Craniomandibular Osteopathy (CMO) in German Drahthaar

Craniomandibular osteopathy is a rare bone disease that first appears in young dogs between three and six months of age. Affected animals suffer from bilateral symmetrical, non-inflammatory and non-neoplastic proliferations of bone in the mandible, temporomandibular joints and, less commonly, other bones of the skull. Typically, affected dogs are reluctant to eat, exhibit increased salivation, and are reluctant to be touched in the area of the head. This is due to tremendous painfulness of the lesions and an inability, often mechanical, to open the jaw and chew. Periodic episodes of fever may also occur. In addition, sick animals are often very fatigued and listless.
Usually, this disease is self-limiting. When the animal reaches skeletal maturity at over one year of age, bone proliferations cease and regression of existing changes may also occur. However, some dogs are euthanized at the owner's request due to very poor condition and extreme painfulness of the lesions. X-rays of the skull are necessary for a definite diagnosis, and in the best case a computer tomography is performed to show the typical changes in the bone. A blood test usually shows no changes. The occurrence of cases of craniomandibular osteopathy has been described in the past most frequently in terrier breeds such as the West Highland White Terrier, Scottish Terrier, Cairn Terrier and Boston Terrier, but this condition also occurs in other dog breeds. To date, it has not been possible to identify the cause of CMO, but a genetic basis is suspected. Previous studies at the Institute for Animal Breeding and Genetics at the University of Veterinary Medicine Hanover indicate that a genetic alteration is also the trigger of this disease in the Deutsch Drahthaar.
For further clarification of CMO in Deutsch Drahthaar we are grateful for the submission of further blood samples from affected dogs.

You can find the documents to fill in here:

Submission form + questionnaire

Dog owners or veterinarians who have already sent in a sample are asked to fill in a questionnaire about the course of CMO and send it to us (also by email or fax):

Questionnaire