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Genomics and Bioinformatics of Infectious Diseases

Head:

Prof. Dr. Klaus Jung


Staff & students:

Mrs. Magdalena Kircher, M.Sc.

Mr. Moritz Kohls, M.Sc.

Mrs. Jessica Krepel, M.Sc.

Mrs. Pamela Liebig, Veterinarian

Mr. Babak Saremi, M.Sc.

Mrs. Christine Winter, M.Sc., Veterinarian

Our Research

The research activities of our working group follow two directions. First, we employ existing bioinformatic tools to investigate infectious diseases on different 'omics' levels, for example to identify viral sequences in host samples. In this context, we collaborate closely with other groups at the University of Veterinary Medicine Hannover who are working in the area of infection research - one of the main research foci of the University. Second, we develop new computational and statistical methods for the analysis of data from high-throughput experiments (e.g. NGS, Microarrays, Proteomics).

Funded Research Projects

FibroOmics (Translating Omics studies into clinically relevant insights for lung fibrosis patients)

This project, funded by the Ministry of Science and Culture of the State Lower Saxony, will contribute to an improved knowledge of the mechanisms of lung fibrosis by using integrative analysis of transcriptome data. It will also lead to new therapeutic and diagnostic strategies. The interdisciplinary constorium with partners from the TiHo, the MHH and Frauenhofer ITEM combines clinical and molecularbiologic expertise with bioinformatics expertices. This enables the integration of data using the new technology of RNA-sequencing of single cells. The project aims to develope new instruments for improved diagnostics and therapies of lung fibrosis.

RTG 2485 VIPER (Virus detection, pathogenesis and interaction)

The Research Training Group (RTG) ‘Virus detection, pathogenesis and intervention’ (VIPER, speaker Prof. Dr. W. Baumgärtner), funded by the DFG, aims at training next generation scientists to tackle complex health issues caused by emerging and re-emerging viruses using an inter-disciplinary approach. In the bioinformatics subproject we focus on robust algorithms for the analysis of next-generation sequencing data.

DigiStep (Digitalization of teaching contents in the study of veterinary medicine)

Within a subproject of DigiStep, funded by the Ministry of Science and Culture of Lower Saxony, we develope interactive graphics as teaching material in the study of veterinary medicine). These graphics are based on the statistical programming environment R and the Shiny plattform. The graphics can be displayed in a browser window and can be modified by the lecturer in real time during explanation to the students (using different regulator elements).

N-RENNT (Niedersachsen-Research Network on Neuroinfectiology)

From 2016 to 2018, our group participates in the Niedersachsen-Research Network on Neuroinfectiology (N-RENNT), funded by the Ministry of Science and Culture of Lower Saxony. In the subproject Bioinformatics we aim to identify virus sequences in sequencing data from host samples. For that purpose we use mapping approaches as well as unsupervised classification methods. In addition, we work on new methods for analyzing high-throughput transcriptomic data from DNA microarrays or RNA-seq experiments.

GlykoViroLectinTools (Research on Lectin-sequences)

GlykoViroLectinTools is a joint project with Prof. Stefanie Becker and Prof. Bernd Lepenies, funded by the German Research Platform for Zoonoses from 2017 to 2018. The Bioinformatics part of this projects concentrates on analyzing the amino acid sequences of lectins. Lectins play an important role in immune defense.

Teaching material

Lecture slides are provided during courses only.

Current Topics for Bachelor- and Master-Theses

Announcements of current topics for bachelor and master theses are provided here.

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