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Prof. Dr. Gisa Gerold

Gisa Gerold studied at the Eberhard Karls University Tübingen, Germany, where she graduated with a diploma in biochemistry (minors: physical chemistry and microbiology). In 2008, she received a PhD in biology and biochemistry from the Humboldt University Berlin, Germany. She performed her PhD research at the Max Planck Institute for Infection Biology under the supervision of Professor Arturo Zychlinsky on the innate immunity to bacterial infections. The work was awarded the Otto Hahn Medal for Outstanding Scientific Achievements by the Max Planck Society.

 

During her three-year postdoctoral stay at the "Center of Hepatitis C" of the Rockefeller University, New York, USA headed by Professor Charles M. Rice, she worked on various aspects of hepatitis C virus (HCV) infection, including the species tropism and HCV-related viruses in animals. From 2012 until 2017 she continued her work at the Twincore, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research. There, she investigated mechanisms of HCV entry into liver cells using a combination of mass spectrometry based protein analytics and virological methods. For her postdoc positions she received independent stipends from the National Academy of Sciences Leopoldina, the  Human Frontiers Science Program (HFSP) and the German Research Foundation (DFG). Her postdoc work was awarded the Robert Koch postdoctoral prize in Virology in 2017.

From 2017 until 2020 Gisa Gerold headed the research group „Virus Interaction Proteomics“ at Twincore and since 2018 she holds a Guest Professorship at Umeå University in Schweden. Her work at the Wallenberg Center for Molecular Medicine (WCMM) is funded by the Knut and Alice Wallenberg Foundation and the Kempe Foundation. Gisa Gerold’s German-Swedish team is driven by the interest to understand the entry of diverse human pathogenic viruses including HCV, noroviruses and Chikungunyavirus into their host cells and by the interest to shed light on the innate defense of host cells against viruses. Using state of the art technologies including label free proteomics her team wants to delineate fundamental principles of virus entry and virus recognition by cells.

Since 2019 Gisa Gerold is a board member of the Center for Infection Biology (ZIB) of Hannover Medical School and since 2020 associated member of the Excellence Cluster RESIST. From 2017 until 2018 Gisa Gerold organized –together with her colleague Dr. Pierre-Yves Lozach (Universität Lyon) the annual workshop “Cell Biology of Viral Infections” oft he German Society for Virology (GfV), in which she was elected advisory board member in 2020.

Gisa Gerold became Professor for Biochemistry – Focus Molecular and Clinical Infectiology at the Veterinary University Hannover in 2020. Here her team is a member of the Institute of Biochemistry and is located at the „Research Center for Emerging Infections and Zoonoses“ (RIZ), where they investigate pathogenic viruses, which are transmitted from animals to humans. The focus of her work is on mosquito-transmitted viruses of the alphavirus genus, but also other zoonotic pathogens such as arenaviruses and gastrointestinal pathogens such as noroviruses are under investigation.

Methodologically the team of Gisa Gerold uses modern proteomics approaches to identify host factors of viruses with the potential to cause future epidemics. Thereby the group aims to understand, which hosts can be infected and how the viruses cause disease in the specific tissues of man and animals.

 

The work in Germany is funded by the German Research Foundation (DFG), the Lower Saxony Ministry of Science and Culture (MWK), the Federal Ministry of Education and Research (BMBF) and the German Academic Exchange Service (DAAD).

The Swedish research is supported by the Knut and Alice Wallenberg Foundation, the Kempe Foundation and the Erling-Persson Foundation.

 

 

 

Publications

Peer-reviewed original articles

 

1.    Palor M, Stejskal L, Mandal P, Lenman A, Alberione MP, Kirui J, Moeller R, Ebner S, Meissner F, Gerold G, Shepherd AJ, Grove J (2020) Cholesterol sensing by CD81 is important for hepatitis C virus entry. J Biol Chem. jbc.RA120.014761. doi: 10.1074/ jbc.RA120.014761 PMID: 32900848

 

2.    Pía Alberione MP, Moeller R, Kirui J, Ginkel C, Doepke M, Ströh LJ, Machtens JP, Pietschmann T, Gerold G (2020) Single-Nucleotide Variants in Human CD81 Influence Hepatitis C Virus Infection of Hepatoma Cells. Medical Microbiology and Immunology 209(4) PMID: 32322956

 

3.    Uckeley ZM, Moeller R, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voß Y, Sommerauer C, Kampmann M, Goffinet C, Felix Meissner F, Överby AK, Lozach PY, Gerold G (2019) Quantitative proteomics of Uukuniemi virus - host cell interactions reveals GBF1 as proviral host factor for phleboviruses. Mol Cell Proteomics 18(12) PMID:31570497

 

4.    Moreno H, Moeller R, Fedeli C, Gerold G, Kunz S (2019) Comparison of the innate immune response to pathogenic and non-pathogenic Clade B New World arenaviruses. J Virol 93(19). PMID:31270228

 

5.    Herrador A, Fedeli C, Radulovic E, Moreno H, Campbell K, Gerold G*, and Kunz S* (2019) Dynamic dystroglycan complexes mediate cell entry of Lassa virus. mBio 10(2)*co-corresponding. PMID:30914516

 

6.    Zapatero-Belinchón FJ , Dietzel E , Dolnik O, Döhner K, Costa R, Hertel B, Veselkova B, Kirui J, Klintworth A, Manns MP, Pöhlmann SH, Pietschmann T, Krey T, Ciesek S, Gerold G, Sodeik B, Becker S, von Hahn T (2019) Characterization of the filovirus resistant cell line SH-SY5Y reveals redundant role of cell surface entry factors. Viruses. 11(3). PMID:30893855

 

7.    Bruening J, Banse P, Kahl S, Vondran FW, Kaderali L, Marinach C, Silvie O, Pietschmann T, Meissner F*, Gerold G*. (2018) Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB. PLOS Pathogens. 14(7): e1007111. *contributed equally. PMID:30024968

8.    Abere B, Samarina N, Gramolelli S, Rückert J, Gerold G, Pich A, Schulz TF. (2018) The Kaposi Sarcoma Herpesvirus non-structural membrane protein pK15 recruits the class II PI3K Phosphatidylinositol 4-phosphate 3-kinase C2 alpha to activate productive viral replication. J Virol. 92(17). pii: e00544-18. PMID: 29950425

9.    Banse P, Moeller R, Bruening J, Lasswitz L, Kahl S, Khan AG, Marcotrigiano J, Pietschmann T, Gerold G. (2018) CD81 receptor regions outside the large extracellular loop determine hepatitis C virus susceptibility. Viruses 10(4). pii: E207. PMID: 29677132

 

10.  Fedeli C, Torriani G, Galan-Navarro C, Moraz ML, Moreno H, Gerold G, Kunz S (2018) Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan. J Virol. 92(5). pii: e01613-17. PMID: 29237830

 

 

11.  von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz J, Gerold G, Suerbaum S, Rice CM, Meuleman P, and Pietschmann T, Ploss A (2016) Expanding the host range of hepatitis C virus through viral adaptation. mBio. 7(6). pii: e01915-16. PMID: 27834208

 

12.  Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran FW, Kaderali L, Pietschmann T. (2016) ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production. PLoS Pathogens. 12(4):e1005568. PMID:27124600

13.  Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J*, and Münch J*. (2015) A molecular tweezer antagonizes seminal amyloids and HIV infection. eLife. 4:e05397. PMID: 26284498

 

14.  Gerold G, Meissner F, Bruening J, Welsch K, Perin PM, Thomas F. Baumert, Vondran FW, Kaderali L, Marcotrigiano J, Khan AG, Mann M, Rice CM, Pietschmann T. (2015) Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. Cell Reports. 4;12(5):864-78. PMID: 26212323

 

15.  Scull MA, Shi C, de Jong YP, Gerold G, Ries M, von Schaewen M, Donovan BM, Labitt RN, Horwitz JA, Gaska JM, Hrebikova G, Xiao JW, Flatley B, Fung C, Chiriboga L, Walker CM, Evans DT, Rice CM, Ploss A. (2015) Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice. Hepatology. 62(1):57-67. PMID: 25820364

16.  Vogt A, Scull MA, Friling T, Horwitz JA, Donovan BM, Dorner M, Gerold G, Labitt RN, Rice CM, Ploss A. (2013) Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines. Virology. 444(1-2):1-11. PMID: 23777661

 

17.  Kapoor A, Simmonds P, Gerold G, Qaisar N, Jain K, Henriquez JA, Firth C, Hirschberg DL, Rice CM, Shields S, Lipkin WI. (2011) Characterization of a canine homolog of hepatitis C virus. PNAS. 108(28):11608-13. PMCID: PMC3136326

18.  Gerold G, Abu Ajaj K, Bienert M, Laws HJ, Zychlinsky A, de Diego JL. (2008) A Toll-like receptor 2–integrin beta3 complex senses bacterial lipopeptides via vitronectin. Nature Immunology. 9(7):761-8. PMID: 18516040

19.  Loll B*, Gerold G*, Slowik D, Voelter W, Jung C, Saenger W, Irrgang KD. (2005) Thermostability and Ca2+ binding properties of wild type and heterologously expressed PsbO protein from cyanobacterial photosystem II. Biochemistry. 44(12):4691-8. * these authors contributed equally PMID: 15779895

Peer-reviewed book chapters

 

1.    Gerold G*, Moeller R, Pietschmann T* Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion. Cold Spring Harb Perspect Med. "The Hepatitis C Viruses" volume. 2019 Aug 19. pii: a036830. *co-corresponding authors. PMID:31427285

 

Peer-reviewed reviews and commentaries

 

1.    Lasswitz L, Chandra N, Arnberg N*, Gerold G*. (2018) Glycomics and proteomics approaches to investigate early adenovirus - host cell interactions. J Mol Biol. doi: 10.1016/j.jmb.2018.04.039. * these authors contributed equally PMID:29746851 [IF 4.9]

 

2.    Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann. (2017) Protein interactions during the flavivirus and hepacivirus life cycle. Mol Cell Proteomics. pii: mcp.R116.065649. PMID: 28077444

 

 

3.    Janina Bruening, Bettina Weigel, and Gisa Gerold. (2017) The role of type III interferons in hepatitis C virus infection and therapy. J Immunol Res. 2017:7232361. PMID: 28255563

<pre style="margin-top:.1pt; margin-right:0cm; margin-bottom:12.0pt; margin-left: 21.3pt; text-align:justify; text-indent:-18.0pt">4.    Gerold G, Bruening J, Pietschmann T. (2015) Decoding protein networks during virus entry by quantitative proteomics. Virus Research. 218:25-39. PMID: 26365680 </pre>

5.    Gerold G, Pietschmann T. (2014) The HCV life cycle: In vitro tissue culture systems and therapeutic targets. Digestive Diseases. 32(5):525-37. PMID:25034285

6.    Gerold G, Pietschmann T. (2014) A circuit of paracrine signals between liver sinusoid endothelial cells and hepatocytes regulates hepatitis C virus replication. Hepatology. 59(2):363-5. PMID: 2385746

 

7.    Gerold G, Pietschmann T. (2013) Opportunities and risks of host-targeting antiviral strategies for hepatitis C. Current Hepatitis Reports. 12(4): 200-213.

 

8.    Gerold G, Pietschmann T. (2013) Hepatitis C virus NS5B polymerase primes innate immune signaling. Hepatology. 57(3):1275-7. PMID: 23426794

 

9.    Gerold G, Rice CM. (2011) Locking out hepatitis C. Nature Medicine.17(5):542-4. PMID: 21546968

 

10.  Gerold G, Rice CM, Ploss A. (2010) Teaching new tricks to an old foe: murinizing hepatitis C virus. Hepatology. 52(6):2233-6. PMC4509484

 

11.  Gerold G, Zychlinsky A, de Diego JL. (2007) What is the role of Toll-like receptors in bacterial infections? Semin Immunol. 19(1):41-7. PMID: 17280841

 

12.  de Diego JL, Gerold G, Zychlinsky A. (2007) Sensing, presenting, and regulating PAMPs. Ernst Schering Found Symp Proc. 3:83-95. PMID: 18510100

 

Contact
Tel.:+49 511 953-6146
Fax.:+49 511 953-8585
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