köckritz-Blickwede. The effect of β-glucan on formation and functionality of neutrophil extracellular traps in carp (Cyprinus carpio L.). Dev Comp Immunol. 44(2):280-5 (2014). Impact factor: 3.705.

 

K.R. Short, M. von Köckritz-Blickwede, J.D. Langereis, K.Y. Chew, E.R. Job, C.W. Armitage, B. Hatcher, K. Fujihashi, P.C. Reading, P.W. Hermans, O.L. Wijburg, D.A. Diavatopoulos. Antibodies mediate the formation of neutrophil extracellular traps (NETs) in the middle ear and facilitate secondary pneumococcal otitis media. Infect Immun. 81(1):364-370 (2014). Impact factor: 4.156.

 

2013

N.M. van Sorge, F.C. Beasley, I. Gusarov, D.J. Gonzalez, M. von Köckritz-Blickwede, S. Anik, A.W. Borkowski, P.C. Dorrestein, E. Nudler, V. Nizet. Methicillin-resistant Staphylococcus aureusBacterial Nitricoxide Synthase Affects Antibiotic Sensitivity and Skin Abscess Development. J Biol Chem. 288(9):6417-6426 (2013). Impact factor: 4.600.

 

2012

G. Brogden*, M. von Köckritz-Blickwede*, M. Adamek, F. Reuner, V. Jung-Schroers, H.Y. Naim, D. Steinhagen. β-glucan protects neutrophil extracellular traps against degradation by Aeromonas hydrophila in carp (Cyprinus carpio). Fish Shellfish Immunol. 33(4):1060-1064 (2012). [* contributed equally to the manuscript]. Impact factor: 3.034.

 

K. Akong-Moore, O.A. Chow, M. von Köckritz-Blickwede, V. Nizet. Influences of chloride and hypochlorite on neutrophil extracellular trap formation. PLoS One. 7(8):e42984 (2012). Impact factor: 3.534.

 

K. Branitzki-Heinemann, C.Y. Okumura, L. Völlger, Y. Kawakami, T. Kawakami, H.Y. Naim, V. Nizet, M. von Köckritz-Blickwede. A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps. Biochem J. 446(1):159-163 (2012). Impact factor: 4.779.

 

C.Y. Okumura, A. Hollands, D.N. Tran, J. Olson, S. Dahesh, M. von Köckritz-Blickwede, W. Thienphrapa, C. Corle, S.N. Jeung, A. Kotsakis, R.A. Shalwitz, R.S. Johnson, V. Nizet. A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med (Berl). 90(9):1079-1089 (2012). Impact factor: 4.739.

 

I. Jongerius*, M. von Köckritz-Blickwede*, M.J. Horsburgh, M. Ruyken, V. Nizet, S.H. Rooijakkers. Staphylococcus aureus virulence is enhanced by secreted factors that block innate immune defenses. J Innate Immun. 4(3):301-311 (2012). [* contributed equally to the manuscript]. Impact factor: 4.557.

 

A.S. Zinkernagel, P. Hruz, S. Uchiyama, M. von Köckritz-Blickwede, R.A. Schuepbach, T. Hayashi, D.A. Carson, V. Nizet. Importance of Toll-like receptor 9 in host defense against M1T1 Group A Streptococcus infections. J Innate Immun. 4:213-218 (2012). Impact factor: 4.557.

 

2011

T. Kisseleva, M. von Köckritz-Blickwede, D. Reichart, S.M. McGillvray, G. Wingender, M. Kronenberg, C.K. Glass, V. Nizet, D.A. Brenner. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med. 89:997-1013 (2011). Impact factor: 4.739.

 

2010

O.A. Chow*, M. von Köckritz-Blickwede*, A.T. Bright, M.E. Hensler, A.S. Zinkernagel, A.L. Cogen, R.L. Gallo, Y. Wang, C.K. Glass, V. Nizet. Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe. 8:445-454 (2010). [* contributed equally to the manuscript]. Impact factor: 12.194.

 

E.T.M. Berends, A.R. Horswill, N.M. Haste, V. Nizet, M. von Köckritz-Blickwede. Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun. 2:576-586 (2010). Impact factor: 4.557.

 

J.N. Cole, M.A. Pence, M. von Köckritz-Blickwede, A. Hollands, R.L. Gallo, M.J. Walker, V. Nizet. M protein and hyaluronic acid capsule are essential for the genetic switch underlying hypervirulence in M1T1 group A streptococcus. mBio. 1(4), pii:e00191-10 (2010). Impact factor: 6.875.

 

L.E. Crotty Alexander, H.C. Maisey, A.M. Timmer, S.H.M. Rooijakkers, R.L. Gallo, M. von Köckritz-Blickwede, V. Nizet. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med. 88:371-381 (2010). Impact factor: 4.739.

 

M. von Köckritz-Blickwede, S. Konrad, S. Foster, J.E. Gessner, E. Medina. Protective role of complement C5a in an experimental model of Staphylococcus aureus bacteremia. J Innate Immun. 2:87–92 (2010). Impact factor: 4.557.

 

2009

M. von Köckritz-Blickwede, O.A. Chow, V. Nizet. Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps. Blood. 114:5245-5246 (2009). Impact factor: 9.775.

 

M. von Köckritz-Blickwede, V. Nizet. Innate immunity turned inside-out: Antimicrobial defense by phagocyte extracellular traps. J Mol Med. 87:775-783 (2009). Impact factor: 4.739.

 

X. Lauth*, M. von Köckritz-Blickwede*, C.W. McNamara, S. Myskowski, A.S. Zinkernagel, B. Beall, P. Ghosh, R.L. Gallo, V. Nizet. M1 protein allows group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun. 1:202-214 (2009). [* contributed equally to the manuscript]. Impact factor: 4.557.

 

S. Oehmcke, O. Shannon, M. von Köckritz-Blickwede, M. Mörgelin, A. Linder, A.I. Olin,

L. Björck, H. Herwald. Treatment of invasive streptococcal infection with a peptide derived from human highmolecular weight kininogen. Blood. 114:444-451 (2009). Impact factor: 9.775.

 

2008

M. von Köckritz-Blickwede, M. Rohde, S. Oehmcke, L.S. Miller, A.L. Cheung, H. Herwald, S. Foster, E. Medina. Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model. Am J Pathol. 173:1657-1668 (2008). Impact factor: 4.602.

 

M. von Köckritz-Blickwede, O. Goldmann, K. Heinemann, P. Thulin, A. Norrby-Teglund,

M. Rohde, E. Medina. Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation. Blood. 111:3070-3080 (2008). Impact factor: 9.775.

 

2007

O. Goldmann, M. von Köckritz-Blickwede, C. Höltje, G.S. Chatwal, R. Geffers, E. Medina. Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program. Infect Immun. 75:4148-4157 (2007). Impact factor: 4.156.

 

P. Lüthje, M. von Köckritz-Blickwede and S. Schwarz. Identification and characterization of nine novel types of small staphylococcal plasmids carrying the lincosamide nucleotidyltransferase gene lnu(A). J Antimicrob Chemother. 59:600-606 (2007). Impact factor: 5.439.

 

2006

T. Hansen, M. Blickwede, J. Borlak. Primary rat alveolar epithelial cells for use in biotransformation and toxicity studies. Toxicol In Vitro. 20:757-766 (2006). Impact factor: 3.207.

 

2005

M. Blickwede, J. Borlak. Isolation and characterization of metabolically competent pulmonary epithelial cells from pig lung tissue. Xenobiotica. 35:927-941 (2005). Impact factor: 2.101.

 

J. Borlak, M. Blickwede, T. Hansen, W. Koch, M. Walles, K. Levsen. Metabolism of verapamil in culturesof rat alveolar epithelial cells and pharmacokinetics after administration by intravenous and inhalation routes. Drug Metab Dispos. 33:1108-1114 (2005). Impact factor: 3.334.

 

M. Blickwede, C. Wolz, P. Valentin-Weigand, S. Schwarz. Influence of clindamycin on mRNA stability of coa and fnbB transcripts and adherence properties of Staphylococcus aureus Newman. FEMS Microbiol Lett. 252:73-78 (2005). Impact factor: 2.046.

 

M. Blickwede, R. Goethe, C. Wolz, P. Valentin-Weigand, S. Schwarz. Molecular basis of florfenicolinduced increase in adherence of Staphylococcus aureus strain Newman. J Antimicrob Chemother. 56:315-323 (2005). Impact factor: 5.439.

 

2004

M. Blickwede, P. Valentin-Weigand, M. Rohde, S. Schwarz. Effects of subinhibitory concentrations of florfenicol on morphology, growth, and viability of Staphyloccus aureus. J Vet Med. B 51:293-296 (2004). Impact factor: -.

 

M. Blickwede, P. Valentin-Weigand, S. Schwarz. Subinhibitory concentrations of florfenicol enhance the adherence of florfenicol-susceptible and florfenicol-resistant Staphylococcus aureus. J Antimicrob Chemother. 54:286-288 (2004). Impact factor: 5.439.

 

M. Blickwede, S. Schwarz. Molecular analysis of florfenicol-resistant Escherichia coli isolates from pigs. J Antimicrob Chemother. 53:58-64 (2004). Impact factor: 5.439.

 

2003

S. Schwarz, M. Blickwede, C. Kehrenberg, G. Michael Brenner. Phänotypische und genotypische Verfahren zur Typisierung veterinärmedizinisch relevanter bakterieller Erreger im Rahmen infektionsepidemiologischer Fragestellungen, dargestellt am Beispiel von Bakterien der Genera Staphylococcus, Salmonella und Pasteurella. Berl Münch Tierärztl Wschr. 116:401-416 (2003). Impact

factor: 0.931.

 

2002

M. Blickwede, H. Dolz, M.V. Herrero, S.M. Tomlinson, M. Salman. Neutralizing antibodies against vesicular stomatitis viruses (serotypes New Jersey and Indiana) in horses in Costa Rica. J Vet Diagn Invest. 14:438-441 (2002). Impact factor: 1.232.