Research

Food Toxicology:

Molecular mechanisms of colon cancer formation

• Endogenously formed N-nitroso compounds from red meat: Potential to contribute to malignant transformation of human colon epithelial cells and underlying mechanisms

• Intestinal bacteria-mediated formation of N-nitroso compounds from red meat and their potential to contribute to malignant transformation of human colon epithelial cells

• The role of the bacterial pathogen Streptococcus gallolyticus ssp. gallolyticus in colon cancer formation

 Risk assessment of genetically modified maize

• Safety assessment of genetically modified maize NK603

 Bioanalytics and Metabolomics

• Analytics of parasitic fatty acid pattern by means of gas chromatography

• Impact of food ingredients and contaminants on endogenous inflammation mediators - Targeted metabolomics of the eicosanoid pathway

Alternative and Complementary Methods for Animal Testing:

Development of Alternative and Complementary Methods for Animal Testing

• Development of an in vitro assay for the evaluation of Botulinum toxin activity based on transgenic human stem cells

• Development of a transformation assay based on human epithelial cells

• Development of an in vitro model for the investigation of pathogenic mechanisms of intestinal disorders caused by zoonotic agents