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Prof. Dr. Hassan Y. Naim

Prof. Dr. Hassan Y. Naim erhielt sein Ph.D. Abschluss in Biochemie von der Universität Bern, Schweiz. Nach Anstellungen am Institut für Biochemie der Universität Lausanne (Membrantransport in T-Zellen) und der Kinderklinik der Universität Bern (Struktur und Funktion von Bürstensaummembranproteinen) zog er 1989 ans Department of Biochemistry, University of Texas Southwestern Medical Center in Dallas, USA, um seine Arbeit an den Struktur-Funktionsbeziehungen von Bürstensaumproteinen fortzuführen. 1991 wurde er als Nachwuchsgruppenleiter im Rahmen des Schwerpunktes "Biokatalyse" an der Universität Düsseldorf, Deutschland, eingestellt. 1997 wurde er zum Professor und Leiter des Instituts für Physiologische Chemie an der Tierärztlichen Hochschule Hannover, Deutschland, berufen. Die aktuellen Forschungsinteressen im Naim-Labor richten sich auf die molekularen Mechanismen, die dem Proteintransport unterliegen, insbesondere polarisierte Proteinsortierung in Epithelzellen, in gesunden und pathologischen Zuständen.

 

 

Publikationen (seit 2000)

Yaseen R, Branitzki-Heinemann K, Moubasher H, Setzer WN, Naim HY, von Köckritz-Blickwede M.

In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus.

Biomedicines. 2017 Jul 5;5(3). pii: E40. doi: 10.3390/biomedicines5030040.

 

Kleinsorgen C, Kankofer M, Gradzki Z, Mandoki M, Bartha T, von Köckritz-Blickwede M, Naim HY, Beyerbach M, Tipold A, Ehlers JP.

Utilization and acceptance of virtual patients in veterinary basic sciences - the vetVIP-project.

GMS J Med Educ. 2017 May 15;34(2):Doc19. doi: 10.3205/zma001096. eCollection 2017.

 

Möllerherm H, Branitzki-Heinemann K, Brogden G, Elamin AA, Oehlmann W, Fuhrmann H, Singh M, Naim HY, von Köckritz-Blickwede M.

Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection.

Front Immunol. 2017 May 11;8:541. doi: 10.3389/fimmu.2017.00541. eCollection 2017.

 

Gericke B, Schecker N, Amiri M, Naim HY.

Structure-function analysis of human sucrase-isomaltase identifies key residues required for catalytic activity.

J Biol Chem. 2017 May 18. pii: jbc.M117.791939. doi: 10.1074/jbc.M117.791939. [Epub ahead of print]

 

Brogden G, Neumann A, Husein DM, Reuner F, Naim HY, von Köckritz-Blickwede M.

Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps.

J Vis Exp. 2017 Mar 29;(121). doi: 10.3791/54667.

 

Brogden G, Shammas H, Maalouf K, Naim SL, Wetzel G, Amiri M, von Köckritz-Blickwede M, Das AM, Naim HY.

Case study on the pathophysiology of Fabry Disease: Abnormalities of cellular membranes can be reversed by substrate reduction in vitro.

Biosci Rep. 2017 Mar 28. pii: BSR20160402. doi: 10.1042/BSR20160402. [Epub ahead of print]

 

Yaseen R, Blodkamp S, Lüthje P, Reuner F, Völlger L, Naim HY, von Köckritz-Blickwede M.

Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus.

J Negat Results Biomed. 2017 Feb 19;16(1):2. doi: 10.1186/s12952-017-0067-2.

 

Gericke B, Amiri M, Ronald Scott C, Naim HY.

Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients.

Biochim Biophys Acta. 2017 Jan 3. pii: S0925-4439(16)30354-4. doi: 10.1016/j.bbadis.2016.12.017. [Epub ahead of print]

 

Branitzki-Heinemann K, Möllerherm H, Völlger L, Husein DM, de Buhr N, Blodkamp S, Reuner F, Brogden G, Naim HY, von Köckritz-Blickwede M.

 

Henström M, Diekmann L, Bonfiglio F, Hadizadeh F, Kuech EM, von Köckritz-Blickwede M, Thingholm LB, Zheng T, Assadi G, Dierks C, Heine M, Philipp U, Distl O, Money ME, Belheouane M, Heinsen FA, Rafter J, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Walter S, Simrén M, Karling P, Ohlsson B, Schmidt PT, Lindberg G, Dlugosz A, Agreus L, Andreasson A, Mayer E, Baines JF, Engstrand L, Portincasa P, Bellini M, Stanghellini V, Barbara G, Chang L, Camilleri M, Franke A, Naim HY, D'Amato M.

Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.

Gut. 2016 Nov 21. pii: gutjnl-2016-312456. doi: 10.1136/gutjnl-2016-312456. [Epub ahead of print]

 

Kuech EM, Brogden G, Naim HY.

Alterations in membrane trafficking and pathophysiological implications in lysosomal storage disorders.

Biochimie. 2016 Nov;130:152-162. doi: 10.1016/j.biochi.2016.09.011. Review.

 

Zeitouni NE, Fandrey J, Naim HY, von Köckritz-Blickwede M.

Measuring oxygen levels in Caco-2 cultures.

Hypoxia (Auckl). 2015 Oct 9;3:53-66.

 

Diekmann L, Behrendt M, Amiri M, Naim HY.

Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein.

Biochim Biophys Acta. 2016 Oct 21. pii: S0304-4165(16)30391-9. doi: 10.1016/j.bbagen.2016.10.016. [Epub ahead of print]

 

Perico ME, Grasso S, Brunelli M, Martignoni G, Munari E, Moiso E, Fracasso G, Cestari T, Naim HY, Bronte V, Colombatti M, Ramarli D.

Prostate-specific membrane antigen (PSMA) assembles a macromolecular complex regulating growth and survival of prostate cancer cells "in vitro" and correlating with progression "in vivo".

Oncotarget. 2016 Oct 3. doi: 10.18632/oncotarget.12404. [Epub ahead of print]

 

Jerjomiceva N, Seri H, Yaseen R, de Buhr N, Setzer WN, Naim HY, von Köckritz-Blickwede M.

Guarea kunthiana Bark Extract Enhances the Antimicrobial Activities of Human and Bovine Neutrophils.

Nat Prod Commun. 2016 Jun;11(6):767-70.

 

Naim HY, Zimmer KP, Nichols B.

Molecular biology of the gut.

Mol Cell Pediatr. 2016 Dec;3(1):32. doi: 10.1186/s40348-016-0059-1. No abstract available.

 

Al-Ghadban S, Kaissi S, Homaidan FR, Naim HY, El-Sabban ME.

Cross-talk between intestinal epithelial cells and immune cells in inflammatory bowel disease.

Sci Rep. 2016 Jul 15;6:29783. doi: 10.1038/srep29783.

 

Noack A, Noack S, Buettner M, Naim HY, Löscher W.

Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors.

Sci Rep. 2016 Jul 4;6:29253. doi: 10.1038/srep29253.

 

Völlger L, Akong-Moore K, Cox L, Goldmann O, Wang Y, Schäfer ST, Naim HY, Nizet V, von Köckritz-Blickwede M.

 

Blodkamp S, Kadlec K, Gutsmann T, Quiblier C, Naim HY, Schwarz S, von Köckritz-Blickwede M.

Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus.

Vet Microbiol. 2016 Mar 31. pii: S0378-1135(16)30074-8. doi: 10.1016/j.vetmic.2016.03.021. [Epub ahead of print]

 

Zeitouni NE, Chotikatum S, von Köckritz-Blickwede M, Naim HY.

The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens.

Mol Cell Pediatr. 2016 Dec;3(1):14. doi: 10.1186/s40348-016-0041-y. Epub 2016 Mar 22. Review.

 

Lena Völlger; Kathryn Akong-Moore; Linda Cox; Oliver Goldmann; Yanming Wang; Simon T. Schäfer; Hassan Y Naim; Victor Nizet; Maren von Köckritz-Blickwede

Iron chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils

Bioscience Reports Mar 30, 2016; DOI: 10.1042/BSR20160031

 

Zimmer KP, de Laffolie J, Barone MV, Naim HY.

Endocytosis in enterocytes.

Wien Med Wochenschr. 2016 Mar 18. [Epub ahead of print]

 

Gericke B, Amiri M, Naim HY.

The multiple roles of sucrase-isomaltase in the intestinal physiology.

Mol Cell Pediatr. 2016 Dec;3(1):2. doi: 10.1186/s40348-016-0033-y. Epub 2016 Jan 26.

 

Erben T, Ossig R, Naim HY, Schnekenburger J.

What to do with high autofluorescence background in pancreatic tissues - an efficient Sudan Black B quenching method for specific immunofluorescence labeling.

Histopathology. 2016 Jan 23. doi: 10.1111/his.12935. [Epub ahead of print]

 

Zeitouni NE, Dersch P, Naim HY, von Köckritz-Blickwede M.

Hypoxia Decreases Invasin-Mediated Yersinia enterocolitica Internalization into Caco-2 Cells.

PLoS One. 2016 Jan 5;11(1):e0146103. doi: 10.1371/journal.pone.0146103. eCollection 2016.

 

Metzger J, Wöhlke A, Mischke R, Hoffmann A, Hewicker-Trautwein M, Küch EM, Naim HY, Distl O.

A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis.

PLoS One. 2015 Oct 27;10(10):e0141514. doi: 10.1371/journal.pone.0141514. eCollection 2015.

 

Möllerherm H, Neumann A, Schilcher K, Blodkamp S, Zeitouni NE, Dersch P, Lüthje P, Naim HY, Zinkernagel AS, von Köckritz-Blickwede M.

Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs).

FEMS Microbiol Lett. 2015 Oct 12. pii: fnv192. [Epub ahead of print]

 

Blodkamp S, Kadlec K, Gutsmann T, Naim HY, von Köckritz-Blickwede M, Schwarz S.

In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus.

Vet Microbiol. 2015 Sep 28. pii: S0378-1135(15)30036-5. doi: 10.1016/j.vetmic.2015.09.018. [Epub ahead of print]

 

Amiri M, Diekmann L, von Köckritz-Blickwede M, Naim HY.

The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers.

Nutrients. 2015 Aug 28;7(9):7209-30. doi: 10.3390/nu7095332. Review.

 

Amiri M, Kuech EM, Shammas H, Wetzel G, Naim HY.

The Pathobiochemistry of Gastrointestinal Symptoms in a Patient with Niemann-Pick Type C Disease.

JIMD Rep. 2015 Jun 30. [Epub ahead of print]

 

Brogden G, Adamek M, Proepsting MJ, Ulrich R, Naim HY, Steinhagen D.

Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle.

Vet Microbiol. 2015 Sep 30;179(3-4):204-12. doi: 10.1016/j.vetmic.2015.05.024. Epub 2015 May 31.

 

Raddatz BB, Sun W, Brogden G, Sun Y, Kammeyer P, Kalkuhl A, Colbatzky F, Deschl U, Naim HY, Baumgärtner W, Ulrich R. Central nervous system de- and remyelination is independent from systemic cholesterol level in Theiler's murine encephalomyelitis.

Brain Pathology. 2015 May 11. doi: 10.1111/bpa.12266. [Epub ahead of print].

 

Diekmann L, Pfeiffer K, Naim HY. Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene.

BMC Gastroenterology, 2015 Mar 21;15(1):36.

 

de Buhr N, Stehr M, Neumann A, Naim HY, Valentin-Weigand P, von Köckritz-Blickwede M, Baums CG. Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap (NET) degradation during exponential growth.

Microbiology. 2015 Feb 9.; 161(Pt 4):838-50

 

Punyadarsaniya D, Winter C, Mork AK, Amiri M, Naim HY, Rautenschlein S, Herrler G. Precision-cut intestinal slices as a culture system to analyze the infection of differentiated intestinal epithelial cells by avian influenza viruses.

Journal of Virological Methods. 2015 Feb;212:71-5.

 

Limbourg A, Schnabel S, Lozanovski VJ, Napp LC, Ha TC, Maetzig T, Bauersachs J, Naim HY, Schambach A, Limbourg FP. Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin.

Cell Regeneration (Lond). 2014 Jun 14;3(1):9.

 

Neumann A, Berends ET, Nerlich A, Molhoek EM, Gallo RL, Meerloo T, Nizet V, Naim HY, von Köckritz-Blickwede M*2 . The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. Biochemical Journal. 2014 Nov 15;464(1):3-11. doi: 10.1042/BJ20140778.

 

Neumann A, Brogden G, Jerjomiceva N, Brodesser S, Naim HY, von Köckritz-Blickwede M*1. Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps.

European Journal of Cell Biology. 2014 Aug-Sep;93(8-9):347-54. doi: 10.1016/j.ejcb.2014.07.005. Epub 2014 Aug 2.

 

Angelbeck-Schulze M, Mischke R, Rohn K, Hewicker-Trautwein M, Naim HY, Bäumer W. Canine epidermal lipid sampling by skin scrub revealed variations between different body sites and normal and atopic dogs.

BMC Veterinary Research. 2014 Jul 10;10:152.

 

Neumann A, Völlger L, Berends ET, Molhoek EM, Stapels DA, Midon M, Friães A, Pingoud A, Rooijakkers SH, Gallo RL, Mörgelin M, Nizet V, Naim HY, von Köckritz-Blickwede M. Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases.

Journal of Innate Immunity.  2014;6(6):860-8.

 

Amiri M, Naim HY. Long term differential consequences of miglustat therapy on intestinal disaccharidases.

Journal of Inherited Metabolic Disease. 2014 Nov;37(6):929-37.

 

Tappenbeck K, Schmidt S, Feige K, Naim HY, Huber K. Lidocaine effect on flotillin-2 distribution in detergent-resistant membranes of equine jejunal smooth muscle in vitro.

Veterinary Journal. 2014 May;200(2):325-7.

 

Jerjomiceva N, Seri H, Völlger L, Wang Y, Zeitouni N, Naim HY, von Köckritz-Blickwede M. Enrofloxacin enhances the formation of neutrophil extracellular traps in bovine granulocytes. Journal of Innate Immunity. 2014;6(5):706-12.

 

Noack A, Noack S, Hoffmann A, Maalouf K, Buettner M, Couraud PO, Romero IA, Weksler B, Alms D, Römermann K, Naim HY, Löscher W. Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C.

PLoS One. 2014 Feb 4;9(2):e88154.

 

Schmidt S, Gericke B, Fracasso G, Ramarli D, Colombatti M, Naim HY. Discriminatory Role of Detergent-Resistant Membranes in the Dimerization and Endocytosis of Prostate-Specific Membrane Antigen.

PLoS One. 2013 Jun 19;8(6):e66193.

 

Angelbeck-Schulze M, Stahl J, Brodesser S, Rohn K, Naim H, Hewicker-Trautwein M, Kietzmann M, Bäumer W, Mischke R. Comparison of three different sampling methods for canine skin lipids. Veterinary Dermatology. 2013 Apr;24(2):233-e51.

 

Schmidt S, Fracasso G, Colombatti M, Naim HY Cloning and characterization of canine prostate-specific membrane antigen.

Prostate. 2013 May;73(6):642-50

 

Swadzba ME, Hauck SM, Naim HY, Amann B, Deeg CA. Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis.

PLoS One. 2012;7(12):e50929.

 

Zimmer KP, Scholz D, Naim HY. Transient sucrose and starch intolerance.

Journal of Pediatric Gastroenterology and  Nutrition. 2012 Nov;55 Suppl 2:S39-40. doi: 10.1097/01.mpg.0000421411.10999.ad.

 

Chumpitazi BP, Robayo-Torres CC, Opekun AR, Nichols BL Jr, Naim HY. Congenital sucrase-isomaltase deficiency: summary of an evaluation in one family.

Journal of Pediatric Gastroenterology and  Nutrition. 2012 Nov;55 Suppl 2:S36.

 

Jones K, Eskandari R, Naim HY, Pinto BM, Rose DR. Investigations of the structures and inhibitory properties of intestinal maltase glucoamylase and sucrase isomaltase.

Journal of Pediatric Gastroenterology and  Nutrition. 2012 Nov;55 Suppl 2:S20-4.

 

Naim HY, Heine M, Zimmer KP. Congenital sucrase-isomaltase deficiency: heterogeneity of inheritance, trafficking, and function of an intestinal enzyme complex.

Journal of Pediatric Gastroenterology and  Nutrition. 2012 Nov;55 Suppl 2:S13-20.

 

Gilger M, Hamaker B, Nichols BL Jr, Auricchio S, Treem WR, Naim HY, Heine M, Zimmer KP, Jones K, Eskandari R, Pinto BM, Rose DR, Lee BH, Quezada-Calvillo R, Adams B, Roach CM, Ma CX, Baker SS, Slawson MH, Robayo-Torres CC, Chumpitazi BP, Lecea CE, Opekun AR, Uhrich S, Wu Z, Huang JY, Scott CR, Chumpitazi BP, McMeans AR, Scholz D, Shulman RJ, Ao Z, Sterchi EE, Lin AH. Research progress reported at the 50th Anniversary of the Discovery of Congenital Sucrase-Isomaltase Deficiency Workshop.

Journal of Pediatric Gastroenterology and  Nutrition. 2012 Nov;55 Suppl 2:S1.

 

Lin AH, Lee BH, Nichols BL, Quezada-Calvillo R, Rose DR, Naim HY, Hamaker BR. Starch source influences dietary glucose generation at the mucosal α-glucosidase level.

The Journal of Biological Chemistry. 2012 Oct 26;287(44):36917-21.

 

Amiri M, Naim HY. Miglustat-induced intestinal carbohydrate malabsorption is due to the inhibition of α-glucosidases, but not β-galactosidases.

Journal of Inherited Metabolic Disease. 2012 Nov;35(6):949-54.

 

Brogden G, von Köckritz-Blickwede M, Adamek M, Reuner F, Jung-Schroers V, Naim HY, Steinhagen D. β-Glucan protects neutrophil extracellular traps against degradation by Aeromonas hydrophila in carp (Cyprinus carpio).

Fish and Shellfish Immunology. 2012 Oct;33(4):1060-4.

 

Branitzki-Heinemann K, Okumura CY, Völlger L, Kawakami Y, Kawakami T, Naim HY, Nizet V, Von Köckritz-Blickwede M. A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.

Biochemical Journal 2012 Aug 15;446(1):159-63.

 

Behrendt M, Krahn MP, Al-Bayati H, Amiri M, Rizk S, Naim HY. Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions. Biological Chemistry. 2012 May;393(6):495-503.

 

Lin AH, Nichols BL, Quezada-Calvillo R, Avery SE, Sim L, Rose DR, Naim HY, Hamaker BR. Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.

PLoS One. 2012;7(5):e35473.

 

Jones K, Sim L, Mohan S, Kumarasamy J, Liu H, Avery S, Naim HY, Quezada-Calvillo R, Nichols BL, Pinto BM, Rose DR. Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.

Bioorganic and Medicinal Chemistry, 2011 Jul 1;19(13):3929-34.

 

Reinke Y, Behrendt M, Schmidt S, Zimmer KP, Naim HY. Impairment of protein trafficking by direct interaction of gliadin peptides with actin.

Experimental Cell Research, 2011 Sep 10;317(15):2124-35.

 

Meyer W, Schmidt J, Busche R, Jacob R, Naim HY. Demonstration of free fatty acids in the integument of semi-aquatic and aquatic mammals.

Acta Histochemica. 2012 Feb;114(2):145-50.

 

Hein Z, Schmidt S, Zimmer KP, Naim HY. The dual role of annexin II in targeting of brush border proteins and in intestinal cell polarity.

Differentiation. 2011 Apr;81(4):243-52.

 

Zimmer KP, Heine M, Weissen-Plenz G, Scholand KA, Herbst H, Naim HY TGF{alpha}-associated MUC2 and MUC3 expression of the gastric epithelium in Menetrier's disease during remission of ulcerative colitis.

Gut  2011 Nov;60(11):1607-8.

 

Maalouf K, Jia J, Rizk S, Brogden G, Keiser M, Das A, Naim HY.  A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV.

Journal of Inherited Metabolic Disease. 2010 Aug;33(4):445-9

 

Sim L, Willemsma C, Mohan S, Naim HY, Pinto BM, Rose DR Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.
The Journal of Biological Chemistry, 2010 Jun 4;285(23):17763-70

 

Krahn MP, Rizk S, Alfalah M, Behrendt M, Naim HY Protocadherin of the liver, kidney and colon associates with detergent-resistant membranes during cellular differentiation.

The Journal of Biological Chemistry, 2010 Apr 23;285(17):13193-200

 

Zimmer KP, Fischer I, Mothes T, Weissen-Plenz G, Schmitz M, Wieser H, Mendez E, Buening J, Lerch MM, Ciclitira PC, Weber P, Naim HY Endocytotic Segregation of Gliadin Peptide 31-49 in Enterocytes.

Gut. 2010 Mar;59(3):300-10

 

Behrendt M, Polaina J, Naim HY Structural hierarchy of regulatory elements in the folding and transport of an intestinal multi-domain protein.

The Journal of Biological Chemistry, 2010 Feb 5;285(6):4143-52

 

Lücke T, Keiser M, Illsinger S, Lentze MJ, Naim HY, Das AM Congenital and putatively acquired forms of sucrase-isomaltase deficiency in infancy: effects of sacrosidase therapy.

Journal of Pediatric Gastroenterology and Nutrition, 2009 Oct;49(4):485-7

 

Lindner R, Naim HY Domains in biological membranes

Experimental Cell Research, 2009 Oct 15;315(17):2871-8

 

Kahlisch D, Buettner FF, Naim HY, Gerlach GF Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection.

Veterinary Research, 2009 Nov-Dec;40(6):60

 

Reinke Y, Zimmer KP, Naim HY Toxic peptides in Frazer's fraction interact with the actin cytoskeleton and affect the targeting and function of intestinal proteins.

Experimental Cell Research, 2009 Nov 15;315(19):3442-52

 

Wetzel G, Heine M, Rohwedder A, Naim HY Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase.

Biological Chemistry,  2009 Jul;390(7):545-9

 

Colombatti M, Grasso S, Porzia A, Fracasso G, Scupoli MT, Cingarlini S, Poffe O, Naim HY, Heine M, Tridente G, Mainiero F, Ramarli D The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways.

PLoS One. 2009;4(2):e4608. Epub 2009 Feb 26

 

Behrendt M, Keiser M, Hoch M, Naim HY Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency.

Gastroenterology. 2009 Jun;136(7):2295-303

 

Meyer W, Schmidt J, Busche R, Jacob R, Naim HY Demonstration of lipids in plastic resin-embedded sections of skin material Journal of  Microscopy. 2009 Jan;233(1):5-9

 

Alfalah M, Keiser M, Leeb T, Zimmer KP, Naim HY Compound Heterozygous Mutations Affect Protein Folding and Function in Patients With Congenital Sucrase-Isomaltase Deficiency Gastroenterology. 2009 Mar;136(3):883-92

 

 

Hein Z, Hooper NM, Naim HY Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway.

Experimental Cell Research, 2009 Jan 15;315(2):348-56

 

Gemeinhardt A, Alfalah M, Gück T, Naim H, Fuhrmann H. The influence of linoleic and linolenic acid on activity and intracellular localisation of phospholipase D in COS-1 cells. Biological Chemistry,  2009, 390(3):253-8.

 

Glende, J., Schwegmann-Wessels, C., Al-Falah, M., Pfefferle, S., Qu, X., Deng, H., Drosten, C., Naim, H.Y., Herrler, G. (2008)
Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2.

Virology, 381, 215-221

 

Templin, C., Kotlarz, D., Faulhaber, J., Schnabel, S., Grote, K., Salguero, G., Luchtefeld, M., Hiller, K.H., Jakob, P., Naim, H.Y., Schieffer, B., Hilfiker-Kleiner, D., Landmesser, U., Limbourg, F.P., Drexler, H. (2008).

Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: Role of β-catenin transduction and cell dose.

Journal of Molecular and Cellular Cardiology, 45, 394-403

 

Kreutzer, R., Kreutzer, M., Pröpsting, M.J., Sewell, A.C., Leeb, T., Naim, H.Y., Baumgärtner, W. (2008)

Insights into post-translational processing of beta-galactosidase in an animal model resembling late infantile human G(M1)-gangliosidosis.

Journal of Cellular and Molecular Medicine, 12,1661-1671

 

Reinshagen, K., Keller, K.M., Haase, B., Leeb, T., Naim, H.Y., Zimmer, K.P. (2008)
Mosaic Pattern of Sucrase Isomaltase Deficiency in Two Brothers
Pediatric Research, 63, 79-83

 

Castelletti, D., Alfalah, M., Heine, M., Hein, Z., Schmitte, R., Fracasso, G., Colombatti, M., Naim, H.Y. (2008). Different glycoforms of prostate-specific membrane antigen are intracellularly transported through their association with distinct detergent-resistant membranes.

Biochemical Journal, 409, 149-157

 

Liman, M., Peiser, L., Zimmer, G., Pröpsting, M., Naim, H.Y., Rautenschlein, S. (2007) A genetically engineered prime-boost vaccination strategy for oculonasal delivery with poly(D,L-lactic-co-glycolic acid) microparticles against infection of turkeys with avian Metapneumovirus. 

Vaccine, 25, 7914-7926.

 

Seeliger, F., Hess, O., Pröpsting, M.J., Naim, H.Y., Kleinschmidt, S., Woehrmann, T., Germann, P.G., Baumgärtner, W. (2007) Confocal laser scanning analysis of an equine oral mast cell tumor with atypical expression of tyrosine kinase receptor C-KIT.

Veterinary Pathology, 44, 225-228.

 

Frerker, N., Wagner, L., Wolf, R., Heiser, U., Hoffmann, T., Rahfeld, J.U., Schade, J., Karl, T., Naim, H.Y., Alfalah, M., Demuth, H.U., von Hörsten, S.  (2007).

Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4.

Peptides, 28, 257-268.

 

Reinshagen, K., Naim, H., Heusipp, G., Zimmer, K.P. (2006). Pathophysiology in Microvillus inclusion disease.

Zeitschrift für Gastroenterologie, 44, 667-671.

 

Mundhenk, L., Alfalah, M., Elble, R.C., Pauli, B.U., Naim, H.Y., Gruber, A.D. (2006). Both cleavage products of the mCLCA3 protein are secreted soluble proteins.    

The Journal of Biological Chemistry, 281, 30072-30080.

 

Templin, C., Kotlarz, D., Marquart, F., Faulhaber, J., Brendecke, V., Schaefer, A., Tsikas, D., Bonda, T., Hilfiker-Kleiner, D., Ohl, L., Naim, H.Y., Foerster, R., Drexler, H., Limbourg, F.P. (2006). Transcoronary delivery of bone marrow cells to the infarcted murine myocardium : Feasibility, cellular kinetics, and improvement in cardiac function.

Basic Researh in Cardiology, 101, 301-310.

 

Keiser, M., Alfalah, M., Pröpsting, M., Castelletti, D., Naim, H.Y. (2006). Altered folding, turnover, and polarized sorting act in concert to define a novel pathomechanism of congenital sucrase-isomaltase deficiency.

The Journal of Biological Chemistry, 281, 14393-14399.

 

Alfalah, M., Krahn, M.P., von Hörsten, S., Wolke, C., Hooper, N., Naim, H.Y., Lendeckel, U. (2006). A mutation in aminopeptidase N (CD13) isolated from a patient with leukaemia leads to an arrest in the endoplasmic reticulum.

The Journal of Biological Chemistry, 281, 11894-11900.

 

Ren X., Glende, J., Al-Falah, M., de Vries, V., Schwegmann-Weßels, C., Tschernig, T., Deng, H., Naim, H.Y., Herrler, G. (2006). Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for SARS-associated coronavirus.

Journal of General Virology, 87, 1691-1695.

 

van Barneveld, A., Stanke, F., Ballmann, M., Naim, H.Y., Tümmler, B. (2006). Ex vivo bio chemical analysis of CFTR in human rectal biopsies.

Biochimica et Biophysica Acta Molecular Basis of Disease, 1762, 393-397.

 

Delacour, D., Cramm-Behrens, C.I, Drobecq, H., Le Bivic, A., Naim, H.Y., Jacob, R. (2006). Requirement for galectin-3 in apical protein sorting.

Current Biology 16, 408-414.

 

Sander, B., Alfalah, M., Keiser, M., Jacob, R., Leeb, T., Naim, H.Y. (2006). Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption. 

Human Mutation 27(1): 119

 

Castelletti, D., Fracasso, G., Alfalah, M., Cingarlini, S., Colombatti, M. and Naim, H.Y. (2005). Apical transport and folding of prostate specific membrane antigen occurs independent of glycans processing.

The Journal of Biological Chemistry 281, 3505-3512

 

Alfalah, M., Wetzel, G., Fischer, I., Busche, R., Zimmer, K.P., Sallmann, H.P., Naim, H.Y. (2005). A novel type of detergent-resistnat membranes may contribute to an early protein sorting event  in epithelial cells.

The Journal of Biological Chemistry 280, 42636-42643.

 

Schmitz, M., Alfalah, M., Aerts, J.M., Naim, H.Y., Zimmer, K.P. (2005). Impaired trafficking of mutants of lysosomal glucocer ebrosidase in Gauc her's disease.

International Journal of Biochemistry and Cell Biology 37, 2310-2320

 

Pröpsting, M.J, Kanapin, H., .Jacob, R., Naim, H.Y.  (2005). A phenylalanine-based folding determinant in intestinal sucrase-isomaltase that functions in the context of a quality control mechanism beyond the endoplasmic reticulum.

Journal of Cell Science 118, 2775-2784.

 

Heine, M., Cramm-Behrens, C.I., Ansari, A., Chu, H.P., Ryazanov, A.G., Naim, H.Y., Jacob, R. (2005).  Alpha-kinase 1, a new component in apical protein transport.

The Journal of Biological Chemistry 280, 25637-25643.

 

Breidert, S., Jacob, R., Ngezahayo, A., Kolb, H.A., Naim, H.Y. (2005). Trafficking pathways of Cx49-GFP in living mammalian cells.

Biological Chemistry 386, 155-160.

 

Vetterkind, S., Illenberger, S., Kubicek, J., Boosen, M., Appel, S., Naim, H.Y., Scheidtmann, K.H., Preuss, U. (2005). Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis.

Experimental Cell Research 305, 392-408.

 

Schwegmann-Wessels, C., Alfalah, M., Escors, D., Zimmer, G., Deng, H., Enjuanes, L., Naim, H.Y., Herrler, G. (2004). A novel sorting signal for intracellular localization is present in the S protein of a porcine coronavirus but absent from severe acute respiratory syndrome-associated coronavirus.

The Journal of Biological Chemistry 279, 43661-43666.

 

Kersting, S., Bruewer, M., Schürmann, G., Klotz, A., Utech, M., Hansmerten, M., Krieglstein, C.F., Senninger N., Schulzke, J.-D., Naim, H.Y., Zimmer, K.-P. (2004). Antigen transport and cytoskeleton of a distinct enterocyte population in inflammatory bowel disease.

American Journal of Pathology 165, 425-437

 

Jacob, R., Heine, M., Eikemeyer, J., Frerker, N., Zimmer, K.-P., Rescher, U., Gerke, V., Naim, H.Y. (2004). Annexin II is required for apical transport in polarized epithelial cells.

The Journal of Biological Chemistry 279, 3680-3684.

 

79.   Ritz, V., Alfalah, M., Zimmer, K.-P., Schmitz, J., Jacob, R., Naim, H.Y. (2003). Congenital sucrase-isomaltase deficiency arising from a mutant form of sucrase-isomaltase that accumulates in the endoplasmic reticulum.

Gastroenterology 125, 1678-1685.

 

Pröpsting, M., Jacob, R., Naim, H.Y. (2003). A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the ER and cis-Golgi.

The Journal of Biological Chemistry 278, 16310-1614.

 

Jacob, R., Heine, M., Alfalah, M., Naim, H.Y. (2003) Distinct cytoskeletal tracks direct individual vesicle populations to the apical membrane of epithelial cells.

Current Biology 13, 607-612

 

Nemeth, K., Plumb, G.W., Berrin, J.-G., Juge, N., Jacob, R., Naim, H.Y., Williamson, G., Swallow, D.M., Kroon, P.A. (2003) Deglycosylation by small intestinal epithelial cell b-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.

European Journal of Nutrition 42, 29-42

 

Backofen, B., Jacob, R., Serth, K., Gossler, A., Naim, H.Y., Leeb, T. (2002) Cloning and characterization of the mammalian specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein.

European Journal of Biochemistry 269, 5240-5245

 

Jacob, R., Pürschel, B., Naim, H.Y. (2002) Sucrase is an intramolecular chaperone located at the C-terminal end of the sucrase-isomaltase enzyme complex.

The Journal of Biological Chemistry 277, 32141-32148

 

Reinshagen, K., Naim, H., Zimmer, K.P. (2002) Autophagocytosis of the apical membrane in microvillus inclusion disease.

Gut 51, 514-521.

 

Jacob, R., Peters, K., Naim, H.Y. (2002) The pro-sequence of human intestinal lactase-phlorizin hydrolase modulates the folding of the mature enzyme.

The Journal of Biological Chemistry 277, 8217-8225

 

Alfalah, M., Jacob, R., Naim, H.Y. (2001) Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-linked glycans as well as association with lipid micordomains.

The Journal of Biological Chemistry 277, 10683-10690

 

Spodsberg, N., Alfalah, M., Naim, H.Y. (2001). Characteristics and structural requirements of apical sorting of the rat growth hormone through the O-glycosylated stalk region of intestinal sucrase-isomaltase.

The Journal of Biological Chemistry  276, 46597-46604

 

Spodsberg, N., Jacob, R., Zimmer, K.-P., Naim, H.Y. (2001). Molecular basis of aberrant apical protein transport in an intestinal enzyme disorder.

The Journal of Biological Chemistry 276, 23506-23510

 

Jacob, R., Naim, H.Y. (2001). Apical membrane proteins are transported in distinct vesicular carriers.

Current  Biology 11, 1444-1450

 

Alfalah, M., Parkin, E.T., Jacob, R., Sturrock, E.D., Mentele, R., Turner, A.J.,  Hooper, N.M., Naim, H.Y. (2001). A point mutation in the juxtamembrane stalk of human angiotensin converting enzyme invokes the action of a distinct secretase.

The Journal of Biological Chemistry  276, 21105-21109

 

Jacob, R., Zimmer, K.-P., Schmitz, J., Naim, H.Y. (2000). Congenital sucrase-isomaltase deficiency arising from cleavage and secretion of a mutant form of the enzyme.

The Journal of Clinical Investigation 106, 281-287.

 

Jacob, R., Weiner, J., Stadge, S., Naim, H.Y. (2000). Additional N-glycosylation sites and their impact on the folding of intestinal lactase-phlorizin hydrolase.

The Journal of Biological Chemistry 275, 10630-10637

 

Jacob, R., Alfalah, M., Grünberg, J., Obendorf, M., Naim, H.Y. (2000). Structural determinants required for apical sorting of an apical brush-border membrane protein.

The Journal of Biological Chemistry 275, 6566-6572

 

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