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Dr. Graham Brogden

Publikationen

  • Hypoxia modulates the response of mast cells to Staphylococcus aureus infection. Möllerherm H, Branitzki-Heinemann K, Brogden G, Elamin AA, Oehlmann W, Fuhrmann H, Singh M, Naim HY, von Köckritz-Blickwede M. Front Immunol. 2017 May 11;8:541. doi: 10.3389/fimmu.2017.00541. eCollection 2017.

  • Case study on the pathophysiology of Fabry disease: Abnormalities of cellular membranes can be reversed by substrate reduction in vitro. Brogden G*, Shammas H*, Maalouf K, Naim SL, Wetzel G, Amiri M, von Köckritz-Blickwede M, Das AM, Naim HY. Biosci Rep. 2017 Apr 28;37(2). pii: BSR20160402. doi: 10.1042/BSR20160402. Print 2017 Apr 30.

  • Methods to study lipid alterations in neutrophils and the subsequent formation of neutrophil extracellular traps.  Brogden G*, Neumann A*, Husein DM, Reuner F, Naim HY, von Köckritz-Blickwede M. J Vis Exp. 2017 Mar 29;(121). doi: 10.3791/54667.

  • Formation of neutrophil extracellular traps under low oxygen level. Branitzki-Heinemann K, Möllerherm H, Völlger L, Husein DM, de Buhr N, Blodkamp S, Reuner F, Brogden G, Naim HY, von Köckritz-Blickwede M. Front Immunol. 2016 Nov 25;7:518. eCollection 2016.

  • Alterations in membrane trafficking and pathophysiological implications in lysosomal storage disorders Kuech EM*, Brogden G*, Naim HY. Biochimie. 2016 Nov;130:152-162. doi: 10.1016/j.biochi.2016.09.011. Epub 2016 Sep 21. Review.

  • Brogden G*, Adamek M*, Proepsting M, Ulrich R, Hassan Y. Naim H. Y, Steinhagen D.  Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle. Veterinary Microbiology. 2015 doi:10.1016/j.vetmic.2015.05.024.
  • Raddatz B. B. R, Sun W, Brogden G, Sun Y, Kammeyer P, Kalkuhl A, Colbatzky F, Naim H. Y, Deschl U, Baumgärtner W, Ulrich R. Central nervous system de- and remyelination is independent from systemic cholesterol level in Theiler´s murine encephalomyelitis. Brain Pathology. 2015 DOI: 10.1111/bpa.12266
  • Adamek M, Rauch G, Brogden G, Steinhagen D. Effect of small interfering RNA based treatment of the Cyprinid herpesvirus 3 infection of common carp (Cyprinus carpio L.) cells in vitro. Pol J Vet Sci. 2014 17 (4): 733-735
  • Adamek M, Rakus KL, Brogden G, Matras M, Chyb J, Hirono I, Kondo H, Aoki T, Irnazarow I, Steinhagen D. Interaction between type 1 interferon and Cyprinus herpesvirus 3 in two genetic lines of common carp (Cyprinus carpio). Dis Aquat Organ. 2014 Sep 30;111(2):107-18
  • Neumann A, Brogden G, Jerjomiceva N, Brodesser S, Naim HY, von Köckritz-Blickwede M. Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps.  Eur J Cell Biol. 2014 Aug-Sept;93(8-9):247-54
  • Brogden G*, Krimmling T*, Adamek M, Naim HY, Steinhagen D, von Köckritz-Blickwede M. The effect of β-glucan on formation and functionality of neutrophil extracellular traps in carp (Cyprinus carpio L.). Dev Comp Immunol. 2014 Jun;44(2):280-5.
  • Brogden G, Propsting M, Adamek M, Naim HY, Steinhagen D. 2014 Isolation and analysis of membrane lipids and lipid rafts in common carp (Cyprinus carpio L.). Comp Biochem Physiol B Biochem Mol Biol. 2014;169:9-15
  • Syakuri H, Jung-Schroers V, Adamek M, Brogden G, Irnazarow I, Steinhagen D. Beta-glucan feeding differentiated the regulation of mRNA expression of claudin genes and prevented an intestinal inflammatory response post Aeromonas hydrophila intubation in common carp, Cyprinus carpio L. J Fish Dis. 2014 Feb 37(2): 149-156.
  • Syakuri H, Adamek M, Brogden G, Rakus KŁ, Matras M, Irnazarow I, Steinhagen D. Intestinal barrier of carp (Cyprinus carpio L.) during a cyprinid herpesvirus 3-infection: molecular identification and regulation of the mRNA expression of claudin encoding genes.Fish Shellfish Immunol. 2013 Jan;34(1):305-14. doi: 10.1016/j.fsi.2012.11.010. Epub 2012 Nov 26.
  • Adamek M, Syakuri H, Harris S, Rakus KŁ, Brogden G, Matras M, Irnazarow I, Steinhagen D. Cyprinid herpesvirus 3 infection disrupts the skin barrier of common carp (Cyprinus carpio L.).Vet Microbiol. 2013 Mar 23;162(2-4):456-70.
  • Brogden G*, von Kockritz-Blickwede M*, Adamek M, Reuner F, Jung-Schroers V, Naim HY, Steinhagen D. beta-Glucan protects neutrophil extracellular traps against degradation by Aeromonas hydrophila in carp (Cyprinus carpio). Fish Shellfish Immunol. 2012 33:1060-4.
  • Adamek M, Rakus KŁ, Chyb J, Brogden G, Huebner A, Irnazarow I, Steinhagen D. Interferon type I responses to virus infections in carp cells: In vitro studies on Cyprinid herpesvirus 3 and Rhabdovirus carpio infections.Fish Shellfish Immunol. 2012 Sep;33(3):482-93.
  • Rakus KŁ, Irnazarow I, Adamek M, Palmeira L, Kawana Y, Hirono I, Kondo H, Matras M, Steinhagen D, Flasz B, Brogden G, Vanderplasschen A, Aoki T. Gene expression analysis of common carp (Cyprinus carpio L.) lines during Cyprinid herpesvirus 3 infection yields insights into differential immune responses. Dev Comp Immunol. 2012 May;37(1):65-76.
  • Maalouf, K., Jia, J., Rizk, S., Brogden, G., Keiser, M., Das, A., Naim, H.Y., 2009. A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV. Journal of Inherited Metabolic Disease 33, 445-449

Lebenslauf

Research positions

 

01/2015-                    

Postdoctoral researcher, Department of Physiological Chemistry/ Fish Disease Research Unit, Infection Biochemistry Research Group, University of Veterinary Medicine, Hannover, Germany.

 

07/2014-12/2014       

Postdoctoral researcher, Department of Physiological Chemistry, Infection Biochemistry Research Group, University of Veterinary Medicine, Hannover, Germany.

 

04/2014-06/2014       

Postdoctoral researcher, Fish Disease Research Unit, University of Veterinary Medicine, Hannover, Germany.

 

08/2012-04/2014       

Postdoctoral researcher, Department of Physiological Chemistry, Infection Biochemistry Research Group, University of Veterinary Medicine, Hannover, Germany.

 

06-08/2012              

Researcher, Fish Disease Research Unit, University of Veterinary Medicine, Hannover, Germany.

 

05/2009-05/2012       

PhD student, Fish Disease Research Unit, University of Veterinary Medicine, Hannover, Germany.

 

2007-2009                 

Master in Scientific Research Training (MRes) Keele University, topic: ‘The production of a recombinant form of carp Tumour Necrosis Factor a1 and a2 in a Eukaryotic system’. 

 

Education

 

2009-2013                 

PhD, University of Veterinary Medicine Hannover, Germany

 

2007-2009                

MRes, Keele University, UK/Wageningen University, NL 

 

2004-2007                 

Bachelor in Biology and Geography, Keele University, UK

 

2002-2004                 

A levels in Biology, Chemistry, Geography and General Studies, Clitheroe Royal Grammar School Sixth Form, UK

Kontakt Labor
Tel.:+49 511 953-8704
Fax.:+49 511 953-8585
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