Neuronal ceroid lipofuscinosis of the dog was first described more than 20 years ago, yet this disease is still known to very few veterinarians and dog owners. In this monogenic autosomal recessive inherited disease, ceroid lipofuscin, a degradation product of the cells, is deposited mainly in the nerve cells of the retina and brain, causing them to perish. The most common symptoms observed in this disease are: Behavioral changes (aggressiveness, anxiety, restlessness, sudden housebreaking), impaired vision up to complete blindness, seizures and changes in gait (stumbling, ataxia) CCL disease has been detected in several breeds of dogs so far.
We need your active help in the research for the clarification of Canine Ceroid Lipofuscinosis, should your dog, the symptoms described in the respective breeds, then contact us or send us an EDTA blood sample of your dog. If possible, EDTA blood samples from the parents and littermates of the affected dog should also be sent in, as these samples greatly facilitate the clarification of CCL.
The processing fee is 50 € per sample sent in from a Tibetan Terrier/American Bulldog and 42 € for English Setters.
You can download the required sample submission form here on this page. Furthermore we would like to ask you to fill in the questionnaire about the symptoms of your dog completely and to send it in as well.
The symptoms described on this page are not sufficient to diagnose CCL. If you suspect your dog has CCL based on the symptoms described, please consult your veterinarian or be referred to a veterinary neurologist or eye specialist.
If you, as a veterinarian, have a patient in your practice who has the symptoms described or who you suspect may have CCL, please make the owner(s) aware of participation in our research project.
In collaboration with the Clinic for Small Animals of the University of Veterinary Medicine Hanover Foundation, a study is taking place to investigate CCL using MRI. Interested owners of dogs suffering from CCL are welcome to contact us for this purpose.
We kindly ask you to send us EDTA blood samples of the following dog breeds
- American Staffordshire Terrier
- Australian Cattle Dog
- Australian Shepherd
- Border Collie
- Cocker Spaniel
- Badger spaniel
- English Setter
- Golden Retriever
- Japanese Retriever
- Labrador Retriever
- Pit Bull Terrier
- Welsh Corgi
- Miniature Schnauzer