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Dr. rer. hum. biol. Jochen Kruppa

 

Research Fellow, Genomics and Bioinformatics of Infectious Diseases

 

Institute for Animal Breeding and Genetics

University of Veterinary Medicine Hannover, Foundation
Bünteweg 17p
D-30559 Hannover


Telefon: +49 511 953-8869
Fax:        +49 511 953-8582

E-Mail:   jochen.kruppa@tiho-hannover.de

Curriculum Vitae

Since 01.2016

Postdoctoral Research Fellow, Genomics and Bioinformatics of Infectious Diseases, Institute for Animal Breeding and Genetics, University of Veterinary Medicince Hannover

 

2014 - 2015

Postdoctoral Research Fellow, Core Facility Medical Biometry and Statistical Bioinformatics, Department of Medical Statistics, University Medical Center Göttingen

 

2013 - 2014

Postdoctoral Research Fellow, Animal Breeding and Genetics, University Göttingen

 

2013

PhD (Dr. rer. hum. biol.), Institute of Medical Biometry and Statistics, University of Lübeck

 

2009 - 2013

Postdoctoral Research Fellow, Institute of Medical Biometry and Statistics, University of Lübeck

 

2007 - 2009

Studies of Plant Biotechnology (Master of Sience) with major biostatistics, Leibniz Universität Hannover

 

2004 - 2007

Studies of Plant Biotechnology (Bachelor of Sience) with major quantitative genetics, Leibniz Universität Hannover

 

1983

Born in Uelzen

Publications

Journal Articles

 

Kruppa J, Kramer K, Beißbarth T and Jung K (2016): A simulation framework for correlated count data of feature subsets in high-throughput sequencing or proteomics experiments. Statistical Applications in Genetics and Molecular Biology, 15, 401-414. [abstract]

 

Stitzieli, N.O.*, Stirrupsiii, K.E.*, Mascav, N.G.D.*,  Erdmann, J.*, Ferrario, P., Weeke P.E., Auer, P.L., Schick, U., Lu, Y.,  Zhang, H., Dube, M-P., Goel, A., Farrall, M., Koenig, I., Do, R., Peloso,  G.M., van Iperen, E., Kanoni, S., Kruppa, J., Mahajan, A., Scott, R.A., Webb, T.R., Willenborg, C., Braund, P.S., van Capelle, J., Doney,   A.S.F., Donnely, L.A., Asselta, R., Merlin, P., Duga, S., Marzilian, N.,   Denny, J.C., Shaffer, C., El-Mokhtar, N.E., Franke, A.,, Gottesman, O.,  Heilmann, S.,  Hengstenberg, C., Hoffmann, P., Holmen, O.L., Hveem, K.,  Jansson, J-H., Jöcke, K-H., Kessler, T., Kriebel, J., Laugwitz K.L.,  Marouli, E., Martinell, N., McCarthy, M.I., Meisinger, C., Esko, T., Mihailov, E., Escher, S.A., Alver, M., Moebus, S., Morris, A.D.,  Müller-Nurasyid, M., Nikpay, M., Olivier, O., Perreault, L-P.L., Qarawi,  A., Robertson, N.R., Akinsansya, K.O., Reilly, D.F., Vogt, T.F., Yin, W.,  Asselbergs, F.W., Kooperberg, C., Jackson, R., Stahl, E., Strauch, K., Varga,  T.V., Waldenberger, M., Wellcome Trust Case Control Consortium, Zeng, L., Chowdhury, R., Ferrario, M., Ford, I., Howson J.M.M., Jukemal, J.W.,  Keel, F., Kuulasmaa, K., MORGAM Investigators,  Müller-Nurasyid, M.,  Nordestgaard, B.G., Perola, M. Saleheen, D., Sattar,  N., Surendran, P.,  Tregouet, D., Young, R., utterworth, A.S., Danesh, J., Ardissino, D.,  Bottinger, E.P.,  Erbel, R., Franks, P.W., Girell, D.,  all, A.S.,  Hovingh, G.K., Kastrati, A., Lieb, W., Meitinger, T., Kraus, W.E., Shah,  S.H., McPherson, R., Orho-Melanderxcii, M., Melander, O.,  Metspalu, A.,  Palmer, C., Peters, A., Rader, D.J., Reilly, M.P., Loos,  R.J.F., Reiner  A.P., Roden, D.M., Tardiff, J-C., Thompson, J.R., Wareham,  N.J.,  Watkins, H., Willer, C.J., Kathiresan, S.*, Deloukas, P.*, Samani,  N.*,  and Schunkert, H.* (2016) Coding variation in ANGPTL4, LPL,  and SVEP1 and risk of coronary disease. N Engl J Med, 374(12), 1134-44 [abstract]

 

Homuth, G., Wahl, S., Müller, C., Schurmann, C., Mäder, U., Blankenberg, S., Carstensen, M., Dörr, M., Endlich, K., Englbrecht, C., Felix, S.B., Gieger, C., Grallert, H., Herder, C., Illig, T., Kruppa, J., Marzi, C.S., Mayerle, J., Meitinger, T., Metspalu, A., Nauck, M., Peters, A., Rathmann, W., Reinmaa, E., Rettig, R., Roden, M, Schillert, A., Schramm, K., Steil, L., Strauch, K., Teumer, A., Völzke, H., Wallaschofski, H., Wild, P.S., Ziegler, A., Völker, U., Prokisch, H. and Zeller, T. (2015) Extensive Alterations of the Whole-Blood Transcriptome are associated with Body Mass Index: Results of an mRNA Profiling Study involving two large Population-based Cohorts. BMC Med Genomics, 8(1), 65 [abstract

 

Brockmeyer, P., Hemmerlein, B., Kruppa, J., Kauffmann, P., Tröltzsch, M., Schliephake, H., Gruber, R.M. (2015) The time interval between primary surgery and adjuvant therapy determines prognosis of oral squamous cell carcinomas. Oral Oncol, 51(11), e82-5 [abstract]

 

Kunz, M., König, I., Schillert, A. Kruppa, J., Ziegler, A., Grallert, H., Müller-Nurasyid, M., Lieb, W., Franke, A., Ranki, A., Panelius, J., Koskenmies, S., Hasan, T., Kere, J., Rönn, A-C., Simon, J., Schmidt, E., Wenzel, J., Tüting, T., Landsberg, J., Zeller, T., Blankenberg, S., Gläser, R., Patsinakidis, N., Kuhn, A. and Ibrahim S. (2015) Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus. Exp Dermatol 24(7), 510-5 [abstract]

 

Crosby, J., Peloso, G.M., Auer, P.L., Crosslin, D. C., Stitziel, N. O., Lange, L. A., Lu, Y., Tang, Z.-Z., Zhang, H., Hindy, G., Masca, N., Stirrups, K., Kanoni, S., Do, R., Jun, G., Hu, Y., Min Kang, H., Xue, C., Goel, A., Farrall, M., Duga, S., Merlini, S. A., Asselta, R., Girelli, D., Olivieri, O., Martinelli, N., Yin, W., Reilly, D., Speliotes, E., Fox, C. S., Hveem, K., Holmen, O. L., Nikpay, M., Farlow, D. N., Assimes, T. L., Franceschini, N., Robinson, J., North, K. E., Martin, L. W., DePristo, M., Gupta, N., Escher, S. A., Jansson, J.-H., Van Zuydam, N., Palmer, C. N. A., Wareham, N., Koch, W., Meitinger, T., Peters, A., Lieb, W., Erbel, R., König, I. R., Kruppa, J., Degenhardt, F., Gottesman, O., Bottinger, E. P., O'Donnell, C. J., Psaty, B. M., Ballantyne, C. M., Abecasis, G., Ordovas, J. M., Melander, O., Watkins, H., Orho-Melander, M., Ardissino, D., Loos, R. J. F., McPherson, R., Willer, C. J., Erdmann, J., Hall, A. S., Samani, N. J., Deloukas, P., Schunkert, H., Wilson, J. G., Kooperberg, C., Rich, S. S., Tracy, R. P., Lin, D.-Y., Altshuler, D., Gabriel, S., Nickerson D. A., Jarvik, G. P., Cupples, L. A., Reiner, A. P.*, Boerwinkle, E.*, Kathiresan, S.*, (2014) Rare Loss-of-Function Mutations in the APOC3 Gene, Plasma Triglycerides, and Risk for Coronary Heart Disease. New Engl J Med 371, 22-31 [abstract]

 

Kruppa, J.*, Liu, Y.*, Biau, G., Kohler, M., König, I. R., Malley, J. D. und Ziegler A. (2013) Probability estimation with machine learning methods for dichotomous and multi-category outcome: Theory. Bim J 56, 534-63 [abstract]

 

Kruppa, J.*, Liu, Y.*, Biau, G., Kohler, M., König, I. R., Malley, J. D. und Ziegler A. (2013) Probability estimation with machine learning methods for dichotomous and multi-category outcome: Application. Bim J 56, 564-83 [abstract]

 

Kruppa, J.*, Schwarz, A.*, Arminger, G. and Ziegler A. (2013) Consumer credit risk: Individual probability estimates using machine learning. Expert Syst App. 40, 5125-5131 [abstract]

 

Boulesteix, A.-L., Janitza, S., Kruppa, J. und König I. R. (2012) Overview of Random Forest methodology and practical guidance with emphasis on computational biology and bioinformatics. WIREs Data Mining Knowl Discov 2, 493-507 [abstract]

 

Kruppa, J., Ziegler, A. und König, I. R. (2012) Risk estimation and risk prediction using machine-learning methods. Hum Genet 131, 1639-1654 [abstract]

 

Malley, J. D., Kruppa, J., Dasgupta, A., Malley, K. G. und Ziegler, A. (2012) Probability machines: consistent probability estimation using nonparametric learning machines. Methods Inf Med 51, 74-81 [abstract]

 

Schäfer, A., Emmert, S., Kruppa, J., Schubert, S., Tzvetkov, M., Mössner, R., Reich, K., Berking, C., Volkenandt, M., Pföhler, C., Schön, M. P., Vogt, T., König, I. R. und Reichrath, J. (2012) No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study. Arch Dermatol Res 304, 353-361 [abstract]

 

Schurmann, C.*, Heim, K.*, Schillert, A.*, Blankenberg, S., Carstensen, M., Dörr, M., Endlich, K., Felix, S. B., Gieger, C., Grallert, H., Herder, C., Hoffmann, W., Homuth, G., Illig, T. Kruppa, J., Meitinger, T., Müller, C., Nauck, M., Peters, A., Rettig, R., Roden, R, Strauch, K., Völker, U., Völzke, H., Wahl, S,. Wallaschofski, H., Wild, P.S., Zeller, T., Teumer, A.*, Prokisch, H.* und Ziegler, A.* (2012) Analyzing Illumina gene expression microarray data from different tissues: Methodological aspects of data analysis in the MetaXpress consortium. PLOS ONE 7, e50938 [abstract]

 

Books Chapter

 

Kruppa, J. and Jung, K. (2015) Set-based Test Procedures for the Functional Analysis of Protein Lists from Differential Analysis in Jung, K. (Hrsg.) Statistical Analysis in Proteomics (Methods in Molecular Biology) Humana Press. New York City.

 

Kruppa, J. (2014) Aktivierende Methoden für Biostatistik in Anwendungsfächern in Rauch, G., Muche, R., und Vonthein R. (Hrsg.) Zeig mir Biostatistik! Ideen und Material für einen guten Biometrie-Unterricht Springer Spektrum, Berlin.

 

Theses

 

Kruppa, J. (2013) Wahrscheinlichkeitsmaschinen: Konsistente maschinelle Lernverfahren zum Schätzen bedingter Wahrscheinlichkeiten. PhD Thesis, Institute of Medical Biometry and Statistics, University of Lübeck.

 

Kruppa, J. (2009) Simultaneous confidence intervals for fixed effect parameters in a linear mixed model. Master Thesis, Institut of Biostatistics, Leibniz Universität Hannover.

 

Kruppa, J. (2007) Analyses of crossover interference in recombinant inbred lines. Bachelor Thesis, Institut of Plant Genetics, Leibniz Universität Hannover.

Awards

3. Price for the best university teaching material in biometry 2013 [abstract]

Other Professional Activities

Anschrift
Stiftung Tierärztliche Hochschule Hannover
Institut für Tierzucht und Vererbungsforschung
Bünteweg 17p
30559 Hannover
Geschäftszimmer
Institutsdirektor
Prof. Dr. Ottmar Distl
Tel.:+49 511 953-8875
Fax.:+49 511 953-8582
Labor für Molekulargenetik
Schnell- & Themenzugriffe
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