Invoicing is done immediately after receipt of the samples together with the confirmation of receipt to the pet owner.
In order for the test to be performed, the invoice amount must be paid in advance by bank transfer.
Costs for the CA-test per horse:
56,- € for hair roots
44,- € for EDTA blood samples
A discount of 5,- €/horse will be granted from 20 samples and from 40 samples from 10,- €/horse. An additional test for SCID costs 27,- €/horse regardless of the sample type.
On average, a period of about two to four weeks is required to perform the test. However, please note that the testing period may vary depending on the quality of the sample.
Results will be kept strictly confidential and will be provided in writing to the submitter.
For members of the VZAP who have expressly agreed to the transmission of the test results to the breeding association on the submission form, the result sheets will be sent to the association and the animal owner.
The test order includes a scientific utilization of the results. When using the data for scientific purposes, all information will be anonymized so that no conclusions can be drawn about the identity of the horse, the owner and the breeder.
The most common symptoms observed in CA, in varying degrees of severity, are.
- uncontrolled movements (ataxia)
- disturbance of head motor function; manifested by high-frequency jerking of the head at rest or when attempting to make a purposeful movement (intention tremor)
- stiff or exaggerated gait from the shoulder
- poor depth perception and general inability to judge space and distance (running into objects and other horses)
- difficulty standing up, backing up, in tight turns
Affected horses are prone to accidents, tend to run into stationary objects, fall sideways when mounting, and often hit their heads, which can mistakenly lead to the impression that a severe head injury caused the ataxia. The affected horse has normal intelligence, clear vision, good appetite, and shows no muscle atrophy (muscle wasting).
Upon examination by the veterinarian, a cerebellar problem can be detected via neurological examination. However, a definitive diagnosis can only be made by histopathological evidence post mortem.
Regardless of the severity of the symptomatology, affected animals are often euthanized or kept as side horses because the risk to the rider is too high. In addition, there is a risk that the animal will severely injure itself via falls.
CA in horses is inherited in a monogenic autosomal recessive manner. In this mode of inheritance, the hereditary predisposition for the disease can be passed on "hidden" from healthy carrier animals (predisposition carriers) to the offspring.
The test procedure is designed to allow the breeder to avoid mating two trait carriers, thereby eliminating the 25% risk of producing trait carriers (diseased animals).
Results of the test are indicated as follows
- N/N: with a very high probability anlage-free. The horse has no markers associated with the CA genomic region.
- N /CA: very likely to be a carrier (1 copy of the CA allele). The horse has markers associated with the CA allele, is considered phenotypically normal and a carrier of the CA allele. In matings with anlage-free mating partners, there is a very high probability that no CA trait carriers will occur.
- CA/CA: trait carrier (2 copies of the CA allele). The horse is very likely to develop CA or has already developed CA. However, there are also known cases that show no signs of the disease despite having a double copy of the CA allele. Which additional mechanisms play a role here is not yet clear at the present time.
The mating of two carriers can result in diseased offspring.