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Publications

2017:

  • T. Johannssen, B. Lepenies*: Glycan-based cell targeting to modulate immune responses. Trends Biotechnol. 2017, in press
  • T.J. Kottom, D.M. Hebrink, P.E. Jenson, M. Wüthrich, H. Wang, B. Klein, S. Yamasaki, B. Lepenies, A.H.        Limper*: The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense Against Infection. J. Immunol. 2017, in press.
  • A.V. Kostarnoy*, P.G. Gancheva, B. Lepenies, A.I. Tukhvatulin, A.S Dzharullaeva, N.B. Polyakov, D.A. Grumov, D.A. Egorova, A.Y. Kulibin, M.A. Bobrov, E.A. Malolina, P.A. Zykin, A.I. Soloviev, E. Riabenko, D.V. Maltseva, D.A. Sakharov, A. Tonevitsky, L.V. Verkhovskaya, D.Y. Logunov, B.S. Naroditsky, A.L. Gintsburg: The receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate. Proc. Natl. Acad. Sci. U.S.A. 2017, in press
  • S. Mayer, M.-K. Raulf, B. Lepenies*: C‑type lectins: their network and roles in pathogen recognition and immunity. Histochem. Cell Biol. 2017, 147(2), 223-37.
  • C. Gao, R. Fujinawa, T. Yoshida, M. Ueno, F. Ota, Y. Kizuka, T. Hirayama, H. Korekane, S. Kitazume, T. Maeno, K. Ohtsubo, K. Yoshida, Y. Yamaguchi, B. Lepenies, J. Aretz, C. Rademacher, H. Kabata, A. Hegab, P.H. Seeberger, T. Betsuyaku, K. Kida, N. Taniguchi*: A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. Am. J. Physiol.-Lung Cell. Mol. Physiol. 2017, 312(2), L268-76.
  • A. Troegeler, I. Mercier, C. Cougoule, D. Pietretti, A. Colom, C. Duval, T.P. Vu Manh, F. Capilla, R. Poincloux, K. Pingris, J. Nigou, J. Rademann, M. Dalod, F.A. Verreck, T. Al Saati, G. Lugo-Villarino, B. Lepenies, D. Hudrisier, O. Neyrolles*: C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 2017, 114(4), E540-49.

 

2016:

  • H. Bavireddi, R.V. Murthy, M. Gade, S. Sangabathuni, P.M. Chaudhari, C. Alex, B. Lepenies, R. Kikkeri*: Understanding carbohydrate–protein interactions using homologous supramolecular chiral Ru(II)-glyconanoclusters. Nanoscale 2016, 8(47), 19696-702.
  • K. Brzezicka, U. Vogel, S. Serna, T. Johannssen, B. Lepenies*, N.-C. Reichardt*: Influence of core β-1,2-xylosylation on glycoprotein recognition by murine C-type lectin receptors and its impact on dendritic cell targeting. ACS Chem. Biol. 2016, 11(8), 2347-56.
  • A. Huber, R.S. Kallerup, H. Franzyk, K.S. Korsholm, B. Lepenies, D. Christensen, C. Foged, R. Lang*: Trehalose-diester glycolipids are superior to monoesters in binding to Mincle, activation of macrophages in vitro, and adjuvant activity in vivo. Innate Immun. 2016, 22(6), 405-18.

 

2015:

  • C.N. LaRock, S. Döhrmann, J. Todd, R. Corriden, J. Olson, T. Johannssen, B. Lepenies, R.L Gallo, P. Ghosh, V. Nizet*: Group A streptococcal M1 protein sequesters cathelicidin to evade innate immune killing. Cell Host Microbe 2015, 18(4), 471-77.
    • C.-H. Lai, J. Hütter, C.-W. Hsu, H. Tanaka, S. Varela-Aramburu, L. De Cola, B. Lepenies*, P.H. Seeberger*: Analysis of carbohydrate-carbohydrate interactions using sugar-functionalized silicon nanoparticles for cell imaging. Nano Lett. 2016, 16(1), 807-11

    • J. Ostrop, K. Jozefowski, S. Zimmermann, K. Hofmann, E. Strasser, B. Lepenies, R. Lang*: Contribution of MINCLE-SYK signaling to activation of primary human antigen-presenting cells by mycobacterial cord factor and the novel adjuvant TDB. J. Immunol. 2015, 195(5), 2417-28. 
    • E. Zacco, J. Hütter, J.L. Heier, J. Mortier, P.H. Seeberger, B. Lepenies, B. Koksch*: Towards a tailored presentation of ligands: coiled coil-based glycopeptides for ASGPR targeting. ACS Chem. Biol. 2015, 10(9), 2065-72.
    • K. Täuber, B. Lepenies, J. Yuan*: Polyvinylpyridinium-type gradient porous membranes – synthesis, actuation and intrinsic cell growth inhibition. Polym. Chem. 2015, 6, 4855-58.
    • O. Redy-Keisar, K. Huth, U. Vogel, B. Lepenies, P.H. Seeberger, R. Haag, D. Shabat*: Enhancement of fluorescent properties of near-infrared dyes using clickable oligoglycerol dendrons. Org. Biomol. Chem. 2015, 13(16), 4727-32.
    • Y.L. Lightfoot, K. Selle, T. Yang, Y.J. Goh, B. Sahay, M. Zadeh, J.L. Owen, N. Colliou, E. Li, T. Johannssen, T. Ganguly, B. Lepenies, T.R. Klaenhammer, M. Mohamadzadeh*: C-type lectin receptor SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO J. 2015, 34(7), 881-95.
    • A. Rabes, S. Zimmermann, K. Reppe, R. Lang, P.H. Seeberger, N. Suttorp, M. Witzenrath, B. Lepenies*, B. Opitz*: The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response. PLOS One 2015, 10(2): e0117022.

     

     

    2014:

    • H. Schoenen, A. Huber, N. Sonda, S. Zimmermann, J. Jantsch, B. Lepenies, V. Bronte, R. Lang*: Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α. J. Immunol. 2014, 193(7), 3664-75.
    • J. Hütter, M. Eriksson, T. Johannssen, R. Klopfleisch, D. von Smolinski,  A.D. Gruber, P.H. Seeberger, B. Lepenies*: Role of the C-type lectin receptors MCL and DCIR in experimental colitis. PLOS One 2014, 9(7): e103281.
    • N.M. van Sorge, J.N. Cole, K. Kuipers, A. Henningham, R.K. Aziz, A. Kasirer-Friede, L. Lin, E.T. Berends, M.R. Davies, G. Dougan, F. Zhang, S. Dahesh, L. Shaw, J. Gin, M. Cunningham, J.A. Merriman, J. Hütter, B. Lepenies, S.H.M. Rooijakkers, R. Malley, M.J. Walker, S.J. Shattil, P.M. Schlievert, B. Choudhury, V. Nizet*: Genetics and virulence role of the classical Group A Streptococcus Lancefield antigen. Cell Host Microbe 2014, 15(6), 729-40.
    • M. Eriksson, S. Serna, M. Maglinao, M.K. Schlegel, P.H. Seeberger, N.C. Reichardt*, B. Lepenies*: Biological evaluation of multivalent Lewis X-MGL-1 interactions. ChemBioChem 2014, 15(6), 844-51.
    • S.M. Miltsch, P.H. Seeberger, B. Lepenies*: The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection. Dev. Comp. Immunol. 2014, 45(1), 67-73.
    • M. Maglinao, M. Eriksson, M.K. Schlegel, S. Zimmermann, T. Johannssen, S. Götze, P.H. Seeberger, B. Lepenies*: A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation. J. Control. Release. 2014, 175, 36-42.

     

    2013:

    • M. Eriksson, T. Johannssen, D. von Smolinski, A.D. Gruber, P.H. Seeberger, B. Lepenies*: The C-type lectin receptor SIGNR3 binds to fungi present in commensal microbiota and influences immune regulation in experimental colitis. Front. Immunol. 2013, 4, 196.
    • M. Maglinao, R. Klopfleisch, P. Seeberger, B. Lepenies*: The C-type lectin receptor DCIR is crucial for the development of experimental cerebral malaria. J. Immunol. 2013, 191(5), 2551-59.
    • K. Shirato, C. Gao, F. Ota, T. Angata, H. Shogomori, K. Ohtsubo, K. Yoshida, B. Lepenies, N. Taniguchi*: Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells. BBRC 2013, 435(3): 460-65.
    • N. Karton-Lifshin, U. Vogel, E. Sella, P.H. Seeberger, D. Shabat*, B. Lepenies*: Enzyme mediated nutrient release: glucose-precursor activation by β-galactosidase to induce bacterial growth. Org. Biomol. Chem. 2013, 11(17): 2903-10.
    • J. Hütter, J.V. Rödig, D. Höper, U. Reichl, P.H. Seeberger, E. Rapp*, B. Lepenies*: Toward animal cell culture-based influenza vaccine design: viral hemagglutinin N-glycosylation markedly impacts immunogenicity. J. Immunol. 2013, 190(1): 220-30.


    2012 and earlier:

    • C.C. Williams, S.H. Thang, T. Hantke, U. Vogel, P.H. Seeberger, J. Tsanaktsidis*, B. Lepenies*: RAFT-derived polymer-drug conjugates: poly(hydroxypropyl methacryl-amide) (HPMA)-7-ethyl-10-hydroxycamptothecin conjugates. ChemMedChem 2012; 7(2): 281-91.
    • M.K. Schlegel, J. Hütter, M. Eriksson, B. Lepenies, P.H. Seeberger*: Defined presentation of carbohydrates on a duplex DNA scaffold. ChemBioChem 2011; 12(18): 2791-800.
    • D. Grünstein, M. Maglinao, R. Kikkeri, M. Collot, K. Barylyuk, B. Lepenies, F. Kamena, R. Zenobi, P.H. Seeberger*: Hexameric supramolecular scaffold orients carbohydrates to sense bacteria. J. Am Chem. Soc. 2011; 133(35): 13957-66.
    • S. Khil’chenko, T. Zaporozhets, N. Shevchenko, T. Zvyagintseva, P.H. Seeberger, B. Lepenies*: Immunostimulatory activity of fucoidan from the brown alga Fucus evanescens: role of sulfates and acetates. J. Carbohydr. Chem. 2011; 30: 291-305. 
    • R. Gentsch, F. Pippig, K. Nilles, P. Theato, R. Kikkeri, M. Maglinao, B. Lepenies, P.H. Seeberger, H.G. Börner*: Modular approach towards bioactive fiber meshes carrying oligosaccharides. Macromolecules 2010; 43(22): 9239-47.
    • G.J. Bernardes, R. Kikkeri, M. Maglinao, P. Laurino, M. Collot, S.Y. Hong, B. Lepenies, P.H. Seeberger*: Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting. Org. Biomol. Chem. 2010; 8(21): 4987-96.
    • R. Kikkeri, B. Lepenies, A. Adibekian, P. Laurino, P.H. Seeberger*: In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots. J. Am. Chem. Soc. 2009; 131(6): 2110-12.
    • S. Boonyarattanakalin, X. Liu, M. Michieletti, B. Lepenies, P.H Seeberger*: Chemical synthesis of all phosphatidylinositol mannoside (PIM) glycans from Mycobacterium tuberculosis. J. Am. Chem. Soc. 2008; 130(49): 16791-16799.
    • J.P. Cramer°, B. Lepenies°, F. Kamena, C. Hölscher, M.A. Freudenberg, G.D. Burchard, H. Wagner, C.J. Kirschning, X. Liu, P.H. Seeberger, T. Jacobs*: MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection. Microbes Infect. 2008; 10(12-13): 1259-65.
    • B. Lepenies, J.P. Cramer, G.D. Burchard, H. Wagner, C.J. Kirschning, T. Jacobs*: Induction of experimental cerebral malaria is independent of TLR2/4/9. Med. Microbiol. Immunol. 2008; 197(1): 39-44.
    • B. Lepenies, K. Pfeffer, M.A. Hurchla, T.L. Murphy, K.M. Murphy, J. Oetzel, B. Fleischer, T. Jacobs*: Ligation of B and T lymphocyte attenuator prevents the genesis of experimental cerebral malaria. J. Immunol. 2007; 179(6): 4093-100.
    • B. Lepenies, I. Gaworski, S. Tartz, J. Langhorne, B. Fleischer, T. Jacobs*: CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections. Microbes Infect. 2007; 9(6): 687-94.
    Kontakt
    Prof. Dr. Bernd Lepenies
    Tel.:+49 511 953-6135
    Fax.:+49 511 953-82 6135
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