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Publikationen

2009

Bock, P., Rohn, K., Beineke, A., Baumgärtner, W. und Wewetzer, K. (2009): Site-specific population dynamics and variable olfactory marker protein expression in the postnatal canine olfactory epithelium. J. Anat. 215: 522-35.

 

Tegenge, M.A., Stern, M. und Bicker, G. (2009): Nitric oxide and cyclic nucleotide signal transduction modulates synaptic vesicle turnover in human model neurons. J. Neurochem. 111: 1434-46.

 

Tegenge, M.A. und Bicker G.(2009): Nitric oxide and cGMP signal transduction positively regulates the motility of human neuronal precursor (NT2) cells. J. Neurochem.110:1828-41.

 

 

 

2010

Brandt, C., Nozadze, M., Heuchert, N., Rattka, M. und Löscher, W. (2010): Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy. J. Neurosci. 30: 8602-12.

 

Ensinger, E.-M., Boekhoff, T.M.A., Carlson, R., Beineke A., Rohn, K., Tipold, A. und Stein, V.M. (2010): Regional topographical differences of canine microglial immunophenotype and function in the healthy spinal cord. J. Neuroimmunol. 227: 144-52.

 

Ensinger, E.-M., Flieshardt, C., Boekhoff, T.M., Fork, M., Kramer, S. und Tipold, A. (2010): Magnetresonanztomographische Befunde des Myelons bei 34 Hunden mit zervikalem Bandscheibenvorfall: Gibt es Hinweise auf die Prognose? Kleintierpraxis 55: 537-46.

 

Löscher, W. und Brandt, C.: (2010): Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research. Pharmacol. Rev. 62: 668-700.

 

Navarrete-Talloni, M.J., Kalkuhl, A., Deschl, U., Ulrich, R., Kummerfeld, M., Rohn, K., Baumgärtner, W. und Beineke, A. (2010): Transient Peripheral Immune Response and Central Nervous System Leaky Compartmentalization in a Viral Model for Multiple Sclerosis. Brain Pathol. 20: 890-901.

 

Podrygajlo, G., Wiegreffe, C., Scaal, M. und Bicker, G. (2010): Integration of Human Model Neurons (NT2) Into Embryonic Chick Nervous System. Dev. Dyn. 239: 496-504.

 

Podrygajlo, G., Song, Y., Schlesinger, F., Krampfl, K. und Bicker, G. (2010): Synaptic currents and transmitter responses in human NT2 neurons differentiated in aggregate culture. Neurosci. Lett. 468: 207-10.

 

Polascheck, N., Bankstahl, M. und Löscher, W. (2010): The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. Exp. Neurol. 224: 219-33.

 

Schwartz, M., Puff, C., Stein, V.M., Baumgärtner, W. und Tipold, A. (2010): Marked MMP-2 transcriptional up-regulation in mononuclear leukocytes invading the subarachnoidal space in aseptic suppurative Steroid-Responsive Meningitis–Arteritis in dogs. Vet. Immunol. Immunopathol. 133: 198-206.

 


2011

Brandes, G., Khayami, M., Peck, C.T., Baumgärtner, W., Bugday, H. und Wewetzer, K. (2011): Cell surface expression of 27C7 by neonatal rat olfactory ensheathing cells in situ and in vitro is independent of axonal contact. Histochem Cell Biol. 135: 397-408.

 

Haist, V., Ulrich, R., Kalkuhl, A., Deschl, U. und Baumgärtner, W. (2011): Distinct spatio-temporal extracellular matrix accumulation within demyelinated spinal cord lesions in Theiler's murine encephalomyelitis. Brain Pathol. 22(2):188-204.

 

Herder, V., Hansmann, F., Stangel, M., Skripuletz, T., Baumgärtner, W. und Beineke, A. (2011): Lack of cuprizone-induced demyelination in the murine spinal cord despite oligodendroglial alterations substantiates the concept of site-specific susceptibilities of the central nervous system. Neuropathol Appl Neurobiol. 37: 676-84.

 

Honndorf, S., Lindemann, C., Töllner, K. und Gernert, M. (2011): Female Wistar rats obtained from different breeders vary in anxiety-like behavior and epileptogenesis. Epilepsy Res. 94: 26-38.

 

Kreutzer, M., Seehusen, F., Kreutzer, R,. Pringproa, K., Kummerfeld, M., Claus, P., Deschl, U., Kalkul, A., Beineke, A., Baumgärtner, W. und Ulrich, R. (2011): Axonopathy Is Associated with Complex Axonal Transport Defects in a Model of Multiple Sclerosis. Brain Pathology 22(4): 454-71.

 

Langer, M., Brandt, C., Zellinger, C. und Löscher, W. (2011): Therapeutic window of opportunity for the neuroprotective effect of valproate versus the competitive AMPA receptor antagonist NS1209 following status epilepticus in rats. Neuropharmacology. 61: 1033-47.

 

Langer, M., Brandt, C. und Löscher, W. (2011): Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats Strain and substrain differences in an epilepsy model in rats. Epilepsy Res. 96(3): 207-24.

 

Löscher, W. (2011): Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure. 20: 359-68.

 

Omar, M., Bock, P., Kreutzer, R., Ziege, S., Imbschweiler, I., Hansmann, F., Peck, C.T.,Baumgärtner, W. und Wewetzer, K.  (2011): Defining the morphological phenotype: 2',3'-cyclicnucleotide 3'-phosphodiesterase (CNPase) is a novel marker for in situ detection of canine but not rat olfactory ensheathing cells. Cell Tissue Res. 344: 391-405.

 

Potschka, H., Baltes, S., Fedrowitz, M. und Löscher, W. (2011): Impact of seizure activity on free extracellular phenytoin concentrations in amygdala-kindled rats. Neuropharmacology. 61: 909-17.

 

Radtke, C., Wewetzer, K., Reimers, K. und Vogt, P. M. (2011): Transplantation of olfactory ensheathing cells as adjunct cell-therapy for peripheral nerve injury. Cell transplantation: 20: 145-521.

 

Radtke, C., Allmeling, C., Waldmann, K.H., Reimers, K., Thies, K., Schenk, H.C., Hillmer, A., Guggenheim. M., Brandes, G. und Vogt, P.M. (2011): Spider silk constructs enhance axonal regeneration and remyelination in long nerve defects in sheep. PLoS One. 6(2): e16990.

 

Radtke, C., Sasaki, M., Lankford, K.L., Gallo, V. und Kocsis, JD. (2011): CNPase expression in olfactory ensheathing cells. J Biomed Biotechnol, 2011: 608496.

 

Rattka, M., Brandt, C., Bankstahl, M., Bröer, S. und Löscher, W. (2011): Enhanced susceptibility to the GABA antagonist pentylenetetrazole duringthe latent period following a pilocarpine-induced status epilepticus in rats. Neuropharmacology. 60: 505-12.

 

Seeger, N., Zellinger, C., Rode, A., Wagner, S., Roloff, F., Bicker, G., Russmann, V., Fischborn, S., Wendt, H. und Potschka, H. (2011): The erythropoietin-derived peptide mimetic pHBSP affects cellular, behavioral and cognitive consequences in a rat post-status epilepticus model. Epilepsia, 52: 2333-2343

 

Spitzbarth, I., Bock, P., Haist, V., Stein, V.M., Tipold, A., Wewetzer, K., Baumgärtner, W. und Beineke, A. (2011): Prominent microglial activation in the early proinflammatory immune response in naturally occurring canine spinal cord injury. J Neuropathol Exp Neurol. 70: 703-14.

 

Stein, V.M., Puff, C., Genini, S., Bono Contioso, V., Baumgärtner, W. und Tipold, A. (2011): Variations on brain microglial gene expression of MMPs, RECK, and TIMPs in inflammatory and non-inflammatory diseases in dogs. Vet. Immunol. Immunopathol. 144(1-2): 17-26.

 

Tegenge, M.A., Roloff, F. und Bicker, G. (2011): Rapid differentiation of human embryonal carcinoma stem cells (NT2) into neurons for neurite outgrowth analysis. Cell Mol Neurobiol. 31: 635-43.

 

Tegenge, M.A., Rockel, T.D., Fritsche, E. und Bicker, G. (2011): Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction. Cell Mol Life Sci. 68: 2089-99.

 

Wendt, H., Soerensen, J., Wotjak, C.T. und Potschka, H. (2011): Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice. Epilepsia. 52: e62-5.

doi: 10.1111/j.1528-1167.2011.03079.x.   

 

Wewetzer, K., Radtke, C., Kocsis, J. und Baumgärtner, W. (2011): Species-specific control of cellular proliferation and the impact of large animal models for the use of olfactory ensheathing cells and Schwann cells in spinal cord repair. Exp. Neurol. 229: 80-87.

 

Zellinger, C., Hadamitzky, M., Bock, E., Berezin, V. und Potschka, H. (2011): Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus. Neurosci Lett.

501: 173-78.

 

Zellinger, C., Seeger, N., Hadamitzky, M., Fischborn, S., Russmann, V., Wendt, H., Pankratova, S., Bock, E., Berezin, V. und Potschka, H. (2011): Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus. Epilepsy Res. 96(3): 241-9.

 

2012

Bankstahl, M., Müller, C.J., Wilk, E., Schughart, K. und Löscher, W. (2012): Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy. Behav.Brain Res 230: 182-191.

 

Bock, P., Spitzbarth, I., Haist, V., Stein, V.M., Tipold, A., Puff, C., Beineke, A. und Baumgärtner, W. (2012): Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for non-experimental spinal cord injury. Brain Pathol. 23(1): 82-99. 

 

Boekhoff, T.M., Ensinger, E.M., Carlson, R., Bock, P., Baumgärtner, W., Rohn, K., Tipold, A. und Stein, V.M. (2012): Microglial contribution to secondary injury evaluated in a large animal model of human spinal cord trauma. J. Neurotrauma 29: 1000-1011.


Boekhoff, T.M., Flieshardt, C., Ensinger, E.-M., Fork, M., Kramer, S. und Tipold, A. (2012): Quantitative magnetic resonance imaging characteristics: evaluation of prognostic value in the dog as a translational model for spinal cord injury. Journal of Spinal Disorders and Techniques 25(3): 81-87.


Brauer, C., Kästner, S.B.R., Rohn, K., Schenk, H.C., Tünsmeyer, J. und Tipold, A. (2012): Electroencephalographic recordings in dogs suffering from idiopathic and symptomatic epilepsy: Diagnostic value of interictal short time EEG protocols supplemented by two activation techniques. Vet J. 193(1): 185-92.

 

Bröer, S., Backofen-Wehrhahn, B., Bankstahl, M., Gey, L., Gernert, M. und Löscher, W. (2012): Vigabatrin for focal drug delivery in epilepsy: bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiol Dis. 46(2): 362-76.


Herder, V., Hansmann, F., Stangel, M., Schaudien, D., Baumgärtner, W. und Beineke, A. (2012): Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis. Journal of Neuroimmunology 244: 84-93.

 

Herder, V., Gerhauser, I., Klein, S.K., Almeida, P., Kummerfeld, M., Ulrich, R., Seehusen, F., Rohn, K., Schaudien, D., Baumgärtner, W., Huehn, J. und Beineke, A. (2012): Interleukin-10 Expression during the Acute Phase Is a Putative Prerequisite for Delayed Viral Elimination in a Murine Model for Multiple Sclerosis. Journal of Neuroimmunology 249: 27-39.

 

Jafari, M., Haist, V., Baumgärtner, W., Wagner, S., Stein, V., Tipold, A., Wendt, H. und Potschka, H. (2012): Impact of Theiler’s virus infection on hippocampal neuronal progenitor cells: differential effects in two mouse strains. Neuropathol Appl Neurobiol. 38(7): 647-64.

 

Jafari, M., Soerensen, J., Bogdanović, R.M., Dimou, L., Götz, M. und Potschka, H. (2012): Long-term genetic fate mapping of adult generated neurons in a mouse temporal lobe epilepsy model. Neurobiol Dis. 48(3): 454-63.

 

Kobow, K., Auvin, S., Jensen, F., Löscher, W., Mody, I., Potschka, H., Prince, D., Sierra, A., Simonato, M., Pitkanen, A., Nehlig, A. und Rho, J.M.: Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia 53: 1868-1876.

 

Kreutzer, M., Seehusen, F., Kreutzer, R., Pringproa, K., Kummerfeld, M., Claus, P., Deschl, U., Kalkul, A., Beineke, A., Baumgärtner, W und Ulrich, R. (2012): Axonopathy is associated with complex axonal transport defects in a model of multiple sclerosis. Brain Pathology 22: 454-471.

 

Kummerfeld, M., Seehusen, F., Klein, S., Ulrich, R., Kreutzer, R., Gerhauser, I., Herder, V., Baumgärtner, W. und Beineke, A. (2012): Periventricular demyelination and axonal pathology is associated with subependymal virus spread in a murine model for multiple sclerosis. Intervirology. 55(6): 401-16. 

 

Rattka, M., Brandt, C. und Löscher, W. (2012): Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy. Eur.J.Neurosci. 36: 2505-2520.

 

Spitzbarth, I., Baumgärtner, W. und Beineke, A. (2012): The role of pro- and anti-inflammatory cytokines in the pathogenesis of spontaneous canine CNS diseases. Vet. Immunol. Immunopathol. 147: 6-24.


Stein, V.M., Genini, S., Puff, C., Baumgärtner, W. und Tipold, A. (2012): Seizure activity in dogs associated with enhanced TIMP-2 expression of microglia. Vet. Immunol. Immunopathol. 146: 101-105.

 

von Rüden, E.L., Avemary, J., Zellinger, C., Algermissen, D., Bock, P., Beineke, A., Baumgärtner, W., Stein, V.M., Tipold, A. und Potschka, H. (2012): Distemper virus encephalitis exerts detrimental effects on hippocampal neurogenesis. Neuropathol Appl Neurobiol. 38(5): 426-42.

2013

Gernert, M. (2013): Intrasubthalamic cell transplants for epilepsy therapy: hopes and concerns. Neuroreport. 24(18): 1062-6.

 

Hobert, M.K., Stein, V.M., Dziallas, P., Ludwig, D.C. und Tipold, A. (2013): Evaluation of normal appearing spinal cord by diffusion tensor imaging, fiber tracking, fractional anisotropy, and apparent diffusion coefficient measurement in 13 dogs. Acta Vet Scand. 55:36.

 

Jeffery, N.D., Levine, J.M., Olby, N.J. und Stein, V.M (2013): Intervertebral disk degeneration in dogs: consequences, diagnosis, treatment, and future directions. J Vet Intern Med. 27(6): 1318-33.

 

Löscher, W., Klitgaard, H., Twyman, R.E. und Schmidt, D. (2013): New avenues for anti-epileptic drug discovery and development. Nat Rev Drug Discov. 12(10): 757-76.

 

Nessler, J., Bénardais, K., Gudi, V., Hoffmann, A., Salinas Tejedor, L., Janßen, S., Prajeeth,C.K., Baumgärtner, W., Kavelaars, A., Heijnen, C.J., van Velthoven, C., Hansmann, F., Skripuletz, T. und Stangel, M. (2013): Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination. PLoS One. 8(7): 69795.

 

Noe, F.M., Polascheck, N., Frigerio, F., Bankstahl, M., Ravizza, T., Marchini, S., Beltrame, L., Banderó, C.R., Löscher, W. und Vezzani, A. (2013): Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. Neurobiol Dis. 59: 183-93.

 

Pitkänen, A., Nehlig, A., Brooks-Kayal, A.R., Dudek, F.E., Friedman, D., Galanopoulou, A.S., Jensen, F.E., Kaminski, R.M., Kapur, J., Klitgaard, H., Löscher, W., Mody, I. und Schmidt, D. (2013): Issues related to development of antiepileptogenic therapies. Epilepsia. 54 Suppl 4:35-43.

 

Potschka, H., Fischer, A., von Rüden, E.L., Hülsmeyer, V. und Baumgärtner, W. (2013): Canine epilepsy as a translational model? Epilepsia. 54:571-579.

 

Qeska, V., Barthel, Y., Iseringhausen, M., Tipold, A., Stein, V.M., Khan, M.A., Baumgärtner, W. und Beineke, A. (2013): Dynamic changes of Foxp3(+) regulatory T cells in spleen and brain of canine distemper virus-infected dogs. Vet Immunol Immunopathol. 156(3-4): 215-22.

 

Qeska, V., Baumgärtner, W. und Beineke, A. (2013): Species-specific properties and translational aspects of canine dendritic cells. Vet Immunol Immunopathol. 151(3-4):181-92.

 

Rattka, M., Brandt, C. und Löscher, W. (2013): The intrahippocampal kainate model of temporal lobe epilepsy revisited: epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats. Epilepsy Res 103: 135-152.

 

Roerig, A., Carlson, R., Tipold, A. und Stein, V.M. (2013): Cerebrospinal fluid tau protein as biomarker for severity of spinal cord injury in dogs with intervertebral disc herniation. Vet J. 197(2): 253-8.

 

Roloff, F., Ziege, S., Baumgärtner, W., Wewetzer K. und Bicker, G. (2013): Schwann cell-free adult canine olfactory ensheathing cell preparations from olfactory bulb and mucosa display differential migratory and neurite growth-promoting properties in vitro. BMC Neurosci. 14: 141.


Russmann, V., Seeger, N., Zellinger, C., Hadamitzky, M., Pankratova, S., Wendt, H., Bock, E., Berezin, V. und Potschka, H. (2013): The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model. Neurosci Lett. 556: 170-5.

 

Steinmetz, S., Tipold, A. und Löscher, W. (2013): Epilepsy after head injury in dogs: a natural model of posttraumatic epilepsy. Epilepsia, 54: 580-588.

 

Strauß, S., Reimers, K., Allmeling, C., Kuhbier, J.W., Radtke, C., Schäfer-Nolte, F., Wendt, H. und Vogt, P.M. (2013): Spider Silk - a Versatile Biomaterial for Tissue Engineering and Medical Applications. Biomed Tech (Berl). pii: /j/bmte.2013.58.issue-s1-C/bmt-2013-4068/bmt-2013-4068.xml.

 

 Ziege, S., Baumgärtner, W. und Wewetzer, K. (2013): Toward defining the regenerative potential of olfactory mucosa: establishment of Schwann cell-free adult canine olfactory ensheathing cell preparations suitable for transplantation. Cell Transplant. 22:355-367.

2014

Bankstahl, J.P., Brandt, C. und Löscher, W. (2014): Prolonged depth electrode implantation in the limbic system increases the severity of status epilepticus in rats. Epilepsy Res. 108(4): 802-5.

 

Bartels, J., Darrow, B.G., Schatzberg, S.J., Bu, L., Carlson, R. und Tipold, A. (2014): 1MIP-3β/CCL19 is associated with the intrathecal invasion of mononuclear cells in neuroinflammatory and non-neuroinflammatory CNS diseases in dogs. BMC Vet Res. 10:157.

 

Baraban, S.C. und Löscher, W. (2014): What new modeling approaches will help us identify promising drug treatments? Adv Exp Med Biol. 813: 283-94.

 

Bogdanović, R.M., Syvänen, S., Michler, C., Russmann, V., Eriksson, J., Windhorst, A.D., Lammertsma, A.A., de Lange, E.C., Voskuyl, R.A. und Potschka, H. (2014): (R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model. Neuropharmacology. 85:104-112.

 

Handreck, A., Backofen-Wehrhahn, B., Bröer, S., Löscher, W. und Gernert, M. (2014): Anticonvulsant effects by bilateral and unilateral transplantation of GABA-producing cells into the subthalamic nucleus in an acute seizure model.Cell Transplant. 23(1): 111-32.  

 

Herder, V., Iskandar, C.D., Kegler, K., Hansmann, F., Elmarabet, S.A., Khan, M.A., Kalkuhl, A., Deschl, U., Baumgärtner, W., Ulrich, R. und Beineke, A. (2014): Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis. Brain Pathol. doi: 10.1111/bpa.12238.

 

Klein, S., Bankstahl, M., Gramer, M., Hausknecht, M. und Löscher, W. (2014): Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. Epilepsy Res. 108(10): 1719-27.

 

Ongerth, T., Russmann, V., Fischborn, S., Boes, K., Siegl, C. und Potschka, H. (2014): Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models. Eur J Pharmacol. 740:72-80.

 

Prajeeth, C.K., Beineke, A., Iskandar, C., Gudi, V., Herder, V., Gerhauser, I., Haist, V., Teich, R., Huehn, J., Baumgärtner., W. und Stangel, M. (2014): Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. J Neuroinflammation. 11(1): 180.

 

Prajeeth, C.K., Löhr, K., Floess, S., Zimmermann, J., Ulrich, R., Gudi, V., Beineke, A., Baumgärtner, W., Müller, M., Huehn, J. und Stangel, M. (2014): Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia. Brain Behav Immun. 37: 248-59

 

Qeska, V., Barthel, Y., Herder, V., Stein, V.M., Tipold, A., Urhausen, C., Günzel-Apel, A.R., Rohn, K., Baumgärtner, W. und Beineke, A. (2014): Canine distemper virus infection leads to an inhibitory phenotype of monocyte-derived dendritic cells in vitro with reduced expression of co-stimulatory molecules and increased interleukin-10 transcription. PLoS One. 9(4):e96121.  

 

Radtke, C. und Kocsis, J.D. (2014): Olfactory-ensheathing cell transplantation for peripheral nerve repair: update on recent developments. Cells Tissues Organs. 200(1): 48-58.

 

Roloff, F., Strauß, S., Vogt, P.M., Bicker, G., und Radtke, C. (2014): Spider silk as guiding biomaterial for human model neurons. Biomed Res Int. 2014: 906819.

 

Scheiblich, H., Roloff, F., Singh, V., Stangel, M., Stern, M. und Bicker, G. (2014): Nitric oxide/cyclic GMP signaling regulates motility of a microglial cell line and primary microglia in vitro. Brain Res. 1564: 9-21.

 

Skripuletz, T., Manzel, A., Gropengießer, K., Schäfer, N., Gudi, V., Singh, V., Salinas Tejedor, L., Jörg, S., Hammer, A., Voss, E., Vulinovic, F., Degen, D., Wolf, R., Lee, D.H., Pul, R., Moharregh-Khiabani, D., Baumgärtner, W., Gold, R., Linker, R.A. und Stangel, M. (2014): Pivotal role of choline metabolites in remyelination. Brain. 138(2): 398-413.

 

Töllner, K., Brandt, C., Töpfer, M., Brunhofer, G., Erker, T., Gabriel, M., Feit, P.W., Lindfors, J., Kaila, K. und Löscher, W. (2014): A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. Ann Neurol. 75(4): 550-62.

 

Töpfer, M., Töllner, K., Brandt, C., Twele, F., Bröer, S., und Löscher, W. (2014): Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy. Eur J Neurosci. 39(4): 673-87.

 

White, H.S. und Löscher, W. (2014): Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategies. Neurotherapeutics. 11(2): 373-84.

 

Zellinger, C., Salvamoser, J.D., Seeger, N., Russmann, V. und Potschka, H. (2014): Impact of the Neural Cell Adhesion Molecule-Derived Peptide FGL on Seizure Progression and Cellular Alterations in the Mouse Kindling Model. ACS Chem Neurosci. 5(3): 185-93.

2015

Brandt, C., Töllner, K., Klee, R., Bröer, S. und Löscher, W. (2015): Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. Neurobiol Dis. 75: 78-90.  

 

Handreck, A., Mall, E.M., Elger, D.A., Gey, L. und Gernert, M. (2015): Different preparations, doses, and treatment regimens of cyclosporine A cause adverse effects but no robust changes in seizure thresholds in rats. Epilepsy Res. 112: 1-17.

 

Heinrich, F., Contioso, V.B., Stein, V.M., Carlson, R., Tipold, A., Ulrich, R., Puff, C., Baumgärtner, W. und Spitzbarth, I. (2015): Passage-dependent morphological and phenotypical changes of a canine histiocytic sarcoma cell line (DH82 cells). Vet Immunol Immunopathol. 163(1-2):86-92.  

 

Kegler, K., Spitzbarth, I., Imbschweiler, I., Wewetzer, K., Baumgärtner, W. und Seehusen, F. (2015): Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. PLoS One. 10:e0133916.

 

Klein, S., Bankstahl, M. und Löscher, W. (2015): Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. Neuropharmacology. 90: 53-62

 

Klein, S., Bankstahl, J.P., Löscher, W. und Bankstahl, M. (2015): Sucrose consumption test reveals pharmacoresistant depression-associated behavior in two mouse models of temporal lobe epilepsy. Exp Neurol. 263:263-271.

 

Löscher, W. (2015): Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. Epilepsy Behav. 49:20-25.

 

Rettenbeck, M.L., von Rüden, E.L., Bienas, S., Carlson, R., Stein, V.M., Tipold, A. und Potschka, H. (2015): Microglial ROS production in an electrical rat post-status epilepticus model of epileptogenesis. Neurosci Lett. 599:146-151.

 

Ridder, D.A., Wenzel, J., Müller, K., Töllner, K., Tong, X.K., Assmann, J.C., Stroobants, S., Weber, T, Niturad, C., Fischer, L., Lembrich, B., Wolburg, H., Grand'Maison, M., Papadopoulos, P., Korpos, E., Truchetet, F., Rades, D., Sorokin, L.M.7 Schmidt-Supprian, M., Bedell, B.J., Pasparakis, M., Balschun, D., D'Hooge, R., Löscher, W., Hamel, E. und Schwaninger, M. (2015): Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med. 212:1529-1549.

 

Roloff, F., Scheiblich, H., Dewitz, C., Dempewolf, S., Stern, M. und Bicker, G. (2015): Enhanced neurite outgrowth of human model (NT2) neurons by small-molecule inhibitors of Rho/ROCK signaling. PLoS One. 10:e0118536.

 

Salinas Tejedor, L., Berner, G., Jacobsen, K., Gudi, V., Jungwirth, N., Hansmann, F., Gingele, S., Prajeeth, C.K., Baumgärtner, W., Hoffmann, A., Skripuletz, T. und Stangel, M. (2015): Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system. Brain Behav Immun.

50:155-165.  

 

Salinas Tejedor, L., Gudi, V., Kucman, V., Pul, R., Gingele, S., Sühs, K.W., Stangel, M. und Skripuletz, T. (2015): Oligodendroglial markers in the cuprizone model of CNS de- and remyelination. Histol Histopathol. 30:1455-1464.

 

Scheiblich, H. und Bicker, G. (2015): Regulation of microglial migration, phagocytosis, and neurite outgrowth by HO-1/CO signaling. Dev Neurobiol. 75:854-876.

 

Spitzbarth, I., Cana, A., Hahn, K., Hansmann, F. und Baumgärtner, W. (2015): Associated occurrence of p75 neurotrophin receptor expressing aldynoglia and microglia/macrophages in long term organotypic murine brain slice cultures. Brain Res. 1595: 29-42.

 

Töllner, K., Brandt, C., Römermann, K. und Löscher, W. (2015): The organic anion transport inhibitor probenecid increases brain concentrations of the NKCC1 inhibitor bumetanide. Eur J Pharmacol.746: 167-173.

 

Töllner, K., Brandt, C., Erker, T. und Löscher, W. (2015): Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models. Eur J Pharmacol. 746: 78-88.  

 

Twele, F., Bankstahl, M., Klein, S., Römermann, K. und Löscher, W. (2015): The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy. Neuropharmacology. 95:234-242.

 

von Rüden, E.L., Jafari, M., Bogdanovic, R.M., Wotjak, C.T. und Potschka, H (2015): Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm. Neurobiol Dis. 73:334-347.

 

2016

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