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Univ. Prof. Dr. rer. nat. Georg Herrler

Universitäts-Professor

 

Institut für Virologie

Zentrum für Infektionsmedizin

Stiftung Tierärztliche Hochschule Hannover
Bünteweg 17
D-30559 Hannover


Telefon: +49 511 953-8857
Fax:        +49 511 953-8898

E-Mail:   georg.herrler(at)tiho-hannover.de

Team

Forschungsschwerpunkte

  • Transport und biologische Aktivität der Oberflächenglykoproteine von RNA-Viren
  • Virus-Interaktionen mit differenzierten Atemwegsepithelzellen
  • Viral-bakterielle Co-Infektionen des Respirationstrakts
  • Adaptation von Influenzaviren an neue Wirte
  • Glykoprotein-abhängige Rrestriktionen bei der Replikation von Fledermausviren  

Aktuelle Projekte

  • Oberflächenglykoproteine von zwei Fledermausparamyxoviren: funktionelle Characterisierung und Rolle beim Wirtswechsel
  • Viral-bakterielle Co-Infektionen: Auswirkung von Streptococcus suis auf die Influenzavirus-Infektion in differenzierten porzinen Atemwegsepithelzellen
  • Adapatation  aviärer Influenzaviren an die Vermehrung in differenzierten respiratorischen Epithelzellen

Jüngste Publikationen

Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M.

Dynamic viral-bacterial interactions in a porcine precision-cut lung slice co-infection model: swine influenza virus paves the way for Streptococcus suis infection in a two-step process.

Infect Immun. 2015 Apr 27

 

Dahlmann F, Biedenkopf N, Babler A, Jahnen-Dechent W, Karsten CB, Gnirß K, Schneider H, Wrensch F, O'Callaghan CA, Bertram S, Herrler G, Becker S, Pöhlmann S, Hofmann-Winkler H.

Analysis of Ebola Virus Entry Into Macrophages.

J Infect Dis. 2015 Apr 14.

 

Krüger N, Hoffmann M, Drexler JF, Müller MA, Corman VM, Sauder C, Rubin S, He B, Örvell C, Drosten C, Herrler G.

Functional properties and genetic relatedness of the fusion and hemagglutinin-neuraminidase proteins of a mumps virus-like bat virus.

J Virol, 2015; 89:4539-48.

 

Cong Y, Li X, Bai Y, Lv X, Herrler G, Enjuanes L, Zhou X, Qu B, Meng F, Cong C, Ren X, Li G.

Porcine aminopeptidase N mediated polarized infection by porcine epidemic diarrhea virus in target cells.

Virology. 2015; 478:1-8.

 

Punyadarsaniya D, Winter C, Mork AK, Amiri M, Naim HY, Rautenschlein S, Herrler G.

Precision-cut intestinal slices as a culture system to analyze the infection of differentiated intestinal epithelial cells by avian influenza viruses.

J Virol Methods. 2015; 212:71-5.

 

Krüger N, Hoffmann M, Drexler JF, Müller MA, Corman VM, Drosten C, Herrler G.

The attachment protein G of an African bat henipavirus is differentially restricted in chiropteran and non-chiropteran cells.

J Virol. 2014; 88:11973-80.

 

Mork AK, Hesse M, Abd El Rahman S, Rautenschlein S, Herrler G, Winter C.

Differences in the tissue tropism to chicken oviduct epithelial cells between avian coronavirus IBV strains QX and B1648 are not related to the sialic acid binding properties of their spike proteins.

Vet Res. 2014; 45:67

 

Delgado-Ortega M, Melo S, Punyadarsaniya D, Ramé C, Olivier M, Soubieux D, Marc D, Simon G, Herrler G, Berri M, Dupont J, Meurens F.

Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine trachea cells, alveolar macrophages, and precision-cut lung slices.

Vet Res. 2014; 45:42.

 

Kirchhoff J, Uhlenbruck S, Keil GM, Schwegmann-Wessels C, Ganter M, Herrler G. 2014.

Infection of differentiated airway epithelial cells from caprine lungs by viruses of the bovine respiratory disease complex.

Vet Microbiol. 2014; 170(1-2):58-64.

 

Paul A, Trincone A, Siewert S, Herrler G, Schwegmann-Weßels C.

A lysine-methionine exchange in a coronavirus surface protein transforms a retention motif into an endocytosis signal.

Biol Chem. 2014; 395(6):657-65.


Sauer AK, Liang CH, Stech J, Peeters B, Quéré P, Schwegmann-Wessels C, Wu CY, Wong CH, Herrler G.

Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

PLoS One. 2014; 9(2):e89529.

 

Kirchhoff J, Uhlenbruck S, Goris K, Keil GM, Herrler G. 2014.

Three viruses of the bovine respiratory disease complex apply different strategies to initiate infection.

Vet Res. 45:20.

 

Weis M, Behner L, Hoffmann M, Krüger N, Herrler G, Drosten C, Drexler JF, Dietzel E, Maisner A.

Characterization of African bat henipavirus GH-M74a glycoproteins.

J Gen Virol. 2014; 95:539-48.

 

Meng F, Punyadarsaniya D, Uhlenbruck S, Hennig-Pauka I, Schwegmann-Wessels C, Ren X, Dürrwald R, Herrler G.

Replication characteristics of swine influenza viruses in precision-cut lung slices reflect the virulence properties of the viruses.

Vet Res. 2013; 44:110

 

Krüger N, Hoffmann M, Weis M, Drexler JF, Müller MA, Winter C, Corman VM, Gützkow T, Drosten C, Maisner A, Herrler G.

Surface glycoproteins of an African henipavirus induce syncytium formation in a cell line derived from an African fruit bat, Hypsignathus monstrosus.

J Virol. 2013; 87:13889-91.

 

Hoffmann M, Müller MA, Drexler JF, Glende J, Erdt M, Gützkow T, Losemann C, Binger T, Deng H, Schwegmann-Weßels C, Esser KH, Drosten C, Herrler G.

Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.

PLoS One 2013; 8(8):e72942.

 

Matrosovich M, Herrler G, Klenk HD.

Sialic Acid Receptors of Viruses.

Top Curr Chem. 2013;

 

Corman VM, Rasche A, Diallo TD, Cottontail VM, Stöcker A, Souza BF, Corrêa JI, Carneiro AJ, Franke CR, Nagy M, Metz M, Knörnschild M, Kalko EK, Ghanem SJ, Morales KD, Salsamendi E, Spínola M, Herrler G, Voigt CC, Tschapka M, Drosten C, Drexler JF.

Highly diversified coronaviruses in neotropical bats.

J Gen Virol. 2013; 94:1984-94.

 

Drexler JF, Corman VM, Müller MA, Maganga GD, Vallo P, Binger T, Gloza-Rausch F, Cottontail VM, Rasche A, Yordanov S, Seebens A, Knörnschild M, Oppong S, Adu Sarkodie Y, Pongombo C, Lukashev AN, Schmidt-Chanasit J, Stöcker A, Carneiro AJ, Erbar S, Maisner A, Fronhoffs F, Buettner R, Kalko EK, Kruppa T, Franke CR, Kallies R, Yandoko ER, Herrler G, Reusken C, Hassanin A, Krüger DH, Matthee S, Ulrich RG, Leroy EM, Drosten C.

Bats host major mammalian paramyxoviruses.

Nat Commun. 2012; 3:796.

 

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