Prof. Dr. Hassan Y. Naim

• Jones K, Sim L, Mohan S, Kumarasamy J, Liu H, Avery S, Naim HY, Quezada-Calvillo R, Nichols BL, Pinto BM, Rose DR
  Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase
  Bioorg Med Chem. 2011 Jul 1;19(13):3929-34
• Reinke Y, Behrendt M, Schmidt S, Zimmer KP, Naim HY
  Impairment of protein trafficking by direct interaction of gliadin peptides with actin
  Exp Cell Res. 2011 Sep 10;317(15):2124-35
• Meyer W, Schmidt J, Busche R, Jacob R, Naim HY
  Demonstration of free fatty acids in the integument of semi-aquatic and aquatic mammals
  Acta Histochem. 2011 Apr 25. [Epub ahead of print]
• Hein Z, Schmidt S, Zimmer KP, Naim HY
  The dual role of annexin II in targeting of brush border proteins and in intestinal cell polarity
  Differentiation. 2011 Apr;81(4):243-52
• Zimmer KP, Heine M, Weissen-Plenz G, Scholand KA, Herbst H, Naim HY
  TGF{alpha}-associated MUC2 and MUC3 expression of the gastric epithelium in Menetrier's disease during remission of ulcerative colitis
  Gut 2011 Feb 8 [Epub ahead of print]
• Maalouf K, Jia J, Rizk S, Brogden G, Keiser M, Das A, Naim HY
  A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV
  J Inherit Metab Dis. 2010 Aug;33(4):445-9
• Sim L, Willemsma C, Mohan S, Naim HY, Pinto BM, Rose DR
  Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains
  J Biol Chem. 2010 Mar 31. [Epub ahead of print]
• Krahn MP, Rizk S, Alfalah M, Behrendt M, Naim HY
  Protocadherin of the liver, kidney and colon associates with detergent-resistant membranes during cellular differentiation
  J Biol Chem. 2010 Apr 23;285(17):13193-200
• Zimmer KP, Fischer I, Mothes T, Weissen-Plenz G, Schmitz M, Wieser H, Mendez E, Buening J, Lerch MM, Ciclitira PC, Weber P, Naim HY
  Endocytotic Segregation of Gliadin Peptide 31-49 in Enterocytes
  Gut. 2010 Mar;59(3):300-10
• Behrendt M, Polaina J, Naim HY
  Structural hierarchy of regulatory elements in the folding and transport of an intestinal multi-domain protein
  J Biol Chem. 2010 Feb 5;285(6):4143-52
• Das AM, Naim HY
  Biochemical basis of Fabry disease with emphasis on mitochondrial function and protein trafficking
  Adv Clin Chem. 2009;49:57-71
• Lücke T, Keiser M, Illsinger S, Lentze MJ, Naim HY, Das AM
  Congenital and putatively acquired forms of sucrase-isomaltase deficiency in infancy: effects of sacrosidase therapy
  J Pediatr Gastroenterol Nutr. 2009 Oct;49(4):485-7
• Kahlisch D, Buettner FF, Naim HY, Gerlach GF
  Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection
  Vet Res. 2009 Nov-Dec;40(6):60
• Lindner R, Naim HY
  Domains in biological membranes
  Exp Cell Res. 2009 Oct 15;315(17):2871-8
• Reinke Y, Zimmer KP, Naim HY
  Toxic peptides in Frazer's fraction interact with the actin cytoskeleton and affect the targeting and function of intestinal proteins
  Exp Cell Res. 2009 Nov 15;315(19):3442-52
• Wetzel G, Heine M, Rohwedder A, Naim HY
  Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase
  Biol Chem. 2009 Jul;390(7):545-9
• Colombatti M, Grasso S, Porzia A, Fracasso G, Scupoli MT, Cingarlini S, Poffe O, Naim HY, Heine M, Tridente G, Mainiero F, Ramarli D
  The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways
  PLoS ONE. 2009;4(2):e4608. Epub 2009 Feb 26
• Behrendt M, Keiser M, Hoch M, Naim HY
  Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency
  Gastroenterology. 2009 Jun;136(7):2295-303
• Meyer W, Schmidt J, Busche R, Jacob R, Naim HY
  Demonstration of lipids in plastic resin-embedded sections of skin material
  J Microsc. 2009 Jan;233(1):5-9
• Alfalah M, Keiser M, Leeb T, Zimmer KP, Naim HY
  Compound Heterozygous Mutations Affect Protein Folding and Function in Patients With Congenital Sucrase-Isomaltase Deficiency
  Gastroenterology. 2009 Mar;136(3):883-92
• Gemeinhardt A, Alfalah M, Gück T, Naim H, Fuhrmann H
  The influence of linoleic and linolenic acid on activity and intracellular localisation of phospholipase D in COS-1 cells
  Biol Chem. 2009 Mar;390(3):253-8
• Hein Z, Hooper NM, Naim HY
  Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway
  Exp Cell Res. 2009 Jan 15;315(2):348-56
• Glende J, Schwegmann-Wessels C, Al-Falah M, Pfefferle S, Qu X, Deng H, Drosten C, Naim HY, Herrler G
  Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2
  Virology. 2008 Nov 25;381(2):215-21
• Templin C, Kotlarz D, Faulhaber J, Schnabel S, Grote K, Salguero G, Luchtefeld M, Hiller KH, Jakob P, Naim HY, Schieffer B, Hilfiker-Kleiner D, Landmesser U, Limbourg FP, Drexler H
  Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: Role of β-catenin transduction and cell dose
  J Mol Cell Cardiol. 2008 Sep;45(3):394-403
• Kreutzer R, Kreutzer M, Pröpsting MJ, Sewell AC, Naim HY, Leeb T, Baumgärtner W
  Insights into post-translational processing of beta-galactosidase in an animal model resembling late infantile human G(M1)-gangliosidosis
  J Cell Mol Med. 2008 Sep-Oct;12(5A):1661-712007
• Reinshagen K, Keller KM, Haase B, Leeb T, Naim HY, Zimmer KP
  Mosaic Pattern of Sucrase Isomaltase Deficiency in Two Brothers
  Pediatr Res. 2008 Jan;63(1):79-83
• Castelletti D, Alfalah M, Heine M, Hein Z, Schmitte R, Fracasso G, Colombatti M, Naim HY
  Different glycoforms of prostate-specific membrane antigen are intracellularly transported through their association with distinct detergent-resistant membranes
  Biochem J. 2008 Jan 1;409(1):149-57
• Liman M, Peiser L, Zimmer G, Propsting M, Naim HY, Rautenschlein S
  A genetically engineered prime-boost vaccination strategy for oculonasal delivery with poly(d,l-lactic-co-glycolic acid) microparticles against infection of turkeys with avian Metapneumovirus
  Vaccine 2007 Nov 14;25(46):7914-26
• Seeliger F, Hess O, Propsting MJ, Naim HY, Kleinschmidt S, Woehrmann T, Germann PG, Baumgartner W
  Confocal laser scanning analysis of an equine oral mast cell tumor with atypical expression of tyrosine kinase receptor C-KIT
  Vet Pathol. 2007 Mar;44(2):225-8. Erratum in: Vet Pathol. 2007 May;44(3):427
• Frerker N, Wagner L, Wolf R, Heiser U, Hoffmann T, Rahfeld JU, Schade J, Karl T, Naim HY, Alfalah M, Demuth HU, von Horsten S
  Neuropeptide Y (NPY) cleaving enzymes: Structural and functional homologues of dipeptidyl peptidase 4
  Peptides 2007 Feb;28(2):257-68
• Mundhenk L, Alfalah M, Elble RC, Pauli BU, Naim HY, Gruber AD
  Both cleavage products of the mCLCA3 protein are secreted soluble proteins
  J Biol Chem. 2006 Oct 6;281(40):30072-80
  
• Templin C, Kotlarz D, Marquart F, Faulhaber J, Brendecke V, Schaefer A, Tsikas D, Bonda T, Hilfiker-Kleiner D, Ohl L, Naim HY, Foerster R, Drexler H, Limbourg FP
  Transcoronary delivery of bone marrow cells to the infarcted murine myocardium: Feasibility, cellular kinetics, and improvement in cardiac function
  Basic Res Cardiol. 2006 Jul;101(4):301-10
• Ren X, Glende J, Al-Falah M, de Vries V, Schwegmann-Wessels C, Qu X, Tan L, Tschernig T, Deng H, Naim HY, Herrler G
  Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus
  J Gen Virol. 2006 Jun;87(Pt 6):1691-5.
• Keiser M, Alfalah M, Propsting MJ, Castelletti D, Naim HY
  Altered folding, turnover, and polarized sorting act in concert to define a novel pathomechanism of congenital sucrase-isomaltase deficiency
  J Biol Chem. 2006 May 19;281(20):14393-9
  
• Alfalah M, Krahn MP, Wetzel G, von Hoersten S, Wolke C, Hooper NM, Kalinski T, Krueger S, Naim HY, Lendeckel U
  A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukaemia leads to an arrest in the endoplasmic reticulum
  J Biol Chem. 2006 Apr 28;281(17):11894-900
  
• Delacour D, Cramm-Behrens CI, Drobecq H, Le Bivic A, Naim HY, Jacob R
  Requirement for galectin-3 in apical protein sorting
  Curr Biol. 2006 Feb 21;16(4):408-14
  
• van Barneveld A, Stanke F, Ballmann M, Naim HY, Tummler B
  Ex vivo biochemical analysis of CFTR in human rectal biopsies
  Biochim Biophys Acta. 2006 Apr;1762(4):393-7
• Sander, P, Alfalah M, Keiser, M, Korponay-Szabo I, Kovacs JB, Leeb T, Naim HY Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption
  Hum Mutat. 2006 Jan;27(1):119
• Castelletti D, Fracasso G, Alfalah M, Cingarlini S, Colombatti M, Naim HY
  Apical transport and folding of prostate specific membrane antigen occurs independent of glycans processing
  J Biol Chem. 2006;281(6):3505-12
• Schmitz M, Alfalah M, Aerts JM, Naim HY, Zimmer KP
  Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease
  Int J Biochem Cell Biol. 2005 Nov; 37(11):2310-20
• Vetterkind S, Illenberger S, Kubicek J, Boosen M, Appel M, Naim HY, Scheidtmann KH, Preuss U
  Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis
  Exp Cell Res. 2005 May 1; 305(2):392-408
• Heine M, Cramm-Behrens CI, Ansari A, Chu HP, Ryazanov AG, Naim HY, Jacob R
  Alpha-kinase 1, a new component in apical protein transport
  J Biol Chem. 2005 May 9 280(27):25637-43
• Breidert S, Jacob R, Ngezahayo A, Kolb HA, Naim HY
  Trafficking pathways of Cx49-GFP in living mammalian cells
  Biol Chem. 2005 Feb; 386(2):155-60
• Marcus J. Pröpsting, Heike Kanapin, Ralf Jacob, and Hassan Y. Naim
  A Phenylalanine-based Folding Determinant in Intestinal Sucrase-Isomaltase that Functions in the Context of a Quality Control Mechanism beyond the Endoplasmic Reticulum
  J Cell Science. 2005 June; 118: 2763-2773
• Schwegmann-Wessels C, Al-Falah M, Escors D, Wang Z, Zimmer G, Deng H, Enjuanes L, Naim HY, Herrler G
  A novel sorting signal for intracellular localization is present in the S protein of a porcine coronavirus but absent from SARS-associated coronavirus
  J Biol Chem. 2004; 279(42):43661-66
• Kersting S, Bruewer M, Schuermann G, Klotz A, Utech M, Hansmerten M, Krieglstein CF, Senninger N, Schulzke JD, Naim HY, Zimmer KP
  Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases
  Am J Pathol. 2004 Aug;165(2):425-37
• Jacob R, Heine M, Eikemeyer J, Frerker N, Zimmer KP, Rescher U, Gerke V, Naim HY
  Annexin II is required for apical transport in polarized epithelial cells
  J Biol Chem. 2004 Jan 30;279(5):3680-4
• Valentina Ritz, Marwan Alfalah, Klaus-Peter Zimmer, Jacques Schmitz, Ralf Jacob and Hassan Y. Naim
  Congenital sucrase-isomaltase deficiency arising from a mutant form of sucrase-isomaltase that accumulates in the endoplasmic reticulum
  Gastroenterology. 2003; 125(6):1678-1685
• Proepsting MJ, Jacob R, Naim HY
  A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the ER and cis-Golgi
  J Biol Chem. 2003 May 2;278(18):16310-4
• Jacob R, Heine M, Alfalah M, Naim HY
  Distinct cytoskeletal tracks direct individual vesicle populations to the apical membrane of epithelial cells
  Curr Biol. 2003 Apr 1;13(7):607-12
• Nemeth K, Plumb GW, Berrin JG, Juge N, Jacob R, Naim HY, Williamson G, Swallow DM, Kroon PA
  Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
  Eur J Nutr. 2003 Feb;42(1):29-42
• Alfalah M, Jacob R, Naim HY
  Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains
  J Biol Chem. 277 12, (2002) 10683-90
• Backofen B, Jacob R, Serth K, Gossler A, Naim HY, Leeb T
  Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein
  Eur J Biochem. 269, 21 (2002) 5240-5
• Jacob R, Peters K, Naim HY
  The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme
  J Biol Chem.277 10, (2002) 8217-25
• Jacob R, Purschel B, Naim HY
  Sucrase is an intramolecular chaperone located at the C-terminal end of the sucrase-isomaltase enzyme complex
  J Biol Chem. 277 35, (2002) 32141-8
• Reinshagen K, Naim HY, Zimmer KP
  Autophagocytosis of the apical membrane in microvillus inclusion disease
  Gut. 51 4, (2002) 514-21
• Alfalah M, Parkin ET, Jacob R, Sturrock ED, Mentele R, Turner AJ, Hooper NM, Naim HY
  A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase
  J Biol Chem. 2001 Jun 15;276(24):21105-9
• Jacob R, Naim HY
  Apical membrane proteins are transported in distinct vesicular carriers
  Curr Biol. 2001 Sep 18;11(18):1444-50
• Naim HY
  Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase
  Histol Histopathol. 2001 Apr;16(2):553-61
• Spodsberg N, Jacob R, Alfalah M, Zimmer KP, Naim HY
  Molecular basis of aberrant apical protein transport in an intestinal enzyme disorder
  J Biol Chem. 2001 Jun 29;276(26):23506-10
• Spodsberg N, Alfalah M, Naim HY
  Characteristics and structural requirements of apical sorting of the rat growth hormone through the O-glycosylated stalk region of intestinal sucrase-isomaltase
  J Biol Chem. 2001 Dec 7;276(49):46597-604
• Jacob R, Zimmer KP, Schmitz J, Naim HY
  Congenital sucrase-isomaltase deficiency arising from cleavage and secretion of a mutant form of the enzyme
  J Clin Invest. 2000 Jul;106(2):281-7
• Jacob R, Weiner JR, Stadge S, Naim HY
  Additional N-glycosylation and its impact on the folding of intestinal lactase-phlorizin hydrolase.
  J Biol Chem. 2000 Apr 7;275(14):10630-7
• Jacob R, Alfalah M, Grunberg J, Obendorf M, Naim HY
  Structural determinants required for apical sorting of an intestinal brush-border membrane protein.
  J Biol Chem. 2000 Mar 3;275(9):6566-72

     (seit 2000)