Genetic test for Lundehundsyndrome
Lundehundsyndrome is a severe gastro-enteropathic disease for which the Lundehund has a breed predisposition. The syndrome includes chronic inflammatory defects of the intestine, Protein-Losing Enteropathies (PLE), lymphatic vasodilatation of the intestine, and gastric problems. Affected dogs react to varying degrees to the gastrointestinal disorders with vomiting, diarrhea, weight loss, and even apathy. Euthanasia is often unavoidable in severe cases or in the case of a persistent chronic course of the disease.
The Institute for Animal Breeding and Genetics has investigated the genetic cause of this problem and published a paper in the scientific journal "BMC Genomics". A causal mutation in the gene LEPREL1 could be detected, which leads to a change in the protein and thus acts as a trigger of the Lundehund syndrome. The age of onset of the disease is highly variable, with some dogs developing Lundehundsyndrome as late as 10 years of age. Therefore, detection of the mutation allows early detection of the problem and can allow dog breeders to make specific breeding decisions to prevent the disease.
The following test results are possible:
N/N : Non-predisposition; No disposition for the Lundehundsyndrome.
N/LS : carrier for a disposition for the Lundehundsyndrome
LS/LS : trait carrier; disposition for Lundehundsyndrome is present
The test allows an assessment of the risk of the dog developing Lundehundsyndrom and can estimate the possible transmission of a disposition to the offspring in examined parents.
The form for requesting the TiHo Lundehundsyndrome gene test and an information sheet on blood sample collection and shipment of samples can be found here: