Head of Group

Prof. Dr. phil. nat. Hassan Y. Naim
Universitätsprofessor Institutsdirektor
direct dial +49 511 953-8780
fax +49 511 953-8585
zu sehen ist Prof. Dr. Hassan Y. Naim
© Prof. Dr. Hassan Y. Naim

Prof. Dr. Hassan Y. Naim

Hassan Y. Naim received his Ph.D. Degree in biochemistry from the University of Bern, Switzerland. After positions at the Institute of Biochemistry at the University of Lausanne (membrane transport in T cells) and the Children's Clinic at the University of Bern (structure and function of brush border membrane proteins), he moved to the Department of Biochemistry, University of Texas, Southwestern Medical Center in Dallas, USA, in 1989 to continue work on the structure-function relationships, protein and membrane transport of intestinal brush border proteins. In 1991 he was hired as a junior research group leader within the framework of the "Biocatalysis" focus at the University of Düsseldorf, Germany. In 1997 he was appointed professor and head of the Institute for Physiological Chemistry at the University of Veterinary Medicine, Hanover, Germany. The research interests of the Naim group focus on the molecular mechanisms underlying protein and membrane transport and polarized protein sorting in epithelial cells in healthy and pathological conditions, in particular on the role of lipid rafts and glycosylation. These questions are addressed in (1) genetic malabsorption disorders of carbohydrates in sucrase-isomaltase and lactase deficiency and in irritable bowel syndrome and (2) in lysosomal storage diseases (Niemann-Pick type C and Fabry diseases). More recently, the group has started to investigate the modulatory roles of lipid rafts and glycosylation in the interactions between pathogens and the small intestine on a biochemical and cellular level.

 

Staff

Dr. Abdullah Hoter
Wissenschaftlicher Assistent; Labor
direct dial +49 511 953-8523
fax +49 511 953-8585
Diab Husein, MSc
Doktorand; Labor
direct dial +49 511 953-8762
fax +49 511 953-8585
Sandra Pfeifer
Tierpflegerin; Labor
direct dial +49 511 953-8789
mobile +49 151 70104925
fax +49 511 953-8585
TA Friederike Walters
Veterinärmedizinisch-technische Assistentin; Labor
direct dial +49 511 953-8702
fax +49 511 953-8585
Dr. Dalanda Wanes
Wissenschaftliche Mitarbeiterin; Labor
direct dial +49 511 953-8788
fax +49 511 953-8585
Nawaphat Wanphen
Sekretärin; Geschäftszimmer
direct dial +49 511 953-8781
fax +49 511 953-8585
Marianne El Khoury , MSc
Doktorandin; Labor
direct dial +49 511 953-8705
fax +49 511 953-8585
TA Alexander Prokscha
Technischer Mitarbeiter; Labor
direct dial +49 511 953-8703
fax +49 511 953-8585
Stephanie Tannous, MSc
Doktorandin; Labor
direct dial +49 511 953-8705
fax +49 511 953-8585
zu sehen ist Abdullah Hoter
© Abdullah Hoter
zu sehen ist Diab Husein
© Diab Husein
zu sehen ist Sandra Pfeifer
© Sandra Pfeifer
zu sehen ist Friederike Walters
© Friederike Walters
zu sehen ist Dalanda Wanes
© Dalanda Wanes
zu sehen ist Nawaphat Wanphen
© Nawaphat Wanphen
TA Heike Kanapin
Technische Mitarbeiterin; Labor
direct dial +49 511 953-8707
fax +49 511 953-8585
Tammy Stellbrinck, MSc
Doktorandin; Labor
direct dial +49 511 953-8523
fax +49 511 953-8585

In collaboration with the Hannover Medical School (MHH)

zu sehen ist Hadeel Shammas
© Hadeel Shammas

Hadeel Shammas, PhD

Hannover Medical School (MHH)
shammas.hadeel(at)mh-hannover.de

NPC Project

NPC is a serious neurodegenerative disease that is mainly caused by mutations in the NPC1 gene. In her research, Hadeel uses targeted mutagenesis to generate various mutations in the NPC1 gene and investigates the influence of the mutations on the folding and transport of the NPC1 protein. In addition, the influence of the mutations on lipid rafts and the cellular lipid composition will be investigated, followed by the consequences for intracellular transport and activity of intestinal disaccharidases such as sucrase isomaltase. Results from Hadeel's work may help explain the very varied, especially gastrointestinal, symptoms of NPC patients.