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Publications

2014

 

Raddatz B, Hansmann F, Spitzbarth I, Kalkuhl A, Deschl U, Baumgärtner W, Ulrich R (2014):   Transcriptomic meta-analyses of Multiple Sclerosis and its experimental models. PLOS ONE. 2014 Jan 27;9(1):e86643. doi:10.1371/journal.pone.0086643.

 

Hensel N, Stockbrügger I, Rademacher S, Broughton N, Brinkmann H, Grothe C, Claus P (2014): Bilateral Crosstalk of Rho- and Extracellular-Signal-Regulated -Kinase (ERK) Pathways is Confined to an Unidirectional Mode in Spinal Muscular Atrophy (SMA). Cellular Signalling 2014, 26: 540-548.

 

 Kobeleva X, Wegner F, Brunotte I, Dadak M, Dengler R, Stangel M (2014): Varicella-zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with Natalizumab.J. Neuroinflammation. 2014 Jan 30;11(1):19. doi: 10.1186/1742-2094-11-19.

 

Seitz M, Beineke A, Singpiel A, Willenborg J, Dutow P, Goethe R, Valentin-Weigand P, Klos A, Baums DG (2014): Role of capsule and suilysin in mucosal infection of complement-deficient mice with Streptococcus suis. Infect Immun. 2014. Uun;82(6)2460-71.doi 10.1128/IAI.00080-14

Ulrich R, Puff C, Wewetzer K, Kalkuhl A, Deschl U, Baumgärtner W (2014): Transcriptional Changes in Canine Distemper Virus-Induced Demyelinating Leukoencephalitis Favor a Biphasic Mode of Demyelination. PLOS ONE.

2014 Apr 22;9(4):e95917. doi: 10.1371/journal.pone.0095917.

 

Jungwith N, Bodewes R, Osterhaus AD, Baumgärtner W, Wohlsein P (2014):

First report of a new alphaherpesvirus in a freshwater turtle (Pseudemys concinna concinna) kept in Germany. Vet  Microbiol. 2014 Jun 4;170(3-4):403-7. doi: 10.1016/j.vetmic.2014.02.029.

 

Dahm L, Ott, C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stocker W, Ehrenreich H (2014): Seroprevalence of autoantibodies against brain antigens in health and disease. Ann Neurol. 2014 May 23. doi: 10.1002/ana.24189.

 

Warnke C, von Geldern G, Markwerth P, Ehmel T, Hoepner R, gold R, Pawlita M, Mümpfel T, Mäurer M, Stangel M, Wegner F, Hohlfeld R, Straeten V, Limmroth V, Weber T, Hermsen D, Kleinschnitz C, Artung HP, Wattjes MP, Svenningson A, Major E, Olsson T, Kieseier BC, Adams O. (2014): Cerebrospinal Fluid JC Virus Antibody Index for Diagnosis of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy. Ann Neurol. 2014 Apr 11. doi:10.1002/ana.24153. 

 

Hoepner R, Ahlbrecht J, Faissner S, Schneider R, Dahlhaus S, Adams O, Raab P, Lukas C, Chan A, Stangel M, Gold R (2014): Clinical and paraclinical findings in natalizumab-associated infratentorial progressive multifocal leukoencephalopathy. J Neurol Neurosurg Psychiatry. 2014 Apr 3. doi: 10.1136/jnnp-2014-307582.

 

 Karelle Benardais K, Gudi V, Gai L, Neßler J, Singh V, Prajeeth C, Skripuletz T, Stangel M (2014): Long-Term Impact of Neonatal Inflammation on Demyelination and Remyelination in the Central Nervous System. GLIA 014 Oct; 62(10): 1659-70. doi:10.1002/glia.22706. Epub 2014 Jun 7
 
Fulde M, Hornef MW (2014): Maturation of the enteric mucosal innate immune system during the postnatal period. Immunological Reviews Vol. 260:21-34.
 

Pfaender  S, Cavalleri JM, Walter S, Doerrbecker J, Campana B, Brown RJ, Burbelo PD, Postel A, Hahn K, Kusuma A, Riebesehl N, Baumgärtner W, Becher P, Heim MH, Pietschmann T, Feige K, Steinmann E (2014): Clinical course of infection and viral tissue tropism of hepatitis C virus-like non-primate hepaciviruses. Hepatology 2014 Sep 12. doi: 10.1002/hep.27440.

 

Zhang K, Dupont A, Torow N, Gohde F, Leschner S, Lienenklaus S, Weiss S, Brinkmann MM, Kühnel M, Hensel M, Fulde M, Hornef MW (2014): Age-dependent enterocyte invation and microcolony formation by salmonella. PLoS Pathogen 2014 Sep 11;10(9): e1004385. doi: 10.1371/journal.ppat.1004385.

 

Stockinger S, Duerr CU, Fulde M, Dolowschiak T, Pott J, Yang I, Eibach D, Bäckhed F, Akira S, Suerbaum S, Brugman M, Hornef MW (2014): TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression. J Immunol. 2014 Sep 10. pii: 1302708.

 

Bodewes R, Lapp S, Hahn K, Habierski A, Förster C, König M, Wohlsein P, Osterhaus AD, Baumgärtner W. (2014): Novel canine bocavirus strain associated with severe enteritis in a dog litter. Vet Microbiol. 2014 1-8; Sep 6 pii: S0378-1135(14)00401-5. doi: 10.1016/j.vetmic.2014.08.025. 

 
Bodewes R, Lempp C, Schürch A, Habierski A, Hahn K, Lamers M, von Dörnberg K, Wohlsein P, Drexler JF, Haagmans B, Smits SL, Baumgärtner W, Osterhaus AD (2014): Novel divergent nidovirus in a python with pneumonia. J Gen Virol. 2014 Nov;95(Pt 11):2480-5. doi: 10.1099/vir.0.068700-0. Epub 2014 Jul 25.

 

Prajeeth CK, Beineke A, Iskandar CD, Gudi V, Herder V, Gerhauser I, Haist V, Teich R, Huehn J, Baumgärtner W, Stangel M (2014): Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. Journal of Neuroinflammation 2014;11:180.


Hornef MW, Fulde M (2014): Ontogeny of intestinal epithelial innate immune responses. Front. Immunol., 09 October 2014, doi: 10.3389/fimmu.2014.00474.

 

Skripuletz T, Schwenkenbecher P, Pars K, Stoll M, Conzen J, Bolat S, Pul R, Vonberg RP, Sedlacek L, Wurster U, Stangel M, Trebst C (2014): Importance of Follow-Up Cerebrospinal Fluid Analysis in Cryptococcal Meningoencephalitis. Dis Markers 2014;2014:162576.

 

Warnke C, Stettner M, Lehmensiek V, Dehmel T, Mausberg AK, von Geldern G, Gold R, Kümpfel T, Hohlfeld R, Mäurer M, Stangel M, Straeten V, Limmroth V, Weber T, Kleinschnitz C, Wattjes MP, Svenningson A, Olsson T, Hartung HP, Hermsen D, Tumani H, Adams O, Kieseier BC (2014): Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF. Mult Scler. 2014 Nov 12. pii: 1352458514556296



Bodewes R, Ruiz-Gonzalez A, Schapendonk CM, van den Brand JM, Osterhaus AD, Smits SL (2014): Viral metagenomic analysis of feces of wild small carnivores. Virol J. 2014 May 15;11:89. doi: 10.1186/1743-422X-11-89.

 

Bodewes R, Hapsari R, Rubio García A, Sánchez Contreras GJ, van de Bildt MW, de Graaf M, Kuiken T, Osterhaus AD (2014): Molecular epidemiology of seal parvovirus, 1988-2014. PLoS One. 2014 Nov 12;9(11):e112129. doi: 10.1371/journal.pone.0112129. eCollection 2014.


Bodewes R, Ruiz-Gonzalez A, Schürch AC, Osterhaus AD, Smits SL (2014): Novel divergent rhabdovirus in feces of red fox, Spain. Emerg Infect Dis. 2014 Dec;20(12):2172-4. doi: 10.3201/eid2012.140236.


Schläger C, Litke T, Flügel A, Odoardi F. (2014): In Vivo Visualization of (Auto)Immune Processes in the Central Nervous System of Rodents. Methods Mol Biol. 2014 Dec 31.

 

Segura M, Zheng H, de Greeff A, Gao GF, Grenier D, Jiang Y, Lu C, Maskell D, Oishi K, Okura M, Osawa R, Schultsz C, Schwerk C, Sekizaki T, Smith H, Srimanote P, Takamatsu D, Tang J, Tenenbaum T, Tharavichitkul P, Hoa NT, Valentin-Weigand P, Wells JM, Wertheim H, Zhu B, Gottschalk M, Xu J. (2015): Latest developments on Streptococcus suis: an emerging zoonotic pathogen. Part 1. Future Microbiol. 2014; 9:441–444; Part 2. Future Microbiol. 2014; 9:587-91 

 

2015

Bodewes R, Sánchez Contreras GJ, Rubio García A, Hapsari R, van de Bildt MW, Kuiken T, Osterhaus AD. (2014): Identification of DNA sequences that imply a novel gammaherpesvirus in seals. J Gen Virol. 2014 Dec 18. pii: vir.0.000029. doi: 10.1099/vir.0.000029.

 

Detje C, Lienenklaus S, Chhatbar C, Spanier J, Prajeeth C, Soldner , Tovey M, Schlüter D, Weiss S, Stangel M, Kalinke U (2015): Upon intranasal VSV infection astrocytes in the olfactory bulb are important IFN-β producers that protect from lethal encephalitis. J Virol. 2015 Mar;89(5):2731-8. doi: 10.1128/JVI.02044-14. Epub 2014 Dec 24

 

Krawczyk A, Dirks M, Kasper M, Buch A, Dittmer U , Giebel B, Wildschütz L, Busch M, Goergens A, Schneweis KE, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M & Bauer D (2015): Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody. PLOS One 2015, 14;10(1):e0116800.

 

Linker RA, Lee H, Flach AC, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F. (2015): Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage. Eur J Immunol. 2015 Jan 27. doi: 10.1002/eji.201444985.

 

Willenborg J, Huber C, Koczula A, Lange B, Eisenreich W, Valentin-Weigand P, Goethe R. (2015): Characterization of the Pivotal Carbon Metabolism of Streptococcus suis Serotype 2 under ex Vivo and Chemically Defined in Vitro Conditions by Isotopologue Profiling. J Biol Chem. 2015 Feb 27;290(9):5840-54. doi: 10.1074/jbc.M114.619163. Epub 2015 Jan 9.

 

Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgärtner W, Ulrich R. (2015): STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler’s murine encephalomyelitis. Neuropathology and Applied Neurobiology 2015 Apr, 41 (3) 347–370 doi: 10.1111/nan.12133

 

Bodewes R , Bestebroer TM , van der Vries E , Verhagen JH, Herfst S , Koopmans MP, Fouchier RAM, Pfankuche V, Wohlsein P, Siebert U, Baumgärtner W and Osterhaus ADME (2015):  Avian influenza A/H10N7 virus –associated mass deaths among harbor seals. Emerging Infectious Diseases, 2015 Apr;21(4):720-2.

 

De Buhr N, Stehr M, Neumann A, Naim HY, Valentin-Weigand P, von Köckritz-Blickwede M, Baums CG. (2015): Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap (NET) degradation during exponential growth. Microbiology 2015 Apr;161(Pt 4):838-50. doi: 10.1099/mic.0.000040. Epub 2015 Feb 9.

 

Raddatz BB, Lehmbecker A, Kalkuhl A, Deschl U, Baumgärtner W, Ulrich R. (2015): Transcriptional analysis of glial cell differentiation in postnatal murine spinal cord. Int J Dev Neurosci. 2015 May;42:24-36. doi: 10.1016/j.ijdevneu.2015.02.005. Epub 2015 Feb 19. 

 

Hammer C, Wanitchakool P, Sirianant L, Papiol S, Monnheimer M, Faria D, Ousingsawat J, Schramek N, Schmitt C, Margos G, Michel A, Kraiczy P, Pawlita M, Schreiber R, Schulz TF, Fingerle V, Tumani H, Ehrenreich H, Kunzelmann K. (2015): A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity. Mol Med. 2015 Feb 23;21(1):26-37. doi: 10.2119/molmed.2014.00219.

 

Förthmann B, Grothe C, Claus P (2015): A nuclear odyssey: Fibroblast Growth Factor -2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system. Cell Mol Life Sci. 2015 May;72(9):1651-62. doi: 10.1007/s00018-014-1818-6. Epub 2015 Jan 1. Review. 

 

Raddatz BB, Sun W, Brogden G, Sun Y, Kammeyer P, Kalkuhl A, Colbatzky F, Deschl U, Naim HY, Baumgärtner W, Ulrich R. (2015): Central Nervous System Demyelination and Remyelination is Independent from Systemic Cholesterol Level in Theiler's Murine Encephalomyelitis. Brain Pathol. 2015 May 11. doi: 10.1111/bpa.12266.

 

Funk C, Ott M, Raschbichler V, Nagel CH, Binz A, Sodeik B, Bauerfeind R, Bailer SM. (2015): The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. PLoS Pathog. 2015 Jun 17;11(6):e1004957. doi: 10.1371/journal.ppat.1004957. eCollection 2015 Jun. 

 

Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. (2015): Dynamic Virus-Bacterium Interactions in a Porcine Precision-Cut Lung Slice Coinfection Model: Swine Influenza Virus Paves the Way for Streptococcus suis Infection in a Two-Step Process. Infect Immun. 2015 Jul;83(7):2806-15. doi: 10.1128/IAI.00171-15. Epub 2015 Apr 27.

 

Förthmann B, Aletta JM, Lee YW, Terranova C, Birkaya B, Stachowiak EK, Stachowiak MK, Claus P. (2015):  Coalition of Nuclear Receptors in the Nervous System. J Cell Physiol. 2015 May 12. doi: 10.1002/jcp.25036.

 

Torow N, Yu K, Hassani K, Freitag J, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Förster R, Pabst O, Hornef MW (2015): Active suppression of intestinal CD4(+)TCR alpha beta (+) T-lymphocyte maturation  during the postnatal period. Nat Commun 2015 Jul 21;6: 7725.doi 10.1038/ncomms8725 

 

Zhang K, Hornef MW, Fulde M (2015): The deadly bite of Salmonella Typhi. EMBO Rep. 2015 Aug; 16(8):887-8. doi 10.15252/embr.201540748

 

Mitkovski M, Dahm L, Heinrich R, Monnheimer M, Gerhart S, Stegmüller J, Hanisch UK, Nave KA, Ehrenreich H. (2015): Erythropoietin dampens injury-induced microglial motility. J Cereb Blook Flow Metab. 2015 Aug;35(8):1233-6. 10.1038/jcbfm.2015.100.

 

Zerche M, Weissenborn K, Ott C, Dere E, Asif AR, Worthmann H, Hassouna I, Rentzsch K, Tryc AB, Dahm L, Steiner J, Binder L, Wiltfang J, Sirén AL, Stöcker W, Ehrenreich H (2015): Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke. Stroke, May;46(5):1180-6. doi: 10.1161/STROKEAHA.114.008323. 

 

 

Hensel N, Rademacher S, Claus P (2015): Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders. Front Neurosci. 2015 Jun 2;9:198. doi: 10.3389/fnins.2015.00198. eCollection 2015.


Crouse J, Kalinke U, Oxenius A. (2015): Regulation of antiviral T cell responses by type I interferons.Nat Rev Immunol. 2015 Apr;15(4):231-42. doi: 10.1038/nri3806. Epub 2015 Mar 20. Review.

 

Cabrera J, Viejo-Borbolla A (2015): Herpes Simplex Virus and Neurotrophic Factors Journal of Human Virology & Retrovirology, 2015 2(1): 00027

 

Skripuletz, T., Salinas Tejedor, L., Prajeeth, C.K., Hansmann, F., Chhatbar, C., Kucman, V., Zhang, N., Raddatz, B. B. Detje, C.D., Sühs, K.H., Pul, R., Gudi, V., Kalinke, U., Baumgärtner, W. and M. Stangel (2015): The antiviral drug ganciclovir does not inhibit microglial proliferation and activation. Scientific Reports Sci Rep. 2015 Oct 8;5:14935. doi: 10.1038/srep14935.IF 5.578

 

 Beineke, A., Baumgärtner, W., and P. Wohlsein (2015). Cross-species transmission of canine distemper virus - an update. One Health, doi: 10.1016/j.onehlt.2015.09.002 accepted 2015 

 

Raddatz, B.B., Lehmbecker, A., Kalkuhl, A., Deschl, U., Baumgärtner W. and R, Ulrich (2015): Transcriptional analysis of glial cell differentiation in postnatal murine spinal cord. International Journal of Developmental Neuroscience, 2015 May;42:24-36. doi: 10.1016/j.ijdevneu.2015.02.005. Epub 2015 Feb 19.

 

Smits, S., Bodewes, R., Ruiz-Gonzalez, A., Baumgärtner, W., Marion Koopmans, M. Osterhaus, A.D.M.E. and Schürch, A.C. Recovering full-length viral genomes from metagenomes. Frontiers in Microbiology, 2015 Oct 1;6:1069. doi: 10.3389/fmicb.2015.01069. eCollection 2015.

 

Vezzani, A., R. S. Fujinami, H.S. White, P.-M. Preux, I. Blümcke, J.W. Sander and W. Löscher Infections, inflammation and epilepsy. Acta Neuropathologica.  2015 Sep 30. [Epub ahead of print]


Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, Stadler H, Kawabe H, Zimmermann WH, Nave KA, Schulz-Schaeffer W, Jahn O, Ehrenreich H. (2015): Widespread expression of erythropoietin receptor in brain and its induction by injury. Mol Med. 2015 Sep 1. doi: 10.2119/molmed.2015.00192.

 
Hammer C, Begemann M, McLaren PJ, Bartha I, Michel A, Klose B, Schmitt C, Waterboer T, Pawlita M, Schulz TF, Ehrenreich H, Fellay J. (2015): Amino acid variation in HLA class II proteins is a major determinant of humoral response to common viruses, Am J Hum Genet. 2015 Oct 6. pii: S0002-9297(15)00372-9. doi: 10.1016/j.ajhg. 2015.09.008. IF: 10.931

 

Castillo-Gomez E, Kästner A, Steiner J, Schneider A, Hettling B, Poggi G, Ostehr K, Uhr M, Asif AR, Matzke M, Schmidt U, Pfander V, Hammer C, Schulz TF, Binder L, Stöcker W, Weber F, Ehrenreich H. (2015): The brain as ′immunoprecipitator′ of serum autoantibodies directed against the NMDAR subunit NR1. Ann Neurol. 2015 Oct 27. doi: 10.1002/ana.24545.

 

Bröer S and Löscher W (2015): Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats. Epilepsy Behav. 2015 Nov 2;53:98-107. doi: 10.1016/j.yebeh.2015.09.028.

 

van Nierop GP, Janssen M, Mitterreiter JG, van de Vijver DA, de Swart RL, Haagmans BL, Verjans GM, Hintzen RQ (2015): Intrathecal CD4+ and CD8+ T cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients. Eur J Immunol. 2015 Oct 28. doi: 10.1002/eji.201545921.

 

van Nierop GP, Mautner J, Mitterreiter JG, Hintzen RQ, Verjans GM (2015): Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins. Mult Scler. 2015 Jun 3. pii: 1352458515588581.

 

Bosse JB, Hogue IB, Feric M, Thiberge SY, Sodeik B, Brangwynne CP, Enquist LW. (2015): Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5725-33. doi: 10.1073/pnas.1513876112. Epub 2015 Oct 5.

 

Haagmans B , van den Brand J,  Raj S , Volz A , Wohlsein P, Smits S, Schipper D , Bestebroer T, Okba N, Fux R,
Bensaid A, Foz D, Kuiken T, Baumgärtner W, Segalés J, Sutter G, Osterhaus A. An orthopoxvirus-based vaccine reduces virus excretion after MERS coronavirus infection in dromedary camels. Science. Accepted 

 

 

 

...in progress :-)

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