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Originalarbeiten, invited Reviews und Buchbeiträge (bis 2012)

I. Originalarbeiten:

  1. Brehm R, Marks A, Rey R, Kliesch S, Bergmann M, Steger K (2002) Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma. J Pathol 197:647-653.
  2. Donner J, Kliesch S, Brehm R, Bergmann M (2004) From carcinoma-in-situ to testicular germ cell tumor. APMIS 112:79-88.
  3. Fischer P, Brehm R, Konrad L, Hartmann S, Kliesch S, Bergmann M (2005) Connexin33: A Rodent-Specific Member of the Gap Junction Protein Family? J Androl 26:75-84.
  4. Gashaw I, Grümmer R, Klein-Hitpass L, Dushaj O, Bergmann M, Brehm R, Grobholz R, Kliesch S, Neuvians TP, Schmid KW, vonOstau C, Winterhager E (2005) Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4. Cell Mol Life Sci 62:2359-2368.
  5. Fink C, Hembes H, Brehm R, Weigel R, Heeb C, Pfarrer C, Bergmann M, Kressin M (2006) Specific localization of gap junction protein connexin 32 in the gastric mucosa of horses. Histochem Cell Biol 125:307-313.
  6. Pauls K, Schorle H, Jeske W, Brehm R, Steger K, Wernert N, Buttner R, Zhou H (2006) Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study. Hum Reprod 21: 397-404.
  7. Lekhkota O, Brehm R, Claus R, Wagner A, Bohle RM, Bergmann M (2006) Cellular localisation of estrogen receptor-alpha (ERa) and -beta (ERb) in the boar testis. Histochem Cell Biol 125:259-264.
  8. Brehm R, Rey R, Kliesch S, Steger K, Marks A, Bergmann M (2006) Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome. Anat Embryol 211: 223-236.
  9. Brehm R, Rüttinger C, Fischer P, Gashaw I, Winterhager E, Kliesch S, Bohle RM, Steger K, Bergmann M (2006) Transition from pre-invasive carcinoma in situ to seminoma is accompanied with a reduction of connexin 43 expression in Sertoli cells and germ cells. Neoplasia 8: 499-509.
  10. Barrios-de-Tomasi J, Nayudu PL, Brehm R, Heistermann M, Zarinan T, Ulloa-Aguirre A (2006) Effects of human pituitary FSH isoforms on mouse follicles in vitro. RBM Online 12:428-441.
  11. Fink C, Weigel R, Hembes T, Lauke-Wettwer H, Kliesch S, Bergmann M, Brehm R (2006) Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of functional integrity of the blood-testis barrier in testicular carcinoma-in-situ. Neoplasia 8: 1019-1027.
  12. Omisanjo OA, Biermann K, Hartmann S, Heukamp LC, Sonnack V, Hild A, Brehm R, Bergmann M, Weidner W, Steger K (2007) DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer. Histochem Cell Biol 127: 175-181.
  13. Zayed AE, Abd-Elnaeim M, Abd-Elghaffar S, Hild A, Brehm R, Steger K (2007) Prenatal development of murine gonads with special reference to germ cell differentiation: a morphological and immunohistochemical study. Andrologia 39: 93-100.
  14. Brehm R, Zeiler M, Rüttinger C, Kibschull M, Winterhager E, Willecke K, Guillou F, Lécureuil C, Steger K, Konrad L, Biermann K, Failing K, Bergmann M (2007) A Sertoli cell-specific knockout of connexin43 prevents initiation of  spermatogenesis. Am J Pathol 171: 19-31.
  15. Herde K, Hartmann S, Brehm R, Kilian O, Heiss C, Hild A, Alt V, Bergmann M, Schnettler R, Wenisch S (2007) Connexin43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite. Biomaterials 28: 4912-4921.
  16. Gashaw I, Dushaj O, Behr R, Biermann K, Brehm R, Rübben H, Grobholz R, Schmid KW, Bergmann M, Winterhager E (2007) Novel germ cell markers characterise testicular seminoma and fetal testis. Mol Hum Reprod 13: 721-727.
  17. Biermann K, Heukamp LC, Steger K, Zhou H, Franke FE, Guetgemann I, Sonnack V, Brehm R, Berg J, Bastian PJ, Müller SC, Wang-Eckert L, Schorle H, Büttner R (2007) Gene expression profiling identifies new biological markers of neoplastic germ cells. Anticancer Res 27: 3091-3100.
  18. Biermann K, Heukamp LC, Steger K, Zhou H, Franke FE, Sonnack V, Brehm R, Berg J, Bastian PJ, Müller SC, Wang-Eckert L, Büttner R (2007) Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors. Cancer Genomics Proteomics 4: 359-367.
  19. Biermann K, Heukamp LC, Nettersheim D, Steger K, Zhou H, Franke FE, Guetgemann I, Sonnack V, Brehm R, Berg J, Bastian PJ, Müller SC, Wang-Eckert L, Schorle H, Büttner R (2007) Embryonal germ cells and germ cell tumors. Verh Dtsch Ges Pathol 91: 39-48.
  20. Rüttinger C, Bergmann M, Fink L, Pesch S, Seitz K, Trautmann A, Steger K, Konrad L, Brehm R (2008) Expression of Connexin 43 in normal canine testes and canine testicular tumors. Histochem Cell Biol 130: 537-548.
  21. Fink C, Weigel R, Fink L, Wilhelm J, Kliesch S, Zeiler M, Bergmann M, Brehm R (2009) Claudin-11 is over-expressed and dislocated from the blood-testis barrier in Sertoli cells associated with testicular intraepithelial neoplasia in men. Histochem Cell Biol 131: 755-764.
  22. Anniballo R, Brehm R, Steger K (2010). Recognising the Sertoli-cell-only (SCO) syndrome: a case study. Andrologia 43:78-83.

  23. Carrette D, Weider K, Gilleron J, Giese S, Dompierre J, Bergmann M, Brehm R, Denizot JP, Segretain D, Pointis G (2010) Major involvement of connexin43 in seminiferous epithelial junction dynamics and male fertility. Dev. Biol. 346:54-67.

  24. Weider K, Bergmann M, Giese S, Guillou F, Failing K, Brehm R (2011). Altered differentiation and clustering of Sertoli cells in transgenic mice showing a Sertoli cell specific knockout of the connexin 43 gene. Differentiation 82: 38-49
  25. Weider K, Bergmann M, Brehm R (2011) Connexin43: its regulatory role in testicular junction dynamics and spermatogenesis. Histol. Histopathol. 26:1343-1352.
  26. Klisch K, Contreras D, Sun X, Brehm R, Bergmann M, Albeiro R (2011) The Sda/GM2-glycan is a carbohydrate marker of porcine primordial germ cells and of a subpopulation of spermatogonia in cattle, pigs, horses and llama. Reproduction 142: 667-674.
  27. Giese S, Hossain HM, Markmann M, Chakraborty T, Tchatalbachev S, Guillou F, Bergmann M, Failing K, Weider K, Brehm R (2012) A Sertoli cell specific Knockout of Connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice. Disease Models & Mechanisms (in press).
  28. Chojnacka K, Brehm R, Weider K, Hejmej A, Lydka M, Kopera-Sobota I, Bilinska B (2012) Expression of the androgen receptor in the testis of mice with a Sertoli cell specific knock-out of the connexin 43 gene (SCCx43KO-/-). Reprod Biol (in press).

II. Invited Reviews und Buchbeiträge

  1. Brehm R, Steger K (2005) Regulation of Sertoli cell and germ cell differentiation. Adv Anat Embryol Cell Biol 181:1-93.
  2. Sridharan S, Brehm R, Bergmann M, Cooke PS (2007) Role of connexin43 in Sertoli cells of testis. Ann N Y Acad Sci 1120: 131-143.
  3. Brehm R, Zeiler M, Bergmann M (2009) Connexin 43 and spermatogenesis. In: Glander HJ, Paasch U (eds) Biology of male germ cells. Shaker Publisher GmbH, Aachen, Germany (Buchbeitrag, in pre
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