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Emmy Noether-Nachwuchsgruppe

Anschrift:

Bünteweg 17, 30559 Hannover

Kontaktdaten:

Frau PD Dr. med. vet. Christel Schwegmann-Weßels
Telefon: 0511-953 8842

Fax: 0511-953 8898
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Team

 

Forschungsschwerpunkte

  • RNA-Viren: Virusinfektionen des Schweins, respiratorische und enterale Virusinfektionen (Coronaviren, Influenzaviren)
  •  Wirtsadaptation von Corona- und Influenzaviren
  •  Mechanismen des Zusammenbaus von Viruspartikeln, der Virusreifung und des Virusaustritts
  • Zellbiologie der Infektion mit Coronaviren
  • Etablierung von ex vivo Infektionsmodellen (Lunge, Darm)

Ausgewählte Projekte

  • “Die Retention des S-Proteins des Virus der übertragbaren Gastroenteritis der Schweine (TGEV): Bedeutung der Interaktion mit viralen und wirtszelleigenen Proteinen)“ (DFG, Emmy Noether-Programm, seit 2008)
  • “Mechanismen des Speziesübergangs bei tier- und humanpathogenen Coronaviren in Fledermäusen” (EWI-Zoonosen (Erreger-Wirt-Interaktionen bei Zoonosen) Programm)
  • “Importance of the haemagglutinin in the adaptation of influenza viruses to the respiratory epithelium of new hosts” (BMBF, Zoonosen-Forschungsverbund FluReserachNet, 2008 – 2013)

Ausgewählte Publikationen

Trincone, A. and C. Schwegmann-Weßels.2014.

Looking for a needle in a haystack: Cellular proteins that may interact with the tyrosine-based sorting signal of the TGEV S protein.
Virus Res. 2014 Dec 3. pii: S0168-1702(14)00504-8. doi: 10.1016/j.virusres.2014.11.029. [Epub ahead of print]

 

Gelhaus, S., Thaa, B., Eschke, K., Veit, M., C. Schwegmann-Weßels. 2014.

Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S-M interaction.
Virology 2014 Sep;464-465:397-405. doi: 10.1016/j.virol.2014.07.035. Epub 2014 Aug 9.

Paul, A., Trincone, A., Siewert, S., Herrler, G., C. Schwegmann-Weßels. 2014.

A lysine-methionine exchange in a coronavirus surface protein transforms a retention motif into an endocytosis signal.
Biol Chem. 2014 Jun;395(6):657-65. doi: 10.1515/hsz-2013-0282.

Kirchhoff, J., Uhlenbruck, S., Keil, G.M., Schwegmann-Wessels, C., Ganter, M., G. Herrler. 2014.

Infection of differentiated airway epithelial cells from caprine lungs by viruses of the bovine respiratory disease complex.
Vet Microbiol. 2014 May 14;170(1-2):58-64. doi: 10.1016/j.vetmic.2014.01.038. Epub 2014 Feb 9.

Sauer, A.K., Liang, C.H., Stech, J., Peeters, B., Quéré, P., Schwegmann-Wessels, C., Wu, C.Y., Wong, C.H., G. Herrler. 2014.

Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.
PLoS One. 2014 Feb 21;9(2):e89529. doi: 10.1371/journal.pone.0089529. eCollection 2014.

Meng, F., Punyadarsaniya, D., Uhlenbruck, S., Hennig-Pauka, I., Schwegmann-Wessels, C., Ren, X., Dürrwald, R., G. Herrler. 2013.

Replication characteristics of swine influenza viruses in precision-cut lung slices reflect the virulence properties of the viruses.
Vet Res. 2013 Nov 13;44:110. doi: 10.1186/1297-9716-44-110.

Hoffmann, M., Müller, M.A., Drexler, J.F., Glende, J., Erdt, M., Gützkow, T., Losemann, C., Binger, T., Deng, H., Schwegmann-Weßels, C., Esser, K.H., Drosten, C., G. Herrler. 2013.

Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.
PLoS One. 2013 Aug 30;8(8):e72942. doi: 10.1371/journal.pone.0072942. eCollection 2013.

 

Meng, F., Ren, Y., Suo, S., Sun, X., Li, X., Li, P., Yang, W., Li, G., Li, L., Schwegmann-Wessels, C., Herrler, G., X. Ren. 2013.
Evaluation on the efficacy and immunogenicity of recombinant DNA plasmids expressing spike genes from porcine transmissible gastroenteritis virus and porcine epidemic diarrhea virus.
PLoS One. 2013; 8(3):e57468. Epub 2013 Mar 19.

 

Punyadarsaniya, D., Liang, C.H., Winter, C., Petersen, H., Rautenschlein, S., Hennig-Pauka, I., Schwegmann-Wessels, C., Wu, C.Y., Wong, C.H., G. Herrler. 2011.
Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses.
PLoS One.2011; 6(12):e28429. Epub 2011 Dec 9.

 

Pfefferle, S., Schöpf, J., Kögl, M., Friedel, C.C., Müller, M.A., Carbajo-Lozoya, J., Stellberger, T., von Dall'armi, E., Herzog, P., Kallies, S., Niemeyer, D., Ditt, V., Kuri, T., Züst, R., Pumpor, K., Hilgenfeld, R., Schwarz, F., Zimmer, R., Steffen, I., Weber, F., Thiel, V., Herrler, G., Thiel, H.J., Schwegmann-Weßels, C., Pöhlmann, S., Haas, J., Drosten, C., A. von Brunn. 2011.
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors.
PLoS Pathog. Oct 7(10):e1002331. Epub 2011 Oct 27.

 

Schwegmann-Wessels, C., Bauer, S., Winter, C., Enjuanes, L., Laude, H., G. Herrler. 2011.
The sialic acid binding activity of the S protein facilitates infection by porcine transmissible gastroenteritis coronavirus.
Virol J. Sep 12;8(1):435.


Yin, J., Glende, J., Schwegmann-Wessels, C., Enjuanes, L., Herrler, G., X. Ren. 2010.
Cholesterol is important for a post-adsorption step in the entry process of transmissible gastroenteritis virus.
Antiviral Res. 88(3):311-6.

 

Schwegmann-Weßels, C., J. Glende, X. Ren, X. Qu, H. Deng, L. Enjuanes, G. Herrler. 2009.
Comparison of vesicular stomatitis virus pseudotyped with the S proteins from a porcine and a human coronavirus.
J. Gen. Virol. 90:1724-1729.

 

Goris, K., S. Uhlenbruck, C. Schwegmann-Weßels, W. Köhl, F. Niedorf, M. Stern, M. Hewicker-Trautwein, R. Bals, G. Taylor, A. Braun, G. Bicker, M. Kietzmann and G. Herrler. 2009.
Differential sensitivity of differentiated epithelial cells to respiratory viruses reveals different viral strategies of host infection.
J. Virol. 83:1962-1968.

 

Schwegmann-Weßels C. and G. Herrler. 2008.
Identification of sugar residues involved in the binding of TGEV to porcine brush border membranes.
Methods Mol Biol. 454:319-329.

 

Glende, J., C. Schwegmann-Weßels, M. Al-Falah, S. Pfefferle, X. Qu, H. Deng, C. Drosten, H. Y. Naim, and G. Herrler. 2008.
Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS coronavirus with the cellular receptor angiotensin-converting enzyme 2.
Virology. 381(2):215-221.

 

Ren, X., J. Glende, J. Yin, C. Schwegmann-Weßels, and G. Herrler. 2008.
Importance of cholesterol for infection of cells by transmissible gastroenteritis virus.
Virus Res. 137(2):220-224.

 

Winter, C., C. Schwegmann-Wessels, U. Neumann, and G. Herrler. 2008.
The Spike Protein of Infectious Bronchitis Virus Is Retained Intracellularly by a Tyrosine Motif.
J. Virol. 82:2765-2771.

 

Schwegmann-Wessels, C. and G. Herrler. 2006.
Transmissible gastroenteritis virus infection: a vanishing specter.
Dtsch. Tierarztl. Wochenschr. 113:157-159.

 

Schwegmann-Weßels, C., X. Ren, and G. Herrler. 2006.
Intracellular transport of the S proteins of coronaviruses.
Adv. Exp. Med. Biol. 581:271-275.

 

Ren, X., J. Glende, M. Al Falah, V. de Vries, C. Schwegmann-Wessels, X. Qu, L. Tan, T. Tschernig, H. Deng, H. Y. Naim, and G. Herrler. 2006.
Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus.
J. Gen. Virol. 87:1691-1695.

 

Winter, C., C. Schwegmann-Wessels, D. Cavanagh, U. Neumann, and G. Herrler. 2006.
Sialic acid is a receptor determinant for infection of cells by avian Infectious bronchitis virus.
J. Gen. Virol. 87:1209-1216.

 

Schwegmann-Wessels, C. and G. Herrler. 2006.
Sialic acids as receptor determinants for coronaviruses. Minireview.
Glycoconj. J. 23:51-58.

 

Hanika, A., B. Larisch, E. Steinmann, C. Schwegmann-Wessels, G. Herrler, and G. Zimmer. 2005.
Use of influenza C virus glycoprotein HEF for generation of vesicular stomatitis virus pseudotypes.
J. Gen. Virol. 86:1455-1465.

 

Schwegmann-Wessels C, Al-Falah M, Escors D, Wang Z, Zimmer G, Deng H, Enjuanes L, Naim HY, Herrler G. 2004.

A novel sorting signal for intracellular localization is present in the S protein of a porcine coronavirus but absent from severe acute respiratory syndrome-associated coronavirus.

J Biol Chem. 279(42):43661-6. Epub 2004 Aug 10.

 

Schwegmann-Wessels C, Zimmer G, Schroder B, Breves G, Herrler G. 2003.

Binding of transmissible gastroenteritis coronavirus to brush border membrane sialoglycoproteins.

J Virol. 77(21):11846-8.

 

Schwegmann-Wessels C, Zimmer G, Laude H, Enjuanes L, Herrler G. 2002.

Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins.

J Virol. 76(12):6037-43.

 

Schwegmann C, Zimmer G, Herrler G. 2001.

Are intestinal mucins involved in the pathogenicity of transmissible gastroenteritis coronavirus?

Adv Exp Med Biol. 494:219-23.

 

Schwegmann C, Zimmer G, Yoshino T, Enss M, Herrler G. 2001.

Comparison of the sialic acid binding activity of transmissible gastroenteritis coronavirus and E. coli K99.

Virus Res. 75(1):69-73.

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