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Group Members

Prof. Dr. Maren von Köckritz-Blickwede

 

Prof. Dr. Maren von Köckritz-Blickwede studied biology at the University of Hanover. During this time, she spent one year at the Universidad Nacional de Heredia, Costa Rica, where she performed epidemiological studies about vesicular stomatitis viruses in horses in Costa Rica. In 2001 she completed her Diplom research studies with the title “Isolation and characterization of metabolically competent pulmonary epithelial cells from pig and rat lung tissue for the use in biotransformation and toxicity studies” at the Fraunhofer Institute for Toxicology and Experimental Medicine in Hanover, Germany.

 

After graduation, she started a Ph.D. research fellowship of the DFG-graduate school "Mucosal Host-Pathogen Interactions" at the Federal Agricultural Research Centre for Animal Science in Neustadt-Mariensee, Germany. The topic of her PhD thesis was: “Antibiotic-dependent modulation of staphylococcal virulence properties”. She received her Dr. rer. nat. title in December 2004 at the University of Veterinary Medicine in Hannover, Germany.

 

After that she spent three years as a PostDoc at the Helmholtz Centre for Infection Research in Braunschweig, Germany, where she studied the role of host genetic and immune factors involved in the susceptibility and resistance against Streptococcus pyogenes and Staphylococcus aureus infections. During this time she discovered that mast cells have the ability to kill bacterial pathogens by the formation of antimicrobial extracellular traps (Blood, 2008).

 

Based on this work, she obtained a prestigious grant from the Deutsche Akademie der Naturforscher Leopoldina to study the role of extracellular traps during bacterial infections, to identify bacterial strategies that avoid entrapment and killing by these structures, and to search for novel pharmacological agents that boost the formation of extracellular traps. She performed these studies from September 2008 until June 2010 in the laboratory of Prof. Victor Nizet, at the University of California, San Diego School of Medicine, La Jolla, California. Her research shed new light on the importance of extracellular traps in host defense and provides new therapeutic opportunities to enhance the local innate immune response against bacterial infections.

 

Since July 2010 Dr. Maren von Köckritz-Blickwede is leading the research group Infection Biochemistry at the Department of Physiological Chemistry and is continuing her research on the host innate immune defense (with special focus on extracellular traps) as therapeutic target against bacterial infections. In February 2015 she received the position as a full professor for Biochemistry of Infection at the Department of Physiological Chemistry and the Research Center for Emerging Infections (RIZ), TiHo.

Since April 2019 Prof. Dr. Maren von Köckritz-Blickwede has been "Director for Scientific Administration and Biosafety" at the RIZ of TiHo.

 

Publications

Nicole de Buhr, PhD

Nicole de Buhr studied veterinary medicine at the University of Veterinary Medicine Hannover from 2006 to 2012. During this time she completed various internships in research institutions. For example, she worked with influenza-virus in the Institute of Virology at the University of Veterinary Medicine Hannover. She also completed an internship at the Institute for Infection Medicine and the Department for Experimental Animal Husbandry and Biorisk at the Federal Research Institute for Animal Health (FLI) Riems, where she worked with fish cell cultures, fish pathogens (e.g. herpes virus CyHV-1) and influenza-A-virus. Afterwards she worked 4 months at the Institute of Microbiology at the University of Veterinary Medicine Hannover on an immunoproteomics project with Streptococcus suis.

She also did her PhD thesis at the Institute of Microbiology on the topic "Interaction of Streptococcus suis and neutrophil extracellular traps (NETs)". In November 2015 she received her PhD title for this work and was awarded with the Gerhard-Domagk Prize for Life Sciences in 2016.
Since October 2015 she is a member of the research group Infection Biochemistry at the Institute of Physiological Chemistry of the University of Veterinary Medicine Hannover. Her research area is "The function of neutrophil extracellular traps (NETs) in different animal species" with a focus on

- NETs in immune privileged regions of the body

- Importance of NETs in autoimmune diseases

- Infectious diseases and NETs formation

 

Institute of Physiological Chemistry

 

 

 Publications:

 

2020


F. Armando, M. Gambini, A. Corradi, K. Becker, K. Marek, V. M. Pfankuche, A. E. Mergani, G. Brogden, N. de Buhr, M. von Köckritz-Blickwede, H. Y. Naim, W. Baumgärtner, C. Puff. Mesenchymal to Epithelial Transition Driven by Canine Distemper Virus Infection of Canine Histiocytic Sarcoma Cells Contributes to a Reduced Cell Motility in Vitro. J. Cell. Mol. Med. 2020: doi: 10.1111/jcmm.15585.


Y. Lu, H. Jiang, B. Li, L. Cao, Q. Shen, W. Yi, Z. Ju, L. Chen, F. Han, D. Appelgren, M. Segelmark, N. de Buhr, M. von Köckritz-Blickwede, J. Chen. Telomere Dysfunction Promotes Small Vessel Vasculitis via the LL37-NETs-dependent Mechanism. Ann. Transl. Med. 2020: 8(6):357.


S. H. Baien, J. Seele, T. Henneck, C. Freibrodt, G. Szura, H. Moubasher, R. Nau, G. Brogden, M. Mörgelin, M. Singh, M. Kietzmann, M. von Köckritz-Blickwede, N. de Buhr. Antimicrobial and Immunomodulatory Effect of Gum Arabic on Human and Bovine Granulocytes Against Staphylococcus aureus and Escherichia coli. Front Immunol. 2020: 10:3119.


M. Meurer, N. de Buhr, L. M. Unger, M. C. Bonilla, J. Seele, R. Nau, C. G. Baums, T. Gutsmann, S. Schwarz, M. von Köckritz-Blickwede. Comparing Cathelicidin Susceptibility of the Meningitis Pathogens Streptococcus suis and Escherichia coli in Culture Medium in Contrast to Porcine or Human Cerebrospinal Fluid. Front Microbiol. 2020: 10:2911.


F. S. Hohnstein, M. Meurer, N. de Buhr, M. von Köckritz-Blickwede, C. G Baums, G. Alber, N. Schütze. Analysis of Porcine Pro- And Anti-Inflammatory Cytokine Induction by S. suis In Vivo and In Vitro. Pathogens. 2020: 9(1):40.


N. de Buhr & M. von Köckritz-Blickwede. Detection, Visualization, and Quantification of Neutrophil Extracellular Traps (NETs) and NET Markers. Methods Mol Biol. 2020:2087:425-442.


V. Rungelrath, S. Öhlmann, G. Alber, W. Schrödl, M. von Köckritz-Blickwede, N. de Buhr, A. Martens, C. G. Baums, N. Schütze. Survival of Streptococcus Suis in Porcine Blood Is Limited by the Antibody- And Complement-Dependent Oxidative Burst Response of Granulocytes. Infect Immun. 2020: 88(3):e00598-19.



2019

L. Fingerhut, B. Ohnesorge, M. von Borstel, A. Schumski, K. Strutzberg-Minder, M. Mörgelin, C. A. Deeg, H. P. Haagsman, A. Beineke, M. von Köckritz-Blickwede, N. de Buhr. Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU). Cells. 2019: 8(12):1528.


N. de Buhr, M. C. Bonilla, J. Pfeiffer, S. Akhdar, C. Schwennen, B. C. Kahl, K.-H. Waldmann, P. Valentin-Weigand, I. Hennig-Pauka, M. von Köckritz-Blickwede. Degraded Neutrophil Extracellular Traps Promote the Growth of Actinobacillus Pleuropneumoniae. Cell. Death. Dis. 2019: 10(9):657.


S. Herzog, F. Dach, N. de Buhr, S. Niemann, J. Schlagowski, D. Chaves-Moreno, C. Neumann, J. Goretzko, V. Schwierzeck, A. Mellmann, A. Dübbers, P. Küster, H. Schültingkemper, U. Rescher, D. H. Pieper, M. von Köckritz-Blickwede, B. C. Kahl. High Nuclease Activity of Long Persisting Staphylococcus aureus Isolates Within the Airways of Cystic Fibrosis Patients Protects Against NET-Mediated Killing. Front Immunol. 2019:10:2552.

 


2018

S. H. Baien, M. N. Langer, M. Heppelmann, M. von Köckritz-Blickwede, N. de Buhr. Comparison Between K 3 EDTA and Lithium Heparin as Anticoagulant to Isolate Bovine Granulocytes From Blood. Front. Immunol. 2018: 9:1570.


N. de Buhr, M. C. Bonilla, M. Jimenez-Soto, M. von Köckritz-Blickwede, G. Dolz. Extracellular Trap Formation in Response to Trypanosoma cruzi Infection in Granulocytes Isolated From Dogs and Common Opossums, Natural Reservoir Hosts. Front. Microbiol. 2018:9:966.



2017

M. N. Langer, S. Blodkamp, M. Bayerbach, A. T. Feßler, N. de Buhr, T. Gutsmann, L. Kreienbrock, S. Schwarz, M. von Köckritz-Blickwede. Testing Cathelicidin Susceptibility of Bacterial Mastitis Isolates: Technical Challenges and Data Output for Clinical Isolates. Vet. Microbiol. 2017: 210:107-115.


N. de Buhr, F. Reuner, A. Neumann, C. Stump-Guthier, T. Tenenbaum, H. Schroten, H. Ishikawa, K. Müller, A. Beineke, I. Hennig-Pauka, T. Gutsmann, P. Valentin-Weigand, C. G. Baums, M. von Köckritz-Blickwede. Neutrophil Extracellular Trap Formation in the Streptococcus Suis-Infected Cerebrospinal Fluid Compartment. Cell. Microbiol. 2017: 19(2).

 


2016

K. Branitzki-Heinemann, H. Möllerherm, L. Völlger, D.M. Husein, N. de Buhr, S. Blodkamp, F. Reuner, G. Brogden, H.Y. Naim, M. von Köckritz-Blickwede. Formation of Neutrophil Extracellular Traps under Low Oxygen Level. Front Immunol. 2016:7:518.


N. de Buhr, F. Reuner, A. Neumann, C. Stump-Guthier, T. Tenenbaum, H. Schroten, H. Ishikawa, K. Müller, A. Beineke, I. Hennig-Pauka, T. Gutsmann, P. Valentin-Weigand, C.G. Baums, M. von Köckritz-Blickwede. Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment. Cell Microbiol. 2017 Feb;19(2). Epub 2016 Aug 31.


N. Jerjomiceva, H. Seri, R. Yaseen, N. de Buhr, W. N. Setzer, H. Y. Naim, M. von Köckritz-Blickwede. Guarea Kunthiana Bark Extract Enhances the Antimicrobial Activities of Human and Bovine Neutrophils. Nat. Prod. Commun. 2016: 11(6):767-70.


N. Jerjomiceva, H. Seri, R. Yaseen, N. de Buhr, W.N. Setzer, H.Y. Naim, M. von Köckritz-Blickwede. Guarea kunthiana Bark Extract Enhances the Antimicrobial Activities of Human and Bovine Neutrophils. Nat Prod Commun. 2016 Jun;11(6):767-70.


N. de Buhr, M. von Köckritz-Blickwede. How Neutrophil Extracellular Traps Become Visible. J. Immunol. Res. 2016: 4604713.


N. de Buhr, M. Stehr, A. Neumann, H.Y. Naim, P. Valentin-Weigand, M. von Köckritz-Blickwede, C.G. Baums. Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth. Microbiology. 2015: 161(Pt 4):838-50.


 
2014

N. de Buhr, A. Neumann, N. Jerjomiceva, M. von Köckritz-Blickwede, C.G. Baums. Streptococcus suis DNase SsnA contributes to degradation of neutrophil extracellular traps (NETs) and evasion of NETmediated antimicrobial activity. Microbiology. 2014: 160(Pt 2):385-95.


 

Dr. Claudia Schulz

Publications:

 

P. Jendrny, C. Schulz, F. Twele, S. Meller, M. von Köckritz-Blickwede, A. D. M. E. Osterhaus, J. Ebbers, V. Pilchová, I. Pink, T. Welte, M. P. Manns, A. Fathi, C. Ernst, M. M. Addo, E. Schalke & H. A. Volk. Scent dog identification of samples from COVID-19 patients – a pilot study. BMC Infectious Diseases 2020: (20)536.

Alexander Martens, PhD

Leonie Fingerhut, M.Sc

Leonie Fingerhut completed her studies of veterinary medicine at the University of Leipzig in 2018.

She then worked on a project on animal welfare indicators in dairy farming at the Faculty of Organic Agricultural Sciences at the University of Kassel and joined the University of Veterinary Medicine Hannover in early 2019.

As a PhD student in the PhD program "Animal and Zoonotic Infections" at the Hannover Graduate School for Veterinary Pathobiology, Neuroinfectiology, and Translational Medicine (HGNI) she is investigating the role of neutrophil extracellular networks in equine recurrent uveitis. Leonie is supervised by Prof. Dr. Maren von Köckritz-Blickwede, Dr. Nicole de Buhr and Prof. Dr. Bernhard Ohnesorge in a cooperative project of the Institute of Physiological Chemistry and the Clinic for Horses. In this project, the cellular processes of this widespread eye disease of the horse will be investigated.

 

Institute of Physiological Chemistry

 

 

Publications:

 

2020

 

L. Fingerhut, G. Dolz, N. de Buhr. What Is the Evolutionary Fingerprint in Neutrophil Granulocytes? Int J Mol Sci. 2020: 21(12):E4523.

 

 

2019

 

L. Fingerhut, B. Ohnesorge, M. von Borstel, A. Schumski, K. Strutzberg-Minder, M. Mörgelin, C. A. Deeg, H. P. Haagsman, A. Beineke, M. von Köckritz-Blickwede, N. de Buhr. Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU). Cells. 2019: 8(12):1528.

 

Marta Bonilla González, M.Sc.

                                      

 

Marta Bonilla studied veterinary medicine and graduated from the National University of Costa Rica (Universidad Nacional de Costa Rica - UNA) in 2014 with a Bachelor (cum laude). The title of her thesis was "Prevalence of Anaplasma phagocytophilum and Anaplasma platys in blood and ticks of dogs visiting public parks of Costa Rica". Afterwards, she was a master student in the program "Tropical Diseases of Regional Postgraduates in Tropical Veterinary Medicine" at the National University of Costa Rica (Universidad Nacional de Costa Rica - UNA). In May 2018 she received her degree (cum laude) as Master of Science (M.Sc). The title of the thesis was "Detection of antibodies against Trypanosoma cruzi in canines of Costa Rica and evaluation of new cases of canine trypanosomiasis in the community of Getsemaní in Heredia".

During her bachelor and master studies she worked in the Laboratory of Entomology, Population Medicine (MEDPOB) and was involved in projects with infectious diseases, zoonoses and their vectors. Marta is a PhD student in the research group Infection Biochemistry at the Institute of Physiological Chemistry of the University of Veterinary Medicine Hannover since July 2018. She is supervised by Prof. Dr. Maren von Köckritz-Blickwede and Nicole de Buhr, PhD. Within the scope of her PhD she is affiliated to the program "Animal and Zoonotic Infections". She investigates the host-pathogen interaction of bacterial pathogens and neutrophil extracellular DNA networks (NETs) in pigs.

 

 

 

Publications:

 

2020

 

Meurer, M.; Öhlmann, S.; Bonilla, M.C.; Valentin-weigand, P.; Hennig-pauka, I.; Schwerk, C.; Schroten, H.; Baums, C.G. Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis. 1–21.

 

Meurer, M.; de Buhr, N.; Unger, L.M.; Bonilla, M.C.; Seele, J.; Nau, R.; Baums, C.G.; Gutsmann, T.; Schwarz, S.; von Köckritz-Blickwede, M. Comparing Cathelicidin Susceptibility of the Meningitis Pathogens Streptococcus suis and Escherichia coli in Culture Medium in Contrast to Porcine or Human Cerebrospinal Fluid. Front. Microbiol. 2020: 10, 1–10.


Guzmán-Gómez, N.; Bermúdez-Salas, F.R.; Schmidt, L.J.; Bonilla, M.C.; Dolz, G.; Urbina-Villalobos, A. Detección de anticuerpos anti-Toxocara spp. en caninos de una comunidad periurbana de la provincia de Heredia, Costa Rica. Ciencias Vet. 2020: 38, 28–42.

 


2019

Bonilla, M.C.; Castro-Vásquez, R.M.; Herrero-Acosta, M.V.; Urbina-Villalobos, A.; Dolz, G. Canine trypanosomiasis in an endemic Costa Rican community: Demonstration of the active infection cycle. Vet. Parasitol. Reg. Stud. Reports 2019: 17, 100307.


de Buhr, N.; Bonilla, M.C.; Pfeiffer, J.; Akhdar, S.; Schwennen, C.; Kahl, B.C.; Waldmann, K.-H.; Valentin-Weigand, P.; Hennig-Pauka, I.; von Köckritz-Blickwede, M. Degraded neutrophil extracellular traps promote the growth of Actinobacillus pleuropneumoniae. Cell Death Dis. 2019: 10, 657.

 

 

2018

 

de Buhr, N.; Bonilla, M.C.; Jimenez-Soto, M.; von Köckritz-Blickwede, M.; Dolz, G. Extracellular trap formation in response to Trypanosoma cruzi infection in granulocytes isolated from dogs and common opossums, natural reservoir hosts. Front. Microbiol. 2018: 9, 1–12.


Bonilla, M.C.; Herrero-Acosta, M.V.; Urbina-Villalobos, A.; Dolz, G. Detección de anticuerpos contra Trypanosoma cruzi en caninos de Costa Rica. Rev. Ciencias Vet. 2018: 35, 1.


Dolz, G.; Barrantes González, A.; Bonilla, M.C.; Campos, L.; Bouza Mora, L.; Jiménez Soto, M.; Romero Zúñiga, J.J.; Jiménez, A.E. ¿Qué sabemos y qué nos falta estudiar sobre agentes infecciosos transmitidos por garrapatas en Costa Rica? Ciencias Vet. 2018: 36, 48.

 

 

2017

 

Bonilla, M.C.; Campos-Calderón, L.; Jiménez-Rocha, A.E.; Romero-Zúñiga, J.J.; Alberti, A.; Zobba, R.; Dolz, G. Characterization of Anaplasma spp. infection in dogs from Costa Rica. Vet. Parasitol. Reg. Stud. Reports 2017: 8, 60–65.


Montenegro, V.M.; Bonilla, M.C.; Kaminsky, D.; Romero-Zúñiga, J.J.; Siebert, S.; Krämer, F. Serological detection of antibodies to Anaplasma spp., Borrelia burgdorferi sensu lato and Ehrlichia canis and of Dirofilaria immitis antigen in dogs from Costa Rica. Vet. Parasitol. 2017: 236, 97–107.

 

 

2013

 

Dolz, G.; Solórzano-Morales, Á.; Angelova, L.; Tien, C.; Fonseca, L.; Bonilla, M.C. Chlamydia psittaci genotype B in a pigeon (Columba livia) inhabiting a public place in San José, Costa Rica. Open Vet. J. 2013: 3, 135–139.

 

 

 

Institute of Physiological Chemistry

 

 

Timo Henneck, M.Sc.

Timo Henneck studied biology at the Georg-August-University of Göttingen and received his bachelor's degree in 2016, and in the same year he started the master's programme "Animal Biology and Biomedical Sciences" at the TiHo in Hanover. In the research group of Prof. Maren von Köckritz-Blickwede Timo completed his master thesis with the title "Cellular mechanisms leading to LL-37 mediated formation of neutrophil extracellular traps (NETs)" and graduated in 2018.

Since August 2018 Timo supports the research group of Prof. von Köckritz-Blickwede as a PhD student within the PhD program "Animal and Zoonotic Infections" of the HGNI. His research focuses on the mechanism of NET formation of human neutrophils infected with Staphylococcus aureus under hypoxia. Associated with R2N "Replace and Reduce from Lower Saxony"  with the aim to establish physiologically relevant oxygen conditions for in vitro infection experiments in order to reduce the number of animal experiments in the long run by better in vitro methods.

 

Institute of Physiological Chemistry

 

 

 

Publications:

 

2020

 

S. H. Baien, J. Seele, T. Henneck, C. Freibrodt, G. Szura, H. Moubasher, R. Nau, G. Brogden, M. Mörgelin, M. Singh, M. Kietzmann, M. von Köckritz-Blickwede, N. de Buhr. Antimicrobial and Immunomodulatory Effect of Gum Arabic on Human and Bovine Granulocytes Against Staphylococcus aureus and Escherichia coli. Front Immunol. 2020: 10:3119.

Marita Meurer, M.Sc.

Marita Meurer studied veterinary medicine at the University of Veterinary Medicine Hannover and received her license to practice veterinary medicine here in 2001.

 

After various research projects in industry and public service, she returned to the University of Veterinary Medicine Hannover in March 2017.

 

Currently, Marita is a PhD student in the PhD program "Animal and Zoonotic Infections" at the Hanover Graduate School for Veterinary Pathobiology, Neuroinfectiology, and Translational Medicine (HGNI) of the Foundation of the University of Veterinary Medicine Hannover. Marita is supervised by Prof. Dr. Maren von Köckritz-Blickwede and Dr. Nicole de Buhr.

 

The aim of her work is to investigate the innate immune defence of pigs against the zoonotic pathogen Streptococcus suis. Their findings should contribute to a better understanding of host-pathogen interaction during bacterial meningitis. This should lead to the development of new treatment approaches for meningitis and thus enable a reduction in the use of antibiotics in food-producing animals.

 

Institute of Physiological Chemistry 

 

 

Publications:

 

2020

 

Meurer, M.; Öhlmann, S.; Bonilla, M.C.; Valentin-weigand, P.; Hennig-pauka, I.; Schwerk, C.; Schroten, H.; Baums, C.G. Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis. 1–21.


M. Meurer, N. de Buhr, L. M. Unger, M. C. Bonilla, J. Seele, R. Nau, C. G. Baums, T. Gutsmann, S. Schwarz, M. von Köckritz-Blickwede. Comparing Cathelicidin Susceptibility of the Meningitis Pathogens Streptococcus suis and Escherichia coli in Culture Medium in Contrast to Porcine or Human Cerebrospinal Fluid. Front Microbiol. 2020: 10:2911.


F. S. Hohnstein, M. Meurer, N. de Buhr, M. von Köckritz-Blickwede, C. G Baums, G. Alber, N. Schütze. Analysis of Porcine Pro- And Anti-Inflammatory Cytokine Induction by S. suis In Vivo and In Vitro. Pathogens. 2020: 9(1):40.

 

 

2018

V. Rungelrath, C. Weiße, N. Schütze, U. Müller, M. Meurer, M. Rohde, J. Seele, P. Valentin-Weigand, M. Kirschfink, A. Beineke, W. Schrödl, R. Bergmann, C. G. Baums. IgM Cleavage by Streptococcus Suis Reduces IgM Bound to the Bacterial Surface and Is a Novel Complement Evasion Mechanism. Virulence. 2018: 9(1):1314-1337.

Ahmed Mohamed, M.Sc.

                                    

 

Ahmed Elmontaser Mohamed is a veterinarian, he graduated in veterinary medicine from the Sudan University of Science and Technology. Ahmad received his M.Sc. in Microbiology. His M.Sc. research related to immunology (antimicrobial effect of serum peptides from Sudanese farm animals).

 

Today he is a PhD student in veterinary research and animal biology at the Foundation of the University of Veterinary Medicine Hannover and belongs to the group of Prof. Dr. Maren von Köckritz-Blickwede (Infection Biochemistry) at the Institute of Physiological Chemistry and Research Center for Emerging Infections and Zoonoses (RIZ).

 

His project "Immunomodulatory effect of cow vs. camel milk exosomes" aims to help understand the relationship between exosomes and the immune modulation the immune system can perform against bacterial infections. In the Middle East, camel milk is considered a widely available natural drink, especially in Sudan, where the total number of camels exceeds 45 million. Traditionally, Sudan's indigenous tribes, based on their long experience, believe that camel milk can actually prevent and treat many bacterial infections, such as tuberculosis and other intestinal infections (Saxena and Kavita proved this only a few years ago in 2015). Camel milk exosomes could transfer the potential to cure several diseases. This study will help to identify new therapeutic targets based on dairy products that could be further developed as new therapeutic treatment strategies against antibiotic-resistant bacterial infections. In addition, this project will bring milk-derived exosomes into the spotlight by comparing different isolation and molecular characterisation techniques and testing the exosome effect on human intestinal tissue culture model Caco-2 cells infected with zoonotic bacterial agents.

 

 

Publications:

 

Armando F., Gambini, M., Corradi, A., Becker, K., Marek, K., Pfankuche, V.M., Mergani, A.E., Brogden, G., de Buhr, N., von Köckritz‐Blickwede, M. and Naim, H.Y. Mesenchymal to epithelial transition driven by canine distemper virus infection of canine histiocytic sarcoma cells contributes to a reduced cell motility in vitro. J. Cell. Mol. Med. 2020. doi: 10.1111/jcmm.15585.

 

Orsud H. S., Mergani AE O., Elsanousi S. M. and Mohammed G. E. Isolation, Identification and Biochemical profile of Streptococcus pyogenes from sore throat. Journal of Science and Technology. 2020.

 

Orsud H. S., Mergani AE O., Elsanousi S. M. and Mohammed G. E. Correlation between patient’s risk factors and H.pylori infection and seroprevelence of anti-Helicopacter pylori IgG and IgA among our pateints in Khartoum, Sudan with different diagnostic tests. Journal of Science and Technology. 2020.

 

 

Institute of Physiological Chemistry

Veronika Pilchova, M.Sc.

                             

 

Veronika Pilchová graduated in 2018 from the Veterinary and Pharmaceutical University of Brno, Czech Republic, as Doctor of Veterinary Medicine (MVDr.). Afterwards she worked in a project "Development and validation of a loop-mediated isothermal amplification (LAMP) assay for rapid detection of Glaesserella (Haemophilus) parasuis" at the Institute for Food Quality and Safety, University of Veterinary Medicine, Hannover.

 

Since November 2019 Veronika supports the group of Prof. von Köckritz-Blickwede as a PhD student in the PhD program "Animal and Zoonotic Infections" of the HGNI. Her PhD project is entitled "Validation of inactivation procedures of samples derived from infection experiments with respiratory pathogens as SARS-CoV-2 with the aim to study the role of neutrophils extracellular traps during pathogenesis".

 

 

Publications:

 

P. Jendrny, C. Schulz, F. Twele, S. Meller, M. von Köckritz-Blickwede, A. D. M. E. Osterhaus, J. Ebbers, V. Pilchová, I. Pink, T. Welte, M. P. Manns, A. Fathi, C. Ernst, M. M. Addo, E. Schalke & H. A. Volk. Scent dog identification of samples from COVID-19 patients – a pilot study. BMC Infectious Diseases 2020: (20)536.

 

 

Institute of Physiological Chemistry

Silke Akhdar, TA

Silke Akhdar completed her training as a vet-medical assistant at the Foundation of the University of Veterinary Medicine Hanover in 2007. From 2010 to 2017 she worked as a TA in the fields of reproductive biology, tissue engineering procedures in the oral and maxillofacial area and leukaemia research at the Hanover Medical School.

Since July 2017 she has been working in the Institute of Physiological Chemistry in the Infection Biochemistry group, where she supports the team of Prof. von Köckritz-Blickwede. There she works in the fields of microbiology, neutrophil isolation and investigation of extracellular networks (NETs) as well as in the analysis of RNA samples.

She is also responsible for the supervision of students, PhD students and VMTA students.


Institute of Physiological Chemistry

Rabea Imker, TA

After graduating from high school, Rabea Imker completed training at the Institute for Veterinary Medical Technical Assistant at the University of Veterinary Medicine Hannover.

She moved to Munich to work at the Dr. von Hauner's Children's Hospital of the Ludwig-Maximilians-University in 2005 and at the Comprehensive Pneumology Center of the Helmholtz Zentrum München from 2010, focusing on lung diseases.

After stations at the MHH and the Institute for Parasitology of the TiHo Hannover, she has been working in the group of Infection Biochemistry around Prof. von Köckritz- Blickwede at the Research Center for Emerging Infections and Zoonoses (RIZ) of the TiHo Hannover since the beginning of 2019. She supports the team around Dr. de Buhr in their work with neutrophil extracellular DNA networks (NETs).

 

Institute of Physiological Chemistry

Kontakt
Dr. Tina Basler
Tel.:+49 511 953-6141
Fax.:+49 511 953-8675
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