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Research group Kietzmann

Research

Immunopharmacology

 

Allergic and autoimmune diseases are caused by a dysregulation of the immune system, which leads to misdirected reactions towards harmless environmental antigens or endogenous proteins. Since the skin is particularly frequently affected, such as atopic dermatitis in dogs or psoriasis in humans, it has become the main focus of our research group. Researchers in the working group are concentrating  on the role of antigen-presenting cells (dendritic cells) and keratinocytes, because these cell types are critically important for the development and maintenance of disease. One main focus is placed on whether or not modulators of the histamine-4 receptor can affect the allergic inflammatory process.

 

 

Antibiotic use and bacterial resistance

 

In the working group, various projects are carrying out studies on farm animals (pigs, chickens) with the aim of further reducing the total amount of active substances used by optimizing the treatment conditions. Amongst other aspects, the drug carryover into the direct animal environment (e.g., dust in the stable) and the change in the susceptibility of commensal germs are ascertained/examined.

 

 

Transdermal penetration, permeation and resorption

 

Using suitable model substances, comparative in vitro and ex vivo investigations on transdermal penetration, permeation and resorption are performed. In addition to studies on non-perfused skin of different species in diffusion cells, perfused bovine uterine is also used to perform experiments on perfused skin, which allows predictive statements regarding pharmacological and toxicological issues.

 

 

Implant material, nanoparticles

 

The working group is involved in two research projects investigating the suitability of different alloys as implant material. In addition, studies to optimize the surface quality of such implants using various in vitro models are investigated. Thus, studies on cell and tissue compatibility (biocompatibility) in various cell culture systems and isolated organs are performed. In another project, the biocompatibility and the magnetic field accumulation of drug-loaded magnetic nanoparticles are examined. These nanoparticles should allow a targeted drug release after enrichment in the appropriate tissue.

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