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Publications

2018:

C.D. Shanthamurthy, P. Jain, S. Yehuda, J.T. Monteiro, S. Leviatan Ben-Arye, B. Subramani, B. Lepenies, V. Padler-Karavani, R. Kikkeri. Sci Rep. 2018 Apr 26;8(1):6603. doi: 10.1038/s41598-018-24333-y.

 

F. Ota, T. Hirayama, Y. Kizuka, Y. Yamaguchi, R. Fujinawa, M. Nagata, H.S. Ismanto, B. Lepenies, J. Aretz, C. Rademacher, P.H. Seeberger, T. Angata, S. Kitazume, K. Yoshida, T. Betsuyaku, K. Kida, S. Yamasaki, N. Taniguchi. Biochim Biophys Acta. 2018 Apr 7. pii: S0304-4165(18)30097-7. doi: 10.1016/j.bbagen.2018.04.004. [Epub ahead of print]

 

R.V. Kikkeri, M. Gade, C. Alex, S.L. Ben-Arye, J.T. Monteiro, S. Yehuda, B. Lepenies, V. Padler Karavani. Chembiochem. 2018 Mar 25. doi: 10.1002/cbic.201800037. [Epub ahead of print]

 

N. Zimara, M. Chanyalew, A. Aseffa, G. van Zandbergen, B. Lepenies, M. Schmid, R. Weiss, A. Rascle, A.K. Wege, J. Jantsch, V. Schatz, G.D. Brown, U. Ritter. Front Immunol. 2018 Feb 26;9:263. doi: 10.3389/fimmu.2018.00263. eCollection 2018.

 

S. Mayer, R. Moeller, J.T. Monteiro, K. Ellrott, C. Josenhans, B. Lepenies. Front Immunol. 2018 Feb 13;9:213. doi: 10.3389/fimmu.2018.00213. eCollection 2018.

 

J. Kruppa, B. Lepenies, K. Jung. Comput Biol Med. 2018 Jan 1;92:1-8. doi: 10.1016/j.compbiomed.2017.10.023. Epub 2017 Oct 31.

 

2017:

G. Artigas, J.T. Monteiro, H. Hinou, S.I. Nishimura, B. Lepenies, F. Garcia-Martin. J Med Chem. 2017 Nov 9;60(21):9012-9021. doi: 10.1021/acs.jmedchem.7b01242. Epub 2017 Oct 31.

 

J. Schick, P. Etschel, R. Bailo, L. Ott, A. Bhatt, B. Lepenies, C. Kirschning, A. Burkovski, R. Lang. Infect Immun. 2017 Jun 20;85(7). pii: e00075-17. doi: 10.1128/IAI.00075-17. Print 2017 Jul.

 

J.T. Monteiro, B. Lepenies.

Viruses. 2017 Mar 22;9(3). pii: E59. doi: 10.3390/v9030059. Review.

 

T.J. Kottom, D.M. Hebrink, P.E. Jenson, V. Nandakumar, M. Wüthrich, H. Wang, B. Klein,  S. Yamasaki, B. Lepenies, A.H. Limper. J Immunol. 2017 May 1;198(9):3515-3525. doi: 10.4049/jimmunol.1600744. Epub 2017 Mar 15.

 

A.V. Kostarnoy, P.G. Gancheva, B. Lepenies, A.l. Tukhvatulin, A.S. Dzharullaeva, N.B. Polyakov, D.A. Grumov, D.A. Egorova, A.Y. Kulibin, M.A. Bobrov, E.A. Malolina, P.A. Zykin, A.l. Soloviev, E. Riabenko, D.V. Maltseva, D.A. Sakharov, A.G. Tonevitsky, L.V. Verkhovskaya, D.Y. Logunov, B.S. Naroditsky, A.L. Gintsburg. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2758-E2765. doi: 10.1073/pnas. 1611665114. Epub 2017 Mar 14. 

 

T. Johannssen, B. Lepenies*: Glycan-based cell targeting to modulate immune responses. Trends Biotechnol. 2017, in press

 

T.J. Kottom, D.M. Hebrink, P.E. Jenson, M. Wüthrich, H. Wang, B. Klein, S. Yamasaki, B. Lepenies, A.H. Limper*: The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense Against Infection. J. Immunol. 2017, in press.

 

A.V. Kostarnoy*, P.G. Gancheva, B. Lepenies, A.I. Tukhvatulin, A.S Dzharullaeva, N.B. Polyakov, D.A. Grumov, D.A. Egorova, A.Y. Kulibin, M.A. Bobrov, E.A. Malolina, P.A. Zykin, A.I. Soloviev, E. Riabenko, D.V. Maltseva, D.A. Sakharov, A. Tonevitsky, L.V. Verkhovskaya, D.Y. Logunov, B.S. Naroditsky, A.L. Gintsburg: The receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate. Proc. Natl. Acad. Sci. U.S.A. 2017, in press

 

S. Mayer, M.-K. Raulf, B. Lepenies*: C‑type lectins: their network and roles in pathogen recognition and immunity. Histochem. Cell Biol. 2017, 147(2), 223-37.

 

C. Gao, R. Fujinawa, T. Yoshida, M. Ueno, F. Ota, Y. Kizuka, T. Hirayama, H. Korekane, S. Kitazume, T. Maeno, K. Ohtsubo, K. Yoshida, Y. Yamaguchi, B. Lepenies, J. Aretz, C. Rademacher, H. Kabata, A. Hegab, P.H. Seeberger, T. Betsuyaku, K. Kida, N. Taniguchi*: A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. Am. J. Physiol.-Lung Cell. Mol. Physiol. 2017, 312(2), L268-76.

 

A. Troegeler, I. Mercier, C. Cougoule, D. Pietretti, A. Colom, C. Duval, T.P. Vu Manh, F. Capilla, R. Poincloux, K. Pingris, J. Nigou, J. Rademann, M. Dalod, F.A. Verreck, T. Al Saati, G. Lugo-Villarino, B. Lepenies, D. Hudrisier, O. Neyrolles*: C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 2017, 114(4), E540-49.

 

2016:

H. Bavireddi, R.V. Murthy, M. Gade, S. Sangabathuni, P.M. Chaudhari, C. Alex, B. Lepenies, R. Kikkeri*: Understanding carbohydrate–protein interactions using homologous supramolecular chiral Ru(II)-glyconanoclusters. Nanoscale 2016, 8(47), 19696-702.

 

K. Brzezicka, U. Vogel, S. Serna, T. Johannssen, B. Lepenies*, N.-C. Reichardt*: Influence of core β-1,2-xylosylation on glycoprotein recognition by murine C-type lectin receptors and its impact on dendritic cell targeting. ACS Chem. Biol. 2016, 11(8), 2347-56.

 

A. Huber, R.S. Kallerup, H. Franzyk, K.S. Korsholm, B. Lepenies, D. Christensen, C. Foged, R. Lang*: Trehalose-diester glycolipids are superior to monoesters in binding to Mincle, activation of macrophages in vitro, and adjuvant activity in vivo. Innate Immun. 2016, 22(6), 405-18.

 

2015:

C.N. LaRock, S. Döhrmann, J. Todd, R. Corriden, J. Olson, T. Johannssen, B. Lepenies, R.L Gallo, P. Ghosh, V. Nizet*: Group A streptococcal M1 protein sequesters cathelicidin to evade innate immune killing. Cell Host Microbe 2015, 18(4), 471-77.

 

C.-H. Lai, J. Hütter, C.-W. Hsu, H. Tanaka, S. Varela-Aramburu, L. De Cola, B. Lepenies*, P.H. Seeberger*: Analysis of carbohydrate-carbohydrate interactions using sugar-functionalized silicon nanoparticles for cell imaging. Nano Lett. 2016, 16(1), 807-11

 

J. Ostrop, K. Jozefowski, S. Zimmermann, K. Hofmann, E. Strasser, B. Lepenies, R. Lang*: Contribution of MINCLE-SYK signaling to activation of primary human antigen-presenting cells by mycobacterial cord factor and the novel adjuvant TDB. J. Immunol. 2015, 195(5), 2417-28. 

 

E. Zacco, J. Hütter, J.L. Heier, J. Mortier, P.H. Seeberger, B. Lepenies, B. Koksch*: Towards a tailored presentation of ligands: coiled coil-based glycopeptides for ASGPR targeting. ACS Chem. Biol. 2015, 10(9), 2065-72.

 

K. Täuber, B. Lepenies, J. Yuan*: Polyvinylpyridinium-type gradient porous membranes – synthesis, actuation and intrinsic cell growth inhibition. Polym. Chem. 2015, 6, 4855-58.

 

O. Redy-Keisar, K. Huth, U. Vogel, B. Lepenies, P.H. Seeberger, R. Haag, D. Shabat*: Enhancement of fluorescent properties of near-infrared dyes using clickable oligoglycerol dendrons. Org. Biomol. Chem. 2015, 13(16), 4727-32.

 

Y.L. Lightfoot, K. Selle, T. Yang, Y.J. Goh, B. Sahay, M. Zadeh, J.L. Owen, N. Colliou, E. Li, T. Johannssen, T. Ganguly, B. Lepenies, T.R. Klaenhammer, M. Mohamadzadeh*: C-type lectin receptor SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO J. 2015, 34(7), 881-95.

 

A. Rabes, S. Zimmermann, K. Reppe, R. Lang, P.H. Seeberger, N. Suttorp, M. Witzenrath, B. Lepenies*, B. Opitz*: The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response. PLOS One 2015, 10(2): e0117022.

 

2014:

H. Schoenen, A. Huber, N. Sonda, S. Zimmermann, J. Jantsch, B. Lepenies, V. Bronte, R. Lang*: Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α. J. Immunol. 2014, 193(7), 3664-75.

 

J. Hütter, M. Eriksson, T. Johannssen, R. Klopfleisch, D. von Smolinski,  A.D. Gruber, P.H. Seeberger, B. Lepenies*: Role of the C-type lectin receptors MCL and DCIR in experimental colitis. PLOS One 2014, 9(7): e103281.

 

N.M. van Sorge, J.N. Cole, K. Kuipers, A. Henningham, R.K. Aziz, A. Kasirer-Friede, L. Lin, E.T. Berends, M.R. Davies, G. Dougan, F. Zhang, S. Dahesh, L. Shaw, J. Gin, M. Cunningham, J.A. Merriman, J. Hütter, B. Lepenies, S.H.M. Rooijakkers, R. Malley, M.J. Walker, S.J. Shattil, P.M. Schlievert, B. Choudhury, V. Nizet*: Genetics and virulence role of the classical Group A Streptococcus Lancefield antigen. Cell Host Microbe 2014, 15(6), 729-40.

 

M. Eriksson, S. Serna, M. Maglinao, M.K. Schlegel, P.H. Seeberger, N.C. Reichardt*, B. Lepenies*: Biological evaluation of multivalent Lewis X-MGL-1 interactions. ChemBioChem 2014, 15(6), 844-51.

 

S.M. Miltsch, P.H. Seeberger, B. Lepenies*: The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection. Dev. Comp. Immunol. 2014, 45(1), 67-73.

 

M. Maglinao, M. Eriksson, M.K. Schlegel, S. Zimmermann, T. Johannssen, S. Götze, P.H. Seeberger, B. Lepenies*: A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation. J. Control. Release. 2014, 175, 36-42.

 

2013:

M. Eriksson, T. Johannssen, D. von Smolinski, A.D. Gruber, P.H. Seeberger, B. Lepenies*: The C-type lectin receptor SIGNR3 binds to fungi present in commensal microbiota and influences immune regulation in experimental colitis. Front. Immunol. 2013, 4, 196.

 

M. Maglinao, R. Klopfleisch, P. Seeberger, B. Lepenies*: The C-type lectin receptor DCIR is crucial for the development of experimental cerebral malaria. J. Immunol. 2013, 191(5), 2551-59.

 

K. Shirato, C. Gao, F. Ota, T. Angata, H. Shogomori, K. Ohtsubo, K. Yoshida, B. Lepenies, N. Taniguchi*: Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells. BBRC 2013, 435(3): 460-65.

 

N. Karton-Lifshin, U. Vogel, E. Sella, P.H. Seeberger, D. Shabat*, B. Lepenies*: Enzyme mediated nutrient release: glucose-precursor activation by β-galactosidase to induce bacterial growth. Org. Biomol. Chem. 2013, 11(17): 2903-10.

 

J. Hütter, J.V. Rödig, D. Höper, U. Reichl, P.H. Seeberger, E. Rapp*, B. Lepenies*: Toward animal cell culture-based influenza vaccine design: viral hemagglutinin N-glycosylation markedly impacts immunogenicity. J. Immunol. 2013, 190(1): 220-30.


2012 and earlier:

C.C. Williams, S.H. Thang, T. Hantke, U. Vogel, P.H. Seeberger, J. Tsanaktsidis*, B. Lepenies*: RAFT-derived polymer-drug conjugates: poly(hydroxypropyl methacryl-amide) (HPMA)-7-ethyl-10-hydroxycamptothecin conjugates. ChemMedChem 2012; 7(2): 281-91.

 

2011

M.K. Schlegel, J. Hütter, M. Eriksson, B. Lepenies, P.H. Seeberger*: Defined presentation of carbohydrates on a duplex DNA scaffold. ChemBioChem 2011; 12(18): 2791-800.

 

D. Grünstein, M. Maglinao, R. Kikkeri, M. Collot, K. Barylyuk, B. Lepenies, F. Kamena, R. Zenobi, P.H. Seeberger*: Hexameric supramolecular scaffold orients carbohydrates to sense bacteria. J. Am Chem. Soc. 2011; 133(35): 13957-66.

 

S. Khil’chenko, T. Zaporozhets, N. Shevchenko, T. Zvyagintseva, P.H. Seeberger, B. Lepenies*: Immunostimulatory activity of fucoidan from the brown alga Fucus evanescens: role of sulfates and acetates. J. Carbohydr. Chem. 2011; 30: 291-305.

 

2010

R. Gentsch, F. Pippig, K. Nilles, P. Theato, R. Kikkeri, M. Maglinao, B. Lepenies, P.H. Seeberger, H.G. Börner*: Modular approach towards bioactive fiber meshes carrying oligosaccharides. Macromolecules 2010; 43(22): 9239-47.

 

G.J. Bernardes, R. Kikkeri, M. Maglinao, P. Laurino, M. Collot, S.Y. Hong, B. Lepenies, P.H. Seeberger*: Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting. Org. Biomol. Chem. 2010; 8(21): 4987-96.

 

2009

R. Kikkeri, B. Lepenies, A. Adibekian, P. Laurino, P.H. Seeberger*: In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots. J. Am. Chem. Soc. 2009; 131(6): 2110-12.

 

2008

S. Boonyarattanakalin, X. Liu, M. Michieletti, B. Lepenies, P.H Seeberger*: Chemical synthesis of all phosphatidylinositol mannoside (PIM) glycans from Mycobacterium tuberculosis. J. Am. Chem. Soc. 2008; 130(49): 16791-16799.

 

J.P. Cramer°, B. Lepenies°, F. Kamena, C. Hölscher, M.A. Freudenberg, G.D. Burchard, H. Wagner, C.J. Kirschning, X. Liu, P.H. Seeberger, T. Jacobs*: MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection. Microbes Infect. 2008; 10(12-13): 1259-65.

 

B. Lepenies, J.P. Cramer, G.D. Burchard, H. Wagner, C.J. Kirschning, T. Jacobs*: Induction of experimental cerebral malaria is independent of TLR2/4/9. Med. Microbiol. Immunol. 2008; 197(1): 39-44.

 

2007

B. Lepenies, K. Pfeffer, M.A. Hurchla, T.L. Murphy, K.M. Murphy, J. Oetzel, B. Fleischer, T. Jacobs*: Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria. J. Immunol. 2007; 179(6): 4093-100.

 

B. Lepenies, I. Gaworski, S. Tartz, J. Langhorne, B. Fleischer, T. Jacobs*: CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections. Microbes Infect. 2007; 9(6): 687-94.

Kontakt
Prof. Dr. Bernd Lepenies
Tel.:+49 511 953-6135
Fax.:+49 511 953-82 6135
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