Auswahl wichtiger Veröffentlichungen der letzten Jahre

Arbeitsgruppe Löscher:

Gernert, M., M. Hamann, M. Bennay, W. Löscher, and A. Richter

            Deficit of striatal parvalbumin-reactive GABAergic interneurons and decreased

            basal ganglia output in a genetic rodent model of idiopathic paroxysmal dystonia.

            J. Neurosci. 20: 7052-7058, 2000

 

Altrock, W.D., S. tom Dieck, M. Sokolov, A.C. Meyer, A. Sigler, C. Brakebusch,

            R. Fassler, K. Richter, T.M. Boeckers, H. Potschka, C. Brandt, W. Löscher, D.

            Grimberg, T. Dresbach, A. Hempelmann, H. Hassan, D. Balschun, J.U. Frey,

            J.H. Brandstatter, C.C. Garner, C. Rosenmund, and E.D. Gundelfinger

            Functional inactivation of a fraction of excitatory synapses in mice deficient for

            the active zone protein bassoon.

            Neuron 37: 787-800, 2003

 

Brandt, C., H. Potschka, W. Löscher, and U. Ebert

            N-methyl-D-aspartate receptor blockade after status epilepticus protects against

            limbic brain damage but not against epilepsy in the kainate model of temporal

            lobe epilepsy.

            Neuroscience 118: 727-40, 2003

 

Rogawski, M. A. and W. Löscher:

            The neurobiology of antiepileptic drugs.

            Nature Rev. Neurosci., 5: 553-564, 2004

 

Rogawski, M. A. and W. Löscher:

            The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.

            Nature Med., 10: 685-692, 2004

 

Volk, H. A. and W. Löscher:

            Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain

            expression of P-glycoprotein compared with rats with drug-responsive seizures.

            Brain, 128, 1358-1368, 2005

 

Löscher, W. and H. Potschka:

            Drug resistance in brain diseases and the role of drug efflux transporters.

            Nature Rev. Neurosci., 6: 591-602, 2005

 

Brandt, C., K. Bethmann, A. M. Gastens, and W. Löscher:

            The multidrug transporter hypothesis of drug resistance in epilepsy:

            proof-of-principle in a rat model of temporal lobe epilepsy.

            Neurobiol. Dis., 24: 202-211, 2006

 

Arbeitsgruppe Kietzmann / Bäumer:

 

Immunpharmakologie

Bäumer W., U. Seegers, M. Braun, T. Tschernig and M. Kietzmann.

            TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis.

            Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. 

            Br. J. Dermatol., 151: 823-830, 2004

 

Bäumer, W., B. Sülzle, H. Weigt, V.C. De Vries, M. Hecht, T. Tschernig and M. Kietzmann

            Cilomilast, tacrolimus, and rapamycin, modulate dendritic cell function in the

            elicitation phase of allergic contact dermatitis.

            Br. J. Dermatol., 153: 136-144, 2005

 

Bäumer, W., J. Hoppmann and C. Rundfeldt

            Highly selective PDE4 inhibitors for the treatment of allergic diseases and psoriasis.

            Inflammation & Allergy-Drug Targets, 6: 17-26, 2007

 

In-vitro-Modelle

Kietzmann, M., W. Löscher, D. Arens, P. Maass and D. Lubach

            The isolated perfused bovine udder as an in vitro model of percutaneous drug absorption.

            Skin viability and percutaneous absorption of dexamethasone, benzoyl peroxide, and etofenamate.

            J. Pharmacol. Toxicol. Methods, 30: 75-84, 1993

Ehinger, A.M., H. Schmidt, M. Kietzmann M

            Tissue distribution of cefquinome after intramammary and “systemic” administration in the isolated perfused bovine udder.

            Vet. J. 172: 147-153, 2006

Braun, M. and M. Kietzmann

            Ischaemia-reperfusion injury in the isolated haemoperfused bovine uterus: an in vitro model of acute inflammation.

            Altern. Lab. Anim., 32: 69-77, 2004

 

Vietmeier, J., F. Niedorf , W. Bäumer, C. Martin, E. Deegen, B. Ohnesorge and M. Kietzmann

            Reactivity of equine airways--a study on precision-cut lung slices.

            Vet. Res. Comm., 31: 611-619, 2007

 

Dermale Resorption

Schäfer-Korting M., U. Bock, A. Gamer, A. Haberland, E. Haltner-Ukomadu, M. Kaca, H. Kamp,

            M. Kietzmann, H.C. Korting, H.U. Krächter, C.M. Lehr, M. Liebsch, A. Mehling, F. Netzlaff,

            F. Niedorf, M.K. Rübbelke, U. Schäfer, E. Schmidt, S. Schreiber, K.R. Schröder, H. Spielmann and A.Vuia

            Reconstructed human epidermis for skin absorption testing: results of the German prevalidation study.

            Altern. Lab. Anim., 34: 283-294, 2006

 

Netzlaff F., U.F. Schaefer, C.M. Lehr, P. Meiers, J. Stahl, M. Kietzmann and F. Niedorf

            Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments.

            Altern Lab Anim., 34: 499-513, 2006

 

Sonstiges

Braun, M., K. Lelieur, M. Kietzmann

            Purinergic substances promote murine keratinocyte proliferation and enhance impaired wound healing.

            Wound Rep. Reg., 14, 153-162, 2006

 

Tansakul N., F. Niedorf, M. Kietzmann

            A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen.

            Food Addit. Contam. 24, 598-604, 2007

 

Machnik M., I. Hegger, M. Kietzmann, M. Thevis, S. Guddat, W. Schänzer

            Pharmacokinetics of altrenogest in horses.

            J. vet. Pharmacol. Therap., 30, 86-90, 2007